Toxicity testing in the 21st century: How will it affect risk assessment?

Journal of Toxicology and Environmental Health - Part B: Critical Reviews

Volumn 13, Issue 2-4, 2010, Pages 361-375

  Rhomberg, Lorenz R ^a  

^a GRADIENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CHEMICAL AGENT; ENVIRONMENTAL CHEMICAL; XENOBIOTIC AGENT;

AUTOMATION; BIOLOGICAL MODEL; BIOTECHNOLOGY; CELL ASSAY; CHEMICAL ANALYSIS; CLINICAL ASSESSMENT TOOL; ENVIRONMENTAL IMPACT; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORK; GENETIC VARIABILITY; HEALTH HAZARD; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MODEL; NONHUMAN; PATTERN RECOGNITION; REVIEW; RISK ASSESSMENT; SCREENING TEST; TOXICITY; TOXICITY TESTING; XENOBIOTIC METABOLISM;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOLOGICAL MARKERS; DATA MINING; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; HUMANS; RISK ASSESSMENT; TOXICITY TESTS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

ANIMALIA;

EID: 77954009528     PISSN: 10937404     EISSN: 15216950     Source Type: Journal    
DOI: 10.1080/10937404.2010.483951     Document Type: Review

References (11)

1. Conolly, R. B. 2009. Commentary on "Toxicity testing in the 21st century: Implications for human health risk assessment" by Krewski, D. Andersen, M. E., Mantus, E. and Zeiss, L. Risk Anal. 29:480-481.
2. Elliott, E. D. 2009. Needed: A strategy for implementing the vision. Risk Anal. 29:482.
3. Hattis, D. 2009. High throughput testing- The NRC vision, the challenge of modeling dynamic changes in biological systems, and the reality of low-throughput environmental health decision making. Risk Anal. 29:483-484.
4. Kavlock, R. J., Austin, C. P., and Tice, R. R. 2009. Toxicity testing in the 21st century: Implications for human health risk assessment. Risk Anal. 29:485-487.
5. Kavlock, R. J., and Dix, D. 2010. Computational toxicology as implemented by the US EPA: Providing high throughput decision support for screening and assessing chemical exposure, hazard and risk. J. Toxicol. Environ Health B, this issue.
6. Krewski, D., Andersen, M. E., Mantus, E., and Zeise, L. 2008. Toxicity testing in the 21st Century: Implications for human health risk assessment. Risk Anal. 29:474-479.
7. Krewski, D., Andersen, M. E., Mantus, E., and Zeise, L. 2009. Reply to invited commentaries on toxicity testing in the 21st century: Implications on health risk assessment. Risk Anal. 29:498-1497
8. Meek, M. E. 2008. Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals. Environ. Mol. Mutagen. 49:110-116.
9. National Research Council. 2007. Toxicity testing in the 21st century: A vision and a strategy. Washington, DC: National Academies Press.
10. Rhomberg, L. 2009. Risk assessment in the 21st century: Changes wrought by changing science. Risk Anal. 29:488-489.
11. Tsuji, J. S., and Garry, M. R. 2009. Advances in toxicology testing herald improvements and challenges for risk assessment. Risk Anal. 29:490-491.