Toxicity testing in the 21st century: A view from the chemical industry

Toxicological Sciences

Volumn 112, Issue 2, 2009, Pages 297-302

  Bus, James S ^a   Becker, Richard A ^b  

^a DOW CHEMICAL COMPANY   (United States)

^b AMERICAN CHEMISTRY COUNCIL   (United States)

Author keywords

Environmental chemicals; Human exposure; Toxicity testing

Indexed keywords

ENVIRONMENTAL CHEMICAL; INDUSTRIAL CHEMICAL; ORGANOPHOSPHATE; PESTICIDE;

CHEMICAL INDUSTRY; ECOTOXICITY; ENVIRONMENTAL EXPOSURE; GOVERNMENT REGULATION; HEALTH HAZARD; HIGH THROUGHPUT SCREENING; HISTORY; MANDATORY TESTING; NATIONAL HEALTH ORGANIZATION; NOTE; PROCESS TECHNOLOGY; PUBLIC HEALTH; RISK ASSESSMENT; TOXICITY TESTING; ARTICLE; HUMAN; LABORATORY DIAGNOSIS; OCCUPATIONAL EXPOSURE;

CHEMICAL INDUSTRY; FALSE NEGATIVE REACTIONS; FALSE POSITIVE REACTIONS; HISTORY, 21ST CENTURY; HUMANS; OCCUPATIONAL EXPOSURE; TOXICITY TESTS;

EID: 74949127956     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp234     Document Type: Note

References (23)

1. st century: bringing the vision to life. Toxicol. Sci. 107, 324-330.
2. Aylward, L. L., and Hays, S. M. (2009). Consideration of "dose" in evaluation of toxcast™ data: use of biomonitoring and pharmacokinetic data. Poster presented at: ToxCast( Data Analysis Summit; May 14, 2009; Available at: http://www.epa.gov/NCCT/toxcast/files/summit/43P%20Aylward%20and% 20Hays%20TDAS.pdf. Accessed August 15, 2009.
3. Becker, R. A., Plunkett, L. M., Borzelleca, J. F., and Kaplan, A. M. (2007). Tiered toxicity testing: evaluation of toxicity-based decision triggers for human health hazard characterization. Food Chem. Toxicol. 45, 2454-2469.
4. Bus, J. S., Canady, R. A., Collier, T. K., Owens, J. W., Pettit, S. D., Scholz, N. L., and Street, A. C. (2007). The extension of molecular and computational information to risk assessment and regulatory decision making. In Genomic Approaches for Cross-Species Extrapolation in Toxicology (W. H. Benson and R. T. DiGiulio, Eds.), pp. 151-180. SETAC Press, Pensacola, FL.
5. Collins, F. S., Gray, G. M., and Bucher, J. R. (2008). Transforming environmental health protection. Science 319, 906-907.
6. Conolly, R. B., Beck, B. D., and Goodman, J. I. (1999). Stimulating research to improve the scientific basis of risk assessment. Toxicol. Sci. 49, 1-4.
7. Guzelian, P. S., Victoroff, M. S., Halmes, N. C., James, R. C., and Guzelian, C. P. (2005). Evidence-based toxicology: a comprehensive framework for causation. Hum. Exp. Toxicol. 24, 161-201.
8. Hays, S. M., Becker, R. A., Leung, H. W., Aylward, L. L., and Pyatt, D. W. (2007). Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health perspective. Regul. Toxicol. Pharmacol. 47, 96-109.
9. Hoffmann, S., and Hartung, T. (2006). Toward an evidence-based toxicology. Hum. Exp. Toxicol. 25, 497-513.
10. MacDonald, J. S., and Robertson, R. T. (2009). Toxicity testing in the 21st century: a view from the pharmaceutical industry. Toxicol. Sci. 110, 40-46.
11. Mattsson, J. L. (2007). Mixtures in the real world: The importance of plant selfdefense toxicants, mycotoxins and the human diet. Toxicol. Appl. Pharmacol. 223, 125-132.
12. Meek, B., and Doull, J. (2009). Pragmatic challenges for the vision of toxicity testing in the 21st century in a regulatory context: another Ames test? or a new edition of "the Red Book"? Toxicol. Sci. 108, 19-21.
13. Meek, M. E., Sonawane, B., and Becker, R. A. (2008). Foreword: biomonitoring equivalents special issue. Regul. Toxicol. Pharmacol. 51, S3.
14. Naciff, J. M., Hess, K. A., Overmann, G. J., Torontali, S. M., Carr, G. J., Tiesman, J. P., Foertsch, L. M., Richardson, B. D., Martinez, J. E., and Daston, G. P. (2005). Gene expression changes induced in the testis by transplacental exposure to high and low doses of 17a-ethynyl estradiol, genistein, or bishphenol A. Toxicol. Sci. 86, 396-416.
15. National Research Council, Committee on Toxicity Testing and Assessment of Environmental Agents, Board of Environmental Studies and Toxicology, Institute for Laboratory Animal Research. (2007a). Toxicity Testing in the 21st Century. A Vision and a Strategy. National Academies Press, Washington, DC.
16. National Research Council, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology, Board of Environmental Studies and Toxicology, Board of Life Studies, Division of Earth and Life Studies. (2007b). Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment. National Academies Press, Washington, DC.
17. National Research Council, Committee on Improving Risk Analysis Approaches Used by the U.S. EPA, Board of Environmental Studies and Toxicology, Division of Earth and Life Studies. (2008a). Science and Decisions, Advancing Risk Assessment. National Academies Press, Washington, DC.
18. National Research Council, Committee on the Health Risks of Phthalates, Board of Environmental Studies and Toxicology, Division of Earth and Life Studies. (2008b). Phthalates and Cumulative Risk Assessment, The Task Ahead. National Academies Press, Washington, DC.
19. Organization for Economic Cooperation and Development (OECD). (2007). Guidance Document on the Validation of (Quantitative) Structure-Activity Relationships [(Q)Sar] Models Available at: http://www.olis.oecd.org/olis/2007doc.nsf/LinkTo/NT00000D92/$FILE/JT03224782.PDF. Accessed August 15, 2009.
20. Pottenger, L. H., Bus, J. S., and Gollapudi, B. B. (2007). Genetic toxicity assessment: employing the best science for human safety evaluation Part VI: when salt and sugar and vegetables are positive, how can genotoxicity data serve to inform risk assessment? Toxicol. Sci. 98, 327-331.
21. Saghir, S. A., Mendrala, A. L., Bartels, M. J., Day, S. J., Hansen, S. C., Sushynski, J. M., and Bus, J. S. (2006). Strategies to assess systemic exposure of chemicals I subchronic/chronic diet and drinking water studies. Toxicol. Appl. Pharmacol. 211, 245-260.
22. Teuschler, L., Klaunig, J., Carney, E., Chambers, J., Conolly, R., Gennings, C., Giesy, J., Hertzberg, R., Klaassen, C., Kodell, R., et al. (2002). Support of science-based decisions concerning the evaluation of the toxicology of mixtures: a new beginning. Regul. Toxicol. Pharmacol. 36, 34-39.
23. Thomas, R. S., Allen, B. C., Nong, A., Yang, L., Bermudez, B., Clewell, H. J., and Andersen, M. E. (2007). Method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure. Toxicol. Sci. 98, 240-248.