Crossing the blood-brain barrier: A potential application of myristoylated polyarginine for in vivo neuroimaging

NeuroImage

Volumn 28, Issue 1, 2005, Pages 287-292

  Pham, Wellington ^a   Zhao, Bing Qiao ^a   Lo, Eng H ^a   Medarova, Zdravka ^a   Rosen, Bruce ^a   Moore, Anna ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Blood brain barrier; In vivo neuroimaging; Myristoylated polyarginine

Indexed keywords

FATTY ACID; POLYARGININE;

ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; ENDOTHELIUM CELL; FEMALE; FLUORESCENCE; IMMUNOHISTOCHEMISTRY; MOUSE; MYRISTYLATION; NERVE CELL; NEUROIMAGING; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLID PHASE SYNTHESIS;

ANIMALS; BETA-ALANINE; BLOOD-BRAIN BARRIER; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIAGNOSTIC IMAGING; DRUG DELIVERY SYSTEMS; FATTY ACIDS; FEMALE; FLUORESCENT DYES; IMAGE PROCESSING, COMPUTER-ASSISTED; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; PEPTIDES; TISSUE DISTRIBUTION;

EID: 25844460460     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2005.06.007     Document Type: Article

References (10)

1. R.S. Bar, A. DeRose, A. Sandra, M.L. Peacock, and W.G. Owen Insulin binding to microvascular endothelium of intact heart: a kinetic and morphometric analysis Am. J. Physiol. 244 1983 E447 E452
2. G. Drin, C. Rousselle, J.M. Scherrmann, A.R. Rees, and J. Temsamani Peptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors AAPS PharmSci. 4 2002 E26
3. F. Galbiati, F. Guzzi, A.I. Magee, G. Milligan, and M. Parenti Chemical inhibition of myristoylation of the G-protein Gi1 alpha by 2-hydroxymyristate does not interfere with its palmitoylation or membrane association. Evidence that palmitoylation, but not myristoylation, regulates membrane attachment Biochem. J. 313 Pt. 3 1996 717 720
4. S.M. Innis Essential fatty acids in growth and development Prog. Lipid Res. 30 1991 39 103
5. V. Krishnan, W.N. Pham, W.S. Messer Jr., and S.M. Peseckis First fatty acylated dipeptides to affect muscarinic receptor ligand binding Bioorg. Med. Chem. Lett. 9 1999 3363 3368
6. J.R. Marszalek, C. Kitidis, A. Dararutana, and H.F. Lodish Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth J. Biol. Chem. 279 2004 23882 23891
7. T. Massoud, and S. Gambhir Molecular imaging in living subjects: seeing fundamental biological processes in a new light Genes Dev. 17 2003 545 580
8. W. Pham, M.F. Kircher, R. Weissleder, and C.H. Tung Enhancing membrane permeability by fatty acylation of oligoarginine peptides Chembiochemistry 5 2004 1148 1151
9. W. Pham, Z. Medarova, and A. Moore Synthesis and application of water-soluble near infrared dye for cancer detection using optical imaging Bioconjugate Chem. 16 2005 735 740
10. A.W. Vorbrodt Ultracytochemical characterization of anionic sites in the wall of brain capillaries J. Neurocytol. 18 1989 359 368