Class III Antiarrhythmic Drugs Block HERG, a Human Cardiac Delayed Rectifier K+ Channel Open-Channel Block by Methanesulfonanilides

Circulation Research

Volumn 78, Issue 3, 1996, Pages 499-503

  Spector, Peter S ^a   Curran, Mark E ^a   Keating, Mark T ^a   Sanguinetti, Michael C ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

Class III antiarrhythmic drug; HERG; K+ current; Xenopus oocytes

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 1' (6 CYANO 1,2,3,4 TETRAHYDRO 2 NAPHTHYL) 3,4 DIHYDRO 6 METHANESULFONAMIDOSPIRO[2H 1 BENZOPYRAN 2,4' PIPERIDIN] 4 OL; ANTIARRHYTHMIC AGENT; MEMBRANE PROTEIN; MESYLIC ACID DERIVATIVE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN HERG; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; HEART MUSCLE CELL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; VOLTAGE CLAMP; XENOPUS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BENZOPYRANS; CATION TRANSPORT PROTEINS; CELLS, CULTURED; DNA-BINDING PROTEINS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; PATCH-CLAMP TECHNIQUES; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PYRIDINES; TRANS-ACTIVATORS; XENOPUS;

EID: 0030058762     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.78.3.499     Document Type: Article

References (13)

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