Structural insights into IKKβ inhibition by natural products staurosporine and quercetin

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 24, 2009, Pages 6907-6910

  Avila, Carolina M ^a   Romeiro, Nelilma C ^a   Sant'Anna, Carlos M R ^a,b   Barreiro, Eliezer J ^a   Fraga, Carlos A M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Antiinflammatory drugs; ATP binding site inhibitors; Homology modeling; IKKbeta; Molecular docking; Quercetin; Serine threonine kinases; Staurosporine

Indexed keywords

ADENOSINE TRIPHOSPHATE; I KAPPA B KINASE BETA; QUERCETIN; STAUROSPORINE; BIOLOGICAL PRODUCT; I KAPPA B KINASE;

ARTICLE; DRUG BINDING SITE; DRUG STRUCTURE; ENZYME INHIBITION; MOLECULAR DOCKING; MOLECULAR MODEL; STRUCTURAL HOMOLOGY; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; STRUCTURE ACTIVITY RELATION;

BIOLOGICAL PRODUCTS; DRUG DESIGN; I-KAPPA B KINASE; QUERCETIN; STAUROSPORINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72149083589     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.076     Document Type: Article

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