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Volumn 82, Issue 3, 1998, Pages 386-395

Molecular determinants of dofetilide block of HERG K+ channels

Author keywords

Antiarrhythmic drug; Bovine ether a go go channel; Dofetilide; Human ether a go go related gene; K+ channel

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 1' (6 CYANO 1,2,3,4 TETRAHYDRO 2 NAPHTHYL) 3,4 DIHYDRO 6 METHANESULFONAMIDOSPIRO[2H 1 BENZOPYRAN 2,4' PIPERIDIN] 4 OL; DOFETILIDE; POTASSIUM CHANNEL;

EID: 0032559552     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.82.3.386     Document Type: Article
Times cited : (276)

References (29)
  • 2
    • 0030025308 scopus 로고    scopus 로고
    • The inward rectification mechanism of the HERG cardiac potassium channel
    • Smith PL, Baukrowitz T, Yellen G. The inward rectification mechanism of the HERG cardiac potassium channel. Nature. 1996;379:833-836.
    • (1996) Nature , vol.379 , pp. 833-836
    • Smith, P.L.1    Baukrowitz, T.2    Yellen, G.3
  • 3
    • 0030054878 scopus 로고    scopus 로고
    • Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel
    • Schönherr R, Heinemann SH. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. J Physiol (Lond). 1996;493:635-642.
    • (1996) J Physiol (Lond) , vol.493 , pp. 635-642
    • Schönherr, R.1    Heinemann, S.H.2
  • 5
    • 0030199529 scopus 로고    scopus 로고
    • Time, voltage and ionic concentration dependence of rectification of h-erg expressed in Xenopus oocytes
    • Wang S, Morales MJ, Liu S, Strauss HC, Rasmusson RL. Time, voltage and ionic concentration dependence of rectification of h-erg expressed in Xenopus oocytes. FEBS Lett. 1996;389:167-173.
    • (1996) FEBS Lett , vol.389 , pp. 167-173
    • Wang, S.1    Morales, M.J.2    Liu, S.3    Strauss, H.C.4    Rasmusson, R.L.5
  • 7
    • 0026640423 scopus 로고
    • + current in cardiac myocytes by dofetilide
    • + current in cardiac myocytes by dofetilide. J Pharmacol Exp Ther. 1992;262: 809-817.
    • (1992) J Pharmacol Exp Ther , vol.262 , pp. 809-817
    • Carmeliet, E.1
  • 10
    • 0029007356 scopus 로고
    • HERG, a human inward rectifier in the voltage-gated potassium channel family
    • Trudeau MC, Warmke JW, Ganetzky B, Robertson GA. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science. 1995;269:92-95.
    • (1995) Science , vol.269 , pp. 92-95
    • Trudeau, M.C.1    Warmke, J.W.2    Ganetzky, B.3    Robertson, G.A.4
  • 11
    • 0029942250 scopus 로고    scopus 로고
    • High affinity open channel block by dofetilide of HERG expressed in a human cell line
    • Snyders DJ, Chaudhary A. High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol. 1996;49:949-955.
    • (1996) Mol Pharmacol , vol.49 , pp. 949-955
    • Snyders, D.J.1    Chaudhary, A.2
  • 16
    • 0028109116 scopus 로고
    • Functional expression of a rat homologue of the voltage gated ether a go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart
    • Ludwig J, Terlau H, Wunder F, Brüggemann A, Pardo LA, Marquardt A, Stühmer W, Pongs O. Functional expression of a rat homologue of the voltage gated ether a go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart. EMBO J. 1994;13:4451-4458.
    • (1994) EMBO J , vol.13 , pp. 4451-4458
    • Ludwig, J.1    Terlau, H.2    Wunder, F.3    Brüggemann, A.4    Pardo, L.A.5    Marquardt, A.6    Stühmer, W.7    Pongs, O.8
  • 18
    • 0028292927 scopus 로고
    • A family of potassium channel genes related to eag in Drosophila and mammals
    • Warmke JW, Ganetzky B. A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A. 1994;91:3438-3442.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3438-3442
    • Warmke, J.W.1    Ganetzky, B.2
  • 19
    • 0030859332 scopus 로고    scopus 로고
    • Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment
    • Terlau H, Heinemann SH, Stühmer W, Pongs O, Ludwig J. Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment. J Physiol (Lond). 1997;502:537-543.
    • (1997) J Physiol (Lond) , vol.502 , pp. 537-543
    • Terlau, H.1    Heinemann, S.H.2    Stühmer, W.3    Pongs, O.4    Ludwig, J.5
  • 20
    • 85036676878 scopus 로고    scopus 로고
    • Inward rectification in HERG mutants with reduced C-type inactivation
    • Abstract
    • Jarolimek W, Brown AM, Ficker E. Inward rectification in HERG mutants with reduced C-type inactivation. Pflugers Arch. 1997;434:R100. Abstract.
    • (1997) Pflugers Arch , vol.434
    • Jarolimek, W.1    Brown, A.M.2    Ficker, E.3
  • 22
    • 0028960949 scopus 로고
    • Silver as a probe of pore-forming residues in a potassium channel
    • Lü Q, Miller C. Silver as a probe of pore-forming residues in a potassium channel. Science. 1995;286:304-307.
    • (1995) Science , vol.286 , pp. 304-307
    • Lü, Q.1    Miller, C.2
  • 23
    • 0030819954 scopus 로고    scopus 로고
    • A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes
    • Wing S, Liu S, Morales MJ, Strauss HC, Rasmusson RL. A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. J Physiol (Lond). 1997;502:45-60.
    • (1997) J Physiol (Lond) , vol.502 , pp. 45-60
    • Wing, S.1    Liu, S.2    Morales, M.J.3    Strauss, H.C.4    Rasmusson, R.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.