(S)-2-amino-6-nitrohexanoic acid binds to human arginase i through multiple nitro-metal coordination interactions in the binuclear manganese cluster

Journal of the American Chemical Society

Volumn 130, Issue 51, 2008, Pages 17254-17255

  Zakharian, Tatiana Y ^a   Di Costanzo, Luigi ^a   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; ENZYME-INHIBITOR COMPLEX; MANGANESE CLUSTER; METAL COORDINATION; X RAY CRYSTAL STRUCTURES;

ACIDS; AMINATION; AMINES; BINDING ENERGY; COORDINATION REACTIONS; MANGANESE; SURFACE PLASMON RESONANCE;

CRYSTAL STRUCTURE;

ARGINASE 1; HEXANOIC ACID DERIVATIVE; MANGANESE; (S) 2 AMINO 6 NITROHEXANOIC ACID; (S)-2-AMINO-6-NITROHEXANOIC ACID; ARGINASE; ARGININE; HEXANOIC ACID; LIGAND; METAL; NITRO DERIVATIVE; NITROGEN;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ASSAY; ENZYME BINDING; ENZYME STRUCTURE; METAL BINDING; NONHUMAN; PROTEIN INTERACTION; SYNTHESIS; BIOPHYSICS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; KINETICS; METHODOLOGY; ORGANIC CHEMISTRY; PROTEIN BINDING; X RAY CRYSTALLOGRAPHY;

ARGINASE; ARGININE; BIOPHYSICAL PROCESSES; CHEMISTRY, ORGANIC; CRYSTALLOGRAPHY, X-RAY; HEXANOIC ACIDS; HUMANS; KINETICS; LIGANDS; MANGANESE; METALS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NITRO COMPOUNDS; NITROGEN; PROTEIN BINDING;

EID: 67849106082     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja807702q     Document Type: Article

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