The low-density lipoprotein receptor gene family: A cellular Swiss army knife?

Trends in Cell Biology

Volumn 12, Issue 6, 2002, Pages 273-280

  Nykjaer, Anders ^a   Willnow, Thomas E ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ANKYRIN; CELL SURFACE PROTEIN; CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUTAMATE RECEPTOR; GLYCOLIPID; GUANINE NUCLEOTIDE BINDING PROTEIN; ION CHANNEL; LIGAND; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MEGALIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PARATHYROID HORMONE RECEPTOR; UROKINASE RECEPTOR; VERY LOW DENSITY LIPOPROTEIN RECEPTOR; VITAMIN;

CELL ACTIVITY; CELL MIGRATION; CELL SPECIFICITY; ENDOSOME; HOMEOSTASIS; LIPID TRANSPORT; MAMMAL; MULTIGENE FAMILY; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ENDOCYTOSIS; HUMANS; LIGANDS; PROTEIN BINDING; RECEPTORS, CELL SURFACE; RECEPTORS, LDL; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 0036607597     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(02)02282-1     Document Type: Review

References (64)

1. Receptors of the low density lipoprotein (LDL) receptor family in man. Multiple functions of the large family members via interaction with complex ligands
2. The LDL receptor gene family, signaling functions during development
3. The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein
4. A structural explanation for the recognition of tyrosine-based endocytotic signals
5. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein
6. Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein
7. Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction
8. The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
9. Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin
10. Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1 (Lrp1) associates with the adaptor protein SHC in SRC-transformed cells
11. Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein
12. Familial hypercholesteremia
13. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist
14. LRP, a multifunctional scavenger and signaling receptor
15. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin
16. Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module
17. Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins
18. Specific binding of α-macroglobulin to complement-type repeat CR4 of the low-density lipoprotein receptor-related protein
19. Cell surface heparan sulfate proteoglycans and lipoprotein metabolism
20. Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor-related protein
21. Cell surface heparan sulfate proteoglycans participate in factor VIII catabolism mediated by low density lipoprotein receptor-related protein
22. Megalin knockout mice as an animal model of low molecular weight proteinuria
23. Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia
24. 3
25. Evidence for an essential role of megalin in transepithelial transport of retinol
26. 12
27. 12 complexes suggests a role of the receptor in vitamin-B12 homeostasis
28. Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia
29. 3
30. Megalin antagonizes activation of the parathyroid hormone receptor
31. The plasminogen activation system in tumor growth, invasion, and metastasis
32. Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes
33. Very low density lipoprotein receptor binds and mediates endocytosis of urokinase-type plasminogen activator-type-1 plasminogen activator inhibitor complex
34. α-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor
35. Recycling of the urokinase receptor upon internalization of the uPA, serpin complexes
36. Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor
37. Apolipoprotein E receptors, linking brain development and Alzheimer's disease
38. The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors
39. Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein, role of the intracellular adapter protein Fe65
40. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation
41. Modulation of β-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease
42. Defective forebrain development in mice lacking gp330/megalin
43. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
44. Cholesterol, hedgehog and embryogenesis
45. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
46. Neuronal position in the developing brain is regulated by mouse disabled-1
47. The reeler mouse as a model of brain development
48. Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain
49. Reelin is a ligand for lipoprotein receptors
50. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of Disabled-1 and modulates Tau phosphorylation
51. Mouse disabled (mDab1), a Src binding protein implicated in neuronal development
52. Proteins of the CNR family are multiple receptors for Reelin
53. v integrin receptors in neuronal migration and laminar organization of the cerebral cortex
54. 1 integrin and inhibits neuronal migration
55. An arrow hits the Wnt signaling pathway
56. An LDL-receptor-related protein mediates Wnt signalling in mice
57. LDL-receptor-related proteins in Wnt signal transduction
58. Arrow encodes an LDL-receptor-related protein essential for Wingless signalling
59. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
60. The C-terminal cytoplasmic Lys-Thr-X-X-X-Trp motif in Frizzled receptors mediates Wnt/β-catenin signalling
61. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
62. Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation
63. Urokinase receptor and integrin partnership, coordination of signaling for cell adhesion, migration and growth
64. Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth