High-throughput testing - The NRC vision, the challenge of modeling dynamic changes in biological systems, and the reality of low-throughput environmental health decision making Commentary

Risk Analysis

Volumn 29, Issue 4, 2009, Pages 483-484

  Hattis, Dale ^a  

^a CLARK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGY; DECISION MAKING; ENVIRONMENTAL HEALTH; FEEDBACK SYSTEM; HIGH THROUGHPUT SCREENING; HOMEOSTASIS; HUMAN; NOTE; POLICY; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; TOXICITY TESTING;

DECISION MAKING; ENVIRONMENTAL HEALTH; HUMANS; MODELS, BIOLOGICAL; TOXICITY TESTS;

EID: 62749189128     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2008.01167.x     Document Type: Note

References (5)

1. Schulkin J. Rethinking homeostasis - Allostatic Regulation in Physiology and Pathophysiology. Cambridge, MA : MIT Press, 2003.
2. Forsen T, Eriksson J, Tuomilehto J, Runanen A, Osmond C, Barker D. The fetal and childhood growth of persons who develop type 2 diabetes. Annales Internae Medicinae, 2000 133 : 176 182.
3. Hattis D. Strategies for assessing human variability in susceptibility, and using variability to infer human risks. Pp. 27 57 in Neumann DA, Kimmel CA (eds). Human Variability in Response to Chemical Exposure: Measures, Modeling, and Risk Assessment. Boca Raton, FL : CRC Press, 1998.
4. Hattis D, Baird S, Goble R. A straw man proposal for a quantitative definition of the RfD, in Final Technical Report, U.S. Environmental Protection Agency STAR Grant R825360, "Human Variability in Parameters Potentially Related to Susceptibility for Noncancer Risks." Available at : http://www2.clarku.edu/faculty/dhattis shortened version in Drug and Chemical Toxicology, 2002 25 : 403 436.
5. Hattis D, Lynch MK. Empirically observed distributions of pharmacokinetic and pharmacodynamic variability in humans - Implications for the derivation of single point component uncertainty factors providing equivalent protection as existing RfDs. Pp. 69 93 in Lipscomb JC, Ohanian EV (eds). Toxicokinetics in Risk Assessment. Informa Healthcare, USA, Inc., 2007.