Cholesterol and plant sterol absorption: Recent insights

American Journal of Cardiology

Volumn 96, Issue 1 SUPPL., 2005, Pages 10-14

  Von Bergmann, Klaus ^a   Sudhop, Thomas ^a   Lütjohann, Dieter ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; BRASSICASTEROL; CAMPESTEROL; CHOLESTEROL; EZETIMIBE; PHYTOSTEROL; SITOSTEROL; STIGMASTEROL;

ARTICLE; BILE SECRETION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; DRUG ABSORPTION; DRUG BINDING; HUMAN; HYPERCHOLESTEROLEMIA; INTESTINE ABSORPTION; INTESTINE MUCOSA; LIPOPROTEIN BLOOD LEVEL; MUCOSA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 21244465525     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2005.03.014     Document Type: Article

References (20)

1. H.Y. Mok, K. von Bergmann, S.M. Grundy Effects of continuous and intermittent feeding on biliary lipid outputs in man application for measurements of intestinal absorption of cholesterol and bile acids J Lipid Res 20 1979 389 398
2. J. Weihrauch, J. Gardner Sterol content of foods of plant origin J Am Diet Assoc 73 1978 39 47
3. T. Sudhop, Y. Sahin, B. Lindenthal, C. Hahn, C. Lürs, H.K. Berthold, K. von Bergmann Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion Gut 51 2002 860 863
4. T. Heinemann, G. Axtmann, K. von Bergmann Comparison of intestinal absorption of cholesterol with different plant sterols in man Eur J Clin Invest 23 1993 827 831
5. D. Lütjohann, I. Björkhem, U.F. Beil, K. von Bergmann Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols effect of sitostanol treatment J Lipid Res 36 1995 1763 1773
6. K.M. Boberg, K. Einarsson, I. Björkhem Apparent lack of conversion of sitosterol into C24-bile acids in humans J Lipid Res 31 1990 1083 1088
7. G. Salen, E.H. Ahrens Jr, S.M. Grundy Metabolism of beta-sitosterol in man J Clin Invest 49 1970 952 967
8. I. Björkhem, K. Muri Boberg, E. Leitersdorf Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol C. Scriver A. Beaudet W. Sly The Metabolic Bases of Inherited Disease 2001 McGraw-Hill New York, NY 2961 2988
9. S.B. Patel, G. Salen, H. Hidaka, P.O. Kwiterovich, A.F. Stalenhoef, T.A. Miettinen, S.M. Grundy, M.H. Lee, J.S. Rubenstein, M.H. Polymeropoulos, M.J. Brownstein Mapping a gene involved in regulating dietary cholesterol absorption the sitosterolemia locus is found at chromosome 2p21 J Clin Invest 102 1998 1041 1044
10. K.E. Berge, H. Tian, G.A. Graf, L. Yu, N.V. Grishin, J. Schultz, P. Kwiterovich, B. Shan, R. Barnes, H.H. Hobbs Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters Science 290 2000 1771 1775
11. M.H. Lee, K. Lu, S. Hazard, H. Yu, S. Shulenin, H. Hidaka, H. Kojima, R. Allikmets, N. Sakuma, R. Pegoraro Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption Nat Genet 27 2001 79 83
12. L. Yu, R.E. Hammer, J. Li-Hawkins, K. von Bergmann, D. Lütjohann, J.C. Cohen, H.H. Hobbs Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion Proc Natl Acad Sci U S A 99 2002 16237 16242
13. E. Sehayek, E.M. Duncan, D. Lütjohann, K. von Bergmann, J.G. Ono, A.K. Batta, G. Salen, J.L. Breslow Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross Proc Natl Acad Sci U S A 99 2002 16215 16219
14. T. Sudhop, D. Lütjohann, A. Kodal, M. Igel, D.L. Tribble, S. Shah, I. Perevozskaya, K. von Bergmann Inhibition of intestinal cholesterol absorption by ezetimibe in humans Circulation 106 2002 1943 1948
15. G. Salen, K. von Bergmann, D. Lütjohann, P. Kwiterovich, J. Kane, S.B. Patel, T. Musliner, P. Stein, B. Musser Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia Circulation 109 2004 966 971
16. B. Skrede, I. Björkhem, O. Bergesen, H.J. Kayden, S. Skrede The presence of 5 alpha-sitostanol in the serum of a patient with phytosterolemia, and its biosynthesis from plant steroids in rats with bile fistula Biochim Biophys Acta 836 1985 368 375
17. M. Igel, U. Giesa, D. Lütjohann, K. von Bergmann Comparison of the intestinal uptake of cholesterol, plant sterols, and stanols in mice J Lipid Res 44 2003 533 538
18. S.W. Altmann, H.R. Davis Jr, L.J. Zhu, X. Yao, L.M. Hoos, G. Tetzloff, S.P. Iyer, M. Maguire, A. Golovko, M. Zeng Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption Science 303 2004 1201 1204
19. H.R. Davis Jr, L.J. Zhu, L.M. Hoos, G. Tetzloff, M. Maguire, J. Liu, X. Yao, S.P. Iyer, M.H. Lam, E.G. Lund Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis J Biol Chem 279 2004 33586 33592
20. W. Kramer, F. Girbig, D. Corsiero, A. Pfenninger, W. Frick, M. Rhein, W. Wendler, F. Lottspeich, E.O. Hochleitner, E. Orso, G. Schmitz Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane J Biol Chem 280 2005 1306 1320