The significance of the complement system for the pathogenesis of age-related macular degeneration - Current evidence and translation into clinical application

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 249, Issue 2, 2011, Pages 163-174

  Charbel Issa, Peter ^a   Victor Chong, N ^b   Scholl, Hendrik P N ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Age related macular degeneration; Complement system; Gene environment interaction; Genotype; Pathogenesis; Pharmacogenetics; Therapy

Indexed keywords

ALPHA TOCOPHEROL; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; ARC 1905; ASCORBIC ACID; BETA CAROTENE; BEVACIZUMAB; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5 INHIBITOR; COMPLEMENT FACTOR D; COMPLEMENT FACTOR H; COMPLEMENT FACTOR H RELATED PROTEIN 1; COMPLEMENT FACTOR H RELATED PROTEIN 3; COMPLEMENT FACTOR I; COMPLEMENT INHIBITOR; ECULIZUMAB; FCFD 4514S; OMEGA 3 FATTY ACID; POT 4; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL GROWTH FACTOR A INHIBITOR; VASCULOTROPIN INHIBITOR; ZINC;

AGING; BRUCH MEMBRANE; CLINICAL PRACTICE; COMPLEMENT ACTIVATION; COMPLEMENT BLOOD LEVEL; COMPLEMENT INHIBITION; COMPLEMENT SYSTEM; DISEASE COURSE; DRUG DOSE ESCALATION; DRUG MECHANISM; DRUSEN; EVIDENCE BASED MEDICINE; FUNCTIONAL PROTEOMICS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; GENOTYPE PHENOTYPE CORRELATION; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; IMMUNOREGULATION; NONHUMAN; ONSET AGE; OXIDATIVE STRESS; PATHOLOGICAL ANATOMY; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA LUTEA; RETINA NEOVASCULARIZATION; REVIEW; RISK FACTOR; RISK REDUCTION; SMOKING; SYSTEMIC DISEASE; TREATMENT RESPONSE; VITAMIN SUPPLEMENTATION;

ANIMALS; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM PROTEINS; GENOTYPE; HUMANS; MACULAR DEGENERATION; PHARMACOGENETICS;

EID: 79952454215     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-010-1568-6     Document Type: Review

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