Phytosterols and phytosterolemia: Gene-diet interactions

Genes and Nutrition

Volumn 6, Issue 1, 2011, Pages 17-26

  Izar, Maria C ^a   Tegani, Daniela M ^a   Kasmas, Soraia H ^a   Fonseca, Francisco A ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cardiovascular disease; Ezetimibe; Gene diet interaction; Phytosterolemia; Plant sterols; Statins

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER G5; ABC TRANSPORTER G8; CARRIER PROTEIN; CHOLESTEROL; EZETIMIBE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NIEMANN PICK C1 LIKE 1 TRANSPORTER; PHYTOSTEROL; PLACEBO; SIMVASTATIN; SITOSTEROL; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; DIET SUPPLEMENTATION; DRUG SAFETY; DYSLIPIDEMIA; FOOD COMPOSITION; FOOD INTAKE; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HYPERCHOLESTEROLEMIA; INTESTINE ABSORPTION; PHENOTYPE; RECOMMENDED DRUG DOSE; REVIEW; SITOSTEROLEMIA; TREATMENT OUTCOME; XANTHOMA;

EID: 79952627862     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-010-0182-x     Document Type: Review

References (88)

1. SW Altmann HR Davis Jr X Yao M Laverty DS Compton LJ Zhu, et al. 2002 The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption Biochim Biophys Acta 1580 77 93 1:CAS:528:DC%2BD38Xjt1Khur4%3D 11923102 (Pubitemid 34260848)
2. SW Altmann HR Davis Jr LJ Zhu X Yao LM Hoos G Tetzloff, et al. 2004 Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption Science 303 1201 1204 1:CAS:528:DC%2BD2cXhsVWgtbc%3D 10.1126/science.1093131 14976318 (Pubitemid 38233587)
3. G Assmann P Cullen JR Erbey DR Ramey F Kannenberg H Schulte 2003 Elevation in plasma sitosterol concentration is associated with an increased risk for coronary events in the PROCAM Study [abstract] Circulation 108 suppl 730
4. G Assmann P Cullen J Erbey DR Ramey F Kannenberg H Schulte 2006 Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: results of a nested case-control analysis of the Prospective Cardiovascular Münster (PROCAM) study Nutr Metab Cardiovasc Dis 16 13 21 1:CAS:528:DC%2BD1cXhvVersbo%3D 10.1016/j.numecd.2005.04.001 16399487
5. M Becker D Staab K von Bergman 1992 Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate Pediatrics 89 138 142 1:STN:280:DyaK38%2FptlCltQ%3D%3D 1727999
6. KE Berge H Tian GA Graf L Yu NV Grishin J Schultz, et al. 2000 Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters Science 290 1771 1775 1:CAS:528:DC%2BD3cXovVOhurg%3D 10.1126/science.290.5497.1771 11099417 (Pubitemid 32004809)
7. AK Bhattacharyya WE Connor 1974 Beta-sitosterolemia and xanthomatosis: a newly described lipid storage disease in two sisters J Clin Invest 53 1033 1043 1:STN:280:DyaE2c7htVKisA%3D%3D 10.1172/JCI107640 4360855
8. K Boesze-Battaglia RJ Schimmel 1999 Cell membrane lipid composition and distribution: implications for cell function and lessons learned from photoreceptors and platelets J Exp Biol 200 2927 2936 (Pubitemid 28029161)
9. MS Bosner LG Lange WF Stenson E Richard J Ostlund 1999 Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry J Lipid Res 40 302 308 1:CAS:528:DyaK1MXhtFyhsLY%3D 9925660 (Pubitemid 29069805)
10. ED Carstea JA Morris KG Coleman SK Loftus D Zhang C Cummings, et al. 1997 Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis Science 277 228 231 1:CAS:528:DyaK2sXksFClu7Y%3D 10.1126/science.277.5323.228 9211849 (Pubitemid 27446076)
11. WP Castelli RJ Garrison PW Wilson RD Abbott S Kalousdian WB Kannel 1986 Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham study JAMA 256 2835 2838 1:STN:280:DyaL2s%2FjslWktA%3D%3D 10.1001/jama.256.20.2835 3773200 (Pubitemid 17178361)
12. NB Cater A Garcia-Garcia GL Vega SM Grundy 1995 Responsiveness of plasma lipids and lipoproteins to plant stanol esters Am J Cardiol 96 suppl 23D 28D
13. CW Chen JJ Hwang CI Tsai NY Su C Hsiang M Shen LP Lai 2009 The g-762T > C polymorphism of the NPC1L1 gene is common in Chinese and contributes to a higher promoter activity and higher serum cholesterol levelsNPC1L1 SNP and cholesterol level J Hum Genet 54 242 247 1:CAS:528:DC%2BD1MXmvVWju7o%3D 10.1038/jhg.2009.18 19265861
14. Cofán M, Escurriol V, Garcia-Otin AL, Moreno-Iribas C, Larrañaga N, Sanchez MJ, et al (2010) Association of plasma markers of cholesterol homeostasis with metabolic syndrome components. Nutr Metab Cardiovasc Dis (e-pub ahead of print)
15. JC Cohen A Pertsemlidis S Fahmi S Esmail GL Vega SM Grundy HH Hobbs 2006 Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels Proc Natl Acad Sci U S A 103 1810 1815 1:CAS:528:DC%2BD28Xhsleht7w%3D 10.1073/pnas.0508483103 16449388 (Pubitemid 43228775)
16. MH Davidson 2003 Ezetimibe: a novel option for lowering cholesterol Expert Rev Cardiovasc Ther 1 11 21 1:CAS:528:DC%2BD3sXlsVelsbc%3D 10.1586/14779072.1.1.11 15030293
17. JP Davies YA Ioannou 2006 The role of the Niemann-Pick C1-like 1 protein in the subcellular transport of multiple lipids and their homeostasis Curr Opin Lipidol 17 221 226 1:CAS:528:DC%2BD28Xkt12qurg%3D 10.1097/01.mol.0000226112. 12684.5e 16680025 (Pubitemid 43786054)
18. JP Davies B Levy Y Ioannou 2000 Evidence for a Niemann-Pick C (NPC) gene family: identification and characterization of NPC1L1 Genomics 65 137 145 1:CAS:528:DC%2BD3cXislaqtr4%3D 10.1006/geno.2000.6151 10783261 (Pubitemid 30314421)
19. HR Davis E Veltri 2007 Zetia: inhibition of Niemann-Pick C1 Like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia J AtherosclerThromb 14 99 108 1:CAS:528:DC%2BD2sXot1Krsrs%3D
20. HR Davis Jr LJ Zhu LM Hoos G Tetzloff M Maguire J Liu, et al. 2004 Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis J Biol Chem 279 33586 33592 1:CAS:528:DC%2BD2cXmtFOitbs%3D 10.1074/jbc.M405817200 15173162 (Pubitemid 39063007)
21. MA Denke 1995 Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia Am J Clin Nutr 61 392 396 1:STN:280:DyaK2M7kt1SmsA%3D%3D 7840080
22. V Escurriol M Cofán C Moreno-Iribas N Larrañaga C Martínez C Navarro, et al. 2010 Phytosterol plasma concentrations and coronary heart disease in the prospective Spanish EPIC cohort J Lipid Res 51 618 624 1:CAS:528:DC%2BC3cXisVekt70%3D 10.1194/jlr.P000471 19786566
23. Expert Panel on Detection, Evaluation, Treatment of High Blood Cholesterol in Adults 2001 Executive summary of the third report of National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) JAMA 285 2486 2497 10.1001/jama.285.19.2486
24. CJ Glueck J Speirs T Tracy P Streicher E Illig J Vandegrift 1991 Relationships of serum plant sterols (phytosterols) and cholesterol in 595 hypercholesterolemic subjects, and familial aggregation of phytosterols, cholesterol, and premature coronary heart disease in hyperphytosterolemic probands and their first-degree relatives Metabolism 40 842 848 1:STN:280:DyaK3MzhvFSjsg%3D%3D 10.1016/0026-0495(91)90013-M 1650421
25. S Grundy 2001 United States Cholesterol Guidelines 2001: expanded scope of intensive low-density lipoprotein-lowering therapy Am J Cardiol 88 7B 23J 27J 1:STN:280:DC%2BD3MrkvVCgsg%3D%3D 10.1016/S0002-9149(01)01931-2 11595195 (Pubitemid 32938248)
26. H Gylling TA Miettinen 2002 Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption J Lipid Res 43 1472 1476 1:CAS:528:DC%2BD38XnsFKhtLk%3D 10.1194/jlr.M200155-JLR200 12235179
27. K Hac-Wydro P Wydro A Jagoda J Kapusta 2007 The study on the interaction between phytosterols and phospholipids in model membranes Chem Phys Lipid 150 22 34 1:CAS:528:DC%2BD2sXhtFGktL3P 10.1016/j.chemphyslip.2007.06.211 (Pubitemid 47538546)
28. MA Hallikainen ES Sarkkinen H Gylling AT Erkkila AA Uusitupa 2000 Comparison of the effects of plant sterol ester or plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet Eur J Clin Nutr 54 715 725 1:CAS:528: DC%2BD3cXnsVCrsbg%3D 10.1038/sj.ejcn.1601083 11002384
29. RA Hegele J Guy MR Ban J Wang 2005 NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe Lipids Health Dis 4 16 10.1186/1476-511X-4-16 16098225 (Pubitemid 41243204)
30. T Heinemann O Leiss K von Bergmann 1986 Effect of low-dose sitostanol on serum cholesterol in patients with hypercholesterolemia Atherosclerosis 61 219 223 1:STN:280:DyaL2s%2Fis1WhsQ%3D%3D 10.1016/0021-9150(86)90141-3 3768090 (Pubitemid 16040333)
31. T Heinemann G Asmann K von Bergmann 1993 Comparison of intestinal absorption of cholesterol with different plant sterol in man Eur J Clin Invest 23 827 832 1:STN:280:DyaK2c7pt1OjsA%3D%3D 10.1111/j.1365-2362.1993.tb00737.x 8143759
32. JD Horton JL Goldstein MS Brown 2002 SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J Clin Invest 109 1125 1131 1:CAS:528:DC%2BD38XjsFals7c%3D 11994399 (Pubitemid 34496588)
33. JA Hubácek KE Berge J Stefková J Pitha Z Skodová V Lánská R Poledne 2004 Polymorphisms in ABCG5 and ABCG8 transporters and plasma cholesterol levels Physiol Res 53 395 401 15311998 (Pubitemid 39094827)
34. SP Iyer X Yao JH Crona LM Hoos G Tetzloff HR Davis Jr, et al. 2005 Characterization of the putative native and recombinant rat sterol transporter Niemann-Pick C1 Like 1(NPC1L1) protein Bioch Biophys Acta 1722 282 292 1:CAS:528:DC%2BD2MXitlekuro%3D (Pubitemid 40354166)
35. ED Jesch TP Carr 2006 Sitosterol reduces micellar cholesterol solubility in model bile Nutr Res 26 579 584 1:CAS:528:DC%2BD28Xht1aisr%2FP 10.1016/j.nutres.2006.08.006 (Pubitemid 44738245)
36. ED Jesch JM Seo TP Carr JY Lee 2009 Sitosterol reduces messenger RNA and protein expression levels of Niemann-Pick C1-like 1 in FHs 74 Int cells Nutr Res 29 859 866 1:CAS:528:DC%2BD1MXhsFanu7jJ 10.1016/j.nutres.2009.10.016 19963159
37. PJ Jones T Howell DE MacDougall JY Feng W Parsons 1998 Short-term administration of tall oil phytosterols improves plasma lipid profiles in subjects with different cholesterol levels Metabolism 47 751 756 1:CAS:528:DyaK1cXjslymur8%3D 10.1016/S0026-0495(98)90041-5 9627377 (Pubitemid 28265182)
38. PJH Jones FY Ntanios M Raeini-Sarjaz CA Vanstone 1999 Cholesterol lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men Am J Clin Nutr 69 1144 1150 1:CAS:528: DyaK1MXjs1Cjurw%3D 10357732 (Pubitemid 29252046)
39. S Kidambi SR Patel 2008 Sitosterolaemia: pathophysiology, clinical presentation and laboratory diagnosis J Clin Pathol 61 588 594 1:CAS:528:DC%2BD1cXmvVyks7o%3D 10.1136/jcp.2007.049775 18441155 (Pubitemid 351678209)
40. M Law 2000 Plant sterol and stanol margarines and health BMJ 320 861 864 1:STN:280:DC%2BD3c7psFGnuw%3D%3D 10.1136/bmj.320.7238.861 10731187
41. MH Lee K Lu S Hazard H Yu S Shulenin H Hidaka, et al. 2001 Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption Nat Genet 27 79 83 1:CAS:528:DC%2BD3MXis1ykuw%3D%3D 10.1038/87170 11138003 (Pubitemid 32044523)
42. MH Lee K Lu SB Patel 2001 Genetic basis of sitosterolemia Curr Opin Lipidol 12 141 149 1:CAS:528:DC%2BD3MXislWgsbY%3D 10.1097/00041433-200104000- 00007 11264985 (Pubitemid 32242921)
43. AH Lichtenstein RJ Deckelbaum 2001 AHA Science Advisory. Stanol/sterol ester-containing foods and blood cholesterol levels. A statement for healthcare professionals from the Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association Circulation 103 1177 1179 1:CAS:528:DC%2BD3MXisFelu78%3D 11222485 (Pubitemid 32200197)
44. K Lu M-H Lee S Hazard 2001 Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively Am J Hum Genet 69 278 290 10.1086/321294 11452359 (Pubitemid 32695201)
45. D Lutjohann K von Bergmann 1997 Phytosterolaemia: diagnosis, characterization and therapeutical approaches Ann Med 29 181 184 1:STN:280:DyaK2szot1KitQ%3D%3D 10.3109/07853899708999333 9240621 (Pubitemid 27292524)
46. L Mannucci O Guardamagna P Bertucci L Pisciotta L Liberatoscioli S Bertolini, et al. 2007 Beta-sitosterolaemia: a new nonsense mutation in the ABCG5 gene Eur J Clin Invest 37 997 1000 1:CAS:528:DC%2BD1cXlslCktA%3D%3D 10.1111/j.1365-2362.2007.01880.x 17976197 (Pubitemid 350151182)
47. TA Miettinen RS Tilvis YA Kesäniemi 1990 Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population Am J Epidemiol 131 20 31 1:STN:280:DyaK3c%2Fos1OmtQ%3D%3D 2293749 (Pubitemid 20014696)
48. TA Miettinen TE Strandberg H Gylling 2000 Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients Arterioscler Thromb Vasc Biol 20 1340 1346 1:CAS:528:DC%2BD3cXjslKhu7g%3D 10807752 (Pubitemid 30262937)
49. TA Miettinen H Gylling N Lindbohm TE Miettinen RA Rajaratnam H Relas Finnish Treat-to-Target Study Investigators 2003 Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins J Lab Clin Med 141 131 137 1:CAS:528:DC%2BD3sXht1GjsL0%3D 10.1067/mlc.2003.9 12577049 (Pubitemid 36216566)
50. L Normen P Dutta A Lia H Andersson 2000 Soy sterol esters and betasitostanol ester as inhibitors of cholesterol absorption in human small bowel Am J Clin Nutr 71 908 913 1:CAS:528:DC%2BD3cXit1yjsbw%3D 10731496 (Pubitemid 30176572)
51. FH O'Neill TAB Sanders GR Thompson 2005 Comparison of Efficacy of plant stanol ester and sterol ester: short-term and longer-term studies Am J Cardiol 96 suppl 29D 36D 10.1016/j.amjcard.2005.03.017 15992513 (Pubitemid 40898167)
52. RE Ostlund Jr CA Spilburg WF Stenson 1999 Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans Am J Clin Nutr 70 826 831 1:CAS:528:DyaK1MXntFCgtbc%3D 10539742 (Pubitemid 29512907)
53. SB Patel G Salen H Hidaka PO Kwiterovich AF Stalenhoef TA Miettinen, et al. 1998 Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21 J Clin Invest 102 1041 1044 1:CAS:528:DyaK1cXlvVCqtb8%3D 10.1172/JCI3963 9727073 (Pubitemid 28419249)
54. DW Peterson 1951 Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks Proc Soc Exp Biol Med 78 143 147 1:CAS:528:DyaG38XmtFal 14891948
55. V Piironen DG Lindsay TA Miettinen J Toivo AM Lampi 2000 Plant sterols: biosynthesis, biological function and their importance to human nutrition J Sci Food Agric 80 939 966 1:CAS:528:DC%2BD3cXjsFals7Y%3D 10.1002/(SICI)1097- 0010(20000515)80:7<939::AID-JSFA644>3.0.CO;2-C (Pubitemid 30319392)
56. S Pinedo MN Vissers K von Bergmann K Elharchaoui D Lütjohann R Luben, et al. 2007 Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study J Lipid Res 48 139 144 1:CAS:528:DC%2BD2sXmslSqug%3D%3D 10.1194/jlr.M600371-JLR200 17074925 (Pubitemid 46052905)
57. E Polisecki I Peter JS Simon RA Hegele M Robertson I Ford on behalf of the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) Investigators, et al. 2010 Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly J Lipid Res 51 1201 1207 1:CAS:528:DC%2BC3cXltlWktb8%3D 10.1194/jlr.P001172 19752398
58. OJ Pollak 1953 Reduction of blood cholesterol in man Circulation 7 702 706 1:CAS:528:DyaG3sXjvVClsw%3D%3D 13042924
59. OJ Pollak 1953 Successive prevention of experimental hypercholesteremia and cholesterol atherosclerosis in the rabbit Circulation 7 696 701 1:CAS:528:DyaG3sXktF2itQ%3D%3D 13042923
60. RA Rajaratnam H Gylling TA Miettinen 2000 Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women J Am Coll Cardiol 35 1185 1191 1:CAS:528: DC%2BD3cXivVSru7g%3D 10.1016/S0735-1097(00)00527-1 10758959 (Pubitemid 30206893)
61. J Rudkowska SS Abu Mweis C Nicolle PJH Jones 2008 Association between non-responsiveness to plant sterol intervention and polymorphisms in cholesterol metabolism genes: a case-control study Appl Physiol Nutr Metab 33 728 734 1:CAS:528:DC%2BD1cXptFSqurk%3D 10.1139/H08-041 18641716
62. J Sakai EA Duncan RB Rawson X Hua MS Brown JL Goldstein 1996 Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment Cell 85 1037 1046 1:CAS:528:DyaK28XjvF2iu7w%3D 10.1016/S0092-8674(00)81304-5 8674110 (Pubitemid 26231170)
63. G Salen EH Ahrens Jr SM Grundy 1970 Metabolism of β-sitosterol in man J Clin Invest 49 952 967 1:CAS:528:DyaE3cXktFajtrk%3D 10.1172/JCI106315 5441548
64. G Salen I Horak M Rothkopf JL Cohen J Speck GS Tint, et al. 1985 Lethal atherosclerosis associated with abnormal plasma and tissue sterol composition in sitosterolemia with xanthomatosis J Lipid Res 26 1126 1133 1:STN:280: DyaL28%2FmtFejsQ%3D%3D 4067433 (Pubitemid 16258297)
65. G Salen S Shefer L Nguyen GC Ness GS Tint ShoreV Sitosterolemia 1992 J Lipid Res 33 945 955 1:CAS:528:DyaK38XltV2isrw%3D 1431587
66. G Salen GS Tint S Shefer V Shore L Nguyen 1992 Increased sitosterol absorption is offset by rapid elimination to prevent accumulation in heterozygotes with sitosterolemia Arterioscler Thromb 12 563 568 1:CAS:528:DyaK3sXltVKm 1576118
67. G Salen K von Bergmann D Lütjohann P Kwiterovich J Kane SB Patel, et al. 2004 Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia Circulation 109 966 971 1:CAS:528:DC%2BD2cXhsFeisbw%3D 10.1161/01.CIR.0000116766.31036.03 14769702 (Pubitemid 38282848)
68. Scandinavian Sinvastatin Survival Group 1994 Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) Lancet 344 1383 1389
69. U Seedorf T Engel A Lueken G Boge S Lorkowski G Assmann 2004 Cholesterol absorption inhibitor ezetimibe blocks uptake of oxidized LDL in human macrophages Biochem Biophys Res Commun 320 1337 1341 1:CAS:528: DC%2BD2cXls1eisbY%3D 10.1016/j.bbrc.2004.06.092 15303279 (Pubitemid 38916690)
70. RS Shulman AK Bhattacharyya WE Connor DS Fredrickson 1976 Betasitosterolemia and xanthomatosis N Engl J Med 294 482 483 1:STN:280:DyaE287gtVOhsg%3D%3D 10.1056/NEJM197602262940907 1246333
71. A Sierksma JA Weststrate GW Meijer 1999 Spreads enriched with plant sterols, either esterified 4, 4-dimethylsterols or free 4-desmethylsterols, and plasma total- and LDL-C concentrations Br J Nutr 82 273 282 1:CAS:528: DyaK1MXmvFaju7g%3D 10655976 (Pubitemid 29481513)
72. JS Simon MC Karnoub DJ Devlin MG Arreaza P Qiu SA Monks, et al. 2005 Sequence variation in NPC1L1 and association with improved LDL-C lowering in response to ezetimibe treatment Genomics 86 648 656 1:CAS:528:DC%2BD2MXht12jurvJ 10.1016/j.ygeno.2005.08.007 16297596 (Pubitemid 41752945)
73. C Solcà Z Stanga B Pandit P Diem J Greeve SB Patel 2005 Sitosterolaemia in Switzerland: molecular genetics links the US Amish-Mennonites to their European roots Clin Genet 68 174 178 10.1111/j.1399-0004.2005.00472.x 15996216 (Pubitemid 40990630)
74. T Sudhop BM Gottwald K von Bergmann 2002 Serum plant sterols as a potential risk factor for coronary heart disease Metabolism 51 1519 1521 1:CAS:528:DC%2BD38XpslCqur8%3D 10.1053/meta.2002.36298 12489060 (Pubitemid 36018822)
75. T Sudhop D Lütjohann A Kodal M Igel DL Tribble S Shah, et al. 2002 Inhibition of intestinal cholesterol absorption by ezetimibe in humans Circulation 106 1943 1948 1:CAS:528:DC%2BD38XnsVartrs%3D 10.1161/01.CIR. 0000034044.95911.DC 12370217 (Pubitemid 35176299)
76. WHF Sutherland MJA Williams ER Nye NJ Restieaux SA de Jong HL Walker 1998 Associations of plasma noncholesterol sterol levels with severity of coronary artery disease Nutr Metab Cardiovasc Dis 8 386 391 (Pubitemid 128584538)
77. RE Temel W Tang Y Ma LL Rudel MC Willingham YA Ioannou, et al. 2007 Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe J Clin Invest 117 1968 1978 1:CAS:528: DC%2BD2sXnvVansLY%3D 10.1172/JCI30060 17571164 (Pubitemid 47036331)
78. MIJ Uusitupa TA Miettinen P Happonen T Ebeling H Turtola E Voutilainen K Pyörälä 1992 Lathosterol and other noncholesterol sterols during treatment of hypercholesterolemia with lovastatin alone and with cholestyramine or guar gum Arterioscler Thromb 12 807 813 1:CAS:528:DyaK38XlsVehsro%3D 1319735
79. H Vanhanen TA Miettinen 1992 Pravastatin and lovastatin similarly reduce serum cholesterol and its precursor levels in familial hypercholesterolemia Eur J Clin Pharmacol 42 127 130 1:STN:280:DyaK38zhs1SrtQ%3D%3D 10.1007/BF00278470 1618241
80. H Vanhanen YA Kesäniemi TA Miettinen 1992 Pravastatin lowers serum cholesterol, cholesterol-precursor sterols, fecal steroids, and cholesterol absorption in man Metabolism 41 588 595 1:STN:280:DyaK38zkvF2qsA%3D%3D 10.1016/0026-0495(92)90050-K 1640845
81. K von Bergmann T Sudhop D Lütjohann 2005 Cholesterol and plant sterol absorption: recent insights Am J Cardiol 96 suppl 10D 14D 10.1016/j.amjcard.2005.03.014 (Pubitemid 40898164)
82. J Wang CM Williams RA Hegele 2005 Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe Clin Genet 67 175 177 1:STN:280:DC%2BD2M%2Flt1Gjtw%3D%3D 10.1111/j.1399-0004.2004. 00388.x 15679830 (Pubitemid 40287525)
83. JA Weststrate GW Meijer 1998 Plant sterol-enriched margarines and reduction of plasma total- and LDL-C concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects Eur J Clin Nutr 52 334 343 1:STN:280:DyaK1c3pt1egtQ%3D%3D 10.1038/sj.ejcn.1600559 9630383 (Pubitemid 28230699)
84. KR Wilund L Yu F Xu GL Vega SM Grundy JC Cohen HH Hobbs 2004 No association between plasma levels of plant sterols and atherosclerosis in mice and men Arterioscler Thromb Vasc Biol 24 2232 2326 10.1161/01.ATV.0000149140. 00499.92 (Pubitemid 39658037)
85. Y Yamanashi T Takada H Suzuki 2007 Niemann-Pick C1-like 1 over expression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 Cells J Pharmacol Exp Ther 320 559 564 1:CAS:528:DC%2BD2sXhs1Wkur4%3D 10.1124/jpet.106.114181 17135346 (Pubitemid 46147934)
86. PL Yeagle 1985 Cholesterol and the cell membrane Biochim Biophys Acta 822 267 287 1:CAS:528:DyaL28Xit1ym 3904832 (Pubitemid 16196320)
87. L Yu 2008 The structure and function of Niemann-Pick C1-like 1 protein Curr Opin Lipidol 19 263 269 1:CAS:528:DC%2BD1cXlsV2rtLY%3D 10.1097/MOL. 0b013e3282f9b563 18460917 (Pubitemid 351653564)
88. HL Zhao AH Houweling CA Vanstone S Jew EA Trautwein GSMJE Duchateau PJH Jones 2008 Genetic variation in ABC G5/G8 and NPC1L1 impact cholesterol response to plant sterols in hypercholesterolemic men Lipids 43 1155 1164 1:CAS:528:DC%2BD1cXhsVentrzL 10.1007/s11745-008-3241-y 18850127