Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans

American Journal of Clinical Nutrition

Volumn 70, Issue 5, 1999, Pages 826-831

  Ostlund Jr , Richard E ^a   Spilburg, Curtis A ^b   Stenson, William F ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Cholesterol absorption; Deuterium; Mass; Phytosterols; Sitostanol lecithin; Spectrum analysis

Indexed keywords

CHOLESTEROL; PHOSPHATIDYLCHOLINE; PHYTOSTEROL; SITOSTANOL; TRACER;

ADULT; ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG FORMULATION; FAT INTAKE; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIPID ABSORPTION; MALE; MASS SPECTROMETRY; MICELLE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; TEST MEAL;

EID: 0345493907     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/70.5.826     Document Type: Article

References (32)

1. Pollak OJ. Reduction of blood cholesterol in man. Circulation 1953;7:702-6.
2. Best MM, Duncan CH, Van Loon EJ, Wathen JD. The effects of sitosterol on serum lipids. Am J Med 1955;19:61-70.
3. Heinemann T, Axtmann G, von Bergmann K. Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur J Clin Invest 1993;23:827-31.
4. Sugano M, Morioka H, Ikeda I. A comparison of hypocholesterolemic activity of beta-sitosterol and beta-sitostanol in rats. J Nutr 1977;107:2011-9.
5. Kesaniemi YA, Grundy SM. Turnover of low density lipoproteins during inhibition of cholesterol absorption by neornycin. Arteriosclerosis 1984;4:41-8.
6. Wilson MD, Rudel LL. Review of cholesterol absorption with emphasis on dietary and biliary cholesterol. J Lipid Res 1994; 35:943-55.
7. Grundy SM. Absorption and metabolism of dietary cholesterol. Annu Rev Nutr 1983;3:71-96.
8. Hassan AS, Rampone AJ. Intestinal absorption and lymphatic transport of cholesterol and beta-sitostanol in the rat. J Lipid Res 1979;20:646-53.
9. Lees AM, Mok HYI, Lees RS, McCluskey MA, Grundy SM. Plant sterols as cholesterol-lowering agents: clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atherosclerosis 1977;28:325-38.
10. Ling WH, Jones PJH. Dietary phylosterols: a review of metabolism, benefits and side effects. Life Sci 1995;57:195-206.
11. Denke MA. Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia. Am J Clin Nutr 1995;61:392-6.
12. Bosner MS, Ostlund RE Jr, Osofisan O, Grosklos J, Fritschle C, Lange LG. Assessment of percent cholesterol absorption in humans with stable isotopes. J Lipid Res 1993;34:1047-53.
13. Ostlund RE Jr. A minimal model for human whole body cholesterol metabolism. Am J Physiol 1993;265:513-20.
14. Goodman DS, Smith FR, Seplowitz AH, Ramakrishnan R, Dell RB. Prediction of the parameters of whole body cholesterol metabolism in humans. J Lipid Res 1980;21:699-713.
15. Bosner MS, Lange LG, Stenson WF, Ostlund RE Jr. Percent cholesterol absorption in normal men and women quantified with dual stable isotopic tracers and negative ion mass spectrometry. J Lipid Res 1999;40:302-8.
16. Ostlund RE Jr, Hsu F-F, Bosner MS, Stenson WF, Hachey DL. Quantification of cholesterol tracers by gas chromatography/negative ion chemical ionization mass spectrometry. J Mass Spectrom 1996; 31:1291-6.
17. Goodman DS, Noble RP. Turnover of plasma cholesterol in man. J Clin Invest 1968;47:231-41.
18. Small DM. The physical chemistry of lipids. New York: Plenum Press, 1986:159-65.
19. Armstrong MJ, Carey MC. Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles. J Lipid Res 1987; 28:1144-55.
20. Grundy SM, Mok HYI. Determination of cholesterol absorption in man by intestinal perfusion. J Lipid Res 1977;18:263-71.
21. Mattson FH, Grundy SM, Grouse JR. Optimizing the effect of plant sterols on cholesterol absorption in man. Am J Clin Nutr 1982; 35:697-700.
22. Miettinen TA, Puska P, Gylling H, Vanhanen H, Vartiainen E. Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N Engl J Med 1995;333:1308-12.
23. Grouse JR, Grundy SM. Evaluation of a continuous isotope feeding method for measurement of cholesterol absorption in man. J Lipid Res 1978;19:967-71.
24. Vanhanen HT, Blomqvist S. Ehnholm C, et al. Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment. J Lipid Res 1993;34:1535-44.
25. Mattson FH, Volpenhein RA, Erickson BA. Effect of plant sterol esters on the absorption of dietary cholesterol. J Nutr 1977;107:1139-46.
26. Miettinen TA, Vanhanen H. Dietary sitostanol related to absorption, synthesis and serum level of cholesterol in different apolipoprotein E phenotypes. Atherosclerosis 1994;105:217-26.
27. Vanhanen HT, Kajander J, Lehtovirta H, Miettinen TA. Serum levels, absorption efficiency, faecal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolaemic subjects. Clin Sci 1994;87:61-7.
28. Hoelscher LM, Savell JW, Smith SB, Cross HR. Subcellular distribution of cholesterol within muscle and adipose tissues of beef loin steaks. J Food Sci 1988;53:718-22.
29. Small DM, Oliva C, Tercyak A. Chemistry in the kitchen. Making ground meat more healthful. N Engl J Med 1991;324:73-7.
30. Weirauch JL, Gardner JM. Sterol content of foods of plant origin. J Am Diet Assoc 1978;3:39-47.
31. Miettinen TA, Kesaniemi YA. Cholesterol absorption: regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels. Am J Clin Nutr 1989;49:629-35.
32. Grundy SM. Comparison of monounsaturated fatty acids and carbohydrates for lowering plasma cholesterol. N Engl J Med 1986; 314:745-8.