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Volumn 39, Issue 2, 2011, Pages 466-471

The tuberous sclerosis complex: Balancing proliferation and survival

Author keywords

Cell growth; Mammalian target of rapamycin (mTOR); Metabolism; Proliferation; Survival; Tuberous sclerosis

Indexed keywords

HAMARTIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; TUBERIN;

EID: 79953172971     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0390466     Document Type: Review
Times cited : (42)

References (50)
  • 1
    • 77949882117 scopus 로고    scopus 로고
    • The tuberous sclerosis complex
    • Orlova, K.A. and Crino, P.B. (2010) The tuberous sclerosis complex. Ann. N.Y. Acad. Sci. 1184, 87-105
    • (2010) Ann. N.Y. Acad. Sci. , vol.1184 , pp. 87-105
    • Orlova, K.A.1    Crino, P.B.2
  • 3
    • 17844369428 scopus 로고    scopus 로고
    • The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
    • DOI 10.1038/sj.onc.1204009
    • Benvenuto, G., Li, S., Brown, S.J., Braverman, R., Vass, W.C., Cheadle, J.P., Halley, D.J., Sampson, J.R., Wienecke, R. and DeClue, J.E. (2000) The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19, 6306-6316 (Pubitemid 32641844)
    • (2000) Oncogene , vol.19 , Issue.54 , pp. 6306-6316
    • Benvenuto, G.1    Li, S.2    Brown, S.J.3    Braverman, R.4    Vass, W.C.5    Cheadle, J.P.6    Halley, D.J.J.7    Sampson, J.R.8    Wienecke, R.9    DeClue, J.E.10
  • 4
    • 33646854721 scopus 로고    scopus 로고
    • TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase
    • Chong-Kopera, H., Inoki, K., Li, Y., Zhu, T., Garcia-Gonzalo, F.R., Rosa, J.L. and Guan, K.L. (2006) TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J. Biol. Chem. 281, 8313-8316
    • (2006) J. Biol. Chem. , vol.281 , pp. 8313-8316
    • Chong-Kopera, H.1    Inoki, K.2    Li, Y.3    Zhu, T.4    Garcia-Gonzalo, F.R.5    Rosa, J.L.6    Guan, K.L.7
  • 6
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
    • DOI 10.1016/S1097-2765(02)00568-3
    • Manning, B.D., Tee, A.R., Logsdon, M.N., Blenis, J. and Cantley, L.C. (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway. Mol. Cell 10, 151-162 (Pubitemid 34876569)
    • (2002) Molecular Cell , vol.10 , Issue.1 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 8
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
    • DOI 10.1016/j.cell.2005.02.031
    • Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P. and Pandolfi, P.P. (2005) Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121, 179-193 (Pubitemid 40546387)
    • (2005) Cell , vol.121 , Issue.2 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 9
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter, C.J., Pedraza, L.G. and Xu, T. (2002) Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4, 658-665
    • (2002) Nat. Cell Biol. , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 10
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • Tee, A.R., Manning, B.D., Roux, P.P., Cantley, L.C. and Blenis, J. (2003) Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13, 1259-1268
    • (2003) Curr. Biol. , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 12
    • 36049043184 scopus 로고    scopus 로고
    • Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38
    • DOI 10.1126/science.1147379
    • Bai, X., Ma, D., Liu, A., Shen, X., Wang, Q.J., Liu, Y. and Jiang, Y. (2007) Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science 318, 977-980 (Pubitemid 350098994)
    • (2007) Science , vol.318 , Issue.5852 , pp. 977-980
    • Bai, X.1    Ma, D.2    Liu, A.3    Shen, X.4    Wang, Q.J.5    Liu, Y.6    Jiang, Y.7
  • 13
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • DOI 10.1101/gad.1110003
    • Inoki, K., Li, Y., Xu, T. and Guan, K.L. (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17, 1829-1834 (Pubitemid 36944560)
    • (2003) Genes and Development , vol.17 , Issue.15 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.-L.4
  • 14
    • 44949215822 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
    • Huang, J., Dibble, C.C., Matsuzaki, M. and Manning, B.D. (2008) The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol. Cell. Biol. 28, 4104-4115
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 4104-4115
    • Huang, J.1    Dibble, C.C.2    Matsuzaki, M.3    Manning, B.D.4
  • 15
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov, D.D., Ali, S.M., Kim, D.H., Guertin, D.A., Latek, R.R., Erdjument-Bromage, H., Tempst, P. and Sabatini, D.M. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302
    • (2004) Curr. Biol. , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 16
    • 0037458733 scopus 로고    scopus 로고
    • The tuberin-hamartin complex negatively regulates β-catenin signaling activity
    • Mak, B.C., Takemaru, K., Kenerson, H.L., Moon, R.T. and Yeung, R.S. (2003) The tuberin-hamartin complex negatively regulates β-catenin signaling activity. J. Biol. Chem. 278, 5947-5951
    • (2003) J. Biol. Chem. , vol.278 , pp. 5947-5951
    • Mak, B.C.1    Takemaru, K.2    Kenerson, H.L.3    Moon, R.T.4    Yeung, R.S.5
  • 17
    • 0036192093 scopus 로고    scopus 로고
    • Retention of membrane-localized β-catenin in cells lacking functional polycystin-1 and tuberin
    • Kugoh, H., Kleymenova, E. and Walker, C.L. (2002) Retention of membrane-localized β-catenin in cells lacking functional polycystin-1 and tuberin. Mol. Carcinog. 33, 131-136
    • (2002) Mol. Carcinog. , vol.33 , pp. 131-136
    • Kugoh, H.1    Kleymenova, E.2    Walker, C.L.3
  • 18
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, β-catenin, and cadherin pathways
    • Nelson, W.J. and Nusse, R. (2004) Convergence of Wnt, β-catenin, and cadherin pathways. Science 303, 1483-1487
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 19
    • 0034778130 scopus 로고    scopus 로고
    • Neuropathology of tuberous sclerosis
    • DOI 10.1016/S0387-7604(01)00304-7, PII S0387760401003047
    • Mizuguchi, M. and Takashima, S. (2001) Neuropathology of tuberous sclerosis. Brain Dev. 23, 508-515 (Pubitemid 32999117)
    • (2001) Brain and Development , vol.23 , Issue.7 , pp. 508-515
    • Mizuguchi, M.1    Takashima, S.2
  • 21
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw, R.J. and Cantley, L.C. (2006) Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441, 424-430
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 22
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis, R.J., Lum, J.J., Hatzivassiliou, G. and Thompson, C.B. (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7, 11-20
    • (2008) Cell Metab. , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 23
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
    • DOI 10.1016/S0092-8674(03)00929-2
    • Inoki, K., Zhu, T. and Guan, K.L. (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590 (Pubitemid 37506046)
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.-L.3
  • 24
    • 77952562382 scopus 로고    scopus 로고
    • Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
    • Choo, A.Y., Kim, S.G., Vander Heiden, M.G., Mahoney, S.J., Vu, H., Yoon, S.O., Cantley, L.C. and Blenis, J. (2010) Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol. Cell 38, 487-499
    • (2010) Mol. Cell , vol.38 , pp. 487-499
    • Choo, A.Y.1    Kim, S.G.2    Vander Heiden, M.G.3    Mahoney, S.J.4    Vu, H.5    Yoon, S.O.6    Cantley, L.C.7    Blenis, J.8
  • 25
    • 0030663735 scopus 로고    scopus 로고
    • Role of the tuberous sclerosis gene-2 product in cell cycle control: Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase
    • Soucek, T., Pusch, O., Wienecke, R., DeClue, J.E. and Hengstschlager, M. (1997) Role of the tuberous sclerosis gene-2 product in cell cycle control: loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase. J. Biol. Chem. 272, 29301-29308
    • (1997) J. Biol. Chem. , vol.272 , pp. 29301-29308
    • Soucek, T.1    Pusch, O.2    Wienecke, R.3    DeClue, J.E.4    Hengstschlager, M.5
  • 26
    • 0032430241 scopus 로고    scopus 로고
    • Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2
    • Soucek, T., Yeung, R.S. and Hengstschlager, M. (1998) Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Proc. Natl. Acad. Sci. U.S.A. 95, 15653-15658
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 15653-15658
    • Soucek, T.1    Yeung, R.S.2    Hengstschlager, M.3
  • 27
    • 0033582748 scopus 로고    scopus 로고
    • Gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
    • Ito, N. and Rubin, G.M. (1999) gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 96, 529-539 (Pubitemid 29106840)
    • (1999) Cell , vol.96 , Issue.4 , pp. 529-539
    • Ito, N.1    Rubin, G.M.2
  • 28
    • 0030044323 scopus 로고    scopus 로고
    • Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells
    • Orimoto, K., Tsuchiya, H., Kobayashi, T., Matsuda, T. and Hino, O. (1996) Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells. Biochem. Biophys. Res. Commun. 219, 70-75
    • (1996) Biochem. Biophys. Res. Commun. , vol.219 , pp. 70-75
    • Orimoto, K.1    Tsuchiya, H.2    Kobayashi, T.3    Matsuda, T.4    Hino, O.5
  • 29
    • 0029814436 scopus 로고    scopus 로고
    • Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region
    • Jin, F., Wienecke, R., Xiao, G.H., Maize, Jr, J.C., DeClue, J.E. and Yeung, R.S. (1996) Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region. Proc. Natl. Acad. Sci. U.S.A. 93, 9154-9159
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 9154-9159
    • Jin, F.1    Wienecke, R.2    Xiao, G.H.3    Maize Jr., J.C.4    DeClue, J.E.5    Yeung, R.S.6
  • 30
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K.L. and Zheng, P. (2008) TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 205, 2397-2408
    • (2008) J. Exp. Med. , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Zheng, P.6
  • 32
    • 0141733228 scopus 로고    scopus 로고
    • Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin
    • Tee, A.R., Anjum, R. and Blenis, J. (2003) Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. J. Biol. Chem. 278, 37288-37296
    • (2003) J. Biol. Chem. , vol.278 , pp. 37288-37296
    • Tee, A.R.1    Anjum, R.2    Blenis, J.3
  • 33
    • 77957353301 scopus 로고    scopus 로고
    • Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival
    • Hsieh, T.C., Nicolay, B.N., Frolov, M.V. and Moon, N.S. (2010) Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival. PLoS Genet. 6, e1001071
    • (2010) PLoS Genet. , vol.6
    • Hsieh, T.C.1    Nicolay, B.N.2    Frolov, M.V.3    Moon, N.S.4
  • 34
    • 0029021621 scopus 로고
    • Identification of tuberin, the tuberous sclerosis-2 product: Tuberin possesses specific Rap1GAP activity
    • Wienecke, R., Konig, A. and DeClue, J.E. (1995) Identification of tuberin, the tuberous sclerosis-2 product: tuberin possesses specific Rap1GAP activity. J. Biol. Chem. 270, 16409-16414
    • (1995) J. Biol. Chem. , vol.270 , pp. 16409-16414
    • Wienecke, R.1    Konig, A.2    DeClue, J.E.3
  • 35
    • 0026656537 scopus 로고
    • Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes
    • Yoshida, Y., Kawata, M., Miura, Y., Musha, T., Sasaki, T., Kikuchi, A. and Takai, Y. (1992) Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes. Mol. Cell. Biol. 12, 3407-3414
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 3407-3414
    • Yoshida, Y.1    Kawata, M.2    Miura, Y.3    Musha, T.4    Sasaki, T.5    Kikuchi, A.6    Takai, Y.7
  • 39
    • 37049024761 scopus 로고    scopus 로고
    • C-myc repression of TSC2 contributes to control of translation initiation and myc-induced transformation
    • DOI 10.1158/0008-5472.CAN-06-4351
    • Ravitz, M.J., Chen, L., Lynch, M. and Schmidt, E.V. (2007) c-Myc repression of TSC2 contributes to control of translation initiation and Myc-induced transformation. Cancer Res. 67, 11209-11217 (Pubitemid 350248546)
    • (2007) Cancer Research , vol.67 , Issue.23 , pp. 11209-11217
    • Ravitz, M.J.1    Chen, L.2    Lynch, M.3    Schmidt, E.V.4
  • 40
    • 65949122722 scopus 로고    scopus 로고
    • Growth controls connect: Interactions between c-myc and the tuberous sclerosis complex-mTOR pathway
    • Schmidt, E.V., Ravitz, M.J., Chen, L. and Lynch, M. (2009) Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway. Cell Cycle 8, 1344-1351
    • (2009) Cell Cycle , vol.8 , pp. 1344-1351
    • Schmidt, E.V.1    Ravitz, M.J.2    Chen, L.3    Lynch, M.4
  • 41
    • 54049120956 scopus 로고    scopus 로고
    • E2F: At the crossroads of life and death
    • Polager, S. and Ginsberg, D. (2008) E2F: at the crossroads of life and death. Trends Cell Biol. 18, 528-535
    • (2008) Trends Cell Biol. , vol.18 , pp. 528-535
    • Polager, S.1    Ginsberg, D.2
  • 42
    • 65949106140 scopus 로고    scopus 로고
    • Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner
    • Di Nardo, A., Kramvis, I., Cho, N., Sadowski, A., Meikle, L., Kwiatkowski, D.J. and Sahin, M. (2009) Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. J. Neurosci. 29, 5926-5937
    • (2009) J. Neurosci. , vol.29 , pp. 5926-5937
    • Di Nardo, A.1    Kramvis, I.2    Cho, N.3    Sadowski, A.4    Meikle, L.5    Kwiatkowski, D.J.6    Sahin, M.7
  • 43
    • 78650174233 scopus 로고    scopus 로고
    • The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis
    • Kang, Y.J., Lu, M.K. and Guan, K.L. (2011) The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. Cell Death Differ. 18, 133-144
    • (2011) Cell Death Differ. , vol.18 , pp. 133-144
    • Kang, Y.J.1    Lu, M.K.2    Guan, K.L.3
  • 44
    • 36549026878 scopus 로고    scopus 로고
    • Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
    • DOI 10.1038/sj.emboj.7601900, PII 7601900
    • Lee, C.H., Inoki, K., Karbowniczek, M., Petroulakis, E., Sonenberg, N., Henske, E.P. and Guan, K.L. (2007) Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J. 26, 4812-4823 (Pubitemid 350191300)
    • (2007) EMBO Journal , vol.26 , Issue.23 , pp. 4812-4823
    • Lee, C.-H.1    Inoki, K.2    Karbowniczek, M.3    Petroulakis, E.4    Sonenberg, N.5    Henske, E.P.6    Guan, K.-L.7
  • 45
    • 58649084625 scopus 로고    scopus 로고
    • Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling
    • Stevens, C., Lin, Y., Harrison, B., Burch, L., Ridgway, R.A., Sansom, O. and Hupp, T. (2009) Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling. J. Biol. Chem. 284, 334-344
    • (2009) J. Biol. Chem. , vol.284 , pp. 334-344
    • Stevens, C.1    Lin, Y.2    Harrison, B.3    Burch, L.4    Ridgway, R.A.5    Sansom, O.6    Hupp, T.7
  • 46
    • 33846015072 scopus 로고    scopus 로고
    • Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway
    • Cao, Y., Kamioka, Y., Yokoi, N., Kobayashi, T., Hino, O., Onodera, M., Mochizuki, N. and Nakae, J. (2006) Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway. J. Biol. Chem. 281, 40242-40251
    • (2006) J. Biol. Chem. , vol.281 , pp. 40242-40251
    • Cao, Y.1    Kamioka, Y.2    Yokoi, N.3    Kobayashi, T.4    Hino, O.5    Onodera, M.6    Mochizuki, N.7    Nakae, J.8
  • 48
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • Shah, O.J., Wang, Z. and Hunter, T. (2004) Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14, 1650-1656
    • (2004) Curr. Biol. , vol.14 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3


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