-
1
-
-
0036007257
-
Why is the global CNS pharmaceutical market so under-penetrated?
-
DOI 10.1016/S1359-6446(01)02082-7
-
Pardridge WM. Why is the global CNS pharmaceutical market so under-penetrated? Drug Discov. Today 7(1), 5-7 (2002). (Pubitemid 34093938)
-
(2002)
Drug Discovery Today
, vol.7
, Issue.1
, pp. 5-7
-
-
Pardridge, W.M.1
-
2
-
-
12344273726
-
The blood-brain barrier: Bottleneck in brain drug development
-
DOI 10.1602/neurorx.2.1.3
-
Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2(1), 3-14 (2005). (Pubitemid 40128022)
-
(2005)
NeuroRx
, vol.2
, Issue.1
, pp. 3-14
-
-
Pardridge, W.M.1
-
3
-
-
25844469583
-
Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery
-
DOI 10.1602/neurorx.2.4.554
-
Alavijeh MS, Chishty M, Qaiser MZ, Palmer AM. Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery NeuroRx 2(4), 554-571 (2005). (Pubitemid 41393265)
-
(2005)
NeuroRx
, vol.2
, Issue.4
, pp. 554-571
-
-
Alavijeh, M.S.1
Chishty, M.2
Qaiser, M.Z.3
Palmer, A.M.4
-
4
-
-
78049397500
-
Penetration of drugs through the blood-cerebrospinal fuid/blood-brain barrier for treatment of central nervous system infections
-
Nau R, Sörgel F, Eiffert H. Penetration of drugs through the blood-cerebrospinal fuid/blood-brain barrier for treatment of central nervous system infections. Clin. Microbiol. Rev. 23(4), 858-883 (2010).
-
(2010)
Clin. Microbiol. Rev.
, vol.23
, Issue.4
, pp. 858-883
-
-
Nau, R.1
Sörgel, F.2
Eiffert, H.3
-
5
-
-
77957328846
-
Vectorial ligand transport through mammalian choroid plexus
-
Spector R, Johanson CE. Vectorial ligand transport through mammalian choroid plexus. Pharm. Res. 27(10), 2054-2062 (2010).
-
(2010)
Pharm. Res.
, vol.27
, Issue.10
, pp. 2054-2062
-
-
Spector, R.1
Johanson, C.E.2
-
6
-
-
42249103294
-
Recent patents review on intranasal administration for CNS drug delivery
-
DOI 10.2174/187221108783331429
-
Jogani V, Jinturkar K, Vyas TK, Misra A. Recent patents review on intranasal administration for CNS drug delivery Recent Pat. Drug Deliv. Formul. 2(1), 25-40 (2008). (Pubitemid 351546432)
-
(2008)
Recent Patents on Drug Delivery and Formulation
, vol.2
, Issue.1
, pp. 25-40
-
-
Jogani, V.1
Jinturkar, K.2
Vyas, T.K.3
Misra, A.4
-
7
-
-
77949833508
-
Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
-
Dhuria SV, Hanson LR, Frey Ii WH. Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J. Pharm. Sci. 99(4), 1654-1673).
-
J. Pharm. Sci.
, vol.99
, Issue.4
, pp. 1654-1673
-
-
Dhuria, S.V.1
Hanson, L.R.2
Frey Ii, W.H.3
-
8
-
-
33750609664
-
Point source concentration of GDNF may explain failure of phase II clinical trial
-
DOI 10.1016/j.expneurol.2006.07.015, PII S0014488606004304
-
Salvatore MF, Ai Y, Fischer B et al. Point source concentration of GDNF may explain failure of Phase II clinical trial. Exp. Neurol. 202(2), 497-505 (2006). (Pubitemid 44692690)
-
(2006)
Experimental Neurology
, vol.202
, Issue.2
, pp. 497-505
-
-
Salvatore, M.F.1
Ai, Y.2
Fischer, B.3
Zhang, A.M.4
Grondin, R.C.5
Zhang, Z.6
Gerhardt, G.A.7
Gash, D.M.8
-
9
-
-
34547642139
-
Blood-brain barrier transport of therapeutics via receptor-mediation
-
DOI 10.1007/s11095-007-9379-0
-
Jones AR, Shusta EV. Blood-brain barrier transport of therapeutics via receptor-mediation. Pharm. Res. 24(9), 1759-1771 (2007). (Pubitemid 47206625)
-
(2007)
Pharmaceutical Research
, vol.24
, Issue.9
, pp. 1759-1771
-
-
Jones, A.R.1
Shusta, E.V.2
-
10
-
-
77953265026
-
Targeting the brain-surmounting or bypassing the blood-brain barrier
-
Potschka H. Targeting the brain-surmounting or bypassing the blood-brain barrier. Handb. Exp. Pharmacol. 197, 411-431 (2010).
-
(2010)
Handb. Exp. Pharmacol.
, vol.197
, pp. 411-431
-
-
Potschka, H.1
-
11
-
-
70449529637
-
Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
-
Gabathuler R. Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiol. Dis. 37(1), 48-57 (2010).
-
(2010)
Neurobiol. Dis.
, vol.37
, Issue.1
, pp. 48-57
-
-
Gabathuler, R.1
-
12
-
-
77952900358
-
Blood-brain barrier transport of drug-loaded nanoparticle: Research advances
-
Wang BY, Xia AX, Chen PP, Ni L, Liu FH, Li FZ. Blood-brain barrier transport of drug-loaded nanoparticle: research advances. J. Int. Pharm. Res. 37(1), 40-42 (2010).
-
(2010)
J. Int. Pharm. Res.
, vol.37
, Issue.1
, pp. 40-42
-
-
Wang, B.Y.1
Xia, A.X.2
Chen, P.P.3
Ni, L.4
Liu, F.H.5
Li, F.Z.6
-
14
-
-
70449529433
-
Structure and function of the blood-brain barrier
-
Abbott NJ, Patabendige AAK, Dolman DEM, Yusof SR, Begley DJ. Structure and function of the blood-brain barrier. Neurobiol. Dis. 37(1), 13-25 (2010).
-
(2010)
Neurobiol. Dis.
, vol.37
, Issue.1
, pp. 13-25
-
-
Abbott, N.J.1
Aak, P.2
Dem, D.3
Yusof, S.R.4
Begley, D.J.5
-
16
-
-
49349115993
-
RNAi-mediated reversible opening of the blood-brain barrier
-
Campbell M, Kiang AS, Kenna PF et al. RNAi-mediated reversible opening of the blood-brain barrier. J. Gene Med. 10(8), 930-947 (2008).
-
(2008)
J. Gene Med.
, vol.10
, Issue.8
, pp. 930-947
-
-
Campbell, M.1
Kiang, A.S.2
Kenna, P.F.3
-
17
-
-
77953832373
-
Systemic delivery of therapeutics to neuronal tissues: A barrier modulation approach
-
Campbell M, Ozaki E, Humphries P. Systemic delivery of therapeutics to neuronal tissues: a barrier modulation approach. Expert Opin. Drug Deliv. 7(7), 859-869 (2010).
-
(2010)
Expert Opin. Drug Deliv.
, vol.7
, Issue.7
, pp. 859-869
-
-
Campbell, M.1
Ozaki, E.2
Humphries, P.3
-
18
-
-
57749193067
-
Brain endothelial cells and the glio-vascular complex
-
Wolburg H, Noell S, Mack A, Wolburg-Buchholz K, Fallier-Becker P. Brain endothelial cells and the glio-vascular complex. Cell Tissue Res. 335(1), 75-96 (2009).
-
(2009)
Cell Tissue Res.
, vol.335
, Issue.1
, pp. 75-96
-
-
Wolburg, H.1
Noell, S.2
MacK, A.3
Wolburg-Buchholz, K.4
Fallier-Becker, P.5
-
19
-
-
0031695039
-
Blood-brain barrier permeation: Molecular parameters governing passive diffusion
-
DOI 10.1007/s002329900434
-
Fischer H, Gottschlich R, Seelig A. Blood-brain barrier permeation: molecular parameters governing passive diffusion. J. Membr. Biol. 165(3), 201-211 (1998). (Pubitemid 28465226)
-
(1998)
Journal of Membrane Biology
, vol.165
, Issue.3
, pp. 201-211
-
-
Fischer, H.1
Gottschlich, R.2
Seelig, A.3
-
20
-
-
33845731767
-
Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding
-
DOI 10.1517/17425255.2.5.733
-
Seelig A, Gerebtzoff G. Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding. Expert Opin. Drug Metabol. Toxicol. 2(5), 733-752 (2006). (Pubitemid 46118318)
-
(2006)
Expert Opinion on Drug Metabolism and Toxicology
, vol.2
, Issue.5
, pp. 733-752
-
-
Seelig, A.1
Gerebtzoff, G.2
-
21
-
-
33646754516
-
Multidrug resistance-associated proteins: Expression and function in the central nervous system
-
Dallas S, Miller DS, Bendayan R. Multidrug resistance-associated proteins: expression and function in the central nervous system. Pharmacol. Rev. 58(2), 140-161 (2006).
-
(2006)
Pharmacol. Rev.
, vol.58
, Issue.2
, pp. 140-161
-
-
Dallas, S.1
Miller, D.S.2
Bendayan, R.3
-
22
-
-
77953687856
-
Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier
-
Miller DS. Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier. Trends Pharmacol. Sci. 31, 246-254 (2010).
-
(2010)
Trends Pharmacol. Sci.
, vol.31
, pp. 246-254
-
-
Miller, D.S.1
-
23
-
-
12344273724
-
Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems
-
DOI 10.1602/neurorx.2.1.54
-
Tsuji A. Small-molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems. NeuroRx 2(1), 54-62 (2005). (Pubitemid 40128026)
-
(2005)
NeuroRx
, vol.2
, Issue.1
, pp. 54-62
-
-
Tsuji, A.1
-
24
-
-
33745032028
-
Delivering drugs to the central nervous system: A medicinal chemistry or a pharmaceutical technology issue?
-
DOI 10.2174/092986706777452461
-
Ricci M, Blasi P, Giovagnoli S, Rossi C. Delivering drugs to the central nervous system: a medicinal chemistry or a pharmaceutical technology issue? Curr. Med. Chem. 13(15), 1757-1775 (2006). (Pubitemid 43871754)
-
(2006)
Current Medicinal Chemistry
, vol.13
, Issue.15
, pp. 1757-1775
-
-
Ricci, M.1
Blasi, P.2
Giovagnoli, S.3
Rossi, C.4
-
26
-
-
77949375780
-
Biopharmaceutical drug targeting to the brain
-
Pardridge WM. Biopharmaceutical drug targeting to the brain. J. Drug Target. 18(3), 11 (2010).
-
(2010)
J. Drug Target.
, vol.18
, Issue.3
, pp. 11
-
-
Pardridge, W.M.1
-
27
-
-
0036896304
-
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs
-
DOI 10.1124/jpet.102.039255
-
Mahar Doan KM, Humphreys JE, Webster LO et al. Passive permeability and P-glycoprotein-mediated effux differentiate central nervous system (CNS) and non-CNS marketed drugs. J. Pharmacol. Exp. Ther. 303(3), 1029-1037 (2002). (Pubitemid 35424386)
-
(2002)
Journal of Pharmacology and Experimental Therapeutics
, vol.303
, Issue.3
, pp. 1029-1037
-
-
Mahar Doan, K.M.1
Humphreys, J.E.2
Webster, L.O.3
Wring, S.A.4
Shampine, L.J.5
Serabjit-Singh, C.J.6
Adkison, K.K.7
Polli, J.W.8
-
28
-
-
70350228485
-
Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer
-
Thomas FC, Taskar K, Rudraraju V et al. Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer. Pharm. Res. 26(11), 2486-2494 (2009).
-
(2009)
Pharm. Res.
, vol.26
, Issue.11
, pp. 2486-2494
-
-
Thomas, F.C.1
Taskar, K.2
Rudraraju, V.3
-
29
-
-
12344262085
-
Drug transport to brain with targeted liposomes
-
DOI 10.1602/neurorx.2.1.99
-
Schnyder A, Huwyler J. Drug transport to brain with targeted liposomes. NeuroRx 2(1), 99-107 (2005). (Pubitemid 40128030)
-
(2005)
NeuroRx
, vol.2
, Issue.1
, pp. 99-107
-
-
Schnyder, A.1
Huwyler, J.2
-
30
-
-
0025223675
-
Evaluation of cationized rat albumin as a potential blood-brain barrier drug transport vector
-
Pardridge WM, Triguero D, Buciak J, Yang J. Evaluation of cationized rat albumin as a potential blood-brain barrier drug transport vector. J. Pharmacol. Exp. Ther. 255(2), 893-899 (1990).
-
(1990)
J. Pharmacol. Exp. Ther.
, vol.255
, Issue.2
, pp. 893-899
-
-
Pardridge, W.M.1
Triguero, D.2
Buciak, J.3
Yang, J.4
-
31
-
-
0024262589
-
Cellular uptake of the tat protein from human immunodeficiency virus
-
DOI 10.1016/0092-8674(88)90263-2
-
Frankel AD, Pabo CO. Cellular uptake of the tat protein from human immunodefciency virus. Cell 55(6), 1189-1193 (1988). (Pubitemid 19020071)
-
(1988)
Cell
, vol.55
, Issue.6
, pp. 1189-1193
-
-
Frankel, A.D.1
Pabo, C.O.2
-
32
-
-
77951902057
-
Arginine-rich cell-penetrating peptides
-
Schmidt N, Mishra A, Lai GH, Wong GCL. Arginine-rich cell-penetrating peptides. FEBS Lett. 584(9), 1806-1813 (2010).
-
(2010)
FEBS Lett.
, vol.584
, Issue.9
, pp. 1806-1813
-
-
Schmidt, N.1
Mishra, A.2
Lai, G.H.3
Wong, G.C.L.4
-
33
-
-
39149103400
-
The design of guanidinium-rich transporters and their internalization mechanisms
-
Wender PA, Galliher WC, Goun EA, Jones LR, Pillow TH. The design of guanidinium-rich transporters and their internalization mechanisms. Adv. Drug Deliv. Rev. 60(4-5), 452-472 (2008).
-
(2008)
Adv. Drug Deliv. Rev.
, vol.60
, Issue.4-5
, pp. 452-472
-
-
Wender, P.A.1
Galliher, W.C.2
Goun, E.A.3
Jones, L.R.4
Pillow, T.H.5
-
34
-
-
0035207025
-
Pharmacokinetics and delivery of tat and tat-protein conjugates to tissues in vivo
-
DOI 10.1021/bc0155061
-
Lee HJ, Pardridge WM. Pharmacokinetics and delivery of tat and t1-protein conjugates to tissues in vivo. Bioconjug. Chem. 12(6), 995-999 (2001). (Pubitemid 33136870)
-
(2001)
Bioconjugate Chemistry
, vol.12
, Issue.6
, pp. 995-999
-
-
Lee, H.J.1
Pardridge, W.M.2
-
35
-
-
11144229887
-
Tumor imaging by means of proteolytic activation of cell-penetrating peptides
-
DOI 10.1073/pnas.0408191101
-
Jiang T, Olson ES, Nguyen QT, Roy M, Jennings PA, Tsien RY. Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc. Natl Acad. Sci. USA 101(51), 17867-17872 (2004). (Pubitemid 40051978)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.51
, pp. 17867-17872
-
-
Jiang, T.1
Olson, E.S.2
Nguyen, Q.T.3
Roy, M.4
Jennings, P.A.5
Tsien, R.Y.6
-
36
-
-
25844460460
-
Crossing the blood-brain barrier: A potential application of myristoylated polyarginine for in vivo neuroimaging
-
DOI 10.1016/j.neuroimage.2005.06.007, PII S1053811905004064
-
Pham W, Zhao BQ, Lo EH, Medarova Z, Rosen B, Moore A. Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging. NeuroImage 28(1), 287-292 (2005). (Pubitemid 41393908)
-
(2005)
NeuroImage
, vol.28
, Issue.1
, pp. 287-292
-
-
Pham, W.1
Zhao, B.-Q.2
Lo, E.H.3
Medarova, Z.4
Rosen, B.5
Moore, A.6
-
37
-
-
0030755944
-
A new function for the LDL receptor: Transcytosis of LDL across the blood-brain barrier
-
DOI 10.1083/jcb.138.4.877
-
Dehouck B, Fenart L, Dehouck MP, Pierce A, Torpier G, Cecchelli R. A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier. J. Cell Biol. 138(4), 877-889 (1997). (Pubitemid 27365049)
-
(1997)
Journal of Cell Biology
, vol.138
, Issue.4
, pp. 877-889
-
-
Dehouck, B.1
Fenart, L.2
Dehouck, M.-P.3
Pierce, A.4
Torpier, G.5
Cecchelli, R.6
-
38
-
-
0033548463
-
Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier
-
Fillebeen C, Descamps L, Dehouck MP et al. Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier. J. Biol. Chem. 274(11), 7011-7017 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, Issue.11
, pp. 7011-7017
-
-
Fillebeen, C.1
Descamps, L.2
Dehouck, M.P.3
-
39
-
-
18744415035
-
High transcytosis of melanotransferrin (P97) across the blood-brain barrier
-
DOI 10.1046/j.1471-4159.2002.01201.x
-
Demeule M, Poirier J, Jodoin J et al. High transcytosis of melanotransferrin (P97) across the blood-brain barrier. J. Neurochem. 83(4), 924-933 (2002). (Pubitemid 35316043)
-
(2002)
Journal of Neurochemistry
, vol.83
, Issue.4
, pp. 924-933
-
-
Demeule, M.1
Poirier, J.2
Jodoin, J.3
Bertrand, Y.4
Desrosiers, R.R.5
Dagenais, C.6
Nguyen, T.7
Lanthier, J.8
Gabathuler, R.9
Kennard, M.10
Jefferies, W.A.11
Karkan, D.12
Tsai, S.13
Fenart, L.14
Cecchelli, R.15
Beliveau, R.16
-
40
-
-
40849085422
-
Identification and design of peptides as a new drug delivery system for the brain
-
DOI 10.1124/jpet.107.131318
-
Demeule M, Regina A, Che C et al. Identifcation and design of peptides as a new drug delivery system for the brain. J. Pharmacol. Exp. Ther. 324(3), 1064-1072 (2008). (Pubitemid 351397849)
-
(2008)
Journal of Pharmacology and Experimental Therapeutics
, vol.324
, Issue.3
, pp. 1064-1072
-
-
Demeule, M.1
Regina, A.2
Che, C.3
Poirier, J.4
Nguyen, T.5
Gabathuler, R.6
Castaigne, J.-P.7
Beliveau, R.8
-
41
-
-
28244449707
-
Single domain antibodies as blood-brain barrier delivery vectors
-
DOI 10.1016/j.ics.2005.02.024, PII S0531513105000956, Drug Transport(ers) and the Diseased Brain
-
Abulrob A, Zhang J, Tanha J, MacKenzie R, Stanimirovic D. Single domain antibodies as blood-brain barrier delivery vectors. Int. Congr. Ser. 1277, 212-223 (2005). (Pubitemid 43693326)
-
(2005)
International Congress Series
, vol.1277
, pp. 212-223
-
-
Abulrob, A.1
Zhang, J.2
Tanha, J.3
MacKenzie, R.4
Stanimirovic, D.5
-
42
-
-
0036480118
-
Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium
-
Muruganandam A, Tanha J, Narang S, Stanimirovic D. Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium. FASEB J. 16(2), 240-242 (2002).
-
(2002)
FASEB J.
, vol.16
, Issue.2
, pp. 240-242
-
-
Muruganandam, A.1
Tanha, J.2
Narang, S.3
Stanimirovic, D.4
-
43
-
-
0642342122
-
Phage display technology for identifying specifc antigens on brain endothelial cells
-
Tanha J, Muruganandam A, Stanimirovic D. Phage display technology for identifying specifc antigens on brain endothelial cells. Methods Mol. Med. 89, 435-449 (2003).
-
(2003)
Methods Mol. Med.
, vol.89
, pp. 435-449
-
-
Tanha, J.1
Muruganandam, A.2
Stanimirovic, D.3
-
44
-
-
28244432240
-
The blood-brain barrier transmigrating single domain antibody: Mechanisms of transport and antigenic epitopes in human brain endothelial cells
-
DOI 10.1111/j.1471-4159.2005.03463.x
-
Abulrob A, Sprong H, Van Bergen En Henegouwen P, Stanimirovic D. The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells. J. Neurochem. 95(4), 1201-1214 (2005). (Pubitemid 41713502)
-
(2005)
Journal of Neurochemistry
, vol.95
, Issue.4
, pp. 1201-1214
-
-
Abulrob, A.1
Sprong, H.2
Van Bergen En Henegouwen, P.3
Stanimirovic, D.4
-
45
-
-
66149130750
-
Differential receptor-mediated drug targeting to the diseased brain
-
Rip J, Schenk GJ, De Boer AG. Differential receptor-mediated drug targeting to the diseased brain. Expert Opin. Drug Deliv. 6(3), 227-237 (2009).
-
(2009)
Expert Opin. Drug Deliv.
, vol.6
, Issue.3
, pp. 227-237
-
-
Rip, J.1
Schenk, G.J.2
De Boer, A.G.3
-
46
-
-
0035940380
-
Brain-specific expression of an exogenous gene after i.v. administration
-
DOI 10.1073/pnas.221450098
-
Shi N, Zhang Y, Zhu C, Boado RJ, Pardridge WM. Brain-specifc expression of an exogenous gene after i.v. administration. Proc. Natl Acad. Sci. USA 98(22), 12754-12759 (2001). (Pubitemid 33026054)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.22
, pp. 12754-12759
-
-
Shi, N.1
Zhang, Y.2
Zhu, C.3
Boado, R.J.4
Pardridge, W.M.5
-
47
-
-
33645781775
-
Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles
-
Mishra V, Mahor S, Rawat A et al. Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles. J. Drug Target. 14(1), 45-53 (2006).
-
(2006)
J. Drug Target.
, vol.14
, Issue.1
, pp. 45-53
-
-
Mishra, V.1
Mahor, S.2
Rawat, A.3
-
48
-
-
59649102668
-
Transferrin-and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB)
-
Ulbrich K, Hekmatara T, Herbert E, Kreuter J. Transferrin-and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB). Eur. J. Pharm. Biopharm. 71(2), 251-256 (2009).
-
(2009)
Eur. J. Pharm. Biopharm.
, vol.71
, Issue.2
, pp. 251-256
-
-
Ulbrich, K.1
Hekmatara, T.2
Herbert, E.3
Kreuter, J.4
-
49
-
-
0025836586
-
Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo
-
Pardridge WM, Buciak JL, Friden PM. Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo. J. Pharmacol. Exp. Ther. 259(1), 66-70 (1991).
-
(1991)
J. Pharmacol. Exp. Ther.
, vol.259
, Issue.1
, pp. 66-70
-
-
Pardridge, W.M.1
Buciak, J.L.2
Friden, P.M.3
-
51
-
-
8344282653
-
Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion
-
DOI 10.1097/01.WCB.0000135592.28823.47
-
Gosk S, Vermehren C, Storm G, Moos T. Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion. J. Cereb. Blood Flow Metab. 24(11), 1193-1204 (2004). (Pubitemid 39482480)
-
(2004)
Journal of Cerebral Blood Flow and Metabolism
, vol.24
, Issue.11
, pp. 1193-1204
-
-
Gosk, S.1
Vermehren, C.2
Storm, G.3
Moos, T.4
-
52
-
-
63949084137
-
Near complete rescue of experimental Parkinson's disease with intravenous, nonviral GDNF gene therapy
-
Zhang Y, Pardridge WM. Near complete rescue of experimental Parkinson's disease with intravenous, nonviral GDNF gene therapy. Pharm. Res. 26(5), 1059-1063 (2009).
-
(2009)
Pharm. Res.
, vol.26
, Issue.5
, pp. 1059-1063
-
-
Zhang, Y.1
Pardridge, W.M.2
-
53
-
-
76249087751
-
Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor
-
Boado RJ, Zhou QH, Lu JZ, Hui EKW, Pardridge WM. Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor. Mol. Pharm. 7(1), 237-244 (2010).
-
(2010)
Mol. Pharm.
, vol.7
, Issue.1
, pp. 237-244
-
-
Boado, R.J.1
Zhou, Q.H.2
Lu, J.Z.3
Ekw, H.4
Pardridge, W.M.5
-
54
-
-
0029009048
-
Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate
-
Pardridge WM, Kang YS, Buciak JL, Yang J. Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate. Pharm. Res. 12(6), 807-816 (1995).
-
(1995)
Pharm. Res.
, vol.12
, Issue.6
, pp. 807-816
-
-
Pardridge, W.M.1
Kang, Y.S.2
Buciak, J.L.3
Yang, J.4
-
55
-
-
33846897981
-
Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier
-
DOI 10.1002/bit.21120
-
Boado RJ, Zhang Y, Pardridge WM. Humanization of antihuman insulin receptor antibody for drug targeting across the human blood-brain barrier. Biotechnol. Bioeng. 96(2), 381-391 (2007). (Pubitemid 46232272)
-
(2007)
Biotechnology and Bioengineering
, vol.96
, Issue.2
, pp. 381-391
-
-
Boado, R.J.1
Zhang, Y.2
Zhang, Y.3
Pardridge, W.M.4
-
56
-
-
77249163613
-
Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein
-
Boado RJ, Hui EKW, Lu JZ, Zhou QH, Pardridge WM. Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein. J. Biotechnol. 146(1-2), 84-91 (2010).
-
(2010)
J. Biotechnol.
, vol.146
, Issue.1-2
, pp. 84-91
-
-
Boado, R.J.1
Ekw, H.2
Lu, J.Z.3
Zhou, Q.H.4
Pardridge, W.M.5
-
57
-
-
0027275566
-
Physiological parameters in laboratory animals and humans
-
DOI 10.1023/A:1018943613122
-
Davis B, Morris T. Physiological parameters in laboratory animals and humans. Pharm. Res. 10(7), 1093-1095 (1993). (Pubitemid 23211439)
-
(1993)
Pharmaceutical Research
, vol.10
, Issue.7
, pp. 1093-1095
-
-
Davies, B.1
Morris, T.2
-
58
-
-
71049162181
-
Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey
-
Boado RJ, Pardridge WM. Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey. Drug Metab. Dispos. 37(12), 2299-2304 (2009).
-
(2009)
Drug Metab. Dispos.
, vol.37
, Issue.12
, pp. 2299-2304
-
-
Boado, R.J.1
Pardridge, W.M.2
-
59
-
-
69949114874
-
Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery
-
Pardridge WM, Boado RJ. Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery. Pharm. Res. 26(10), 2227-2236 (2009).
-
(2009)
Pharm. Res.
, vol.26
, Issue.10
, pp. 2227-2236
-
-
Pardridge, W.M.1
Boado, R.J.2
-
60
-
-
33947686655
-
Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and Aβ fibril disaggregation
-
DOI 10.1021/bc060349x
-
Boado RJ, Zhang Y, Xia CF, Pardridge WM. Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and Ab fibril disaggregation. Bioconjug. Chem. 18(2), 447-455 (2007) (Pubitemid 46493516)
-
(2007)
Bioconjugate Chemistry
, vol.18
, Issue.2
, pp. 447-455
-
-
Boado, R.J.1
Zhang, Y.2
Zhang, Y.3
Xia, C.-F.4
Pardridge, W.M.5
-
61
-
-
34248679586
-
ShRNA and siRNA delivery to the brain
-
DOI 10.1016/j.addr.2007.03.008, PII S0169409X07000221, Opportunities and Challenges for Therapeutic Gene Silencing using RNAi and microRNA Technologies
-
Pardridge WM. shRNA and siRNA delivery to the brain. Adv. Drug Deliv. Rev. 59(2-3), 141-152 (2007). (Pubitemid 46773051)
-
(2007)
Advanced Drug Delivery Reviews
, vol.59
, Issue.2-3
, pp. 141-152
-
-
Pardridge, W.M.1
-
62
-
-
12344251148
-
Tyrosine hydroxylase replacement in experimental Parkinson's disease with transvascular gene therapy
-
DOI 10.1602/neurorx.2.1.129
-
Pardridge WM. Tyrosine hydroxylase replacement in experimental Parkinson's disease with transvascular gene therapy. NeuroRx 2(1), 129-138 (2005). (Pubitemid 40128033)
-
(2005)
NeuroRx
, vol.2
, Issue.1
, pp. 129-138
-
-
Pardridge, W.M.1
-
63
-
-
78650538843
-
Targeting the insulin receptor: Nanoparticles for drug delivery across the blood-brain barrier (BBB)
-
Ulbrich K, Knobloch T, Kreuter J. Targeting the insulin receptor: nanoparticles for drug delivery across the blood-brain barrier (BBB). J. Drug Target. 19(2), 125-132 (2011).
-
(2011)
J. Drug Target.
, vol.19
, Issue.2
, pp. 125-132
-
-
Ulbrich, K.1
Knobloch, T.2
Kreuter, J.3
-
64
-
-
0031017561
-
Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels
-
Golden PL, Maccagnan TJ, Pardridge WM. Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J. Clin. Invest. 99(1), 14-18 (1997). (Pubitemid 27058288)
-
(1997)
Journal of Clinical Investigation
, vol.99
, Issue.1
, pp. 14-18
-
-
Golden, P.L.1
Maccagnan, T.J.2
Pardridge, W.M.3
-
65
-
-
0035681963
-
Limited brain access for leptin in obesity
-
DOI 10.1023/A:1012951214106
-
Couce ME, Green D, Brunetto A, Lloyd RV, Burguera B. Limited brain access for leptin in obesity. Pituitary 4(1-2), 101-110 (2001). (Pubitemid 34081086)
-
(2001)
Pituitary
, vol.4
, Issue.1-2
, pp. 101-110
-
-
Couce, M.E.1
Green, D.2
Brunetto, A.3
Lloyd, R.V.4
Burguera, B.5
-
66
-
-
0346157283
-
The involvement of the blood-brain and the blood-cerebrospinal fluid barriers in the distribution of leptin into and out of the rat brain
-
DOI 10.1016/j.neuroscience.2003.08.061
-
Kurrimbux D, Gaffen Z, Farrell CL, Martin D, Thomas SA. The involvement of the blood-brain and the blood-cerebrospinal fluid barriers in the distribution of leptin into and out of the rat brain. Neuroscience 123(2), 527-536 (2004). (Pubitemid 38032928)
-
(2004)
Neuroscience
, vol.123
, Issue.2
, pp. 527-536
-
-
Kurrimbux, D.1
Gaffen, Z.2
Farrell, C.L.3
Martin, D.4
Thomas, S.A.5
-
67
-
-
67349151056
-
The identification of leptin-derived peptides that are taken up by the brain
-
Barrett GL, Trieu J, Naim T. The identification of leptin-derived peptides that are taken up by the brain. Regul. Pept. 155(1-3), 55-61 (2009).
-
(2009)
Regul. Pept.
, vol.155
, Issue.1-3
, pp. 55-61
-
-
Barrett, G.L.1
Trieu, J.2
Naim, T.3
-
68
-
-
77952289786
-
A leptin derived 30-amino-acid peptide modified pegylated poly-l-lysine dendrigraft for brain targeted gene delivery
-
Liu Y, Li J, Shao K et al. A leptin derived 30-amino-acid peptide modified pegylated poly-l-lysine dendrigraft for brain targeted gene delivery. Biomaterials 31(19), 5246-5257 (2010).
-
(2010)
Biomaterials
, vol.31
, Issue.19
, pp. 5246-5257
-
-
Liu, Y.1
Li, J.2
Shao, K.3
-
70
-
-
0036607597
-
The low-density lipoprotein receptor gene family: A cellular Swiss army knife?
-
DOI 10.1016/S0962-8924(02)02282-1, PII S0962892402022821
-
Nykjaer A, Willnow TE. The low-density lipoprotein receptor gene family: a cellular Swiss army knife? Trends Cell Biol. 12(6), 273-280 (2002). (Pubitemid 34634176)
-
(2002)
Trends in Cell Biology
, vol.12
, Issue.6
, pp. 273-280
-
-
Nykjaer, A.1
Willnow, T.E.2
-
71
-
-
34247557490
-
The LDL receptor-related protein (LRP) family: An old family of proteins with new physiological functions
-
DOI 10.1080/07853890701214881, PII 777639280
-
May P, Woldt E, Matz RL, Boucher P. The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions. Ann. Med. 39(3), 219-228 (2007). (Pubitemid 46676481)
-
(2007)
Annals of Medicine
, vol.39
, Issue.3
, pp. 219-228
-
-
May, P.1
Woldt, E.2
Matz, R.L.3
Boucher, P.4
-
72
-
-
0345824713
-
Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein
-
DOI 10.1172/JCI200319212
-
Yepes M, Sandkvist M, Moore EG, Bugge TH, Strickland DK, Lawrence DA. Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J. Clin. Invest. 112(10), 1533-1540 (2003). (Pubitemid 38056279)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.10
, pp. 1533-1540
-
-
Yepes, M.1
Sandkvist, M.2
Moore, E.G.3
Bugge, T.H.4
Strickland, D.K.5
Lawrence, D.A.6
-
73
-
-
50349092250
-
LDL receptor-related protein 1: Unique tissue-specific functions revealed by selective gene knockout studies
-
Lillis AP, Van Duyn LB, Murphy-Ullrich JE, Strickland DK. LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol. Rev. 88(3), 887-918 (2008).
-
(2008)
Physiol. Rev.
, vol.88
, Issue.3
, pp. 887-918
-
-
Lillis, A.P.1
Van Duyn, L.B.2
Murphy-Ullrich, J.E.3
Strickland, D.K.4
-
74
-
-
58149131290
-
Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: Use of an in vitro model
-
Gosselet F, Candela P, Sevin E, Berezowski V, Cecchelli R, Fenart L. Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model. Brain Res. 1249(C), 34-42 (2009).
-
(2009)
Brain Res.
, vol.1249
, Issue.C
, pp. 34-42
-
-
Gosselet, F.1
Candela, P.2
Sevin, E.3
Berezowski, V.4
Cecchelli, R.5
Fenart, L.6
-
75
-
-
60549085837
-
Physiological pathway for low-density lipoproteins across the blood-brain barrier: Transcytosis through brain capillary endothelial cells in vitro
-
Candela P, Gosselet F, Miller F et al. Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro. Endothelium 15(5-6), 254-264 (2008).
-
(2008)
Endothelium
, vol.15
, Issue.5-6
, pp. 254-264
-
-
Candela, P.1
Gosselet, F.2
Miller, F.3
-
76
-
-
0021030691
-
Interactions of ionic and non-ionic surfactants with plasma low density lipoprotein
-
Tucker IG, Florence AT. Interactions of ionic and nonionic surfactants with plasma low density lipoprotein. J. Pharm. Pharmacol. 35(11), 705-711 (1983). (Pubitemid 14234171)
-
(1983)
Journal of Pharmacy and Pharmacology
, vol.35
, Issue.11
, pp. 705-711
-
-
Tucker, I.G.1
Florence, A.T.2
-
77
-
-
36649031633
-
Prospects and challenges of the development of lipoprotein-based formulations for anti-cancer drugs
-
DOI 10.1517/17425247.4.6.665
-
Lacko AG, Nair M, Prokai L, McConarthy WJ. Prospects and challenges of the development of lipoprotein-based formulations for anticancer drugs. Expert Opin. Drug Deliv. 4(6), 665-675 (2007). (Pubitemid 350193401)
-
(2007)
Expert Opinion on Drug Delivery
, vol.4
, Issue.6
, pp. 665-675
-
-
Lacko, A.G.1
Nair, M.2
Prokai, L.3
McConarthy, W.J.4
-
78
-
-
34250311499
-
Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme
-
DOI 10.1016/j.ijpharm.2006.07.046, PII S0378517306006387
-
Nikanjam M, Blakely EA, Bjornstad KA, Shu X, Budinger TF, Forte TM. Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme. Int. J. Pharm. 328(1), 86-94 (2007). (Pubitemid 44827556)
-
(2007)
International Journal of Pharmaceutics
, vol.328
, Issue.1 SPEC. ISSUE
, pp. 86-94
-
-
Nikanjam, M.1
Blakely, E.A.2
Bjornstad, K.A.3
Shu, X.4
Budinger, T.F.5
Forte, T.M.6
-
79
-
-
36049049858
-
Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme
-
DOI 10.1016/j.jconrel.2007.09.007, PII S016836590700497X
-
Nikanjam M, Gibbs AR, Hunt CA, Budinger TF, Forte TM. Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme. J. Control. Release 124(3), 163-171 (2007). (Pubitemid 350101886)
-
(2007)
Journal of Controlled Release
, vol.124
, Issue.3
, pp. 163-171
-
-
Nikanjam, M.1
Gibbs, A.R.2
Hunt, C.A.3
Budinger, T.F.4
Forte, T.M.5
-
80
-
-
0028911362
-
Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
-
Kreuter J, Alyautdin RN, Kharkevich DA, Ivanov AA. Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles). Brain Res. 674(1), 171-174 (1995).
-
(1995)
Brain Res.
, vol.674
, Issue.1
, pp. 171-174
-
-
Kreuter, J.1
Alyautdin, R.N.2
Kharkevich, D.A.3
Ivanov, A.A.4
-
81
-
-
0035937595
-
Nanoparticulate systems for brain delivery of drugs
-
DOI 10.1016/S0169-409X(00)00122-8, PII S0169409X00001228
-
Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv. Drug Deliv. Rev. 47(1), 65-81 (2001). (Pubitemid 32209233)
-
(2001)
Advanced Drug Delivery Reviews
, vol.47
, Issue.1
, pp. 65-81
-
-
Kreuter, J.1
-
82
-
-
0035984812
-
Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier
-
DOI 10.1080/10611860290031877
-
Kreuter J, Shamenkov D, Petrov V et al. Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier. J. Drug Target. 10(4), 317-325 (2002). (Pubitemid 34746313)
-
(2002)
Journal of Drug Targeting
, vol.10
, Issue.4
, pp. 317-325
-
-
Kreuter, J.1
Shamenkov, D.2
Petrov, V.3
Ramge, P.4
Cychutek, K.5
Koch-Brandt, C.6
Alyautdin, R.7
-
83
-
-
12344307628
-
Drug transport to brain with targeted nanoparticles
-
DOI 10.1602/neurorx.2.1.108
-
Olivier J-C. Drug transport to brain with targeted nanoparticles. NeuroRx 2, 108-119 (2005). (Pubitemid 40128031)
-
(2005)
NeuroRx
, vol.2
, Issue.1
, pp. 108-119
-
-
Olivier, J.-C.1
-
84
-
-
33947630376
-
Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: Role of apolipoproteins on receptor-medicted endocytosis
-
DOI 10.1021/bm060711a
-
Kim HR, Andrieux K, Gil S et al. Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: role of apolipoproteins on receptor-mediated endocytosis. Biomacromolecules 8(3), 793-799 (2007). (Pubitemid 46488459)
-
(2007)
Biomacromolecules
, vol.8
, Issue.3
, pp. 793-799
-
-
Kim, H.R.1
Andrieux, K.2
Gil, S.3
Taverna, M.4
Chacun, H.5
Desmaele, D.6
Taran, F.7
Georgin, D.8
Couvreur, P.9
-
85
-
-
33846985303
-
Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells
-
DOI 10.1007/s00018-007-6390-x
-
Kim HR, Gil S, Andrieux K et al. Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells. Cell Mol. Life Sci. 64(3), 356-364 (2007). (Pubitemid 46440206)
-
(2007)
Cellular and Molecular Life Sciences
, vol.64
, Issue.3
, pp. 356-364
-
-
Kim, H.R.1
Gil, S.2
Andrieux, K.3
Nicolas, V.4
Appel, M.5
Chacun, H.6
Desmaele, D.7
Taran, F.8
Georgin, D.9
Couvreur, P.10
-
86
-
-
75449107968
-
Drug delivery to the brain using surfactant-coated poly(lactide-co- glycolide) nanoparticles: Infuence of the formulation parameters
-
Gelperina S, Maksimenko O, Khalansky A et al. Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: infuence of the formulation parameters. Eur. J. Pharm. Biopharm. 74(2), 157-163 (2010).
-
(2010)
Eur. J. Pharm. Biopharm.
, vol.74
, Issue.2
, pp. 157-163
-
-
Gelperina, S.1
Maksimenko, O.2
Khalansky, A.3
-
87
-
-
67349121612
-
Albumin nanoparticles targeted with Apo e enter the CNS by transcytosis and are delivered to neurones
-
Zensi A, Begley D, Pontikis C et al. Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones. J. Control. Release 137(1), 78-86 (2009).
-
(2009)
J. Control. Release
, vol.137
, Issue.1
, pp. 78-86
-
-
Zensi, A.1
Begley, D.2
Pontikis, C.3
-
88
-
-
78149432751
-
Human serum albumin nanoparticles modifed with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain
-
Zensi A, Begley D, Pontikis C et al. Human serum albumin nanoparticles modifed with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain. J. Drug Target. 18(10), 842-848 (2010).
-
(2010)
J. Drug Target.
, vol.18
, Issue.10
, pp. 842-848
-
-
Zensi, A.1
Begley, D.2
Pontikis, C.3
-
90
-
-
8744266243
-
Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier
-
DOI 10.1242/jcs.01381
-
Pan W, Kastin AB, Zankel TC, van Kerkhof P, Terasaki T, Bu G. Effcient transfer of receptor-associated protein (RAP) across the blood-brain barrier. J. Cell Sci. 117(21), 5071-5078 (2004). (Pubitemid 39517522)
-
(2004)
Journal of Cell Science
, vol.117
, Issue.21
, pp. 5071-5078
-
-
Pan, W.1
Kastin, A.B.2
Zankel, T.C.3
Van Kerkhof, P.4
Terasaki, T.5
Bu, G.6
-
91
-
-
33646450326
-
Development of a potential protein vector (NeuroTrans) to deliver drugs across the blood-brain barrier
-
DOI 10.1016/j.ics.2005.02.021, PII S0531513105000920, Drug Transport(ers) and the Diseased Brain
-
Gabathuler R, Arthur G, Kennard M et al. Development of a potential protein vector (NeuroTrans) to deliver drugs across the blood-brain barrier. Int. Congr. Ser. 1277, 171-184 (2005). (Pubitemid 43693327)
-
(2005)
International Congress Series
, vol.1277
, pp. 171-184
-
-
Gabathuler, R.1
Arthur, G.2
Kennard, M.3
Chen, Q.4
Tsai, S.5
Yang, J.6
Schoorl, W.7
Vitalis, T.Z.8
Jefferies, W.A.9
-
92
-
-
49649119425
-
A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier
-
Karkan D, Pfeifer C, Vitalis TZ et al. A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier. PLoS ONE 3 (6), e2469 (2008).
-
(2008)
PLoS ONE
, vol.3
, Issue.6
-
-
Karkan, D.1
Pfeifer, C.2
Vitalis, T.Z.3
-
93
-
-
72049105345
-
Brain-targeting mechanisms of lactoferrin-modifed DNA-loaded nanoparticles
-
Huang R, Ke W, Han L et al. Brain-targeting mechanisms of lactoferrin-modifed DNA-loaded nanoparticles. J. Cereb. Blood Flow Metab. 29(12), 1914-1923 (2009).
-
(2009)
J. Cereb. Blood Flow Metab.
, vol.29
, Issue.12
, pp. 1914-1923
-
-
Huang, R.1
Ke, W.2
Han, L.3
-
94
-
-
76749159851
-
Lactoferrin-modifed nanoparticles could mediate effcient gene delivery to the brain in vivo
-
Huang R, Ke W, Han L et al. Lactoferrin-modifed nanoparticles could mediate effcient gene delivery to the brain in vivo. Brain Res. Bull. 81(6), 600-604 (2010).
-
(2010)
Brain Res. Bull.
, vol.81
, Issue.6
, pp. 600-604
-
-
Huang, R.1
Ke, W.2
Han, L.3
-
95
-
-
74849115546
-
Gene therapy using lactoferrin-modifed nanoparticles in a rotenone-induced chronic Parkinson model
-
Huang R, Ke W, Liu Y et al. Gene therapy using lactoferrin-modifed nanoparticles in a rotenone-induced chronic Parkinson model. J. Neurol. Sci. 290(1-2), 123-130 (2010).
-
(2010)
J. Neurol. Sci.
, vol.290
, Issue.1-2
, pp. 123-130
-
-
Huang, R.1
Ke, W.2
Liu, Y.3
-
96
-
-
48749095941
-
Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain-delivery vector Angiopep-2
-
Demeule M, Currie JC, Bertrand Y et al. Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain-delivery vector Angiopep-2. J. Neurochem. 106(4), 1534-1544 (2008).
-
(2008)
J. Neurochem.
, vol.106
, Issue.4
, pp. 1534-1544
-
-
Demeule, M.1
Currie, J.C.2
Bertrand, Y.3
-
97
-
-
51349102460
-
Anti-tumor activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2
-
Regina A, Demeule M, Che C et al. Anti-tumor activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2. Br. J. Pharmacol. 155(2), 185-197 (2008).
-
(2008)
Br. J. Pharmacol.
, vol.155
, Issue.2
, pp. 185-197
-
-
Regina, A.1
Demeule, M.2
Che, C.3
-
98
-
-
79952655204
-
Development of new peptide vectors for the transport of therapeutic across the blood-brain barrier
-
Gabathuler R. Development of new peptide vectors for the transport of therapeutic across the blood-brain barrier. Ther. Deliv. 1(4), 571-586 (2010).
-
(2010)
Ther. Deliv.
, vol.1
, Issue.4
, pp. 571-586
-
-
Gabathuler, R.1
-
99
-
-
77950563375
-
New angiopep-modifed doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration
-
Che C, Yang G, Thiot C et al. New angiopep-modifed doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration. J. Med. Chem. 53(7), 2814-2824 (2010).
-
(2010)
J. Med. Chem.
, vol.53
, Issue.7
, pp. 2814-2824
-
-
Che, C.1
Yang, G.2
Thiot, C.3
-
100
-
-
70350200866
-
Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modifed polyamidoamine dendrimer
-
Ke W, Shao K, Huang R et al. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modifed polyamidoamine dendrimer. Biomaterials 30(36), 6976-6985 (2009).
-
(2009)
Biomaterials
, vol.30
, Issue.36
, pp. 6976-6985
-
-
Ke, W.1
Shao, K.2
Huang, R.3
-
101
-
-
34447114618
-
Transvascular delivery of small interfering RNA to the central nervous system
-
DOI 10.1038/nature05901, PII NATURE05901
-
Kumar P, Wu H, McBride JL et al. Transvascular delivery of small interfering RNA to the central nervous system. Nature 448(7149), 39-43 (2007). (Pubitemid 47037001)
-
(2007)
Nature
, vol.448
, Issue.7149
, pp. 39-43
-
-
Kumar, P.1
Wu, H.2
McBride, J.L.3
Jung, K.-E.4
Hee Kim, M.5
Davidson, B.L.6
Kyung Lee, S.7
Shankar, P.8
Manjunath, N.9
-
102
-
-
16244414899
-
Rabies virus receptors
-
DOI 10.1080/13550280590900427
-
Lafon M. Rabies virus receptors. J. Neurovirol. 11(1), 82-87 (2005). (Pubitemid 40458377)
-
(2005)
Journal of NeuroVirology
, vol.11
, Issue.1
, pp. 82-87
-
-
Lafon, M.1
-
103
-
-
49449094458
-
Acetylcholine beyond neurons: The non-neuronal cholinergic system in humans
-
Wessler I, Kirkpatrick CJ. Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br. J. Pharmacol. 154(8), 1558-1571 (2008).
-
(2008)
Br. J. Pharmacol.
, vol.154
, Issue.8
, pp. 1558-1571
-
-
Wessler, I.1
Kirkpatrick, C.J.2
-
104
-
-
11844276603
-
Neuronal nicotinic receptors: From structure to pathology
-
DOI 10.1016/j.pneurobio.2004.09.006, PII S0301008204001777
-
Gotti C, Clementi F. Neuronal nicotinic receptors: from structure to pathology. Prog. Neurobiol. 74(6), 363-396 (2004). (Pubitemid 40092737)
-
(2004)
Progress in Neurobiology
, vol.74
, Issue.6
, pp. 363-396
-
-
Gotti, C.1
Clementi, F.2
-
105
-
-
0036891988
-
Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells
-
DOI 10.1002/jps.10256
-
Abbruscato TJ, Lopez SP, Mark KS, Hawkins BT, Davis TP. Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells. J. Pharm. Sci. 91(12), 2525-2538 (2002). (Pubitemid 35379411)
-
(2002)
Journal of Pharmaceutical Sciences
, vol.91
, Issue.12
, pp. 2525-2538
-
-
Abbruscato, T.J.1
Lopez, S.P.2
Mark, K.S.3
Hawkins, B.T.4
Davis, T.P.5
-
106
-
-
77956205950
-
Liposome-siRNA-peptide complexes cross the blood-brain barrier and signifcantly decrease PrPC on neuronal cells and PrPRES in infected cell cultures
-
Pulford B, Reim N, Bell A et al. Liposome-siRNA-peptide complexes cross the blood-brain barrier and signifcantly decrease PrPC on neuronal cells and PrPRES in infected cell cultures. PLoS ONE 5(6), 1-13 (2010).
-
(2010)
PLoS ONE
, vol.5
, Issue.6
, pp. 1-13
-
-
Pulford, B.1
Reim, N.2
Bell, A.3
-
107
-
-
67649887150
-
Brain-targeting gene delivery and cellular internalization mechanisms for modifed rabies virus glycoprotein RVG29 nanoparticles
-
Liu Y, Huang R, Han L et al. Brain-targeting gene delivery and cellular internalization mechanisms for modifed rabies virus glycoprotein RVG29 nanoparticles. Biomaterials 30(25), 4195-4202 (2009).
-
(2009)
Biomaterials
, vol.30
, Issue.25
, pp. 4195-4202
-
-
Liu, Y.1
Huang, R.2
Han, L.3
-
108
-
-
58049206253
-
Tracking cell surface GABAB receptors using an α-bungarotoxin tag
-
Wilkins ME, Li X, Smart TG. Tracking cell surface GABAB receptors using an α-bungarotoxin tag. J. Biol. Chem. 283(50), 34745-34752 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, Issue.50
, pp. 34745-34752
-
-
Wilkins, M.E.1
Li, X.2
Smart, T.G.3
-
109
-
-
0032511829
-
Sodium and chloride-dependent high and low-affinity uptakes of GABA by brain capillary endothelial cells
-
DOI 10.1016/S0006-8993(98)00767-7, PII S0006899398007677
-
Zhang Y, Liu GQ. Sodium and chloride-dependent high and low-affnity uptakes of GABA by brain capillary endothelial cells. Brain Res. 808(1), 1-7 (1998). (Pubitemid 29003193)
-
(1998)
Brain Research
, vol.808
, Issue.1
, pp. 1-7
-
-
Zhang, Y.1
Liu, G.-Q.2
-
110
-
-
85157166520
-
Targeted brain delivery of itraconazole via RVG29 anchored nanoparticles
-
DOI: 10.3109/1061186X.1062010.1492523 Epub ahead of print
-
Chen W, Zhan C, Gu B et al. Targeted brain delivery of itraconazole via RVG29 anchored nanoparticles. J. Drug Target. DOI: 10.3109/1061186X.1062010. 1492523 (2010) (Epub ahead of print).
-
(2010)
J. Drug Target.
-
-
Chen, W.1
Zhan, C.2
Gu, B.3
-
111
-
-
85157267509
-
Targeted delivery of large fusion protein into hippocampal neurons by systemic administration
-
DOI: 10.3109/1061186X.1062010.1523788 Epub ahead of print
-
Xiang L, Zhou R, Fu A, Xu X, Huang Y, Hu C. Targeted delivery of large fusion protein into hippocampal neurons by systemic administration. J. Drug Target. DOI: 10.3109/1061186X.1062010.1523788 (2010) (Epub ahead of print).
-
(2010)
J. Drug Target.
-
-
Xiang, L.1
Zhou, R.2
Fu, A.3
Xu, X.4
Huang, Y.5
Hu, C.6
-
112
-
-
33646438600
-
Diphtheria toxin receptor-targeted brain drug delivery
-
DOI 10.1016/j.ics.2005.02.022, PII S0531513105000932, Drug Transport(ers) and the Diseased Brain
-
Gaillard PJ, Brink A, de Boer AG. Diphtheria toxin receptor-targeted brain drug delivery Int. Congr. Ser. 1277, 185-198 (2005). (Pubitemid 43693328)
-
(2005)
International Congress Series
, vol.1277
, pp. 185-198
-
-
Gaillard, P.J.1
Brink, A.2
De Boer, A.G.3
-
113
-
-
34548770175
-
A novel opportunity for targeted drug delivery to the brain
-
Gaillard PJ, de Boer AG. A novel opportunity for targeted drug delivery to the brain. J. Control. Release 116(2), e60-e62 (2006).
-
(2006)
J. Control. Release
, vol.116
, Issue.2
-
-
Gaillard, P.J.1
De Boer, A.G.2
-
114
-
-
85157153387
-
To-BBB: Leverages new platform to target brain tumours, form partnerships
-
Anonymous
-
Anonymous. To-BBB: leverages new platform to target brain tumours, form partnerships. Neurotech Insights. 6(8), 19 (2010).
-
(2010)
Neurotech Insights.
, vol.6
, Issue.8
, pp. 19
-
-
|