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Volumn 2, Issue 3, 2011, Pages 311-327

Drug delivery to the brain via the blood-brain barrier: A review of the literature and some recent patent disclosures

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; APROTININ; CHOLINERGIC RECEPTOR; DAUNORUBICIN; DIPHTHERIA TOXIN; DNA; DOXORUBICIN; ETOPOSIDE; GLUTATHIONE; HUMAN SERUM ALBUMIN; IMMUNOLIPOSOME; INSULIN ANTIBODY; INSULIN RECEPTOR; LACTOFERRIN; LEPTIN; LEPTIN RECEPTOR; LEUCINE ENKEPHALIN[2 DEXTRO ALANINE 6 ARGININE]; LIPOSOME; LOPERAMIDE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; NANOPARTICLE; PACLITAXEL; POLYSORBATE 80; PROTEIN P97; SMALL INTERFERING RNA; TRANSFERRIN; TRANSFERRIN RECEPTOR; UNINDEXED DRUG; ZIDOVUDINE;

EID: 79952679752     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.11.3     Document Type: Review
Times cited : (12)

References (114)
  • 1
    • 0036007257 scopus 로고    scopus 로고
    • Why is the global CNS pharmaceutical market so under-penetrated?
    • DOI 10.1016/S1359-6446(01)02082-7
    • Pardridge WM. Why is the global CNS pharmaceutical market so under-penetrated? Drug Discov. Today 7(1), 5-7 (2002). (Pubitemid 34093938)
    • (2002) Drug Discovery Today , vol.7 , Issue.1 , pp. 5-7
    • Pardridge, W.M.1
  • 2
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • DOI 10.1602/neurorx.2.1.3
    • Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2(1), 3-14 (2005). (Pubitemid 40128022)
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 3-14
    • Pardridge, W.M.1
  • 3
    • 25844469583 scopus 로고    scopus 로고
    • Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery
    • DOI 10.1602/neurorx.2.4.554
    • Alavijeh MS, Chishty M, Qaiser MZ, Palmer AM. Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery NeuroRx 2(4), 554-571 (2005). (Pubitemid 41393265)
    • (2005) NeuroRx , vol.2 , Issue.4 , pp. 554-571
    • Alavijeh, M.S.1    Chishty, M.2    Qaiser, M.Z.3    Palmer, A.M.4
  • 4
    • 78049397500 scopus 로고    scopus 로고
    • Penetration of drugs through the blood-cerebrospinal fuid/blood-brain barrier for treatment of central nervous system infections
    • Nau R, Sörgel F, Eiffert H. Penetration of drugs through the blood-cerebrospinal fuid/blood-brain barrier for treatment of central nervous system infections. Clin. Microbiol. Rev. 23(4), 858-883 (2010).
    • (2010) Clin. Microbiol. Rev. , vol.23 , Issue.4 , pp. 858-883
    • Nau, R.1    Sörgel, F.2    Eiffert, H.3
  • 5
    • 77957328846 scopus 로고    scopus 로고
    • Vectorial ligand transport through mammalian choroid plexus
    • Spector R, Johanson CE. Vectorial ligand transport through mammalian choroid plexus. Pharm. Res. 27(10), 2054-2062 (2010).
    • (2010) Pharm. Res. , vol.27 , Issue.10 , pp. 2054-2062
    • Spector, R.1    Johanson, C.E.2
  • 7
    • 77949833508 scopus 로고    scopus 로고
    • Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
    • Dhuria SV, Hanson LR, Frey Ii WH. Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J. Pharm. Sci. 99(4), 1654-1673).
    • J. Pharm. Sci. , vol.99 , Issue.4 , pp. 1654-1673
    • Dhuria, S.V.1    Hanson, L.R.2    Frey Ii, W.H.3
  • 9
    • 34547642139 scopus 로고    scopus 로고
    • Blood-brain barrier transport of therapeutics via receptor-mediation
    • DOI 10.1007/s11095-007-9379-0
    • Jones AR, Shusta EV. Blood-brain barrier transport of therapeutics via receptor-mediation. Pharm. Res. 24(9), 1759-1771 (2007). (Pubitemid 47206625)
    • (2007) Pharmaceutical Research , vol.24 , Issue.9 , pp. 1759-1771
    • Jones, A.R.1    Shusta, E.V.2
  • 10
    • 77953265026 scopus 로고    scopus 로고
    • Targeting the brain-surmounting or bypassing the blood-brain barrier
    • Potschka H. Targeting the brain-surmounting or bypassing the blood-brain barrier. Handb. Exp. Pharmacol. 197, 411-431 (2010).
    • (2010) Handb. Exp. Pharmacol. , vol.197 , pp. 411-431
    • Potschka, H.1
  • 11
    • 70449529637 scopus 로고    scopus 로고
    • Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
    • Gabathuler R. Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiol. Dis. 37(1), 48-57 (2010).
    • (2010) Neurobiol. Dis. , vol.37 , Issue.1 , pp. 48-57
    • Gabathuler, R.1
  • 12
    • 77952900358 scopus 로고    scopus 로고
    • Blood-brain barrier transport of drug-loaded nanoparticle: Research advances
    • Wang BY, Xia AX, Chen PP, Ni L, Liu FH, Li FZ. Blood-brain barrier transport of drug-loaded nanoparticle: research advances. J. Int. Pharm. Res. 37(1), 40-42 (2010).
    • (2010) J. Int. Pharm. Res. , vol.37 , Issue.1 , pp. 40-42
    • Wang, B.Y.1    Xia, A.X.2    Chen, P.P.3    Ni, L.4    Liu, F.H.5    Li, F.Z.6
  • 13
  • 16
    • 49349115993 scopus 로고    scopus 로고
    • RNAi-mediated reversible opening of the blood-brain barrier
    • Campbell M, Kiang AS, Kenna PF et al. RNAi-mediated reversible opening of the blood-brain barrier. J. Gene Med. 10(8), 930-947 (2008).
    • (2008) J. Gene Med. , vol.10 , Issue.8 , pp. 930-947
    • Campbell, M.1    Kiang, A.S.2    Kenna, P.F.3
  • 17
    • 77953832373 scopus 로고    scopus 로고
    • Systemic delivery of therapeutics to neuronal tissues: A barrier modulation approach
    • Campbell M, Ozaki E, Humphries P. Systemic delivery of therapeutics to neuronal tissues: a barrier modulation approach. Expert Opin. Drug Deliv. 7(7), 859-869 (2010).
    • (2010) Expert Opin. Drug Deliv. , vol.7 , Issue.7 , pp. 859-869
    • Campbell, M.1    Ozaki, E.2    Humphries, P.3
  • 19
    • 0031695039 scopus 로고    scopus 로고
    • Blood-brain barrier permeation: Molecular parameters governing passive diffusion
    • DOI 10.1007/s002329900434
    • Fischer H, Gottschlich R, Seelig A. Blood-brain barrier permeation: molecular parameters governing passive diffusion. J. Membr. Biol. 165(3), 201-211 (1998). (Pubitemid 28465226)
    • (1998) Journal of Membrane Biology , vol.165 , Issue.3 , pp. 201-211
    • Fischer, H.1    Gottschlich, R.2    Seelig, A.3
  • 20
    • 33845731767 scopus 로고    scopus 로고
    • Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding
    • DOI 10.1517/17425255.2.5.733
    • Seelig A, Gerebtzoff G. Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding. Expert Opin. Drug Metabol. Toxicol. 2(5), 733-752 (2006). (Pubitemid 46118318)
    • (2006) Expert Opinion on Drug Metabolism and Toxicology , vol.2 , Issue.5 , pp. 733-752
    • Seelig, A.1    Gerebtzoff, G.2
  • 21
    • 33646754516 scopus 로고    scopus 로고
    • Multidrug resistance-associated proteins: Expression and function in the central nervous system
    • Dallas S, Miller DS, Bendayan R. Multidrug resistance-associated proteins: expression and function in the central nervous system. Pharmacol. Rev. 58(2), 140-161 (2006).
    • (2006) Pharmacol. Rev. , vol.58 , Issue.2 , pp. 140-161
    • Dallas, S.1    Miller, D.S.2    Bendayan, R.3
  • 22
    • 77953687856 scopus 로고    scopus 로고
    • Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier
    • Miller DS. Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier. Trends Pharmacol. Sci. 31, 246-254 (2010).
    • (2010) Trends Pharmacol. Sci. , vol.31 , pp. 246-254
    • Miller, D.S.1
  • 23
    • 12344273724 scopus 로고    scopus 로고
    • Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems
    • DOI 10.1602/neurorx.2.1.54
    • Tsuji A. Small-molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems. NeuroRx 2(1), 54-62 (2005). (Pubitemid 40128026)
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 54-62
    • Tsuji, A.1
  • 24
    • 33745032028 scopus 로고    scopus 로고
    • Delivering drugs to the central nervous system: A medicinal chemistry or a pharmaceutical technology issue?
    • DOI 10.2174/092986706777452461
    • Ricci M, Blasi P, Giovagnoli S, Rossi C. Delivering drugs to the central nervous system: a medicinal chemistry or a pharmaceutical technology issue? Curr. Med. Chem. 13(15), 1757-1775 (2006). (Pubitemid 43871754)
    • (2006) Current Medicinal Chemistry , vol.13 , Issue.15 , pp. 1757-1775
    • Ricci, M.1    Blasi, P.2    Giovagnoli, S.3    Rossi, C.4
  • 26
    • 77949375780 scopus 로고    scopus 로고
    • Biopharmaceutical drug targeting to the brain
    • Pardridge WM. Biopharmaceutical drug targeting to the brain. J. Drug Target. 18(3), 11 (2010).
    • (2010) J. Drug Target. , vol.18 , Issue.3 , pp. 11
    • Pardridge, W.M.1
  • 28
    • 70350228485 scopus 로고    scopus 로고
    • Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer
    • Thomas FC, Taskar K, Rudraraju V et al. Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer. Pharm. Res. 26(11), 2486-2494 (2009).
    • (2009) Pharm. Res. , vol.26 , Issue.11 , pp. 2486-2494
    • Thomas, F.C.1    Taskar, K.2    Rudraraju, V.3
  • 29
    • 12344262085 scopus 로고    scopus 로고
    • Drug transport to brain with targeted liposomes
    • DOI 10.1602/neurorx.2.1.99
    • Schnyder A, Huwyler J. Drug transport to brain with targeted liposomes. NeuroRx 2(1), 99-107 (2005). (Pubitemid 40128030)
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 99-107
    • Schnyder, A.1    Huwyler, J.2
  • 30
    • 0025223675 scopus 로고
    • Evaluation of cationized rat albumin as a potential blood-brain barrier drug transport vector
    • Pardridge WM, Triguero D, Buciak J, Yang J. Evaluation of cationized rat albumin as a potential blood-brain barrier drug transport vector. J. Pharmacol. Exp. Ther. 255(2), 893-899 (1990).
    • (1990) J. Pharmacol. Exp. Ther. , vol.255 , Issue.2 , pp. 893-899
    • Pardridge, W.M.1    Triguero, D.2    Buciak, J.3    Yang, J.4
  • 31
    • 0024262589 scopus 로고
    • Cellular uptake of the tat protein from human immunodeficiency virus
    • DOI 10.1016/0092-8674(88)90263-2
    • Frankel AD, Pabo CO. Cellular uptake of the tat protein from human immunodefciency virus. Cell 55(6), 1189-1193 (1988). (Pubitemid 19020071)
    • (1988) Cell , vol.55 , Issue.6 , pp. 1189-1193
    • Frankel, A.D.1    Pabo, C.O.2
  • 32
    • 77951902057 scopus 로고    scopus 로고
    • Arginine-rich cell-penetrating peptides
    • Schmidt N, Mishra A, Lai GH, Wong GCL. Arginine-rich cell-penetrating peptides. FEBS Lett. 584(9), 1806-1813 (2010).
    • (2010) FEBS Lett. , vol.584 , Issue.9 , pp. 1806-1813
    • Schmidt, N.1    Mishra, A.2    Lai, G.H.3    Wong, G.C.L.4
  • 33
    • 39149103400 scopus 로고    scopus 로고
    • The design of guanidinium-rich transporters and their internalization mechanisms
    • Wender PA, Galliher WC, Goun EA, Jones LR, Pillow TH. The design of guanidinium-rich transporters and their internalization mechanisms. Adv. Drug Deliv. Rev. 60(4-5), 452-472 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , Issue.4-5 , pp. 452-472
    • Wender, P.A.1    Galliher, W.C.2    Goun, E.A.3    Jones, L.R.4    Pillow, T.H.5
  • 34
    • 0035207025 scopus 로고    scopus 로고
    • Pharmacokinetics and delivery of tat and tat-protein conjugates to tissues in vivo
    • DOI 10.1021/bc0155061
    • Lee HJ, Pardridge WM. Pharmacokinetics and delivery of tat and t1-protein conjugates to tissues in vivo. Bioconjug. Chem. 12(6), 995-999 (2001). (Pubitemid 33136870)
    • (2001) Bioconjugate Chemistry , vol.12 , Issue.6 , pp. 995-999
    • Lee, H.J.1    Pardridge, W.M.2
  • 36
    • 25844460460 scopus 로고    scopus 로고
    • Crossing the blood-brain barrier: A potential application of myristoylated polyarginine for in vivo neuroimaging
    • DOI 10.1016/j.neuroimage.2005.06.007, PII S1053811905004064
    • Pham W, Zhao BQ, Lo EH, Medarova Z, Rosen B, Moore A. Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging. NeuroImage 28(1), 287-292 (2005). (Pubitemid 41393908)
    • (2005) NeuroImage , vol.28 , Issue.1 , pp. 287-292
    • Pham, W.1    Zhao, B.-Q.2    Lo, E.H.3    Medarova, Z.4    Rosen, B.5    Moore, A.6
  • 37
    • 0030755944 scopus 로고    scopus 로고
    • A new function for the LDL receptor: Transcytosis of LDL across the blood-brain barrier
    • DOI 10.1083/jcb.138.4.877
    • Dehouck B, Fenart L, Dehouck MP, Pierce A, Torpier G, Cecchelli R. A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier. J. Cell Biol. 138(4), 877-889 (1997). (Pubitemid 27365049)
    • (1997) Journal of Cell Biology , vol.138 , Issue.4 , pp. 877-889
    • Dehouck, B.1    Fenart, L.2    Dehouck, M.-P.3    Pierce, A.4    Torpier, G.5    Cecchelli, R.6
  • 38
    • 0033548463 scopus 로고    scopus 로고
    • Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier
    • Fillebeen C, Descamps L, Dehouck MP et al. Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier. J. Biol. Chem. 274(11), 7011-7017 (1999).
    • (1999) J. Biol. Chem. , vol.274 , Issue.11 , pp. 7011-7017
    • Fillebeen, C.1    Descamps, L.2    Dehouck, M.P.3
  • 41
    • 28244449707 scopus 로고    scopus 로고
    • Single domain antibodies as blood-brain barrier delivery vectors
    • DOI 10.1016/j.ics.2005.02.024, PII S0531513105000956, Drug Transport(ers) and the Diseased Brain
    • Abulrob A, Zhang J, Tanha J, MacKenzie R, Stanimirovic D. Single domain antibodies as blood-brain barrier delivery vectors. Int. Congr. Ser. 1277, 212-223 (2005). (Pubitemid 43693326)
    • (2005) International Congress Series , vol.1277 , pp. 212-223
    • Abulrob, A.1    Zhang, J.2    Tanha, J.3    MacKenzie, R.4    Stanimirovic, D.5
  • 42
    • 0036480118 scopus 로고    scopus 로고
    • Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium
    • Muruganandam A, Tanha J, Narang S, Stanimirovic D. Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium. FASEB J. 16(2), 240-242 (2002).
    • (2002) FASEB J. , vol.16 , Issue.2 , pp. 240-242
    • Muruganandam, A.1    Tanha, J.2    Narang, S.3    Stanimirovic, D.4
  • 43
    • 0642342122 scopus 로고    scopus 로고
    • Phage display technology for identifying specifc antigens on brain endothelial cells
    • Tanha J, Muruganandam A, Stanimirovic D. Phage display technology for identifying specifc antigens on brain endothelial cells. Methods Mol. Med. 89, 435-449 (2003).
    • (2003) Methods Mol. Med. , vol.89 , pp. 435-449
    • Tanha, J.1    Muruganandam, A.2    Stanimirovic, D.3
  • 44
    • 28244432240 scopus 로고    scopus 로고
    • The blood-brain barrier transmigrating single domain antibody: Mechanisms of transport and antigenic epitopes in human brain endothelial cells
    • DOI 10.1111/j.1471-4159.2005.03463.x
    • Abulrob A, Sprong H, Van Bergen En Henegouwen P, Stanimirovic D. The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells. J. Neurochem. 95(4), 1201-1214 (2005). (Pubitemid 41713502)
    • (2005) Journal of Neurochemistry , vol.95 , Issue.4 , pp. 1201-1214
    • Abulrob, A.1    Sprong, H.2    Van Bergen En Henegouwen, P.3    Stanimirovic, D.4
  • 45
    • 66149130750 scopus 로고    scopus 로고
    • Differential receptor-mediated drug targeting to the diseased brain
    • Rip J, Schenk GJ, De Boer AG. Differential receptor-mediated drug targeting to the diseased brain. Expert Opin. Drug Deliv. 6(3), 227-237 (2009).
    • (2009) Expert Opin. Drug Deliv. , vol.6 , Issue.3 , pp. 227-237
    • Rip, J.1    Schenk, G.J.2    De Boer, A.G.3
  • 47
    • 33645781775 scopus 로고    scopus 로고
    • Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles
    • Mishra V, Mahor S, Rawat A et al. Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles. J. Drug Target. 14(1), 45-53 (2006).
    • (2006) J. Drug Target. , vol.14 , Issue.1 , pp. 45-53
    • Mishra, V.1    Mahor, S.2    Rawat, A.3
  • 48
    • 59649102668 scopus 로고    scopus 로고
    • Transferrin-and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB)
    • Ulbrich K, Hekmatara T, Herbert E, Kreuter J. Transferrin-and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB). Eur. J. Pharm. Biopharm. 71(2), 251-256 (2009).
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , Issue.2 , pp. 251-256
    • Ulbrich, K.1    Hekmatara, T.2    Herbert, E.3    Kreuter, J.4
  • 49
    • 0025836586 scopus 로고
    • Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo
    • Pardridge WM, Buciak JL, Friden PM. Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo. J. Pharmacol. Exp. Ther. 259(1), 66-70 (1991).
    • (1991) J. Pharmacol. Exp. Ther. , vol.259 , Issue.1 , pp. 66-70
    • Pardridge, W.M.1    Buciak, J.L.2    Friden, P.M.3
  • 51
    • 8344282653 scopus 로고    scopus 로고
    • Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion
    • DOI 10.1097/01.WCB.0000135592.28823.47
    • Gosk S, Vermehren C, Storm G, Moos T. Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion. J. Cereb. Blood Flow Metab. 24(11), 1193-1204 (2004). (Pubitemid 39482480)
    • (2004) Journal of Cerebral Blood Flow and Metabolism , vol.24 , Issue.11 , pp. 1193-1204
    • Gosk, S.1    Vermehren, C.2    Storm, G.3    Moos, T.4
  • 52
    • 63949084137 scopus 로고    scopus 로고
    • Near complete rescue of experimental Parkinson's disease with intravenous, nonviral GDNF gene therapy
    • Zhang Y, Pardridge WM. Near complete rescue of experimental Parkinson's disease with intravenous, nonviral GDNF gene therapy. Pharm. Res. 26(5), 1059-1063 (2009).
    • (2009) Pharm. Res. , vol.26 , Issue.5 , pp. 1059-1063
    • Zhang, Y.1    Pardridge, W.M.2
  • 53
    • 76249087751 scopus 로고    scopus 로고
    • Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor
    • Boado RJ, Zhou QH, Lu JZ, Hui EKW, Pardridge WM. Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor. Mol. Pharm. 7(1), 237-244 (2010).
    • (2010) Mol. Pharm. , vol.7 , Issue.1 , pp. 237-244
    • Boado, R.J.1    Zhou, Q.H.2    Lu, J.Z.3    Ekw, H.4    Pardridge, W.M.5
  • 54
    • 0029009048 scopus 로고
    • Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate
    • Pardridge WM, Kang YS, Buciak JL, Yang J. Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate. Pharm. Res. 12(6), 807-816 (1995).
    • (1995) Pharm. Res. , vol.12 , Issue.6 , pp. 807-816
    • Pardridge, W.M.1    Kang, Y.S.2    Buciak, J.L.3    Yang, J.4
  • 55
    • 33846897981 scopus 로고    scopus 로고
    • Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier
    • DOI 10.1002/bit.21120
    • Boado RJ, Zhang Y, Pardridge WM. Humanization of antihuman insulin receptor antibody for drug targeting across the human blood-brain barrier. Biotechnol. Bioeng. 96(2), 381-391 (2007). (Pubitemid 46232272)
    • (2007) Biotechnology and Bioengineering , vol.96 , Issue.2 , pp. 381-391
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.3    Pardridge, W.M.4
  • 56
    • 77249163613 scopus 로고    scopus 로고
    • Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein
    • Boado RJ, Hui EKW, Lu JZ, Zhou QH, Pardridge WM. Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein. J. Biotechnol. 146(1-2), 84-91 (2010).
    • (2010) J. Biotechnol. , vol.146 , Issue.1-2 , pp. 84-91
    • Boado, R.J.1    Ekw, H.2    Lu, J.Z.3    Zhou, Q.H.4    Pardridge, W.M.5
  • 57
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • DOI 10.1023/A:1018943613122
    • Davis B, Morris T. Physiological parameters in laboratory animals and humans. Pharm. Res. 10(7), 1093-1095 (1993). (Pubitemid 23211439)
    • (1993) Pharmaceutical Research , vol.10 , Issue.7 , pp. 1093-1095
    • Davies, B.1    Morris, T.2
  • 58
    • 71049162181 scopus 로고    scopus 로고
    • Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey
    • Boado RJ, Pardridge WM. Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey. Drug Metab. Dispos. 37(12), 2299-2304 (2009).
    • (2009) Drug Metab. Dispos. , vol.37 , Issue.12 , pp. 2299-2304
    • Boado, R.J.1    Pardridge, W.M.2
  • 59
    • 69949114874 scopus 로고    scopus 로고
    • Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery
    • Pardridge WM, Boado RJ. Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery. Pharm. Res. 26(10), 2227-2236 (2009).
    • (2009) Pharm. Res. , vol.26 , Issue.10 , pp. 2227-2236
    • Pardridge, W.M.1    Boado, R.J.2
  • 60
    • 33947686655 scopus 로고    scopus 로고
    • Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and Aβ fibril disaggregation
    • DOI 10.1021/bc060349x
    • Boado RJ, Zhang Y, Xia CF, Pardridge WM. Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and Ab fibril disaggregation. Bioconjug. Chem. 18(2), 447-455 (2007) (Pubitemid 46493516)
    • (2007) Bioconjugate Chemistry , vol.18 , Issue.2 , pp. 447-455
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.3    Xia, C.-F.4    Pardridge, W.M.5
  • 61
    • 34248679586 scopus 로고    scopus 로고
    • ShRNA and siRNA delivery to the brain
    • DOI 10.1016/j.addr.2007.03.008, PII S0169409X07000221, Opportunities and Challenges for Therapeutic Gene Silencing using RNAi and microRNA Technologies
    • Pardridge WM. shRNA and siRNA delivery to the brain. Adv. Drug Deliv. Rev. 59(2-3), 141-152 (2007). (Pubitemid 46773051)
    • (2007) Advanced Drug Delivery Reviews , vol.59 , Issue.2-3 , pp. 141-152
    • Pardridge, W.M.1
  • 62
    • 12344251148 scopus 로고    scopus 로고
    • Tyrosine hydroxylase replacement in experimental Parkinson's disease with transvascular gene therapy
    • DOI 10.1602/neurorx.2.1.129
    • Pardridge WM. Tyrosine hydroxylase replacement in experimental Parkinson's disease with transvascular gene therapy. NeuroRx 2(1), 129-138 (2005). (Pubitemid 40128033)
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 129-138
    • Pardridge, W.M.1
  • 63
    • 78650538843 scopus 로고    scopus 로고
    • Targeting the insulin receptor: Nanoparticles for drug delivery across the blood-brain barrier (BBB)
    • Ulbrich K, Knobloch T, Kreuter J. Targeting the insulin receptor: nanoparticles for drug delivery across the blood-brain barrier (BBB). J. Drug Target. 19(2), 125-132 (2011).
    • (2011) J. Drug Target. , vol.19 , Issue.2 , pp. 125-132
    • Ulbrich, K.1    Knobloch, T.2    Kreuter, J.3
  • 64
    • 0031017561 scopus 로고    scopus 로고
    • Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels
    • Golden PL, Maccagnan TJ, Pardridge WM. Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J. Clin. Invest. 99(1), 14-18 (1997). (Pubitemid 27058288)
    • (1997) Journal of Clinical Investigation , vol.99 , Issue.1 , pp. 14-18
    • Golden, P.L.1    Maccagnan, T.J.2    Pardridge, W.M.3
  • 65
    • 0035681963 scopus 로고    scopus 로고
    • Limited brain access for leptin in obesity
    • DOI 10.1023/A:1012951214106
    • Couce ME, Green D, Brunetto A, Lloyd RV, Burguera B. Limited brain access for leptin in obesity. Pituitary 4(1-2), 101-110 (2001). (Pubitemid 34081086)
    • (2001) Pituitary , vol.4 , Issue.1-2 , pp. 101-110
    • Couce, M.E.1    Green, D.2    Brunetto, A.3    Lloyd, R.V.4    Burguera, B.5
  • 66
    • 0346157283 scopus 로고    scopus 로고
    • The involvement of the blood-brain and the blood-cerebrospinal fluid barriers in the distribution of leptin into and out of the rat brain
    • DOI 10.1016/j.neuroscience.2003.08.061
    • Kurrimbux D, Gaffen Z, Farrell CL, Martin D, Thomas SA. The involvement of the blood-brain and the blood-cerebrospinal fluid barriers in the distribution of leptin into and out of the rat brain. Neuroscience 123(2), 527-536 (2004). (Pubitemid 38032928)
    • (2004) Neuroscience , vol.123 , Issue.2 , pp. 527-536
    • Kurrimbux, D.1    Gaffen, Z.2    Farrell, C.L.3    Martin, D.4    Thomas, S.A.5
  • 67
    • 67349151056 scopus 로고    scopus 로고
    • The identification of leptin-derived peptides that are taken up by the brain
    • Barrett GL, Trieu J, Naim T. The identification of leptin-derived peptides that are taken up by the brain. Regul. Pept. 155(1-3), 55-61 (2009).
    • (2009) Regul. Pept. , vol.155 , Issue.1-3 , pp. 55-61
    • Barrett, G.L.1    Trieu, J.2    Naim, T.3
  • 68
    • 77952289786 scopus 로고    scopus 로고
    • A leptin derived 30-amino-acid peptide modified pegylated poly-l-lysine dendrigraft for brain targeted gene delivery
    • Liu Y, Li J, Shao K et al. A leptin derived 30-amino-acid peptide modified pegylated poly-l-lysine dendrigraft for brain targeted gene delivery. Biomaterials 31(19), 5246-5257 (2010).
    • (2010) Biomaterials , vol.31 , Issue.19 , pp. 5246-5257
    • Liu, Y.1    Li, J.2    Shao, K.3
  • 70
    • 0036607597 scopus 로고    scopus 로고
    • The low-density lipoprotein receptor gene family: A cellular Swiss army knife?
    • DOI 10.1016/S0962-8924(02)02282-1, PII S0962892402022821
    • Nykjaer A, Willnow TE. The low-density lipoprotein receptor gene family: a cellular Swiss army knife? Trends Cell Biol. 12(6), 273-280 (2002). (Pubitemid 34634176)
    • (2002) Trends in Cell Biology , vol.12 , Issue.6 , pp. 273-280
    • Nykjaer, A.1    Willnow, T.E.2
  • 71
    • 34247557490 scopus 로고    scopus 로고
    • The LDL receptor-related protein (LRP) family: An old family of proteins with new physiological functions
    • DOI 10.1080/07853890701214881, PII 777639280
    • May P, Woldt E, Matz RL, Boucher P. The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions. Ann. Med. 39(3), 219-228 (2007). (Pubitemid 46676481)
    • (2007) Annals of Medicine , vol.39 , Issue.3 , pp. 219-228
    • May, P.1    Woldt, E.2    Matz, R.L.3    Boucher, P.4
  • 72
    • 0345824713 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein
    • DOI 10.1172/JCI200319212
    • Yepes M, Sandkvist M, Moore EG, Bugge TH, Strickland DK, Lawrence DA. Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J. Clin. Invest. 112(10), 1533-1540 (2003). (Pubitemid 38056279)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.10 , pp. 1533-1540
    • Yepes, M.1    Sandkvist, M.2    Moore, E.G.3    Bugge, T.H.4    Strickland, D.K.5    Lawrence, D.A.6
  • 73
    • 50349092250 scopus 로고    scopus 로고
    • LDL receptor-related protein 1: Unique tissue-specific functions revealed by selective gene knockout studies
    • Lillis AP, Van Duyn LB, Murphy-Ullrich JE, Strickland DK. LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol. Rev. 88(3), 887-918 (2008).
    • (2008) Physiol. Rev. , vol.88 , Issue.3 , pp. 887-918
    • Lillis, A.P.1    Van Duyn, L.B.2    Murphy-Ullrich, J.E.3    Strickland, D.K.4
  • 74
    • 58149131290 scopus 로고    scopus 로고
    • Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: Use of an in vitro model
    • Gosselet F, Candela P, Sevin E, Berezowski V, Cecchelli R, Fenart L. Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model. Brain Res. 1249(C), 34-42 (2009).
    • (2009) Brain Res. , vol.1249 , Issue.C , pp. 34-42
    • Gosselet, F.1    Candela, P.2    Sevin, E.3    Berezowski, V.4    Cecchelli, R.5    Fenart, L.6
  • 75
    • 60549085837 scopus 로고    scopus 로고
    • Physiological pathway for low-density lipoproteins across the blood-brain barrier: Transcytosis through brain capillary endothelial cells in vitro
    • Candela P, Gosselet F, Miller F et al. Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro. Endothelium 15(5-6), 254-264 (2008).
    • (2008) Endothelium , vol.15 , Issue.5-6 , pp. 254-264
    • Candela, P.1    Gosselet, F.2    Miller, F.3
  • 76
    • 0021030691 scopus 로고
    • Interactions of ionic and non-ionic surfactants with plasma low density lipoprotein
    • Tucker IG, Florence AT. Interactions of ionic and nonionic surfactants with plasma low density lipoprotein. J. Pharm. Pharmacol. 35(11), 705-711 (1983). (Pubitemid 14234171)
    • (1983) Journal of Pharmacy and Pharmacology , vol.35 , Issue.11 , pp. 705-711
    • Tucker, I.G.1    Florence, A.T.2
  • 77
    • 36649031633 scopus 로고    scopus 로고
    • Prospects and challenges of the development of lipoprotein-based formulations for anti-cancer drugs
    • DOI 10.1517/17425247.4.6.665
    • Lacko AG, Nair M, Prokai L, McConarthy WJ. Prospects and challenges of the development of lipoprotein-based formulations for anticancer drugs. Expert Opin. Drug Deliv. 4(6), 665-675 (2007). (Pubitemid 350193401)
    • (2007) Expert Opinion on Drug Delivery , vol.4 , Issue.6 , pp. 665-675
    • Lacko, A.G.1    Nair, M.2    Prokai, L.3    McConarthy, W.J.4
  • 78
    • 34250311499 scopus 로고    scopus 로고
    • Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme
    • DOI 10.1016/j.ijpharm.2006.07.046, PII S0378517306006387
    • Nikanjam M, Blakely EA, Bjornstad KA, Shu X, Budinger TF, Forte TM. Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme. Int. J. Pharm. 328(1), 86-94 (2007). (Pubitemid 44827556)
    • (2007) International Journal of Pharmaceutics , vol.328 , Issue.1 SPEC. ISSUE , pp. 86-94
    • Nikanjam, M.1    Blakely, E.A.2    Bjornstad, K.A.3    Shu, X.4    Budinger, T.F.5    Forte, T.M.6
  • 79
    • 36049049858 scopus 로고    scopus 로고
    • Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme
    • DOI 10.1016/j.jconrel.2007.09.007, PII S016836590700497X
    • Nikanjam M, Gibbs AR, Hunt CA, Budinger TF, Forte TM. Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme. J. Control. Release 124(3), 163-171 (2007). (Pubitemid 350101886)
    • (2007) Journal of Controlled Release , vol.124 , Issue.3 , pp. 163-171
    • Nikanjam, M.1    Gibbs, A.R.2    Hunt, C.A.3    Budinger, T.F.4    Forte, T.M.5
  • 80
    • 0028911362 scopus 로고
    • Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
    • Kreuter J, Alyautdin RN, Kharkevich DA, Ivanov AA. Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles). Brain Res. 674(1), 171-174 (1995).
    • (1995) Brain Res. , vol.674 , Issue.1 , pp. 171-174
    • Kreuter, J.1    Alyautdin, R.N.2    Kharkevich, D.A.3    Ivanov, A.A.4
  • 81
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • DOI 10.1016/S0169-409X(00)00122-8, PII S0169409X00001228
    • Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv. Drug Deliv. Rev. 47(1), 65-81 (2001). (Pubitemid 32209233)
    • (2001) Advanced Drug Delivery Reviews , vol.47 , Issue.1 , pp. 65-81
    • Kreuter, J.1
  • 83
    • 12344307628 scopus 로고    scopus 로고
    • Drug transport to brain with targeted nanoparticles
    • DOI 10.1602/neurorx.2.1.108
    • Olivier J-C. Drug transport to brain with targeted nanoparticles. NeuroRx 2, 108-119 (2005). (Pubitemid 40128031)
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 108-119
    • Olivier, J.-C.1
  • 84
    • 33947630376 scopus 로고    scopus 로고
    • Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: Role of apolipoproteins on receptor-medicted endocytosis
    • DOI 10.1021/bm060711a
    • Kim HR, Andrieux K, Gil S et al. Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: role of apolipoproteins on receptor-mediated endocytosis. Biomacromolecules 8(3), 793-799 (2007). (Pubitemid 46488459)
    • (2007) Biomacromolecules , vol.8 , Issue.3 , pp. 793-799
    • Kim, H.R.1    Andrieux, K.2    Gil, S.3    Taverna, M.4    Chacun, H.5    Desmaele, D.6    Taran, F.7    Georgin, D.8    Couvreur, P.9
  • 86
    • 75449107968 scopus 로고    scopus 로고
    • Drug delivery to the brain using surfactant-coated poly(lactide-co- glycolide) nanoparticles: Infuence of the formulation parameters
    • Gelperina S, Maksimenko O, Khalansky A et al. Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: infuence of the formulation parameters. Eur. J. Pharm. Biopharm. 74(2), 157-163 (2010).
    • (2010) Eur. J. Pharm. Biopharm. , vol.74 , Issue.2 , pp. 157-163
    • Gelperina, S.1    Maksimenko, O.2    Khalansky, A.3
  • 87
    • 67349121612 scopus 로고    scopus 로고
    • Albumin nanoparticles targeted with Apo e enter the CNS by transcytosis and are delivered to neurones
    • Zensi A, Begley D, Pontikis C et al. Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones. J. Control. Release 137(1), 78-86 (2009).
    • (2009) J. Control. Release , vol.137 , Issue.1 , pp. 78-86
    • Zensi, A.1    Begley, D.2    Pontikis, C.3
  • 88
    • 78149432751 scopus 로고    scopus 로고
    • Human serum albumin nanoparticles modifed with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain
    • Zensi A, Begley D, Pontikis C et al. Human serum albumin nanoparticles modifed with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain. J. Drug Target. 18(10), 842-848 (2010).
    • (2010) J. Drug Target. , vol.18 , Issue.10 , pp. 842-848
    • Zensi, A.1    Begley, D.2    Pontikis, C.3
  • 90
    • 8744266243 scopus 로고    scopus 로고
    • Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier
    • DOI 10.1242/jcs.01381
    • Pan W, Kastin AB, Zankel TC, van Kerkhof P, Terasaki T, Bu G. Effcient transfer of receptor-associated protein (RAP) across the blood-brain barrier. J. Cell Sci. 117(21), 5071-5078 (2004). (Pubitemid 39517522)
    • (2004) Journal of Cell Science , vol.117 , Issue.21 , pp. 5071-5078
    • Pan, W.1    Kastin, A.B.2    Zankel, T.C.3    Van Kerkhof, P.4    Terasaki, T.5    Bu, G.6
  • 92
    • 49649119425 scopus 로고    scopus 로고
    • A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier
    • Karkan D, Pfeifer C, Vitalis TZ et al. A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier. PLoS ONE 3 (6), e2469 (2008).
    • (2008) PLoS ONE , vol.3 , Issue.6
    • Karkan, D.1    Pfeifer, C.2    Vitalis, T.Z.3
  • 93
    • 72049105345 scopus 로고    scopus 로고
    • Brain-targeting mechanisms of lactoferrin-modifed DNA-loaded nanoparticles
    • Huang R, Ke W, Han L et al. Brain-targeting mechanisms of lactoferrin-modifed DNA-loaded nanoparticles. J. Cereb. Blood Flow Metab. 29(12), 1914-1923 (2009).
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , Issue.12 , pp. 1914-1923
    • Huang, R.1    Ke, W.2    Han, L.3
  • 94
    • 76749159851 scopus 로고    scopus 로고
    • Lactoferrin-modifed nanoparticles could mediate effcient gene delivery to the brain in vivo
    • Huang R, Ke W, Han L et al. Lactoferrin-modifed nanoparticles could mediate effcient gene delivery to the brain in vivo. Brain Res. Bull. 81(6), 600-604 (2010).
    • (2010) Brain Res. Bull. , vol.81 , Issue.6 , pp. 600-604
    • Huang, R.1    Ke, W.2    Han, L.3
  • 95
    • 74849115546 scopus 로고    scopus 로고
    • Gene therapy using lactoferrin-modifed nanoparticles in a rotenone-induced chronic Parkinson model
    • Huang R, Ke W, Liu Y et al. Gene therapy using lactoferrin-modifed nanoparticles in a rotenone-induced chronic Parkinson model. J. Neurol. Sci. 290(1-2), 123-130 (2010).
    • (2010) J. Neurol. Sci. , vol.290 , Issue.1-2 , pp. 123-130
    • Huang, R.1    Ke, W.2    Liu, Y.3
  • 96
    • 48749095941 scopus 로고    scopus 로고
    • Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain-delivery vector Angiopep-2
    • Demeule M, Currie JC, Bertrand Y et al. Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain-delivery vector Angiopep-2. J. Neurochem. 106(4), 1534-1544 (2008).
    • (2008) J. Neurochem. , vol.106 , Issue.4 , pp. 1534-1544
    • Demeule, M.1    Currie, J.C.2    Bertrand, Y.3
  • 97
    • 51349102460 scopus 로고    scopus 로고
    • Anti-tumor activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2
    • Regina A, Demeule M, Che C et al. Anti-tumor activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2. Br. J. Pharmacol. 155(2), 185-197 (2008).
    • (2008) Br. J. Pharmacol. , vol.155 , Issue.2 , pp. 185-197
    • Regina, A.1    Demeule, M.2    Che, C.3
  • 98
    • 79952655204 scopus 로고    scopus 로고
    • Development of new peptide vectors for the transport of therapeutic across the blood-brain barrier
    • Gabathuler R. Development of new peptide vectors for the transport of therapeutic across the blood-brain barrier. Ther. Deliv. 1(4), 571-586 (2010).
    • (2010) Ther. Deliv. , vol.1 , Issue.4 , pp. 571-586
    • Gabathuler, R.1
  • 99
    • 77950563375 scopus 로고    scopus 로고
    • New angiopep-modifed doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration
    • Che C, Yang G, Thiot C et al. New angiopep-modifed doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration. J. Med. Chem. 53(7), 2814-2824 (2010).
    • (2010) J. Med. Chem. , vol.53 , Issue.7 , pp. 2814-2824
    • Che, C.1    Yang, G.2    Thiot, C.3
  • 100
    • 70350200866 scopus 로고    scopus 로고
    • Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modifed polyamidoamine dendrimer
    • Ke W, Shao K, Huang R et al. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modifed polyamidoamine dendrimer. Biomaterials 30(36), 6976-6985 (2009).
    • (2009) Biomaterials , vol.30 , Issue.36 , pp. 6976-6985
    • Ke, W.1    Shao, K.2    Huang, R.3
  • 102
    • 16244414899 scopus 로고    scopus 로고
    • Rabies virus receptors
    • DOI 10.1080/13550280590900427
    • Lafon M. Rabies virus receptors. J. Neurovirol. 11(1), 82-87 (2005). (Pubitemid 40458377)
    • (2005) Journal of NeuroVirology , vol.11 , Issue.1 , pp. 82-87
    • Lafon, M.1
  • 103
    • 49449094458 scopus 로고    scopus 로고
    • Acetylcholine beyond neurons: The non-neuronal cholinergic system in humans
    • Wessler I, Kirkpatrick CJ. Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br. J. Pharmacol. 154(8), 1558-1571 (2008).
    • (2008) Br. J. Pharmacol. , vol.154 , Issue.8 , pp. 1558-1571
    • Wessler, I.1    Kirkpatrick, C.J.2
  • 104
    • 11844276603 scopus 로고    scopus 로고
    • Neuronal nicotinic receptors: From structure to pathology
    • DOI 10.1016/j.pneurobio.2004.09.006, PII S0301008204001777
    • Gotti C, Clementi F. Neuronal nicotinic receptors: from structure to pathology. Prog. Neurobiol. 74(6), 363-396 (2004). (Pubitemid 40092737)
    • (2004) Progress in Neurobiology , vol.74 , Issue.6 , pp. 363-396
    • Gotti, C.1    Clementi, F.2
  • 105
    • 0036891988 scopus 로고    scopus 로고
    • Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells
    • DOI 10.1002/jps.10256
    • Abbruscato TJ, Lopez SP, Mark KS, Hawkins BT, Davis TP. Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells. J. Pharm. Sci. 91(12), 2525-2538 (2002). (Pubitemid 35379411)
    • (2002) Journal of Pharmaceutical Sciences , vol.91 , Issue.12 , pp. 2525-2538
    • Abbruscato, T.J.1    Lopez, S.P.2    Mark, K.S.3    Hawkins, B.T.4    Davis, T.P.5
  • 106
    • 77956205950 scopus 로고    scopus 로고
    • Liposome-siRNA-peptide complexes cross the blood-brain barrier and signifcantly decrease PrPC on neuronal cells and PrPRES in infected cell cultures
    • Pulford B, Reim N, Bell A et al. Liposome-siRNA-peptide complexes cross the blood-brain barrier and signifcantly decrease PrPC on neuronal cells and PrPRES in infected cell cultures. PLoS ONE 5(6), 1-13 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.6 , pp. 1-13
    • Pulford, B.1    Reim, N.2    Bell, A.3
  • 107
    • 67649887150 scopus 로고    scopus 로고
    • Brain-targeting gene delivery and cellular internalization mechanisms for modifed rabies virus glycoprotein RVG29 nanoparticles
    • Liu Y, Huang R, Han L et al. Brain-targeting gene delivery and cellular internalization mechanisms for modifed rabies virus glycoprotein RVG29 nanoparticles. Biomaterials 30(25), 4195-4202 (2009).
    • (2009) Biomaterials , vol.30 , Issue.25 , pp. 4195-4202
    • Liu, Y.1    Huang, R.2    Han, L.3
  • 108
    • 58049206253 scopus 로고    scopus 로고
    • Tracking cell surface GABAB receptors using an α-bungarotoxin tag
    • Wilkins ME, Li X, Smart TG. Tracking cell surface GABAB receptors using an α-bungarotoxin tag. J. Biol. Chem. 283(50), 34745-34752 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.50 , pp. 34745-34752
    • Wilkins, M.E.1    Li, X.2    Smart, T.G.3
  • 109
    • 0032511829 scopus 로고    scopus 로고
    • Sodium and chloride-dependent high and low-affinity uptakes of GABA by brain capillary endothelial cells
    • DOI 10.1016/S0006-8993(98)00767-7, PII S0006899398007677
    • Zhang Y, Liu GQ. Sodium and chloride-dependent high and low-affnity uptakes of GABA by brain capillary endothelial cells. Brain Res. 808(1), 1-7 (1998). (Pubitemid 29003193)
    • (1998) Brain Research , vol.808 , Issue.1 , pp. 1-7
    • Zhang, Y.1    Liu, G.-Q.2
  • 110
    • 85157166520 scopus 로고    scopus 로고
    • Targeted brain delivery of itraconazole via RVG29 anchored nanoparticles
    • DOI: 10.3109/1061186X.1062010.1492523 Epub ahead of print
    • Chen W, Zhan C, Gu B et al. Targeted brain delivery of itraconazole via RVG29 anchored nanoparticles. J. Drug Target. DOI: 10.3109/1061186X.1062010. 1492523 (2010) (Epub ahead of print).
    • (2010) J. Drug Target.
    • Chen, W.1    Zhan, C.2    Gu, B.3
  • 111
    • 85157267509 scopus 로고    scopus 로고
    • Targeted delivery of large fusion protein into hippocampal neurons by systemic administration
    • DOI: 10.3109/1061186X.1062010.1523788 Epub ahead of print
    • Xiang L, Zhou R, Fu A, Xu X, Huang Y, Hu C. Targeted delivery of large fusion protein into hippocampal neurons by systemic administration. J. Drug Target. DOI: 10.3109/1061186X.1062010.1523788 (2010) (Epub ahead of print).
    • (2010) J. Drug Target.
    • Xiang, L.1    Zhou, R.2    Fu, A.3    Xu, X.4    Huang, Y.5    Hu, C.6
  • 112
    • 33646438600 scopus 로고    scopus 로고
    • Diphtheria toxin receptor-targeted brain drug delivery
    • DOI 10.1016/j.ics.2005.02.022, PII S0531513105000932, Drug Transport(ers) and the Diseased Brain
    • Gaillard PJ, Brink A, de Boer AG. Diphtheria toxin receptor-targeted brain drug delivery Int. Congr. Ser. 1277, 185-198 (2005). (Pubitemid 43693328)
    • (2005) International Congress Series , vol.1277 , pp. 185-198
    • Gaillard, P.J.1    Brink, A.2    De Boer, A.G.3
  • 113
    • 34548770175 scopus 로고    scopus 로고
    • A novel opportunity for targeted drug delivery to the brain
    • Gaillard PJ, de Boer AG. A novel opportunity for targeted drug delivery to the brain. J. Control. Release 116(2), e60-e62 (2006).
    • (2006) J. Control. Release , vol.116 , Issue.2
    • Gaillard, P.J.1    De Boer, A.G.2
  • 114
    • 85157153387 scopus 로고    scopus 로고
    • To-BBB: Leverages new platform to target brain tumours, form partnerships
    • Anonymous
    • Anonymous. To-BBB: leverages new platform to target brain tumours, form partnerships. Neurotech Insights. 6(8), 19 (2010).
    • (2010) Neurotech Insights. , vol.6 , Issue.8 , pp. 19


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.