Advances in toxicity testing herald improvements and challenges for risk assessment

Risk Analysis

Volumn 29, Issue 4, 2009, Pages 490-491

  Tsuji, Joyce S ^a   Garry, Michael R ^a  

^a EXPONENT INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL IRON; SILICON DIOXIDE; TOXIC SUBSTANCE; TRICHLOROETHYLENE; ZINC OXIDE;

ACCURACY; CYP2E1 GENE; DECISION MAKING; DOSIMETRY; GENE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; LUNG TOXICITY; NOTE; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; SAFETY; TOXICITY TESTING;

RISK ASSESSMENT; TOXICITY TESTS;

EID: 62749188280     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2008.01170.x     Document Type: Note

References (4)

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2. Sayes CM, Reed KL, Warheit DB. Assessing toxicity of fine and nanoparticles: Comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicological Science 2007 97 : 163 180.
3. Lipscomb JC, Keddaris GL. Use of Physiologically Based Pharmacokinetic Models to Quantify the Impact of Human Age and Interindividual Differences. Washington, DC : U.S. Environmental Protection Agency. EPA/600/R-06/014A, 2006.
4. Lipscomb JC, Teuschler LK, Swartout J, Popken D, Cox T, Kedderis GL. The impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome in humans. Risk Analysis 2003 23 : 1221 1238.