Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells

Journal of Pharmaceutical Sciences

Volumn 91, Issue 12, 2002, Pages 2525-2538

  Abbruscato, Thomas J ^a   Lopez, Steve P ^a   Mark, Karen S ^b   Hawkins, Brian T ^b   Davis, Thomas P ^b  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Blood brain barrier; Cotinine; Endothelial cell; Nicotine; Tight junction; ZO 1

Indexed keywords

COTININE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PROTEIN ZO1; RECEPTOR SUBUNIT; SUCROSE; MEMBRANE PROTEIN; PHOSPHOPROTEIN; ZONULA OCCLUDENS 1 PROTEIN; ZONULA OCCLUDENS-1 PROTEIN;

ANIMAL CELL; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN CELL; BRAIN MICROCIRCULATION; CATTLE; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DRUG RECEPTOR BINDING; ENDOTHELIUM CELL; HYPOXIA; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MODEL; NONHUMAN; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STROKE; TIGHT JUNCTION; WESTERN BLOTTING; ANIMAL; ARTICLE; BIOSYNTHESIS; BRAIN; CAPILLARY PERMEABILITY; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANIMALS; BRAIN; CAPILLARY PERMEABILITY; CATTLE; COTININE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; MEMBRANE PROTEINS; NICOTINE; PHOSPHOPROTEINS; RECEPTORS, NICOTINIC;

EID: 0036891988     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10256     Document Type: Conference Paper

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