MicroRNAs in idiopathic pulmonary fibrosis

Translational Research

Volumn 157, Issue 4, 2011, Pages 191-199

  Pandit, Kusum V ^a   Milosevic, Jadranka ^a   Kaminski, Naftali ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

activation protein 1; angiotensin II type I receptor; AP 1; AT1R; EMT; epithelial mesenchymal transition; h mobility group AT hook 2; HMGA2; idiopathic pulmonary fibrosis; IGF1; IL; insulin like growth factor 1; interleukin; IPF; LNA; locked nucleic acid; metalloproteinases; MMP; PDCD4; phosphatase and tensin homolog; programmed cell death 4; PTEN; RECK; reversion inducing cysteine rich protein with kazal motifs; SBE; SMAD binding elements; TGF 1; TIMP3; tissue inhibitor of metalloproteinases 3; transforming growth factor 1; vascular endothelial growth factor; VEGF

Indexed keywords

MICRORNA; MICRORNA 132; MICRORNA 133A; MICRORNA 150; MICRORNA 155; MICRORNA 15B; MICRORNA 16; MICRORNA 192; MICRORNA 194; MICRORNA 208; MICRORNA 21; MICRORNA 215; MICRORNA 216; MICRORNA 217; MICRORNA 27A; MICRORNA 27B; MICRORNA 29; MICRORNA 30; MICRORNA 377; MIRAVIRSEN; PROTEIN P53; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; WNT PROTEIN;

FIBROSING ALVEOLITIS; GENE EXPRESSION; GENE TARGETING; GENETIC ANALYSIS; HEPATITIS C; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 79952790398     PISSN: 19315244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trsl.2011.01.012     Document Type: Review

References (107)

1. G. Raghu, D. Weycker, J. Edelsberg, W.Z. Bradford, and G. Oster Incidence and prevalence of idiopathic pulmonary fibrosis Am J Respir Crit Care Med 174 2006 810 816 (Pubitemid 44511663)
2. M.A. Spruit, D.J. Janssen, F.M. Franssen, and E.F. Wouters Rehabilitation and palliative care in lung fibrosis Respirology 14 2009 781 787
3. H.A. Chapman Disorders of lung matrix remodeling J Clin Invest 113 2004 148 157
4. J.C. Horowitz, and V.J. Thannickal Epithelial-mesenchymal interactions in pulmonary fibrosis Semin Respir Crit Care Med 27 2006 600 612 (Pubitemid 46048040)
5. A. Pardo, and M. Selman Idiopathic pulmonary fibrosis: new insights in its pathogenesis Int J Biochem Cell Biol 34 2002 1534 1538
6. S.H. Phan Fibroblast phenotypes in pulmonary fibrosis Am J Respir Cell Mol Biol 29 2003 S87 S92
7. C.J. Scotton, M.A. Krupiczojc, and M. Konigshoff Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury J Clin Invest 119 2009 2550 2563
8. V.J. Thannickal, and J.C. Horowitz Evolving concepts of apoptosis in idiopathic pulmonary fibrosis Proc Am Thorac Soc 3 2006 350 356 (Pubitemid 43845412)
9. C.L. Fattman Apoptosis in pulmonary fibrosis: too much or not enough? Antioxid Redox Signal 10 2008 379 385
10. L. Hecker, R. Vittal, and T. Jones NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury Nat Med 15 2009 1077 1081
11. K.K. Kim, M.C. Kugler, and P.J. Wolters Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix Proc Natl Acad Sci U S A 103 2006 13180 13185 (Pubitemid 44338936)
12. B.C. Willis, and Z. Borok TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease Am J Physiol Lung Cell Mol Physiol 293 2007 L525 L534
13. K.K. Kim, Y. Wei, and C. Szekeres Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis J Clin Invest 119 2009 213 224
14. M. Selman, A. Pardo, and N. Kaminski Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs? PLoS Med 5 2008 e62
15. L.J. Vuga, A. Ben-Yehudah, and E. Kovkarova-Naumovski WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis Am J Respir Cell Mol Biol 41 2009 583 589
16. F. Zuo, N. Kaminski, and E. Eugui Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans Proc Natl Acad Sci U S A 99 2002 6292 6297 (Pubitemid 34493305)
17. R. Rajkumar, K. Konishi, and T.J. Richards Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension Am J Physiol Heart Circ Physiol 298 2010 H1235 H1248
18. M. Selman, A. Pardo, and L. Barrera Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis Am J Respir Crit Care Med 173 2006 188 198 (Pubitemid 43187891)
19. M. Selman, G. Carrillo, and A. Estrada Accelerated variant of idiopathic pulmonary fibrosis: clinical behavior and gene expression pattern PLoS ONE 2 2007 e482
20. I.O. Rosas, T.J. Richards, and K. Konishi MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis PLoS Med 5 2008 e93
21. K. Konishi, K.F. Gibson, and K.O. Lindell Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis Am J Respir Crit Care Med 180 2009 167 175
22. K. Boon, N.W. Bailey, and J. Yang Molecular phenotypes distinguish patients with relatively stable from progressive idiopathic pulmonary fibrosis (IPF) PLoS ONE 4 2009 e5134
23. I.V. Yang, L.H. Burch, and M.P. Steele Gene expression profiling of familial and sporadic interstitial pneumonia Am J Respir Crit Care Med 175 2007 45 54 (Pubitemid 46105308)
24. A. Pardo, M. Selman, and N. Kaminski Approaching the degradome in idiopathic pulmonary fibrosis Int J Biochem Cell Biol 40 2008 1141 1155
25. N.C. Lau, L.P. Lim, E.G. Weinstein, and D.P. Bartel An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans Science 294 2001 858 862 (Pubitemid 33032104)
26. H.W. Hwang, and J.T. Mendell MicroRNAs in cell proliferation, cell death, and tumorigenesis Br J Cancer 94 2006 776 780
27. M. Galasso, M. Elena Sana, and S. Volinia Non-coding RNAs: a key to future personalized molecular therapy? Genome Med 2 2010 12
28. A.H. Williams, N. Liu, E. van Rooij, and E.N. Olson MicroRNA control of muscle development and disease Curr Opin Cell Biol 21 2009 461 469
29. X. Wu, M.G. Piper-Hunter, and M. Crawford MicroRNAs in the pathogenesis of lung cancer J Thorac Oncol 4 2009 1028 1034
30. B.F. Yang, Y.J. Lu, and Z.G. Wang MicroRNAs and apoptosis: implications in the molecular therapy of human disease Clin Exp Pharmacol Physiol 36 2009 951 960
31. E. Zorio, P. Medina, and J. Rueda Insights into the role of microRNAs in cardiac diseases: from biological signalling to therapeutic targets Cardiovasc Hematol Agents Med Chem 7 2009 82 90
32. K.V. Pandit, D. Corcoran, and H. Yousef Inhibition and role of let-7d in idiopathic pulmonary fibrosis Am J Respir Crit Care Med 182 2010 220 229
33. D. Sheppard Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis Proc Am Thorac Soc 3 2006 413 417 (Pubitemid 44033355)
34. C. Mayr, M.T. Hemann, and D.P. Bartel Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation Science 315 2007 1576 1579 (Pubitemid 46449474)
35. S. Thuault, U. Valcourt, and M. Petersen Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition J Cell Biol 174 2006 175 183 (Pubitemid 44079853)
36. S. Thuault, E.J. Tan, and H. Peinado HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition J Biol Chem 283 2008 33437 33446
37. S. Watanabe, Y. Ueda, and S. Akaboshi HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells Am J Pathol 174 2009 854 868
38. S.M. Johnson, H. Grosshans, and J. Shingara RAS is regulated by the let-7 microRNA family Cell 120 2005 635 647 (Pubitemid 40343076)
39. S. Grunert, M. Jechlinger, and H. Beug Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis Nat Rev Mol Cell Biol 4 2003 657 665 (Pubitemid 36934968)
40. C. Aston, J. Jagirdar, and T.C. Lee Enhanced insulin-like growth factor molecules in idiopathic pulmonary fibrosis Am J Respir Crit Care Med 151 1995 1597 1603
41. G. Liu, A. Friggeri, and Y. Yang miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis J Exp Med 207 2010 1589 1597
42. B.N. Davis, A.C. Hilyard, G. Lagna, and A. Hata SMAD proteins control DROSHA-mediated microRNA maturation Nature 454 2008 56 61 (Pubitemid 351931982)
43. B. Qian, D. Katsaros, and L. Lu High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1 Breast Cancer Res Treat 117 2009 131 140
44. S. Zhu, M.L. Si, H. Wu, and Y.Y. Mo MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1) J Biol Chem 282 2007 14328 14336 (Pubitemid 47100416)
45. L.B. Frankel, N.R. Christoffersen, and A. Jacobsen Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells J Biol Chem 283 2008 1026 1033
46. F. Meng, R. Henson, H. Wehbe-Janek, K. Ghoshal, S.T. Jacob, and T. Patel MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer Gastroenterology 133 2007 647 658 (Pubitemid 47187346)
47. F. Talotta, A. Cimmino, and M.R. Matarazzo An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation Oncogene 28 2009 73 84
48. T.H. Huang, F. Wu, and G.B. Loeb Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion J Biol Chem 284 2009 18515 18524
49. M. Seike, A. Goto, and T. Okano miR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers Proc Natl Acad Sci U S A 106 2009 12085 12090
50. R. Kulshreshtha, M. Ferracin, and S.E. Wojcik A microRNA signature of hypoxia Mol Cell Biol 27 2007 1859 1867
51. G. Gabriely, T. Wurdinger, and S. Kesari MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators Mol Cell Biol 28 2008 5369 5380
52. N. Pottier, T. Maurin, and B. Chevalier Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions PLoS One 4 2009 e6718
53. S. Masaki, R. Ohtsuka, Y. Abe, K. Muta, and T. Umemura Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis Biochem Biophys Res Commun 364 2007 509 514 (Pubitemid 350026496)
54. S. Costinean, N. Zanesi, and Y. Pekarsky Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice Proc Natl Acad Sci U S A 103 2006 7024 7029
55. M.M. Martin, E.J. Lee, J.A. Buckenberger, T.D. Schmittgen, and T.S. Elton MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts J Biol Chem 281 2006 18277 18284 (Pubitemid 44035484)
56. R.P. Marshall, P. Gohlke, and R.C. Chambers Angiotensin II and the fibroproliferative response to acute lung injury Am J Physiol Lung Cell Mol Physiol 286 2004 L156 L164
57. M. Konigshoff, A. Wilhelm, and A. Jahn The angiotensin II receptor 2 is expressed and mediates angiotensin II signaling in lung fibrosis Am J Respir Cell Mol Biol 37 2007 640 650 (Pubitemid 350211634)
58. L. Cushing, P.P. Kuang, and J. Qian MIR-29 is a major regulator of genes associated with pulmonary fibrosis Am J Respir Cell Mol Biol. 2010 Oct 22 [Epub ahead of print]
59. E. van Rooij, L.B. Sutherland, and J.E. Thatcher Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis Proc Natl Acad Sci U S A 105 2008 13027 13032
60. C.A. Gebeshuber, K. Zatloukal, and J. Martinez miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis EMBO Rep 10 2009 400 405
61. B. Maurer, J. Stanczyk, and A. Jungel MicroRNA-29, a key regulator of collagen expression in systemic sclerosis Arthritis Rheum 62 2010 1733 1743
62. H. Wang, R. Garzon, and H. Sun NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma Cancer Cell 14 2008 369 381
63. C. Roderburg, G.W. Urban, and K. Bettermann MicroRNA profiling reveals a role for miR-29 in human and murine liver fibrosis Hepatology 53 2011 209 218
64. B.C. Willis, J.M. Liebler, and K. Luby-Phelps Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis Am J Pathol 166 2005 1321 1332 (Pubitemid 40586504)
65. W. Wu, and N. Kaminski Chronic lung diseases Wiley Interdiscip Rev Syst Biol Med 1 2009 298 308
66. N. Kaminski, and I.O. Rosas Gene expression profiling as a window into idiopathic pulmonary fibrosis pathogenesis: can we identify the right target genes? Proc Am Thorac Soc 3 2006 339 344 (Pubitemid 43852873)
67. S.M. Studer, and N. Kaminski Towards systems biology of human pulmonary fibrosis Proc Am Thorac Soc 4 2007 85 91 (Pubitemid 46084774)
68. C. Vancheri, M. Failla, N. Crimi, and G. Raghu Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology Eur Respir J 35 2010 496 504
69. H.L. Lung, D.K. Bangarusamy, and D. Xie THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma Oncogene 24 2005 6525 6532 (Pubitemid 41486635)
70. Y.Y. Sanders, A. Pardo, and M. Selman Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis Am J Respir Cell Mol Biol 39 2008 610 618
71. E.I. Rabinovich, Z. Yakhini, and P.V. Benos The human CpG islands arrays reveal changes in global methylation patterns in idiopathic pulmonary fibrosis Am J Respir Crit Care Med 181 2010 A2017
72. C.D. Cool, S.D. Groshong, and P.R. Rai Fibroblast foci are not discrete sites of lung injury or repair: the fibroblast reticulum Am J Respir Crit Care Med 174 2006 654 658 (Pubitemid 44395332)
73. T. Thum, C. Gross, and J. Fiedler MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts Nature 456 2008 980 984
74. Y. Liu, N.E. Taylor, and L. Lu Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes Hypertension 55 2010 974 982
75. R.F. Duisters, A.J. Tijsen, and B. Schroen miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling Circ Res 104 2009 170 178
76. S.J. Matkovich, W. Wang, and Y. Tu MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts Circ Res 106 2010 166 175
77. A.C. Chung, X.R. Huang, X. Meng, and H.Y. Lan miR-192 mediates TGF-beta/Smad3-driven renal fibrosis J Am Soc Nephrol 21 2010 1317 1325
78. M. Kato, J. Zhang, and M. Wang MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors Proc Natl Acad Sci U S A 104 2007 3432 3437 (Pubitemid 46364176)
79. B. Wang, M. Herman-Edelstein, and P. Koh E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-beta Diabetes 59 2010 1794 1802
80. M. Kato, S. Putta, and M. Wang TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN Nat Cell Biol 11 2009 881 889
81. Q. Wang, Y. Wang, and A.W. Minto MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy FASEB J 22 2008 4126 4135
82. J. Mann, D.C. Chu, and A. Maxwell MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis Gastroenterology 138 2010 705 714
83. S.K. Venugopal, J. Jiang, and T.H. Kim Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation Am J Physiol Gastrointest Liver Physiol 298 2010 G101 G106
84. C.J. Guo, Q. Pan, D.G. Li, H. Sun, and B.W. Liu miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: an essential role for apoptosis J Hepatol 50 2009 766 778
85. C.J. Guo, Q. Pan, B. Jiang, G.Y. Chen, and D.G. Li Effects of upregulated expression of microRNA-16 on biological properties of culture-activated hepatic stellate cells Apoptosis 14 2009 1331 1340
86. J. Ji, J. Zhang, and G. Huang Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation FEBS Lett 583 2009 759 766
87. E. van Rooij, L.B. Sutherland, and X. Qi Control of stress-dependent cardiac growth and gene expression by a microRNA Science 316 2007 575 579 (Pubitemid 46683138)
88. M.E. Schipper, J. van Kuik, N. de Jonge, H.F. Dullens, and R.A. de Weger Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support J Heart Lung Transplant 27 2008 1282 1285
89. C. Sucharov, M.R. Bristow, and J.D. Port MiRNA expression in the failing human heart: functional correlates J Mol Cell Cardiol 45 2008 185 192
90. N. Liu, S. Bezprozvannaya, and A.H. Williams MicroRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart Genes Dev 22 2008 3242 3254
91. S.V. Naga Prasad, Z.H. Duan, and M.K. Gupta Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks J Biol Chem 284 2009 27487 27499
92. J. Deng, R. Shoemaker, and B. Xie Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming Nat Biotechnol 27 2009 353 360
93. Naga Prasad SV, Karnik SS. MicroRNAs-regulators of signaling networks in dilated cardiomyopathy. J Cardiovasc Transl Res 3:225-34.
94. P.A. da Costa Martins, M. Bourajjaj, and M. Gladka Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling Circulation 118 2008 1567 1576
95. S. Roy, S. Khanna, and S.R. Hussain MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue Cardiovasc Res 82 2009 21 29
96. N.C. Henderson, and J.P. Iredale Liver fibrosis: cellular mechanisms of progression and resolution Clin Sci 112 2007 265 280 (Pubitemid 46392114)
97. C.J. Guo, Q. Pan, and T. Cheng Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways FEBS J 276 2009 5163 5176
98. A. Dolganiuc, J. Petrasek, and K. Kodys MicroRNA expression profile in Lieber-DeCarli 98 diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice Alcohol Clin Exp Res 33 2009 1704 1710
99. H.W. Schnaper, and J.B. Kopp Renal fibrosis Front Biosci 8 2003 e68 e86
100. F.C. Brosius 3rd New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy Rev Endocr Metab Disord 9 2008 245 254
101. J. Gauldie, and M. Kolb Animal models of pulmonary fibrosis: how far from effective reality? Am J Physiol Lung Cell Mol Physiol 294 2008 L151
102. J. Krutzfeldt, N. Rajewsky, and R. Braich Silencing of microRNAs in vivo with "antagomirs" Nature 438 2005 685 689
103. M.S. Kumar, S.J. Erkeland, and R.E. Pester Suppression of non-small cell lung tumor development by the let-7 microRNA family Proc Natl Acad Sci U S A 105 2008 3903 3908 (Pubitemid 351723497)
104. F. Yu, H. Yao, and P. Zhu Let-7 regulates self renewal and tumorigenicity of breast cancer cells Cell 131 2007 1109 1123 (Pubitemid 350235025)
105. F. Takeshita, L. Patrawala, and M. Osaki Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes Mol Ther 18 2010 181 187
106. Lanford RE, Hildebrandt-Eriksen ES, Petri A, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327:198-201.
107. D. Grimm, K.L. Streetz, and C.L. Jopling Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways Nature 441 2006 537 541 (Pubitemid 44050158)