A leptin derived 30-amino-acid peptide modified pegylated poly-l-lysine dendrigraft for brain targeted gene delivery

Biomaterials

Volumn 31, Issue 19, 2010, Pages 5246-5257

  Liu, Yang ^a   Li, Jianfeng ^a   Shao, Kun ^a   Huang, Rongqin ^a   Ye, Liya ^b   Lou, Jinning ^b   Jiang, Chen ^a  

^a FUDAN UNIVERSITY   (China)

^b CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

Author keywords

Brain targeting; Dendrigraft poly l lysine; Gene delivery; Leptin; Non viral vector

Indexed keywords

BLOOD-BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELLS; BRAIN PARENCHYMA; CELLULAR UPTAKE; CENTRAL NERVOUS SYSTEMS; GENE DELIVERY; GENE TRANSFECTION; IN-VITRO; INTRAVENOUS INJECTIONS; LEPTIN; LEPTIN RECEPTORS; LIGAND-RECEPTOR; LIGAND-RECEPTOR BINDING; MICROGLIA; NONVIRAL; NONVIRAL VECTORS; PLASMID DNA; POLY-L-LYSINE; TARGETED GENE DELIVERY; THERAPEUTIC DRUGS;

ACIDS; AMINO ACIDS; BLOOD; ENDOTHELIAL CELLS; GENE TRANSFER; LIGANDS; NUCLEIC ACIDS; PEPTIDES; POLYETHYLENE GLYCOLS;

HORMONES;

DENDRIMER; LEPTIN; LEPTIN RECEPTOR; LEPTIN[61-90]; MACROGOL; NANOPARTICLE; PLASMID DNA; POLYLYSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DRUG TRANSPORT; ENDOCYTOSIS; ENDOTHELIUM CELL; GENE EXPRESSION; IN VITRO GENE TRANSFER; MALE; MICROGLIA; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; QUALITATIVE ANALYSIS;

ANIMALS; BRAIN; DNA; DRUG CARRIERS; LEPTIN; MICE; MICE, NUDE; PEPTIDES; POLYETHYLENE GLYCOLS; POLYLYSINE; TRANSFECTION;

EID: 77952289786     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.03.011     Document Type: Article

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