-
1
-
-
0027404655
-
Peptidases, peptides and the mammalian blood-brain barrier
-
Brownlees J, Williams CH. Peptidases, peptides and the mammalian blood-brain barrier. J. Neurochem. 60, 1089-1096 (1993).
-
(1993)
J. Neurochem.
, vol.60
, pp. 1089-1096
-
-
Brownlees, J.1
Williams, C.H.2
-
3
-
-
0031959341
-
CNS drug design based on principles of blood-brain barrier transport
-
Pardridge WM. CNS drug design based on principles of blood-brain barrier transport. J. Neurochem. 70, 1781-1792 (1998). (Pubitemid 28207799)
-
(1998)
Journal of Neurochemistry
, vol.70
, Issue.5
, pp. 1781-1792
-
-
Pardridge, W.M.1
-
4
-
-
34547637590
-
Drug targeting to the brain
-
DOI 10.1007/s11095-007-9324-2
-
Pardridge WM. Drug targeting to the brain. Pharma. Res. 24, 1733-1744 (2007). (Pubitemid 47206623)
-
(2007)
Pharmaceutical Research
, vol.24
, Issue.9
, pp. 1733-1744
-
-
Pardridge, W.M.1
-
6
-
-
0141764816
-
Drug delivery to the central nervous system: A review
-
Misra A, Ganesh S, Shahiwala A, Shah SP. Drug delivery to the central nervous system: a review. J. Pharm. Pharmaceut. Sci. 6, 252-273 (2003) (Pubitemid 37207232)
-
(2003)
Journal of Pharmacy and Pharmaceutical Sciences
, vol.6
, Issue.2
, pp. 252-273
-
-
Misra, A.1
Ganesh, S.2
Shahiwala, A.3
Shah, S.P.4
-
7
-
-
70449529637
-
Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
-
Gabathuler R. Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiol. Dis. 37, 48-57 (2010).
-
(2010)
Neurobiol. Dis.
, vol.37
, pp. 48-57
-
-
Gabathuler, R.1
-
8
-
-
0033030906
-
Gene therapy in the central nervous system
-
Suhr ST, Gage FH. Gene therapy in the central nervous system. Arch. Neurol. 56, 287-292 (1999).
-
(1999)
Arch. Neurol.
, vol.56
, pp. 287-292
-
-
Suhr, S.T.1
Gage, F.H.2
-
9
-
-
0032982332
-
Novel, highly lipophilic antioxidants readily diffuse across the blood- brain barrier and access intracellular sites
-
Sawada GA, Williams LR, Lutzke BS, Raub TJ. Novel, highly lipophilic antioxidants readily diffuse across the blood-brain barrier and access intracellular sites. J. Pharmacol. Exp. Ther. 288 (3), 1327-1333 (1999). (Pubitemid 29254174)
-
(1999)
Journal of Pharmacology and Experimental Therapeutics
, vol.288
, Issue.3
, pp. 1327-1333
-
-
Sawada, G.A.1
Williams, L.R.2
Lutzke, B.S.3
Raub, T.J.4
-
10
-
-
0027793559
-
Use of a biophysical-kinetic model to understand the roles of protein binding and membrane partitioning on passive diffusion of highly lipophilic molecules across cellular barriers
-
Raub TJ, Barsuhn CL, Williams LR, Decker DE, Sawada GA, Ho NF. Use of a biophysical-kinetic model to understand the roles of protein binding and membrane partitioning on passive diffusion of highly lipophilic molecules across cellular barriers. J. Drug. Target. 1, 269-286 (1993).
-
(1993)
J. Drug. Target.
, vol.1
, pp. 269-286
-
-
Raub, T.J.1
Barsuhn, C.L.2
Williams, L.R.3
Decker, D.E.4
Sawada, G.A.5
Ho, N.F.6
-
11
-
-
0035748363
-
Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability
-
Witt KA, Gillespie TJ, Huber JD, Egleton RD, Davis TP. Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability. Peptides 22, 2329-2343 (2001).
-
(2001)
Peptides
, vol.22
, pp. 2329-2343
-
-
Witt, K.A.1
Gillespie, T.J.2
Huber, J.D.3
Egleton, R.D.4
Davis, T.P.5
-
12
-
-
41149167204
-
Synthesis and biological effects of c(Lys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys- Pro- Tyr-Ile-Leu) (JMV2012), a new analogue of neurotensin that crosses the blood-brain barrier
-
DOI 10.1021/jm700925k
-
Bredeloux P, Cavelier F, Dubuc I, Vivet B, Costentin J, Martinez J. Synthesis and biological effects of c(Lys-Lys-Pro-Tyr-Ile-Leu- Lys-Lys-Pro-Tyr-Ile-Leu) (JMV2012), a new analog of neurotensin that crosses the blood- brain barrier. J. Med. Chem. 51, 1610-1616 (2008). (Pubitemid 351438845)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.6
, pp. 1610-1616
-
-
Bredeloux, P.1
Cavelier, F.2
Dubuc, I.3
Vivet, B.4
Costentin, J.5
Martinez, J.6
-
13
-
-
0036827575
-
Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-d-Ala-Gly-Phe-d-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model
-
Chen W, Yang JZ, Andersen R, Nielsen LH, Borchardt RT. Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-d-Ala-Gly-Phe-d-Leu- OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model. J. Pharmacol. Exp. Ther. 303, 849-857 (2002).
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, pp. 849-857
-
-
Chen, W.1
Yang, J.Z.2
Andersen, R.3
Nielsen, L.H.4
Borchardt, R.T.5
-
14
-
-
0034693398
-
Improved bioavailability to the brain of glycosylated Met-enkephalin analogs
-
Egleton RD, Mitchell SA, Huber JD et al. Improved bioavailability to the brain of glycosylated Met-enkephalin analogs. Brain Res. 881, 37-46 (2000).
-
(2000)
Brain Res.
, vol.881
, pp. 37-46
-
-
Egleton, R.D.1
Mitchell, S.A.2
Huber, J.D.3
-
15
-
-
49749101644
-
Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers
-
Batrakova EV, Kabanov AV. Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers. J. Controlled Rel. 130, 98-106 (2008).
-
(2008)
J. Controlled Rel.
, vol.130
, pp. 98-106
-
-
Batrakova, E.V.1
Kabanov, A.V.2
-
16
-
-
0037457792
-
Pluronic® block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier
-
DOI 10.1016/S0169-409X(02)00176-X, PII S0169409X0200176X
-
Kabanov AV, Batrakova EV, Miller DW. Pluronic block copolymers as modulators of drug efflux transporter activity in the blood- brain barrier. Adv. Drug Deliv. Rev. 55, 151-164 (2003). (Pubitemid 36078456)
-
(2003)
Advanced Drug Delivery Reviews
, vol.55
, Issue.1
, pp. 151-164
-
-
Kabanov, A.V.1
Batrakova, E.V.2
Miller, D.W.3
-
17
-
-
33846266240
-
Carbohydrate-based micelle clusters which enhance hydrophobic drug bioavailability by up to 1 order of magnitute
-
DOI 10.1021/bm0604000
-
Qu X, Khutoryanskiy VV, Stewart A et al. Carbohydrate-based micelle clusters which enhance hydrophobic drug availability by up to one order of magnitude. Biomacromolecules 7, 3452-3459 (2006). (Pubitemid 46111801)
-
(2006)
Biomacromolecules
, vol.7
, Issue.12
, pp. 3452-3459
-
-
Qu, X.1
Khutoryanskiy, V.V.2
Stewart, A.3
Rahman, S.4
Papahadjopoulos-Sternberg, B.5
Dufes, C.6
McCarthy, D.7
Wilson, C.G.8
Lyons, R.9
Carter, K.C.10
Schatzlein, A.11
Uchegbu, I.F.12
-
18
-
-
70449569028
-
The blood-brain barrier
-
Palmer AM. The blood-brain barrier. Neurobiol. Dis. 37, 1-2 (2010).
-
(2010)
Neurobiol. Dis.
, vol.37
, pp. 1-2
-
-
Palmer, A.M.1
-
19
-
-
70349492713
-
Blood-brain barrier transport of drugs for the treatment of brain diseases
-
Gabathuler R. Blood-brain barrier transport of drugs for the treatment of brain diseases. CNS Neurol Disord. Drug Targets 8, 195-294 (2009).
-
(2009)
CNS Neurol Disord. Drug Targets
, vol.8
, pp. 195-294
-
-
Gabathuler, R.1
-
20
-
-
0037369812
-
Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter
-
DOI 10.1124/jpet.102.045856
-
Allen DD, Lockman PR, Roder KE, Dwoskin LP, Crooks PA. Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter. J. Pharmacol. Exp. Ther. 304, 1268-1274 (2003). (Pubitemid 36254440)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.304
, Issue.3
, pp. 1268-1274
-
-
Allen, D.D.1
Lockman, P.R.2
Roder, K.E.3
Dwoskin, L.P.4
Crooks, P.A.5
-
21
-
-
84901063326
-
Development of brain-targeted liposomes with antiviral drugs for treating lethal viral encephalitis
-
International Conference. Sendai, Japan, 28 June-2 July 2009
-
Gaillard PJ, Leyssen P, Appeldoorn C et al. Development of brain-targeted liposomes with antiviral drugs for treating lethal viral encephalitis. Presented at: The 8th Cerebral Vascular Biology (CVB) 2009 International Conference. Sendai, Japan, 28 June-2 July 2009.
-
(2009)
The 8th Cerebral Vascular Biology (CVB)
-
-
Gaillard, P.J.1
Leyssen, P.2
Appeldoorn, C.3
-
22
-
-
0029942499
-
Evidence for the existence of a sodium-dependent glutathione (GSH) transporter
-
Kannan R, Yi JR, Tang D, Zlokovic BV, Kaplowitz N. Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. J. Biol. Chem. 271 (16), 9754-9758 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, Issue.16
, pp. 9754-9758
-
-
Kannan, R.1
Yi, J.R.2
Tang, D.3
Zlokovic, B.V.4
Kaplowitz, N.5
-
23
-
-
0002429624
-
Carrier-mediated GSH transport at the blood-brain barrier and molecular characterisation of novel brain GSH transporters
-
Shaw CA (Ed), Taylor & Francis, Washington, DC, USA
-
Kannan R, Yi J-R, Zlokovic BV, Kaplowitz N. Carrier-mediated GSH transport at the blood-brain barrier and molecular characterisation of novel brain GSH transporters. In:Glutathione in the Nervous System Shaw CA (Ed), Taylor & Francis, Washington, DC, USA 45-62 (1998).
-
(1998)
Glutathione in the Nervous System
, pp. 45-62
-
-
Kannan, R.1
Yi, J.-R.2
Zlokovic, B.V.3
Kaplowitz, N.4
-
24
-
-
0033036416
-
GSH transport in immortalized mouse brain endothelial cells: Evidence for apical localization of a sodium-dependent GSH transporter
-
DOI 10.1046/j.1471-4159.1999.0730390.x
-
Kannan R, Mittur A, Bao Y, Tsuruo T, Kaplowitz N. GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter. J. Neurochem. 73, 390-399 (1999). (Pubitemid 29289148)
-
(1999)
Journal of Neurochemistry
, vol.73
, Issue.1
, pp. 390-399
-
-
Kannan, R.1
Mittur, A.2
Bao, Y.3
Tsuruo, T.4
Kaplowitz, N.5
-
25
-
-
0028298819
-
Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain
-
DOI 10.1006/bbrc.1994.1715
-
Zlokovic BV, Mackic JB, McComb JG, Weiss MH, Kaplovitz N, Kannan R. Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem. Biophys. Res. Comm. 201 (1) 402-408 (1994) (Pubitemid 24213740)
-
(1994)
Biochemical and Biophysical Research Communications
, vol.201
, Issue.1
, pp. 402-408
-
-
Zlokovic, B.V.1
MacKic, J.B.2
McComb, J.G.3
Weiss, M.H.4
Kaplowitz, N.5
Kannan, R.6
-
26
-
-
85042807004
-
Receptor-mediated delivery of drugs across the blood-brain barrier
-
Brussels, Belgium 11-12 February 2010
-
Rip J, Appeldoorn CC, Manca FM, Dorland R, van Kregten JM, Gaillard PJ. Receptor-mediated delivery of drugs across the blood-brain barrier. Presented at: Pharmacology and Toxicology of the Blood- Brain Barrier: State of the Art, Needs for Future Research and Expected Benefits for the EU. Brussels, Belgium, 11-12 February 2010.
-
Pharmacology and Toxicology of the Blood- Brain Barrier: State of the Art, Needs for Future Research and Expected Benefits for the EU
-
-
Rip, J.1
Appeldoorn, C.C.2
Manca, F.M.3
Dorland, R.4
Van Kregten, J.M.5
Gaillard, P.J.6
-
27
-
-
79954454603
-
GSH-conjugation improves efficacy of Doxil against intracranial xenografts
-
17-21 April 2010, Washington DC, USA
-
van Tellingen O, Brandsma D, Appeldoorn CC et al. GSH-conjugation improves efficacy of Doxil against intracranial xenografts. Presented at: The Annual Meeting of the AACR. Washington DC, USA, 17-21 April 2010.
-
The Annual Meeting of the AACR
-
-
Van Tellingen, O.1
Brandsma, D.2
Appeldoorn, C.C.3
-
28
-
-
34250182404
-
Chemotherapy delivery issues in central nervous system malignancy: A reality check
-
DOI 10.1200/JCO.2006.09.9861
-
Muldoon LL, Soussain C, Jahnke K et al. Chemotherapy delivery issues in central nervous system malignancy: a reality check. J. Clin. Oncol. 25 (16), 2295-2305 (2007). (Pubitemid 46954658)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.16
, pp. 2295-2305
-
-
Muldoon, L.L.1
Soussain, C.2
Jahnke, K.3
Johanson, C.4
Siegal, T.5
Smith, Q.R.6
Hall, W.A.7
Hynynen, K.8
Senter, P.D.9
Peereboom, D.M.10
Neuwelt, E.A.11
-
29
-
-
34248679586
-
ShRNA and siRNA delivery to the brain
-
DOI 10.1016/j.addr.2007.03.008, PII S0169409X07000221, Opportunities and Challenges for Therapeutic Gene Silencing using RNAi and microRNA Technologies
-
Pardridge WM. shRNA and siRNA delivery to the brain. Adv. Drug Delivery Rev. 59, 141-152 (2007). (Pubitemid 46773051)
-
(2007)
Advanced Drug Delivery Reviews
, vol.59
, Issue.2-3
, pp. 141-152
-
-
Pardridge, W.M.1
-
30
-
-
77949375780
-
Biopharmaceutical drug targeting to the brain
-
Pardridge WM. Biopharmaceutical drug targeting to the brain. J. Drug Target. 18 (3), 157-167 (2010).
-
(2010)
J. Drug Target.
, vol.18
, Issue.3
, pp. 157-167
-
-
Pardridge, W.M.1
-
31
-
-
33748438120
-
Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion
-
DOI 10.1016/j.brainres.2006.07.005, PII S000689930602049X
-
Zhang Y, Pardridge WM. Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion. Brain Res. 1111, 227-229 (2006). (Pubitemid 44339581)
-
(2006)
Brain Research
, vol.1111
, Issue.1
, pp. 227-229
-
-
Zhang, Y.1
Pardridge, W.M.2
-
32
-
-
0030426639
-
Central nervous system pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood-brain barrier drug delivery system
-
Wu D, Pardridge WM. Central nervous system pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood-brain barrier drug delivery system. J. Pharmacol. Exp. Ther. 279, 77-83 (1996). (Pubitemid 27166896)
-
(1996)
Journal of Pharmacology and Experimental Therapeutics
, vol.279
, Issue.1
, pp. 77-83
-
-
Wu, D.1
Pardridge, W.M.2
-
34
-
-
0036228917
-
Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector
-
DOI 10.1124/jpet.301.2.605
-
Song BW, Vinters HV, Wu D, Pardridge WM. Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector. J. Pharmacol. Exp. Ther. 301, 605-610 (2002). (Pubitemid 34429974)
-
(2002)
Journal of Pharmacology and Experimental Therapeutics
, vol.301
, Issue.2
, pp. 605-610
-
-
Song, B.-W.1
Vinters, H.V.2
Wu, D.3
Pardridge, W.M.4
-
35
-
-
0033572574
-
Imaging brain tumors by targeting peptide radiopharmaceuticals through the blood-brain barrier
-
Kurihara A, Pardridge WM. Imaging brain tumors by targeting peptide radiopharmaceuticals through the blood-brain barrier. Cancer Res. 59, 6159-6163 (1999). (Pubitemid 30035637)
-
(1999)
Cancer Research
, vol.59
, Issue.24
, pp. 6159-6163
-
-
Kurihara, A.1
Pardridge, W.M.2
-
36
-
-
0036173189
-
Imaging brain amyloid of Alzheimer disease in Vivo in transgenic mice with an Aβ peptide radiopharmaceutical
-
Lee HJ, Zhang Y, Zhu C, Duff K, Pardridge WM. Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Ab peptide radiopharmaceutical. J. Cereb. Flow Metab. 22, 223-231 (2002). (Pubitemid 34135653)
-
(2002)
Journal of Cerebral Blood Flow and Metabolism
, vol.22
, Issue.2
, pp. 223-231
-
-
Hwa, J.L.1
Zhang, Y.2
Zhu, C.3
Duff, K.4
Pardridge, W.M.5
-
37
-
-
63949084137
-
Near complete rescue of experimental Parkinson's disease with intravenous nonviral GDNF gene therapy
-
Zhang Y, Pardridge WM. Near complete rescue of experimental Parkinson's disease with intravenous nonviral GDNF gene therapy. Pharma. Res. 26 (5), 1059-1063 (2009).
-
(2009)
Pharma. Res.
, vol.26
, Issue.5
, pp. 1059-1063
-
-
Zhang, Y.1
Pardridge, W.M.2
-
38
-
-
59649102668
-
Transferrin- and transferrinreceptor- antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB)
-
Ulbrich K, Hekmatara T, Herbert E, Kreuter J. Transferrin- and transferrinreceptor- antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB). Eur. J. Pharma. Biopharm. 71, 251-256 (2009).
-
(2009)
Eur. J. Pharma. Biopharm.
, vol.71
, pp. 251-256
-
-
Ulbrich, K.1
Hekmatara, T.2
Herbert, E.3
Kreuter, J.4
-
39
-
-
0033996507
-
Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor
-
DOI 10.1023/A:1007592720793
-
Coloma MJ, Lee HJ, Kurihara A et al. Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor. Pharm. Res. 17, 266-274 (2000). (Pubitemid 30225129)
-
(2000)
Pharmaceutical Research
, vol.17
, Issue.3
, pp. 266-274
-
-
Coloma, M.J.1
Lee, H.J.2
Kurihara, A.3
Landaw, E.M.4
Boado, R.J.5
Morrison, S.L.6
Pardridge, W.M.7
-
40
-
-
44449128659
-
GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier
-
DOI 10.1002/bit.21764
-
Boado RJ, Zhang Y, Wang Y, Pardridge WM. GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier. Biotech. Bioeng. 100, 387-396 (2008). (Pubitemid 351758180)
-
(2008)
Biotechnology and Bioengineering
, vol.100
, Issue.2
, pp. 387-396
-
-
Boado, R.J.1
Zhang, Y.2
Zhang, Y.3
Wang, Y.4
Pardridge, W.M.5
-
41
-
-
69949114874
-
Pharmacokinetics and safety in Rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeting blood-brain barrier delivery
-
Pardridge WM, Boado RJ. Pharmacokinetics and safety in Rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeting blood-brain barrier delivery. Pharma. Res. 26 (10), 2227-2236 (2009).
-
(2009)
Pharma. Res.
, vol.26
, Issue.10
, pp. 2227-2236
-
-
Pardridge, W.M.1
Boado, R.J.2
-
42
-
-
78650538843
-
Targeting the insulin receptor: Nanoparticles for drug delivery across the blood-brain barrier (BBB)
-
DOI:10.3109/10611861003734001 Epub ahead of print
-
Ulbrich K, Knobloch T, Kreuter J. Targeting the insulin receptor: nanoparticles for drug delivery across the blood-brain barrier (BBB). J. Drug Target. DOI:10.3109/10611861003734001 (2010) (Epub ahead of print).
-
(2010)
J. Drug Target.
-
-
Ulbrich, K.1
Knobloch, T.2
Kreuter, J.3
-
43
-
-
67349121612
-
Albumin nanoparticles targeted with Apo e enter the CNS by transcytosis and are delivered to neurones
-
Zensi A, Begley D, Pontikis C et al. Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones. J. Contr. Rel. 137, 78-86 (2009).
-
(2009)
J. Contr. Rel.
, vol.137
, pp. 78-86
-
-
Zensi, A.1
Begley, D.2
Pontikis, C.3
-
44
-
-
0034836428
-
LRP: A multifunctional scavenger and signaling receptor
-
DOI 10.1172/JCI200113992
-
Hertz J, Strickland DK. LRP: a multifunctional scavenger and signalling receptor. J. Clin. Invest. 108, 779-784 (2001). (Pubitemid 32880284)
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.6
, pp. 779-784
-
-
Herz, J.1
Strickland, D.K.2
-
45
-
-
0029128232
-
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted b-amyloid precursor protein and mediates its degradation
-
Kounnas MZ, Moir RD, Rebeck GW et al. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted b-amyloid precursor protein and mediates its degradation. Cell 82, 331-340 (1995).
-
(1995)
Cell
, vol.82
, pp. 331-340
-
-
Kounnas, M.Z.1
Moir, R.D.2
Rebeck, G.W.3
-
46
-
-
34548496491
-
Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway
-
DOI 10.1096/fj.07-8114com
-
Yoon I-S, Chen E, Busse T et al. Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway. FASEB J. 21, 2742-2752 (2007). (Pubitemid 47372742)
-
(2007)
FASEB Journal
, vol.21
, Issue.11
, pp. 2742-2752
-
-
Yoon, I.-S.1
Chen, E.2
Busse, T.3
Repetto, E.4
Lakshmana, M.K.5
Koo, E.H.6
Kang, D.E.7
-
47
-
-
0027374047
-
Apolipoprotein e in sporadic Alzheimer's disease: Allelic variation and receptor interactions
-
DOI 10.1016/0896-6273(93)90070-8
-
Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 11, 575-580 (1993). (Pubitemid 23321768)
-
(1993)
Neuron
, vol.11
, Issue.4
, pp. 575-580
-
-
Rebeck, G.W.1
Reiter, J.S.2
Strickland, D.K.3
Hyman, B.T.4
-
48
-
-
0028298886
-
Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons
-
Bu G, Maksymovitch EA, Nerbonne JM, Schwartz AL. Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. J. Biol. Chem. 269, 18521-18528 (1994). (Pubitemid 24224088)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.28
, pp. 18521-18528
-
-
Bu, G.1
Maksymovitch, E.A.2
Nerbonne, J.M.3
Schwartz, A.L.4
-
49
-
-
0026693345
-
Characterization and immunohistochemical localization of a2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain
-
Wolf BB, Lopes MBS, VandenBerg SR, Gonias SL. Characterization and immunohistochemical localization of a2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. Am. J. Pathol. 141, 37-42 (1992).
-
(1992)
Am. J. Pathol.
, vol.141
, pp. 37-42
-
-
Wolf, B.B.1
Mbs, L.2
Vandenberg, S.R.3
Gonias, S.L.4
-
50
-
-
0026731852
-
Distribution of the a2-macroglobulin receptor/low density lipoprotein receptorrelated protein in human tissues
-
Moestrup SK, Gliemann J, Pallesen G. Distribution of the a2-macroglobulin receptor/low density lipoprotein receptorrelated protein in human tissues. Cell Tissue Res. 269, 375-342 (1992).
-
(1992)
Cell Tissue Res.
, vol.269
, pp. 375-342
-
-
Moestrup, S.K.1
Gliemann, J.2
Pallesen, G.3
-
51
-
-
0030837448
-
Increased expression of low density lipoprotein receptor-related protein/α2-macroglobulin receptor in human malignant astrocytomas
-
Yamamoto M, Ikeda K, Ohshima K, Tsugu H, Kimura H, Tomonaga M. Increased expression of low density lipoprotein receptor-related protein/a2-macroglobulin receptor in human malignant astrocytomas. Cancer Res. 57, 2799-2805 (1997). (Pubitemid 27283795)
-
(1997)
Cancer Research
, vol.57
, Issue.13
, pp. 2799-2805
-
-
Yamamoto, M.1
Ikeda, K.2
Ohshima, K.3
Tsugu, H.4
Kimura, H.5
Tomonaga, M.6
-
52
-
-
0034595799
-
The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein
-
DOI 10.1074/jbc.M000490200
-
Li Y, Marzolo MP, van Kerkhof P, Strous GJ, Bu G. The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low-density lipoprotein receptor-related protein. J. Biol. Chem. 275 (22), 17187-17194 (2000). (Pubitemid 30398967)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.22
, pp. 17187-17194
-
-
Li, Y.1
Marzolo, M.P.2
Van Kerkhof, P.3
Strous, G.J.4
Bu, G.5
-
53
-
-
20944452152
-
Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis
-
DOI 10.1161/01.CIR.0000163542.48611.A2
-
Benchenane K, Berezowski V, Ali C et al. Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis. Circulation 111, 2241-2249 (2005). (Pubitemid 40632441)
-
(2005)
Circulation
, vol.111
, Issue.17
, pp. 2241-2249
-
-
Benchenane, K.1
Berezowski, V.2
Ali, C.3
Fernandez-Monreal, M.4
Lopez-Atalaya, J.P.5
Brillault, J.6
Chuquet, J.7
Nouvelot, A.8
MacKenzie, E.T.9
Bu, G.10
Cecchelli, R.11
Touzani, O.12
Vivien, D.13
-
54
-
-
63049103433
-
Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways
-
Donoso M, Cancino J, Lee J et al. Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways. Mol. Biol. Cell. 20, 481-497 (2009).
-
(2009)
Mol. Biol. Cell.
, vol.20
, pp. 481-497
-
-
Donoso, M.1
Cancino, J.2
Lee, J.3
-
55
-
-
40849102300
-
LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-b peptide in a blood-brain barrier in vitro model
-
Nazer B, Hong S, Selkoe DJ. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-b peptide in a blood-brain barrier in vitro model. Neurobiol. Dis. 30, 94-102 (2008).
-
(2008)
Neurobiol. Dis.
, vol.30
, pp. 94-102
-
-
Nazer, B.1
Hong, S.2
Selkoe, D.J.3
-
56
-
-
0032802253
-
The mammalian low-density lipoprotein receptor family
-
DOI 10.1146/annurev.nutr.19.1.141
-
Hussain MM, Strickland DK, Bakillah A. The mammalian low-density lipoprotein receptor family. Annu. Rev. Nutr. 19, 141-172 (1999). (Pubitemid 29380600)
-
(1999)
Annual Review of Nutrition
, vol.19
, pp. 141-172
-
-
Hussain, M.M.1
Strickland, D.K.2
Bakillah, A.3
-
57
-
-
0033982675
-
Desolvation process and surface characteristics of HSA-nanoparticles
-
DOI 10.1016/S0378-5173(99)00420-2, PII S0378517399004202
-
Weber C, Kreuter J, Langer K. Desolvation process and surface characteristics of HSA-nanoparticles. Int. J. Pharm. 196 (2), 197-200 (2000). (Pubitemid 30105742)
-
(2000)
International Journal of Pharmaceutics
, vol.196
, Issue.2
, pp. 197-200
-
-
Weber, C.1
Kreuter, J.2
Langer, K.3
-
58
-
-
33646796753
-
Covalent linkage of apolipoprotein e to albumin nanoparticles strongly enhances drug transport into the brain
-
DOI 10.1124/jpet.105.097139
-
Michaelis K, Hoffmann MM, Dreis S et al. Covalent linkage of Apolipoprotein E to albumin nanoparticles strongly enhances drug transport into the brain. J. Pharmacol. Exp. Ther. 317 (3), 1246-1253 (2006). (Pubitemid 43764130)
-
(2006)
Journal of Pharmacology and Experimental Therapeutics
, vol.317
, Issue.3
, pp. 1246-1253
-
-
Michaelis, K.1
Hoffmann, M.M.2
Dreis, S.3
Herbert, E.4
Alyautdin, R.N.5
Michaelis, M.6
Kreuter, J.7
Langer, K.8
-
59
-
-
33847116764
-
Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain
-
DOI 10.1016/j.jconrel.2006.12.012, PII S0168365906007103
-
Kreuter J, Hekmatara T, Dreis S, Vogel T, Gelperina S, Langer K. Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles anables drug transport into the brain. J. Contr. Rel. 118, 54-58 (2007). (Pubitemid 46283106)
-
(2007)
Journal of Controlled Release
, vol.118
, Issue.1
, pp. 54-58
-
-
Kreuter, J.1
Hekmatara, T.2
Dreis, S.3
Vogel, T.4
Gelperina, S.5
Langer, K.6
-
60
-
-
33646460828
-
Application of nanoparticles for the delivery of drugs to the brain
-
DOI 10.1016/j.ics.2005.02.014, PII S0531513105000853, Drug Transport(ers) and the Diseased Brain
-
Kreuter J. Application of nanoparticles for the delivery of drugs to the brain. In:Drug Transport(ers) and the Diseased Brain International Congress Series, Esteve Foundation Symposium XI , S'Agaró (Girona), Spain, de Boer AG (Ed), Elsevier 1277, 85-94 (2005). (Pubitemid 43693337)
-
(2005)
International Congress Series
, vol.1277
, pp. 85-94
-
-
Kreuter, J.1
-
61
-
-
0037335187
-
Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles
-
DOI 10.1023/A:1022604120952
-
Kreuter J, Ramge P, Petrov V et al. Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharma. Res. 20, 409-416 (2003). (Pubitemid 36288370)
-
(2003)
Pharmaceutical Research
, vol.20
, Issue.3
, pp. 409-416
-
-
Kreuter, J.1
Ramge, P.2
Petrov, V.3
Hamm, S.4
Gelperina, S.E.5
Engelhardt, B.6
Alyautdin, R.7
Von Briesen, H.8
Begley, D.J.9
-
62
-
-
12144288634
-
Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles
-
DOI 10.1002/ijc.20048
-
Steiniger SCJ, Kreuter J, Khalansky AS et al. Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles. Int. J. Cancer 109, 759-767 (2004). (Pubitemid 38405625)
-
(2004)
International Journal of Cancer
, vol.109
, Issue.5
, pp. 759-767
-
-
Steiniger, S.C.J.1
Kreuter, J.2
Khalansky, A.S.3
Skidan, I.N.4
Bobruskin, A.I.5
Smirnova, Z.S.6
Severin, S.E.7
Uhl, R.8
Kock, M.9
Geiger, K.D.10
Gelperina, S.E.11
-
63
-
-
12344307628
-
Drug transport to brain with targeted nanoparticles
-
Olivier JC. Drug transport to brain with targeted nanoparticles. NeuroRx 2, 108-119 (2005).
-
(2005)
NeuroRx
, vol.2
, pp. 108-119
-
-
Olivier, J.C.1
-
64
-
-
0035984812
-
Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier
-
DOI 10.1080/10611860290031877
-
Kreuter J, Shamenkov D, Petrov V et al. Apolipoprotein-mediated transport of nanoparticles-bound drugs across the blood-brain barrier. J. Drug Target. 10, 317-325 (2002). (Pubitemid 34746313)
-
(2002)
Journal of Drug Targeting
, vol.10
, Issue.4
, pp. 317-325
-
-
Kreuter, J.1
Shamenkov, D.2
Petrov, V.3
Ramge, P.4
Cychutek, K.5
Koch-Brandt, C.6
Alyautdin, R.7
-
65
-
-
70350464733
-
Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles
-
Kurakhmaeva KB, Djindjikhashvili IA, Petro VE et al. Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles. J. Drug Target. 17(8), 564-574 (2009).
-
(2009)
J. Drug Target.
, vol.17
, Issue.8
, pp. 564-574
-
-
Kurakhmaeva, K.B.1
Djindjikhashvili, I.A.2
Petro, V.E.3
-
66
-
-
75449107968
-
Drug delivery to the brain using surfactant-coated poly(lactide- coglycolide) nanoparticles: Influence of the formulation parameters
-
Gelperina S, Maksimenko O, Khalansky A et al. Drug delivery to the brain using surfactant-coated poly(lactide-coglycolide) nanoparticles: influence of the formulation parameters. Eur. J. Pharma. Biopharma. 74, 157-163 (2010).
-
(2010)
Eur. J. Pharma. Biopharma.
, vol.74
, pp. 157-163
-
-
Gelperina, S.1
Maksimenko, O.2
Khalansky, A.3
-
68
-
-
35548959221
-
The use of lactoferrin as a ligand for targeting the polyamidoamine-based gene delivery system to the brain
-
DOI 10.1016/j.biomaterials.2007.09.024, PII S0142961207007430
-
Huang R, Ke W, Liu Y, Jiang C, Pei Y. The use of lactoferrin as a ligand for targeting the polyamidoamine-based gene delivery system to the brain. Biomaterials 29, 238-246 (2008). (Pubitemid 350016299)
-
(2008)
Biomaterials
, vol.29
, Issue.2
, pp. 238-246
-
-
Huang, R.1
Ke, W.2
Liu, Y.3
Jiang, C.4
Pei, Y.5
-
69
-
-
0029935613
-
Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin
-
DOI 10.1016/0006-8993(95)01407-1
-
Jefferies WA, Food M, Gabathuler R, Rothenberger S, Yamada T, McGeer PL. Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin. Brain Res. 712, 122-126 (1996). (Pubitemid 26099932)
-
(1996)
Brain Research
, vol.712
, Issue.1
, pp. 122-126
-
-
Jefferies, W.A.1
Food, M.R.2
Gabathuler, R.3
Rothenberger, S.4
Yamada, T.5
Yasuhara, O.6
McGeer, P.L.7
-
70
-
-
0028111120
-
Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein
-
Food M, Rothenberger S, Gabathuler R, Haidl ID, Reid G, Jefferies WA. Transport and expression in human melanomas of a transferrin like glycosylphosphatidylinositolanchored proteins. J. Biol. Chem. 269, 3034-3040 (1994). (Pubitemid 24235812)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.4
, pp. 3034-3040
-
-
Food, M.R.1
Rothenberger, S.2
Gabathuler, R.3
Haidl, I.D.4
Reid, G.5
Jefferies, W.A.6
-
71
-
-
18744415035
-
High transcytosis of melanotransferrin (P97) across the blood-brain barrier
-
DOI 10.1046/j.1471-4159.2002.01201.x
-
Demeule M, Poirier J, Jodoin J et al. High transcytosis of melanotransferrin (p97) across the blood-brain barrier. J. Neurochem. 83, 924-933 (2002). (Pubitemid 35316043)
-
(2002)
Journal of Neurochemistry
, vol.83
, Issue.4
, pp. 924-933
-
-
Demeule, M.1
Poirier, J.2
Jodoin, J.3
Bertrand, Y.4
Desrosiers, R.R.5
Dagenais, C.6
Nguyen, T.7
Lanthier, J.8
Gabathuler, R.9
Kennard, M.10
Jefferies, W.A.11
Karkan, D.12
Tsai, S.13
Fenart, L.14
Cecchelli, R.15
Beliveau, R.16
-
72
-
-
33646450326
-
Development of a potential protein vector (NeuroTrans) to deliver drugs across the blood-brain barrier
-
DOI 10.1016/j.ics.2005.02.021, PII S0531513105000920, Drug Transport(ers) and the Diseased Brain
-
Gabathuler R, Arthur G, Kennard ML et al. Development of a potential protein vector (NeuroTrans) to deliver drugs across the blood-brain barrier. In:Drug Transport(ers) and the Diseased Brain , Int Congress Series, Esteve Foundation Symposium XI , S'Agaró (Girona), Spain, de Boer AG (Ed), Elsevier 1277, 171-184 (2005). (Pubitemid 43693327)
-
(2005)
International Congress Series
, vol.1277
, pp. 171-184
-
-
Gabathuler, R.1
Arthur, G.2
Kennard, M.3
Chen, Q.4
Tsai, S.5
Yang, J.6
Schoorl, W.7
Vitalis, T.Z.8
Jefferies, W.A.9
-
73
-
-
49649119425
-
A unique carrier for delivery of therapeutical compounds beyond the blood-brain barrier
-
Karkan D, Pfeifer C, Vitalis TZ et al. A unique carrier for delivery of therapeutical compounds beyond the blood-brain barrier. PLoS One 3, e2469 (2008).
-
(2008)
PLoS One
, vol.3
-
-
Karkan, D.1
Pfeifer, C.2
Vitalis, T.Z.3
-
74
-
-
8744266243
-
Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier
-
DOI 10.1242/jcs.01381
-
Pan W, Kastin AJ, Zankel TC, van Kerkhof P, Terasaki T, Bu G. Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier. J. Cell Sci. 117, 5071-5078 (2004). (Pubitemid 39517522)
-
(2004)
Journal of Cell Science
, vol.117
, Issue.21
, pp. 5071-5078
-
-
Pan, W.1
Kastin, A.B.2
Zankel, T.C.3
Van Kerkhof, P.4
Terasaki, T.5
Bu, G.6
-
75
-
-
0038719718
-
Allosteric modulation of ligand binding to low density lipoprotein receptor-related protein by the receptor-associated protein requires critical lysine residues within its carboxyl-terminal domain
-
DOI 10.1074/jbc.M212592200
-
Migliorini MM, Behre EH, Brew S, Ingham KC, Strickland DK. Allosteric modulation of ligand binding to low density lipoprotein receptor-related protein by the receptor-associated protein requires critical lysine residues within the carboxy-terminal domain. J. Biol. Chem. 278, 17986-17992 (2003). (Pubitemid 36799407)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.20
, pp. 17986-17992
-
-
Migliorini, M.M.1
Behre, E.H.2
Brew, S.3
Ingham, K.C.4
Strickland, D.K.5
-
76
-
-
4544321276
-
Lipoprotein receptor binding, cellular uptake, and lysosomal delivery of fusions between the Receptor-associated Protein (RAP) and α-L-iduronidase or acid α-glucosidase
-
DOI 10.1074/jbc.M402630200
-
Prince WS, McCormick LM, Wendt DJ et al. Lipoprotein receptor binding, cellular uptake and lysosomal delivery of fusions between the receptor-associated protein (RAP) and a-l-iduronidase or acid a-glucosidase. J. Biol. Chem. 279, 35037-35046 (2004). (Pubitemid 39318140)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.33
, pp. 35037-35046
-
-
Prince, W.S.1
McCormick, L.M.2
Wendt, D.J.3
Fitzpatrick, P.A.4
Schwartz, K.L.5
Aguilera, A.I.6
Koppaka, V.7
Christianson, T.M.8
Vellard, M.C.9
Pavloff, N.10
Lemontt, J.F.11
Qin, M.12
Starr, C.M.13
Bu, G.14
Zankel, T.C.15
-
77
-
-
0034529953
-
Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands
-
DOI 10.1038/82199
-
Liu Y, Jones M, Hingten CM et al. Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nature Med. 6(12), 1380-1387 (2000). (Pubitemid 32001023)
-
(2000)
Nature Medicine
, vol.6
, Issue.12
, pp. 1380-1387
-
-
Liu, Y.1
Jones, M.2
Hingtgen, C.M.3
Bu, G.4
Laribee, N.5
Tanzi, R.E.6
Moir, R.D.7
Nath, A.8
He, J.J.9
-
78
-
-
40849085422
-
Identification and design of peptides as a new drug delivery system for the brain
-
DOI 10.1124/jpet.107.131318
-
Demeule M, Regina A, Che C et al. Identification and design of peptides as a new drug delivery system for the brain. J. Pharmacol. Exp. Ther. 324, 1064-1072 (2008). (Pubitemid 351397849)
-
(2008)
Journal of Pharmacology and Experimental Therapeutics
, vol.324
, Issue.3
, pp. 1064-1072
-
-
Demeule, M.1
Regina, A.2
Che, C.3
Poirier, J.4
Nguyen, T.5
Gabathuler, R.6
Castaigne, J.-P.7
Beliveau, R.8
-
79
-
-
48749095941
-
Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2
-
Demeule M, Currie J-C, Bertrand Y et al. Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2. J. Neurochem. 106, 1534-1544 (2008).
-
(2008)
J. Neurochem.
, vol.106
, pp. 1534-1544
-
-
Demeule, M.1
Currie, J.-C.2
Bertrand, Y.3
-
80
-
-
77950563375
-
New angiopep-modified doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration
-
Che C, Yang G, Thiot C et al. New angiopep-modified doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration. J. Med. Chem. 53, 2814-2824 (2010).
-
(2010)
J. Med. Chem.
, vol.53
, pp. 2814-2824
-
-
Che, C.1
Yang, G.2
Thiot, C.3
-
81
-
-
78650054460
-
Transport characteristics of a novel peptide platform for CNS therapeutics
-
DOI:10.1111/j.1582-4934.2009.00930.x Epub ahead of print
-
Bertrand Y, Currie JC, Demeule M et al. Transport characteristics of a novel peptide platform for CNS therapeutics. J. Cell. Mol. Med. DOI:10.1111/j.1582-4934.2009.00930.x (2009) (Epub ahead of print).
-
(2009)
J. Cell. Mol. Med.
-
-
Bertrand, Y.1
Currie, J.C.2
Demeule, M.3
-
82
-
-
85157261076
-
Uptake of the new paclitaxel-derivative (ANG1005) by the low-density lipoprotein receptor-related protein1 (LRP1) is related to the aggressive phenotype of glioblastoma cells
-
Washington DC, USA 17-21 April 2010
-
Bertrand Y, Currie JC, Demeule M et al. Uptake of the new paclitaxel-derivative (ANG1005) by the low-density lipoprotein receptor-related protein1 (LRP1) is related to the aggressive phenotype of glioblastoma cells. Presented at: The Annual Meeting of the AACR. Washington DC, USA, 17-21 April 2010.
-
The Annual Meeting of the AACR
-
-
Bertrand, Y.1
Currie, J.C.2
Demeule, M.3
-
83
-
-
0642311333
-
A review of blood-brain barrier transport techniques
-
Smith QR. A review of blood-brain barrier transport techniques. Methods Mol. Med. 89, 193-208 (2003).
-
(2003)
Methods Mol. Med.
, vol.89
, pp. 193-208
-
-
Smith, Q.R.1
-
84
-
-
0000545811
-
An in situ brain perfusion techniques to study cerebrovascular transport in the rat
-
Takasato Y, Rapoport SI, Smith QR. An in situ brain perfusion techniques to study cerebrovascular transport in the rat. Am. J. Physiol. 247, 484-493 (1984).
-
(1984)
Am. J. Physiol.
, vol.247
, pp. 484-493
-
-
Takasato, Y.1
Rapoport, S.I.2
Smith, Q.R.3
-
85
-
-
70350228485
-
Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer
-
Thomas FC, Taskar K, Rudraraju V et al. Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer. Pharma. Res. 26(11) 2486-2494 (2009).
-
(2009)
Pharma. Res.
, vol.26
, Issue.11
, pp. 2486-2494
-
-
Thomas, F.C.1
Taskar, K.2
Rudraraju, V.3
-
86
-
-
85157265405
-
New angiochem-modified doxorubicin with increased brain penetration and efficacy against brain tumors
-
Washington DC, USA 17-21 April 2010
-
Demeule M, Régina A, Yang G et al. New angiochem-modified doxorubicin with increased brain penetration and efficacy against brain tumors. Presented at: The Annual Meeting of the AACR, Washington DC, USA, 17-21 April 2010.
-
The Annual Meeting of the AACR
-
-
Demeule, M.1
Régina, A.2
Yang, G.3
-
87
-
-
51349102460
-
Anti-tumor activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2
-
Regina A, Demeule M, Che C et al. Anti-tumor activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2. Br. J. Pharmacol. 155, 185-197 (2008).
-
(2008)
Br. J. Pharmacol.
, vol.155
, pp. 185-197
-
-
Regina, A.1
Demeule, M.2
Che, C.3
-
88
-
-
70349554656
-
Enhanced drug delivery to brain tumors with a new paclitaxel-peptide conjugate
-
Bichat F, Demeule M, Lawrence B et al. Enhanced drug delivery to brain tumors with a new paclitaxel-peptide conjugate. Eur. J. Cancer Suppl. 6, 45, 139 (2008).
-
(2008)
Eur. J. Cancer Suppl.
, vol.6
, Issue.45
, pp. 139
-
-
Bichat, F.1
Demeule, M.2
Lawrence, B.3
-
89
-
-
73849143110
-
An engineered peptide compound platform technology incorporating Angiopep for crossing the BBB
-
Jain KK (Ed). Humana Press, NY, USA
-
Gabathuler R. An engineered peptide compound platform technology incorporating Angiopep for crossing the BBB. In:Drug Delivery to the CNS Neuromethods 45 Jain KK (Ed). Humana Press, NY, USA, 249-260 (2010).
-
(2010)
Drug Delivery to the CNS Neuromethods
, vol.45
, pp. 249-260
-
-
Gabathuler, R.1
-
90
-
-
84859268551
-
ANG1005: Development of a new engineered peptide compound (EPiC) for the treatment of malignant glioma
-
Chicago, IL, USA, 17-21 October 2009
-
Drappatz J, Brenner A, Rosenfeld S et al. ANG1005: development of a new engineered peptide compound (EPiC) for the treatment of malignant glioma. Presented at: The Annual Neuroscience Conference 2009. Chicago, IL, USA, 17-21 October 2009.
-
(2009)
Development The Annual Neuroscience Conference
-
-
Drappatz, J.1
Brenner, A.2
Rosenfeld, S.3
-
91
-
-
84859268553
-
ANG1005: A promising new engineered peptide compound (EPiC) for patients with advanced solid tumors and brain metastases
-
Chicago, IL, USA, 17-21 October 2009
-
Kurzrock R, Gabrail N, Moulder S et al. ANG1005: a promising new engineered peptide compound (EPiC) for patients with advanced solid tumors and brain metastases. Presented at: The Annual Neuroscience Conference 2009. Chicago, IL, USA, 17-21 October 2009.
-
(2009)
The Annual Neuroscience Conference
-
-
Kurzrock, R.1
Gabrail, N.2
Moulder, S.3
-
92
-
-
85157225454
-
Biowire industry updates: Angiochem presents complete phase 1/2 clinical data for ANG1005: Further benefits of targeting LRP-1 pathway in cancer
-
7 June
-
Biowire industry updates: Angiochem presents complete phase 1/2 clinical data for ANG1005: further benefits of targeting LRP-1 pathway in cancer. Genetic Engineering & Biotechnology News, 7 June (2010)
-
(2010)
Genetic Engineering & Biotechnology News
-
-
-
93
-
-
78049236224
-
ANG1005: Results of a Phase i study in patients with recurrent malignant glioma
-
Drappatz J, Brenner AJ, Rosenfeld S et al. ANG1005: results of a Phase I study in patients with recurrent malignant glioma. J. Clin. Oncol. 28, 7s (Suppl. 2009) (2010).
-
(2009)
J. Clin. Oncol.
, vol.28
, Issue.7 SUPPL.
-
-
Drappatz, J.1
Brenner, A.J.2
Rosenfeld, S.3
-
94
-
-
79954454017
-
ANG1005: Results of a Phase i study in patients with advanced solid tumors and brain metastases
-
Sarantopoulos J, Gabrail NY, Moulder SL et al. ANG1005: results of a Phase I study in patients with advanced solid tumors and brain metastases. J. Clin. Oncol. 28, 7s (Suppl. 2556) (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.7 SUPPL. 2556
-
-
Sarantopoulos, J.1
Gabrail, N.Y.2
Moulder, S.L.3
-
95
-
-
70350200866
-
Gene delivery targeted to the brain using an angiopepconjugated polyethyleneglycol-modified polyamidoamine dendrimer
-
Ke W, Shao K, Huang R et al. Gene delivery targeted to the brain using an angiopepconjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials 30 (36), 6976-6985 (2009).
-
(2009)
Biomaterials
, vol.30
, Issue.36
, pp. 6976-6985
-
-
Ke, W.1
Shao, K.2
Huang, R.3
-
96
-
-
0036570726
-
HH properties
-
DOI 10.1016/S0022-1759(02)00027-3, PII S0022175902000273
-
Tanha J, Dubuc G, Hirama T, Narang SA, MacKenzie CR. Selection by phage display of llama conventional VH fragments with heavy chain antibody VHH properties. J. Immunol. Meth. 263, 97-109 (2002). (Pubitemid 34493813)
-
(2002)
Journal of Immunological Methods
, vol.263
, Issue.1-2
, pp. 97-109
-
-
Tanha, J.1
Dubuc, G.2
Hirama, T.3
Narang, S.A.4
MacKenzie, C.R.5
-
97
-
-
0036480118
-
Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium
-
Muruganandam A, Tanha J, Narang S, Stanimirovic D. Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium. FASEB J. 16, 240-242 (2002).
-
(2002)
FASEB J.
, vol.16
, pp. 240-242
-
-
Muruganandam, A.1
Tanha, J.2
Narang, S.3
Stanimirovic, D.4
-
98
-
-
0642342122
-
Phage display technology for identifying specific antigens on brain endothelial cells
-
Tanha J, Muruganandam A, Stanimirovic D. Phage display technology for identifying specific antigens on brain endothelial cells. Meth. Mol. Med. 89, 435-449 (2003).
-
(2003)
Meth. Mol. Med.
, vol.89
, pp. 435-449
-
-
Tanha, J.1
Muruganandam, A.2
Stanimirovic, D.3
-
99
-
-
28244432240
-
The blood-brain barrier transmigrating single domain antibody: Mechanisms of transport and antigenic epitopes in human brain endothelial cells
-
DOI 10.1111/j.1471-4159.2005.03463.x
-
Abulrob A, Sprong H, Bergen en Henegouwen PV, Stanimirovic D. The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells. J. Neurochem. 95, 1201-1214 (2005). (Pubitemid 41713502)
-
(2005)
Journal of Neurochemistry
, vol.95
, Issue.4
, pp. 1201-1214
-
-
Abulrob, A.1
Sprong, H.2
Van Bergen, E.N.3
Henegouwen, P.4
Stanimirovic, D.5
-
100
-
-
38649113883
-
ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity
-
DOI 10.1002/hep.21950
-
Paulusma CC, Folmer DE, Ho-Mok KS et al. ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity. Hepatology 47, 268-278 (2008). (Pubitemid 351171064)
-
(2008)
Hepatology
, vol.47
, Issue.1
, pp. 268-278
-
-
Paulusma, C.C.1
Folmer, D.E.2
Ho-Mok, K.S.3
De Waart, D.R.4
Hilarius, P.M.5
Verhoeven, A.J.6
Oude Elferink, R.P.J.7
-
101
-
-
85046914841
-
Peptide delivery to the brain via adsorptive-mediated endocytosis: Advances with SynB vectors
-
Drin G, Rousselle C, Scherrmann J-M, Rees AR, Temsamari J. Peptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors. AAPS PharmSci 4(4), 1-7 (2002).
-
(2002)
AAPS PharmSci
, vol.4
, Issue.4
, pp. 1-7
-
-
Drin, G.1
Rousselle, C.2
Scherrmann, J.-M.3
Rees, A.R.4
Temsamari, J.5
-
102
-
-
0042232110
-
Studies on the internalization mechanism of cationic cell-penetrating peptides
-
DOI 10.1074/jbc.M303938200
-
Drin G, Cottin S, Blanc E, Rees AR, Temsamari J. Studies on the internalization mechanism of cationic cell-penetrating peptides. J. Biol. Chem. 278 (33), 31192-31201 (2003). (Pubitemid 36994635)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.33
, pp. 31192-31201
-
-
Drin, G.1
Cottin, S.2
Blanc, E.3
Rees, A.R.4
Temsamani, J.5
-
103
-
-
0034126420
-
New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy
-
Rousselle C, Clair P, Lefauconnier JM, Kaczorek M, Scherrmann JM, Temsamani J. New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy. J. Pharmacol. Exp. Ther. 57, 679-686 (2000). (Pubitemid 30183706)
-
(2000)
Molecular Pharmacology
, vol.57
, Issue.4
, pp. 679-686
-
-
Rousselle, C.1
Clair, P.2
Lefauconnier, J.-M.3
Kaczorek, M.4
Scherrmann, J.-M.5
Temsamani, J.6
-
104
-
-
0038340924
-
Improved brain uptake and pharmacological activity of dalargin using a peptide-vector-mediated strategy
-
DOI 10.1124/jpet.102.048520
-
Rousselle C, Clair P, Smirnova M et al. Improved brain uptake and pharmacological activity of dalargin using a peptide-vectormediated strategy. J. Pharmacol. Exp. Ther. 306, 371-376 (2003). (Pubitemid 36734394)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.306
, Issue.1
, pp. 371-376
-
-
Rousselle, C.1
Clair, P.2
Smirnova, M.3
Kolesnikov, Y.4
Pasternak, G.W.5
Gac-Breton, S.6
Rees, A.R.7
Scherrmann, J.-M.8
Temsamani, J.9
-
105
-
-
18044374814
-
Improved brain uptake and pharmacological activity profile of morphine-6-glucuronide using a peptide vector-mediated strategy
-
DOI 10.1124/jpet.104.081000
-
Temsamani J, Bonnafous C, Rousselle C et al. Improved brain uptake and pharmacological activity profile of morphine-6-glucuronide using a peptide vector-mediated strategy. J. Pharmacol. Exp. Ther. 313, 712-719 (2005). (Pubitemid 40604172)
-
(2005)
Journal of Pharmacology and Experimental Therapeutics
, vol.313
, Issue.2
, pp. 712-719
-
-
Temsamani, J.1
Bonnafous, C.2
Rousselle, C.3
Fraisse, Y.4
Clair, P.5
Granier, L.-A.6
Rees, A.R.7
Kaczorek, M.8
Scherrmann, J.-M.9
-
106
-
-
0034700141
-
The design, synthesis and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
-
Wender PA, Mitchell DJ, Pattabiraman K, Pelkey ET, Steinman L, Rothbard JB. The design, synthesis and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proc. Natl Acad. Sci. USA 97, 13003-13008 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 13003-13008
-
-
Wender, P.A.1
Mitchell, D.J.2
Pattabiraman, K.3
Pelkey, E.T.4
Steinman, L.5
Rothbard, J.B.6
-
107
-
-
0035462420
-
Vector-mediated drug delivery to the brain
-
Temsamani J, Rousselle C, Rees AR, Scherrmann J-M. Vector-mediated drug delivery to the brain. Exp. Opin. Biol. Ther. 1, 773-782 (2001). (Pubitemid 33769737)
-
(2001)
Expert Opinion on Biological Therapy
, vol.1
, Issue.5
, pp. 773-782
-
-
Temsamani, J.1
Rees, A.R.2
Scherrmann, J.-M.3
-
108
-
-
25844460460
-
Crossing the blood-brain barrier: A potential application of myristoylated polyarginine for in vivo neuroimaging
-
DOI 10.1016/j.neuroimage.2005.06.007, PII S1053811905004064
-
Pham W, Zhao B-Q, Lo EH, Medarova Z, Rosen B, Moore A. Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo imaging. Neuroimage 28, 287-292 (2005). (Pubitemid 41393908)
-
(2005)
NeuroImage
, vol.28
, Issue.1
, pp. 287-292
-
-
Pham, W.1
Zhao, B.-Q.2
Lo, E.H.3
Medarova, Z.4
Rosen, B.5
Moore, A.6
-
109
-
-
34447114618
-
Transvascular delivery of small interfering RNA to the central nervous system
-
Kumar P, Wu H, McBride JL et al. Transvascular delivery of small interfering RNA to the central nervous system. Nature 448, 33-40 (2007).
-
(2007)
Nature
, vol.448
, pp. 33-40
-
-
Kumar, P.1
Wu, H.2
McBride, J.L.3
-
110
-
-
77953663542
-
PAMAMdrug complex for delivering anticancer drug across the blood-brain barrier in vitro and in vivo
-
Cui D, Xu Q, Gu S, Shi J, Che X. PAMAMdrug complex for delivering anticancer drug across the blood-brain barrier in vitro and in vivo. Afr. J. Pharm. Pharmacol. 3, 227-233 (2009).
-
(2009)
Afr. J. Pharm. Pharmacol.
, vol.3
, pp. 227-233
-
-
Cui, D.1
Xu, Q.2
Gu, S.3
Shi, J.4
Che, X.5
-
111
-
-
67649887150
-
Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles
-
Liu Y, Huang R, Han L et al. Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles. Biomaterials 30, 4195-4202 (2009).
-
(2009)
Biomaterials
, vol.30
, pp. 4195-4202
-
-
Liu, Y.1
Huang, R.2
Han, L.3
-
112
-
-
22344434521
-
Rapid and effective labeling of brain tissue using TAT-conjugated CdS:Mn/ZnS quantum dots
-
DOI 10.1039/b503234b
-
Santra S, Yang H, Stanley JT et al. Rapid and effective labeling of brain tissue using TAT-conjugated CdS:Mn/ZnS quantum dots. Chem. Commun. 25, 3144-3146 (2005). (Pubitemid 41002376)
-
(2005)
Chemical Communications
, Issue.25
, pp. 3144-3146
-
-
Santra, S.1
Yang, H.2
Stanley, J.T.3
Holloway, P.H.4
Moudgil, B.M.5
Walter, G.6
Mericle, R.A.7
-
113
-
-
38549180565
-
Biologically active core/shell nanoparticles self-assembled from cholesterol-terminated PEG-TAT for drug delivery across the blood-brain barrier
-
Liu L, Guo K, Lu J et al. Biologically active core/shell nanoparticles self-assembled from cholesterol-terminated PEG-TAT for drug delivery across the blood-brain barrier. Biomaterials 29, 1509-1517 (2008).
-
(2008)
Biomaterials
, vol.29
, pp. 1509-1517
-
-
Liu, L.1
Guo, K.2
Lu, J.3
-
114
-
-
50849094554
-
TAT-conjugated nanoparticles for the CNS delivery of anti-HIV drugs
-
Rao KS, Reddy MK, Horning JL, Labhasetwar V. TAT-conjugated nanoparticles for the CNS delivery of anti-HIV drugs. Biomaterials 29, 4429-4438 (2008).
-
(2008)
Biomaterials
, vol.29
, pp. 4429-4438
-
-
Rao, K.S.1
Reddy, M.K.2
Horning, J.L.3
Labhasetwar, V.4
-
115
-
-
34249895458
-
Trans-activating transcriptional activator (TAT) peptidemediated brain drug delivery
-
Rao KS, Labhasetwar V. Trans-activating transcriptional activator (TAT) peptidemediated brain drug delivery. J. Biomed. Nanotech. 2, 173-185 (2006).
-
(2006)
J. Biomed. Nanotech.
, vol.2
, pp. 173-185
-
-
Rao, K.S.1
Labhasetwar, V.2
-
116
-
-
34548760754
-
Interactions of cell penetrating peptide Tat with model membranes: A biophysical study
-
DOI 10.1016/j.bbrc.2007.08.162, PII S0006291X07018797
-
Dennisson SR, Baker RD, Nicholl ID, Phoenix DA. Interactions of cell penetrating peptide TAT with model membranes: a biophysical study. Biochem. Biophys. Res. Commun. 363, 178-182 (2007). (Pubitemid 47430110)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.363
, Issue.1
, pp. 178-182
-
-
Dennison, S.R.1
Baker, R.D.2
Nicholl, I.D.3
Phoenix, D.A.4
|