Structure-based design and biological profile of (E)-N-(4-Nitrobenzylidene) -2-naphthohydrazide, a novel small molecule inhibitor of IκB kinase-β

European Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2011, Pages 1245-1253

  Avila, Carolina M ^a   Lopes, Alexandra B ^a   Gonalves, Arlan S ^b   Da Silva, Leandro L ^a   Romeiro, Nelilma C ^a   Miranda, Ana Luisa P ^a   Sant'Anna, Carlos M R ^a,c   Barreiro, Eliezer J ^a   Fraga, Carlos A M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b Instituto Federal de Educaão Ciência e Tecnologia Do Espírito Santo IFES   (Brazil)

^c FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

anti Inflammatory; IKK inhibitor; Molecular docking; N Acylhydrazone; Privileged structure; Structure based design

Indexed keywords

2 AMINO 4 (THIOPHEN 2 YL)THIOPHENE 3 CARBOXAMIDE; ARACHIDONIC ACID; CHECKPOINT KINASE 2; HYDRAZIDE DERIVATIVE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE INHIBITOR; LASSBIO 1524; N (4 NITROBENZYLIDENE) 2 NAPHTHOHYDRAZIDE; SC 514; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFICACY; DRUG SELECTIVITY; DRUG STRUCTURE; EDEMA; ENZYME ACTIVE SITE; ENZYME INHIBITION; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZYLIDENE COMPOUNDS; CATALYTIC DOMAIN; CELL LINE; DRUG DESIGN; EDEMA; FEMALE; HUMANS; HYDRAZONES; I-KAPPA B KINASE; LIGANDS; MALE; MICE; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PROTEIN KINASE INHIBITORS;

EID: 79952280173     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.045     Document Type: Article

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