The g.762TC polymorphism of the NPC1L1 gene is common in Chinese and contributes to a higher promoter activity and higher serum cholesterol levels

Journal of Human Genetics

Volumn 54, Issue 4, 2009, Pages 242-247

  Chen, Chun Wu ^a   Hwang, Juey Jen ^b   Tsai, Chia Ti ^b   Su, Yi Ning ^b   Hsueh, Chia Hsiang ^a   Shen, Mark J ^a   Lai, Ling Ping ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

cholesterol; NPC1L1; polymorphism; promoter activity

Indexed keywords

CHOLESTEROL; GENOMIC DNA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUCIFERASE; AZETIDINE DERIVATIVE; EZETIMIBE; MEMBRANE PROTEIN; MEVINOLIN; NPC1L1 PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; CELL STRAIN HEPG2; CHINESE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; ENZYME ASSAY; ETHNICITY; FEMALE; GENE; GENE ACTIVITY; GENE IDENTIFICATION; GENETIC POLYMORPHISM; GENETIC SCREENING; HUMAN; HUMAN CELL; MALE; NPC1L1 GENE; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; ASIAN; BLOOD; CHINA; DEMOGRAPHY; GENE FREQUENCY; GENETICS; GENOTYPE; HYPERCHOLESTEROLEMIA; MIDDLE AGED;

ASIAN CONTINENTAL ANCESTRY GROUP; AZETIDINES; CHINA; CHOLESTEROL; DEMOGRAPHY; FEMALE; GENE FREQUENCY; GENOTYPE; HEP G2 CELLS; HUMANS; HYPERCHOLESTEROLEMIA; LOVASTATIN; MALE; MEMBRANE PROTEINS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC;

EID: 66249128960     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1038/jhg.2009.18     Document Type: Article

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