Short-term administration of tall oil phytosterols improves plasma lipid profiles in subjects with different cholesterol levels

Metabolism: Clinical and Experimental

Volumn 47, Issue 6, 1998, Pages 751-756

  Jones, Peter J H ^a,b   Howell, Tanya ^a   MacDougall, Diane E ^a   Feng, Jian Ying ^a   Parsons, William ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPESTANOL; CAMPESTEROL; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL; SITOSTANOL; SITOSTEROL; TALL OIL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIETARY INTAKE; FEMALE; HUMAN; HYPERLIPIDEMIA; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0031749963     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(98)90041-5     Document Type: Article

References (27)

1. Farquhar JW, Smith RE, Dempsey ME: The effect of betasitosterol on the serum lipids of young men with arteriosclerotic heart disease. Circulation 14:77-82, 1956
2. Lees AM, Mok HY, Lees RS, et al: Plant sterols as cholesterollowering agents: Clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atherosclerosis 28:325-338, 1977
3. Schlierf G, Oster P, Heuck CC, et al: Sitosterol in juvenile type II hyperlipoproteinemia. Atherosclerosis 30:245-248, 1978
4. Pollak OJ, Kritchevsky D: Sitosterol. Monogr Atheroscler 10:1-219, 1981
5. Becker M, Staab D, von Bergman K: Long-term treatment of severe familial hypercholesterolemia in children: Effect of Sitosterol and bezafibrate. Pediatrics 89:138-142, 1992
6. Vanhanen HT, Miettinen TA: Effects of unsaturated and saturated dietary plant sterols on their serum contents. Clin Chim Acta 205:97-107, 1992
7. Heinemann T, Kullak-Ublick GA, Pietruck B, et al: Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of Sitosterol and sitostanol. Eur J Clin Pharmacol 40:S59-S63, 1991 (suppl)
8. Pelletier X, Belbraouet S, Mirabel D, et al: A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans. Ann Nutr Metab 39:291-295, 1995
9. Becker M, Staab D, von Bergmann K: Treatment of severe familial hypercholesterolemia in childhood with Sitosterol and sitostanol. J Pediatr 122:292-296, 1993
10. Miettinen TA, Puska P, Gylling H, et al: Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N Engl J Med 333:1308-1312, 1995
11. Mifflin MD, St Jeor ST, Hill LA, et al: A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 51:241-247, 1990
12. Helrich K: Official Methods of Analysis of the Association of Official Chemists. Arlington, VA, Association of Official Analytical Chemists, 1990
13. Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 18:499-505, 1972
14. Jones PJH, Leitch CA, Li ZC, et al: Human cholesterol synthesis measurement using deuterated water: Theoretical and procedural considerations. Arterioscler Thromb 13:247-253, 1993
15. Law MR, Wald NJ, Wu T, et al: Systematic underestimation of association between serum cholesterol concentration and ischaemic heart disease in observational studies: Data from the BUPA Study. BMJ 308:363-366, 1994
16. Law MR, Wald NJ, Thompson SG: By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? BMJ 308:367-372, 1994
17. Denke MA: Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia. Am J Clin Nutr 61:392-396, 1995
18. Ling WH, Jones PJH: Enhanced efficacy of sitostanol-containing versus sitostanol-free phytosterol mixtures in altering lipoprotein cholesterol levels and synthesis in rats. Atherosclerosis 118:319-331, 1995
19. Vanhanen HT, Blomqvist S, Ehnholm C, et al: Serum cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment. J Lipid Res 34:1535-1544, 1993
20. Jones PJH, Lichtenstein AH, Scheafer EJ, et al: Effect of dietary fat selection on plasma cholesterol synthesis in older, moderately hypercholesterolemic humans. Arterioscler Thromb 14:542-548, 1994
21. Jones PJH, Pappu AS, Hatcher L, et al: Dietary cholesterol feeding suppresses human cholesterol synthesis measured using deuterium incorporation and urinary mevalonic acid levels. Arterioscler Thromb 16:1222-1228, 1996
22. Heinemann T, Axtmann G, von Bergmann K: Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur J Clin Invest 23:827-831, 1993
23. Sugano M, Morioka H, Ikeda I: A comparison of hypocholesterolemic activity of beta-sitosterol and beta-sitostanol in rats. J Nutr 107:2011-2019, 1977
24. Gylling H, Siimes MA, Miettinen TA: Sitostanol ester margarine in dietary treatment of children with familial hypercholesterolemia. J Lipid Res 36:1807-1812, 1995
25. Vanhanen HT, Kajander J, Lehtovirta H, et al: Serum levels, absorption efficiency, faecal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolemic subjects. Clin Sci 87:61-67, 1994
26. Gylling H, Miettinen TA: Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolemic NIDDM patients before and during sitostanol ester-margarine treatment. Diabetologia 37:773-780, 1994
27. Miettinen TA, Vanhanen H: Dietary sitostanol related to absorption, synthesis and serum level of cholesterol in different apolipoprotein E phenotypes. Atherosclerosis 105:217-226, 1994