-
1
-
-
0036655059
-
Medulloblastoma: A problem of developmental biology
-
Rubin JB, Rowitch DH. Medulloblastoma: a problem of developmental biology. Cancer Cell 2002; 2: 7-8.
-
(2002)
Cancer Cell
, vol.2
, pp. 7-8
-
-
Rubin, J.B.1
Rowitch, D.H.2
-
2
-
-
33645211987
-
Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes
-
Knoepfler PS, Kenney AM. Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes. Cell Cycle 2006;5:47-52.
-
(2006)
Cell Cycle
, vol.5
, pp. 47-52
-
-
Knoepfler, P.S.1
Kenney, A.M.2
-
3
-
-
0037309324
-
Sonic hedgehog in normal and neoplastic proliferation: Insight gained from human tumors and animal models
-
DOI 10.1016/S0959-437X(03)00002-9
-
Wetmore C. Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models. Curr Opin Genet Dev 2003;13:34-42. (Pubitemid 36143925)
-
(2003)
Current Opinion in Genetics and Development
, vol.13
, Issue.1
, pp. 34-42
-
-
Wetmore, C.1
-
4
-
-
0030913169
-
Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched
-
Pietsch T, Waha A, Koch A, et al. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res 1997;57:2085-2088 (Pubitemid 27247016)
-
(1997)
Cancer Research
, vol.57
, Issue.11
, pp. 2085-2088
-
-
Pietsch, T.1
Waha, A.2
Koch, A.3
Kraus, J.4
Albrecht, S.5
Tonn, J.6
Sorensen, N.7
Berthold, F.8
Henk, B.9
Schmandt, N.10
Wolf, H.K.11
Von Deimling, A.12
Wainwright, B.13
Chenevix-Trench, G.14
Wiestler, O.D.15
Wicking, C.16
-
5
-
-
0031036694
-
Sporadic medulloblastomas contain PTCH mutations
-
Raffel C, Jenkins RB, Frederick L, et al. Sporadic medulloblastomas contain PTCH mutations. Cancer Res 1997;57:842-845 (Pubitemid 27098006)
-
(1997)
Cancer Research
, vol.57
, Issue.5
, pp. 842-845
-
-
Raffel, C.1
Jenkins, R.B.2
Frederick, L.3
Hebrink, D.4
Alderete, B.5
Fults, D.W.6
David James, C.7
-
6
-
-
0035963298
-
Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas
-
DOI 10.1038/sj.onc.1204532
-
Wang JY, Del Valle L, Gordon J, et al. Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas. Oncogene 2001;20:3857-3868 (Pubitemid 32646196)
-
(2001)
Oncogene
, vol.20
, Issue.29
, pp. 3857-3868
-
-
Wang, J.Y.1
Del Valle, L.2
Gordon, J.3
Rubini, M.4
Romano, G.5
Croul, S.6
Peruzzi, F.7
Khalili, K.8
Reiss, K.9
-
7
-
-
20244370527
-
Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells
-
Hartmann W, Koch A, Brune H, et al. Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells. Am J Pathol 2005;166:1153-1162 (Pubitemid 40524439)
-
(2005)
American Journal of Pathology
, vol.166
, Issue.4
, pp. 1153-1162
-
-
Hartmann, W.1
Koch, A.2
Brune, H.3
Waha, A.4
Schuller, U.5
Dani, I.6
Denkhaus, D.7
Langmann, W.8
Bode, U.9
Wiestler, O.D.10
Schilling, K.11
Pietsch, T.12
-
8
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
DOI 10.1038/ng1494
-
Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005;37:19-24. (Pubitemid 40070934)
-
(2005)
Nature Genetics
, vol.37
, Issue.1
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.-L.3
-
9
-
-
0242361321
-
PDGFRB is overexpressed in metastatic medulloblastoma
-
Gilbertson RJ, Clifford SC. PDGFRB is overexpressed in metastatic medulloblastoma. Nat Genet 2003;35:197-198
-
(2003)
Nat Genet
, vol.35
, pp. 197-198
-
-
Gilbertson, R.J.1
Clifford, S.C.2
-
10
-
-
0030663735
-
Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase
-
DOI 10.1074/jbc.272.46.29301
-
Soucek T, Pusch O, Wienecke R, DeClue JE, Hengstschlager M. Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase. J Biol Chem 1997;272:29301-29308 (Pubitemid 27498223)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.46
, pp. 29301-29308
-
-
Soucek, T.1
Pusch, O.2
Wienecke, R.3
Declue, J.E.4
Hengstschlager, M.5
-
11
-
-
0035833356
-
Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression
-
DOI 10.1038/sj.onc.1204627
-
Soucek T, Rosner M, Miloloza A, et al. Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression. Oncogene 2001;20:4904-4909 (Pubitemid 32803162)
-
(2001)
Oncogene
, vol.20
, Issue.35
, pp. 4904-4909
-
-
Soucek, T.1
Rosner, M.2
Miloloza, A.3
Kubista, M.4
Cheadle, J.P.5
Sampson, J.R.6
Hengstschlager, M.7
-
12
-
-
10344243550
-
Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2
-
DOI 10.1074/jbc.M405528200
-
Rosner M, Hengstschlager M. Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2. J Biol Chem 2004;279:48707-48715 (Pubitemid 39625747)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.47
, pp. 48707-48715
-
-
Rosner, M.1
Hengstschlager, M.2
-
13
-
-
34447318622
-
Kip1 localization depends on the tumor suppressor protein tuberin
-
DOI 10.1093/hmg/ddm103
-
Rosner M, Freilinger A, Hanneder M, et al. p27Kip1 localization depends on the tumor suppressor protein tuberin. Hum Mol Genet 2007;16:1541-1556 (Pubitemid 47050668)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.13
, pp. 1541-1556
-
-
Rosner, M.1
Freilinger, A.2
Hanneder, M.3
Fujita, N.4
Lubec, G.5
Tsuruo, T.6
Hengstschager, M.7
-
14
-
-
0034255133
-
A role for p27/Kip1 in the control of cerebellar granule cell precursor proliferation
-
Miyazawa K, Himi T, Garcia V, Yamagishi H, Sato S, Ishizaki Y. A role for p27/Kip1 in the control of cerebellar granule cell precursor proliferation. J Neurosci 2000;20:5756-5763 (Pubitemid 30636904)
-
(2000)
Journal of Neuroscience
, vol.20
, Issue.15
, pp. 5756-5763
-
-
Miyazawa, K.1
Himi, T.2
Garcia, V.3
Yamagishi, H.4
Sato, S.5
Ishizaki, Y.6
-
15
-
-
0033966694
-
Immunohistochemical examination of the INK4 and Cip inhibitors in the rat neonatal cerebellum: Cellular localization and the impact of protein calorie malnutrition
-
Shambaugh GE 3rd, Haines GK 3rd, Koch A, Lee EJ, Zhou J, Pestell R. Immunohistochemical examination of the INK4 and Cip inhibitors in the rat neonatal cerebellum: cellular localization and the impact of protein calorie malnutrition. Brain Res 2000;855:11-22.
-
(2000)
Brain Res
, vol.855
, pp. 11-22
-
-
Shambaugh III, G.E.1
Haines III, G.K.2
Koch, A.3
Lee, E.J.4
Zhou, J.5
Pestell, R.6
-
16
-
-
58649120079
-
Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma
-
Ayrault O, Zindy F, Rehg J, Sherr CJ, Roussel MF. Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma. Mol Cancer Res 2009;7:33-40.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 33-40
-
-
Ayrault, O.1
Zindy, F.2
Rehg, J.3
Sherr, C.J.4
Roussel, M.F.5
-
17
-
-
33746847816
-
Kip1 coordinately regulate cerebellar development
-
DOI 10.1073/pnas.0604727103
-
Zindy F, Knoepfler PS, Xie S, Sherr CJ, Eisenman RN, Roussel MF. N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development. Proc Natl Acad Sci U S A 2006;103:11579-11583 (Pubitemid 44182494)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.31
, pp. 11579-11583
-
-
Zindy, F.1
Knoepfler, P.S.2
Xie, S.3
Sherr, C.J.4
Eisenman, R.N.5
Roussel, M.F.6
-
18
-
-
0037108268
-
N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation
-
Knoepfler PS, Cheng PF, Eisenman RN. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev 2002;16:2699-2712
-
(2002)
Genes Dev
, vol.16
, pp. 2699-2712
-
-
Knoepfler, P.S.1
Cheng, P.F.2
Eisenman, R.N.3
-
19
-
-
0032533225
-
Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
-
Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998;12:3499-3511 (Pubitemid 28553242)
-
(1998)
Genes and Development
, vol.12
, Issue.22
, pp. 3499-3511
-
-
Diehl, J.A.1
Cheng, M.2
Roussel, M.F.3
Sherr, C.J.4
-
20
-
-
20044370087
-
Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain
-
DOI 10.1074/jbc.M411768200
-
Govindarajan B, Brat DJ, Csete M, et al. Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain. J Biol Chem 2005;280:5870-5874 (Pubitemid 40280069)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.7
, pp. 5870-5874
-
-
Govindarajan, B.1
Brat, D.J.2
Csete, M.3
Martin, W.D.4
Murad, E.5
Litani, K.6
Cohen, C.7
Cerimele, F.8
Nunnelley, M.9
Lefkove, B.10
Yamamoto, T.11
Lee, C.12
Arbiser, J.L.13
-
21
-
-
1642474000
-
Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors
-
Kenney AM, Widlund HR, Rowitch DH. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development 2004;131:217-228
-
(2004)
Development
, vol.131
, pp. 217-228
-
-
Kenney, A.M.1
Widlund, H.R.2
Rowitch, D.H.3
-
22
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
Kwiatkowski DJ, Zhang H, Bandura JL, et al. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 2002;11:525-534 (Pubitemid 34257489)
-
(2002)
Human Molecular Genetics
, vol.11
, Issue.5
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
El-Hashemite, N.6
Onda, H.7
-
23
-
-
27744450224
-
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
-
DOI 10.1101/gad.1368605
-
Uziel T, Zindy F, Xie S, et al. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev 2005;19:2656-2667 (Pubitemid 41627933)
-
(2005)
Genes and Development
, vol.19
, Issue.22
, pp. 2656-2667
-
-
Uziel, T.1
Zindy, F.2
Xie, S.3
Lee, Y.4
Forget, A.5
Magdaleno, S.6
Rehg, J.E.7
Calabrese, C.8
Solecki, D.9
Eberhart, C.G.10
Sherr, S.E.11
Plimmer, S.12
Clifford, S.C.13
Hatten, M.E.14
McKinnon, P.J.15
Gilbertson, R.J.16
Curran, T.17
Sherr, C.J.18
Roussel, M.F.19
-
24
-
-
33744941593
-
Lack of Rb and p53 delays cerebellar development and predisposes to large cell anaplastic medulloblastoma through amplification of N-Myc and Ptch2
-
DOI 10.1158/0008-5472.CAN-05-3545
-
Shakhova O, Leung C, van Montfort E, Berns A, Marino S. Lack of Rb and p53 delays cerebellar development and predisposes to large cell anaplastic medulloblastoma through amplification of N-Myc and Ptch2. Cancer Res 2006;66:5190-5200 (Pubitemid 43844942)
-
(2006)
Cancer Research
, vol.66
, Issue.10
, pp. 5190-5200
-
-
Shakhova, O.1
Leung, C.2
Van Montfort, E.3
Berns, A.4
Marino, S.5
-
25
-
-
34447544650
-
Kip1 that causes stem cell expansion and a multiple tumor phenotype
-
DOI 10.1101/gad.1556607
-
Besson A, Hwang HC, Cicero S, et al. Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev 2007;21:1731-1746 (Pubitemid 47076473)
-
(2007)
Genes and Development
, vol.21
, Issue.14
, pp. 1731-1746
-
-
Besson, A.1
Hwang, H.C.2
Cicero, S.3
Donovan, S.L.4
Gurian-West, M.5
Johnson, D.6
Clurman, B.E.7
Dyer, M.A.8
Roberts, J.M.9
-
26
-
-
29944440513
-
Kip1 stability, subcellular localization, and tumor suppression
-
DOI 10.1101/gad.1384406
-
Besson A, Gurian-West M, Chen X, Kelly-Spratt KS, Kemp CJ, Roberts JM. A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev 2006;20:47-64. (Pubitemid 43042667)
-
(2006)
Genes and Development
, vol.20
, Issue.1
, pp. 47-64
-
-
Besson, A.1
Gurian-West, M.2
Chen, X.3
Kelly-Spratt, K.S.4
Kemp, C.J.5
Roberts, J.M.6
-
27
-
-
34447509981
-
Duality of p27Kip1 function in tumorigenesis
-
Sicinski P, Zacharek S, Kim C. Duality of p27Kip1 function in tumorigenesis. Genes Dev 2007;21:1703-1706
-
(2007)
Genes Dev
, vol.21
, pp. 1703-1706
-
-
Sicinski, P.1
Zacharek, S.2
Kim, C.3
-
28
-
-
0037115603
-
Development of mice expressing a single D-type cyclin
-
DOI 10.1101/gad.1023602
-
Ciemerych MA, Kenney AM, Sicinska E, et al. Development of mice expressing a single D-type cyclin. Genes Dev 2002;16:3277-3289 (Pubitemid 36025979)
-
(2002)
Genes and Development
, vol.16
, Issue.24
, pp. 3277-3289
-
-
Ciemerych, M.A.1
Kenney, A.M.2
Sicinska, E.3
Kalaszczynska, I.4
Bronson, R.T.5
Rowitch, D.H.6
Gardner, H.7
Sicinski, P.8
-
29
-
-
0032796826
-
Sonic hedgehog regulates the growth and patterning of the cerebellum
-
Dahmane N, Ruiz i Altaba A. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 1999;126:3089-3100
-
(1999)
Development
, vol.126
, pp. 3089-3100
-
-
Dahmane, N.1
Ruiz I Altaba, A.2
-
30
-
-
0033594537
-
Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum
-
Wallace VA. Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum. Curr Biol 1999;9:445-448
-
(1999)
Curr Biol
, vol.9
, pp. 445-448
-
-
Wallace, V.A.1
-
31
-
-
0032959871
-
Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog
-
DOI 10.1016/S0896-6273(00)80682-0
-
Wechsler-Reya RJ, Scott MP. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 1999;22:103-114 (Pubitemid 29070097)
-
(1999)
Neuron
, vol.22
, Issue.1
, pp. 103-114
-
-
Wechsler-Reya, R.J.1
Scott, M.P.2
-
32
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
DOI 10.1126/science.275.5300.661
-
Dudek H, Datta SR, Franke TF, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (New York, NY) 1997;275:661-665 (Pubitemid 27061332)
-
(1997)
Science
, vol.275
, Issue.5300
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
33
-
-
0030938816
-
Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells
-
Miller TM, Tansey MG, Johnson EM, Jr., Creedon DJ. Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells. J Biol Chem 1997;272:9847-9853
-
(1997)
J Biol Chem
, vol.272
, pp. 9847-9853
-
-
Miller, T.M.1
Tansey, M.G.2
Johnson Jr., E.M.3
Creedon, D.J.4
-
34
-
-
0035803593
-
P27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
-
DOI 10.1093/emboj/20.23.6672
-
Rodier G, Montagnoli A, Di Marcotullio L, et al. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J 2001;20:6672-6682 (Pubitemid 33134197)
-
(2001)
EMBO Journal
, vol.20
, Issue.23
, pp. 6672-6682
-
-
Rodier, G.1
Montagnoli, A.2
Di Marcotullio, L.3
Coulombe, P.4
Draetta, G.F.5
Pagano, M.6
Meloche, S.7
-
35
-
-
0037177386
-
Kip1 on serine 10 is required for its binding to CRM1 and nuclear export
-
DOI 10.1074/jbc.C100762200
-
Ishida N, Hara T, Kamura T, Yoshida M, Nakayama K, Nakayama KI. Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem 2002;277:14355-14358 (Pubitemid 34952496)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.17
, pp. 14355-14358
-
-
Ishida, N.1
Hara, T.2
Kamura, T.3
Yoshida, M.4
Nakayama, K.5
Nakayama, K.I.6
-
36
-
-
44949201143
-
MTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation
-
DOI 10.1016/j.molcel.2008.04.027, PII S1097276508003377
-
Hong F, Larrea MD, Doughty C, Kwiatkowski DJ, Squillace R, Slingerland JM. mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell 2008;30:701-711 (Pubitemid 351815130)
-
(2008)
Molecular Cell
, vol.30
, Issue.6
, pp. 701-711
-
-
Hong, F.1
Larrea, M.D.2
Doughty, C.3
Kwiatkowski, D.J.4
Squillace, R.5
Slingerland, J.M.6
-
37
-
-
7444228699
-
The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of Sonic Hedgehog-induced medulloblastomas
-
DOI 10.1158/0008-5472.CAN-04-1813
-
Hallahan AR, Pritchard JI, Hansen S, et al. The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res 2004;64:7794-7800 (Pubitemid 39446912)
-
(2004)
Cancer Research
, vol.64
, Issue.21
, pp. 7794-7800
-
-
Hallahan, A.R.1
Pritchard, J.I.2
Hansen, S.3
Benson, M.4
Stoeck, J.5
Hatton, B.A.6
Russell, T.L.7
Ellenbogen, R.G.8
Bernstein, I.D.9
Beachy, P.A.10
Olson, J.M.11
-
38
-
-
0037200078
-
Medulloblastoma growth inhibition by hedgehog pathway blockade
-
Berman DM, Karhadkar SS, Hallahan AR, et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002;297:1559-1561
-
(2002)
Science
, vol.297
, pp. 1559-1561
-
-
Berman, D.M.1
Karhadkar, S.S.2
Hallahan, A.R.3
-
39
-
-
33744788672
-
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
-
Corcoran RB, Scott MP. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc Natl Acad Sci U S A 2006;103:8408-8413
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 8408-8413
-
-
Corcoran, R.B.1
Scott, M.P.2
-
40
-
-
27844562649
-
Tuberous sclerosis complex: Linking growth and energy signaling pathways with human disease
-
DOI 10.1038/sj.onc.1209090, PII 1209090
-
Astrinidis A, Henske EP. Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene 2005;24:7475-7481 (Pubitemid 41637987)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7475-7481
-
-
Astrinidis, A.1
Henske, E.P.2
-
41
-
-
57349121020
-
Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion
-
5p following 9.
-
Michael LE, Westerman BA, Ermilov AN, et al. Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion. Neoplasia 2008;10:1343-1349, 5p following 9.
-
(2008)
Neoplasia
, vol.10
, pp. 1343-1349
-
-
Michael, L.E.1
Westerman, B.A.2
Ermilov, A.N.3
-
42
-
-
1642633053
-
Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
-
DOI 10.1038/nature02385
-
Leung C, Lingbeek M, Shakhova O, et al. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 2004;428:337-341 (Pubitemid 38418806)
-
(2004)
Nature
, vol.428
, Issue.6980
, pp. 337-341
-
-
Leung, C.1
Lingbeek, M.2
Shakhova, O.3
Liu, J.4
Tanger, E.5
Saremaslani, P.6
Van Lohuizen, M.7
Marino, S.8
-
43
-
-
33750040886
-
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt
-
DOI 10.1016/j.molcel.2006.09.019, PII S1097276506006678
-
Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell 2006;24:185-197 (Pubitemid 44574477)
-
(2006)
Molecular Cell
, vol.24
, Issue.2
, pp. 185-197
-
-
Zhang, H.H.1
Lipovsky, A.I.2
Dibble, C.C.3
Sahin, M.4
Manning, B.D.5
-
44
-
-
0141705466
-
Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin
-
El-Hashemite N, Walker V, Zhang H, Kwiatkowski DJ. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res 2003;63:5173-5177 (Pubitemid 37139823)
-
(2003)
Cancer Research
, vol.63
, Issue.17
, pp. 5173-5177
-
-
El-Hashemite, N.1
Walker, V.2
Zhang, H.3
Kwiatkowski, D.J.4
-
46
-
-
0034821472
-
Analysis of the TSC2 gene in human medulloblastoma
-
Przkora R, Meyer-Puttlitz B, Schmitt O, et al. Analysis of the TSC2 gene in human medulloblastoma. Acta Neuropathol 2001;102:380-384 (Pubitemid 32894709)
-
(2001)
Acta Neuropathologica
, vol.102
, Issue.4
, pp. 380-384
-
-
Przkora, R.1
Meyer-Puttlitz, B.2
Schmitt, O.3
Berthold, F.4
Nothen, M.5
Krauss, J.6
Tonn, J.C.7
Von Deimling, A.8
Wiestler, O.D.9
Pietsch, T.10
-
47
-
-
33646854721
-
TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase
-
DOI 10.1074/jbc.C500451200
-
Chong-Kopera H, Inoki K, Li Y, et al. TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem 2006;281:8313-8316 (Pubitemid 43847930)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.13
, pp. 8313-8316
-
-
Chong-Kopera, H.1
Inoki, K.2
Li, Y.3
Zhu, T.4
Garcia-Gonzalo, F.R.5
Rosa, J.L.6
Guan, K.-L.7
-
48
-
-
27744588780
-
Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways
-
Kwiatkowski DJ, Manning BD. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet 2005;14 Spec No. 2:R251-8.
-
(2005)
Hum Mol Genet
, vol.14
, Issue.SPEC NO. 2
-
-
Kwiatkowski, D.J.1
Manning, B.D.2
-
49
-
-
41149150219
-
The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy
-
Chu IM, Hengst L, Slingerland JM. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 2008;8:253-267
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 253-267
-
-
Chu, I.M.1
Hengst, L.2
Slingerland, J.M.3
-
50
-
-
0034092911
-
Regulation of the Cdk inhibitor p27 and its deregulation in cancer
-
DOI 10.1002/(SICI)1097-4652(200004)183:1<10::AID-JCP2>3.0.CO;2-I
-
Slingerland J, Pagano M. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 2000;183:10-17 (Pubitemid 30130220)
-
(2000)
Journal of Cellular Physiology
, vol.183
, Issue.1
, pp. 10-17
-
-
Slingerland, J.1
Pagano, M.2
-
51
-
-
20444468917
-
Targeting medulloblastoma: Small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics
-
DOI 10.1158/0008-5472.CAN-05-0481
-
Romer J, Curran T. Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics. Cancer Res 2005;65:4975-4978 (Pubitemid 40827300)
-
(2005)
Cancer Research
, vol.65
, Issue.12
, pp. 4975-4978
-
-
Romer, J.1
Curran, T.2
-
52
-
-
33749368571
-
The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
-
DOI 10.1186/1475-4924-1-9
-
Stecca B, Ruiz i Altaba A. The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway. J Biol 2002;1:9. (Pubitemid 44496923)
-
(2002)
Journal of Biology
, vol.1
, Issue.2
, pp. 9
-
-
Stecca, B.1
Ruiz I Altaba, A.2
-
53
-
-
40149091426
-
Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure
-
DOI 10.1016/j.ccr.2008.01.027, PII S1535610808000378
-
Kimura H, Ng JM, Curran T. Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell 2008;13:249-260 (Pubitemid 351324879)
-
(2008)
Cancer Cell
, vol.13
, Issue.3
, pp. 249-260
-
-
Kimura, H.1
Ng, J.M.Y.2
Curran, T.3
-
54
-
-
0032764126
-
The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor rapamycin
-
Louro ID, McKie-Bell P, Gosnell H, Brindley BC, Bucy RP, Ruppert JM. The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor rapamycin. Cell Growth Differ 1999;10:503-516 (Pubitemid 29344692)
-
(1999)
Cell Growth and Differentiation
, vol.10
, Issue.7
, pp. 503-516
-
-
Louro, I.D.1
McKie-Bell, P.2
Gosnell, H.3
Brindley, B.C.4
Bucy, R.P.5
Ruppert, J.M.6
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