Sitosterol reduces micellar cholesterol solubility in model bile

Nutrition Research

Volumn 26, Issue 11, 2006, Pages 579-584

  Jesch, Elliot D ^a   Carr, Timothy P ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Cholesterol absorption; Micelles; Model bile; Plant sterols; Sitosterol; Vesicles

Indexed keywords

BILE SALT; CHOLESTEROL; PHOSPHATIDYLCHOLINE; PHYTOSTEROL; SITOSTEROL; SODIUM CHLORIDE;

ARTICLE; BILE; GEL FILTRATION; HEPATOBILIARY SYSTEM; IN VITRO STUDY; LIPID ABSORPTION; LIPID ANALYSIS; LIPID SOLUBILITY; MICELLE; PRIORITY JOURNAL;

EID: 33750955973     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2006.08.006     Document Type: Article

References (37)

1. Kesaniemi Y.A., and Miettinen T.A. Cholesterol absorption efficiency regulates plasma cholesterol level in the Finnish population. Eur J Clin Invest 17 (1987) 391-395
2. Rudel L.L., Deckelman C., Wilson M.D., Scobey M., and Anderson R. Dietary cholesterol and downregulation of cholesterol 7α-hydroxylase and cholesterol absorption in African green monkeys. J Clin Invest 93 (1994) 2463-2472
3. Gylling H., and Miettinen T.A. The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level. Atherosclerosis 117 (1995) 305-308
4. Wilson M.D., and Rudel L.L. Review of cholesterol absorption with emphasis on dietary and biliary cholesterol. J Lipid Res 35 (1994) 943-955
5. Matthan N.R., and Lichtenstein A.H. Approaches to measuring cholesterol absorption in humans. Atherosclerosis 174 (2004) 197-205
6. Mazer N.A., and Carey M.C. Quasielastic light scattering studies of aqueous biliary lipid systems. Cholesterol solubilization and precipitation in model bile solutions. Biochemistry (Mosc) 22 (1983) 426-442
7. Sömjen G., and Gilat T. Contribution of vesicular and micellar carriers to cholesterol transport in human bile. J Lipid Res 26 (1985) 699-704
8. Donovan J.M., Timofeyeva N., and Carey M.C. Influence of total lipid concentration, bile salt:lecithin ratio, and cholesterol content on inter-mixed micellar/vesicular (non-lecithin-associated) bile salt concentration in model bile. J Lipid Res 32 (1991) 1501-1512
9. Woollett L.A., Wang Y., Buckley D.D., Yao L., Chin S., Granholm N., et al. Micellar solubilisation of cholesterol is essential for absorption in humans. Gut 55 (2006) 197-204
10. Carr T.P., and Jesch E.D. Food ingredients that reduce cholesterol absorption. Adv Food Nutr Res 51 (2006) 165-204
11. Ntanios F.Y., and Jones P.J.H. Dietary sitostanol reciprocally influences cholesterol absorption and biosynthesis in hamsters and rabbits. Atherosclerosis 143 (1999) 341-351
12. Carr T.P., Cornelison R.M., Illston B.J., Stuefer-Powell C.L., and Gallaher D.D. Plant sterols alter bile acid metabolism and reduce cholesterol absorption in hamsters fed a beef-based diet. Nutr Res 22 (2002) 745-754
13. Ellegard L., Bosaeus I., and Andersson H. Will recommended changes in fat and fibre intake affect cholesterol absorption and sterol excretion? An ileostomy study. Eur J Clin Nutr 54 (2000) 306-313
14. Heinemann T., Kullak-Ublick G.-K., Pietruck B., and von Bergmann K. Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol. Eur J Clin Pharmacol 40 (1991) S50-S63
15. Ikeda I., and Sugano M. Some aspects of mechanism of inhibition of cholesterol absorption by β-sitosterol. Biochim Biophys Acta 732 (1983) 651-658
16. Weihrauch J.L., and Gardner J.M. Sterol content of foods of plant origin. J Am Diet Assoc 73 (1978) 39-47
17. Jimenez-Escrig A., Santos-Hidalgo A.B., and Saura-Calixto F. Common sources and estimated intake of plant sterols in the Spanish diet. J Agric Food Chem 54 (2006) 3462-3471
18. Cohen D.E., and Carey M.C. Rapid (1 hour) high performance gel filtration chromatography resolves coexisting simple micelles, mixed micelles, and vesicles in bile. J Lipid Res 31 (1990) 2103-2112
19. Cowles R.L., Lee J.-Y., Gallaher D.D., Stuefer-Powell C.L., and Carr T.P. Dietary stearic acid alters gallbladder bile acid composition in hamsters fed cereal-based diets. J Nutr 132 (2002) 3119-3122
20. Stone B.G., Larsen L.J., Knoll D.A., Bloomfield V.A., and Duane W.C. Separation of bile vesicles and micelles by gel filtration chromatography: the importance of the intermicellar bile salt concentration. J Lab Clin Med 119 (1992) 557-565
21. Schneider C.L., Cowles R.L., Stuefer-Powell C.L., and Carr T.P. Dietary stearic acid reduces cholesterol absorption and increases endogenous cholesterol excretion in hamsters fed cereal-based diets. J Nutr 130 (2000) 1232-1238
22. Carr T.P., Andresen C.J., and Rudel L.L. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin Biochem 26 (1993) 39-42
23. Yao L., Heubi J.E., Buckley D.D., Fierra H., Setchell K.D., Granholm N.A., et al. Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal. J Lipid Res 43 (2002) 654-660
24. Duane W.C. The intermicellar bile salt concentration in equilibrium with the mixed micelles of human bile. Biochim Biophys Acta 398 (1975) 275-286
25. Higuchi W.I., Arakawa M., Lee P.H., and Noro S. Simple micelle-mixed micelle coexistence equilibria for taurocholate-, taurochenodeoxycholate-, and tauroursodeoxycholate-lecithin systems. J Colloid Interface Sci 119 (1987) 30-37
26. Ikeda I., Tanaka K., Sugano M., Vahouny G.V., and Gallo L.L. Inhibition of cholesterol absorption in rats by plant sterols. J Lipid Res 29 (1988) 1573-1582
27. Ikeda I., Tanabe Y., and Sugano M. Effects of sitosterol and sitostanol on micellar solubility of cholesterol. J Nutr Sci Vitaminol (Tokyo) 35 (1989) 361-369
28. Nissinen M., Gylling H., Vuoristo M., and Miettinen T.A. Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. Am J Physiol 282 (2002) G1009-G1015
29. Armstrong M.J., and Carey M.C. Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles. J Lipid Res 28 (1987) 1144-1155
30. Mel'nikov S.M., Seijen ten Hoorn J.W., and Eijkelenboom A.P. Effect of phytosterols and phytostanols on the solubilization of cholesterol by dietary mixed micelles: an in vitro study. Chem Phys Lipids 127 (2004) 121-141
31. Katan M.B., Grundy S.M., Jones P., Law M., Miettinen T., and Paoletti R. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 78 (2003) 965-978
32. Chen J.T., Wesley R., Shamburek R.D., Pucino F., and Csako G. Meta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol. Pharmacotherapy 25 (2005) 171-183
33. O'Neill F.H., Sanders T.A.B., and Thompson G.R. Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies. Am J Cardiol 96 Suppl (2005) 29D-36D
34. Law M. Plant sterol and stanol margarines and health. Br Med J 320 (2000) 861-864
35. National Institutes of Health. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III): final report. Circulation 106 (2002) 3143-3421
36. Ostlund Jr. R.E. Phytosterols in human nutrition. Annu Rev Nutr 22 (2002) 533-549
37. Kendall C.W., and Jenkins D.J. A dietary portfolio: maximal reduction of low-density lipoprotein cholesterol with diet. Curr Atheroscler Rep 6 (2004) 492-498