Induction of leptin resistance by activation of cAMP-Epac signaling

Cell Metabolism

Volumn 13, Issue 3, 2011, Pages 331-339

  Fukuda, Makoto ^a   Williams, Kevin W ^a   Gautron, Laurent ^a   Elmquist, Joel K ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR EPAC; LEPTIN; PROOPIOMELANOCORTIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPOTHALAMUS; MOUSE; NERVE CELL; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TISSUE SLICE;

ANIMALS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HYPOTHALAMUS; LEPTIN; MICE; NEURONS; PHOSPHORYLATION; RAP1 GTP-BINDING PROTEINS; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 79952154035     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2011.01.016     Document Type: Article

References (51)

1. R. Banno, D. Zimmer, B.C. De Jonghe, M. Atienza, K. Rak, W. Yang, and K.K. Bence PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice J. Clin. Invest. 120 2010 720 734
2. K.K. Bence, M. Delibegovic, B. Xue, C.Z. Gorgun, G.S. Hotamisligil, B.G. Neel, and B.B. Kahn Neuronal PTP1B regulates body weight, adiposity and leptin action Nat. Med. 12 2006 917 924 (Pubitemid 44175143)
3. C. Bjørbaek, and B.B. Kahn Leptin signaling in the central nervous system and the periphery Recent Prog. Horm. Res. 59 2004 305 331
4. C. Bjørbaek, K. El-Haschimi, J.D. Frantz, and J.S. Flier The role of SOCS-3 in leptin signaling and leptin resistance J. Biol. Chem. 274 1999 30059 30065
5. C. Bousquet, V. Chesnokova, A. Kariagina, A. Ferrand, and S. Melmed cAMP neuropeptide agonists induce pituitary suppressor of cytokine signaling-3: novel negative feedback mechanism for corticotroph cytokine action Mol. Endocrinol. 15 2001 1880 1890 (Pubitemid 33022529)
6. R.D. Cone Anatomy and regulation of the central melanocortin system Nat. Neurosci. 8 2005 571 578 (Pubitemid 40594196)
7. R.V. Considine, M.K. Sinha, M.L. Heiman, A. Kriauciunas, T.W. Stephens, M.R. Nyce, J.P. Ohannesian, C.C. Marco, L.J. McKee, and T.L. Bauer Serum immunoreactive-leptin concentrations in normal-weight and obese humans N. Engl. J. Med. 334 1996 292 295 (Pubitemid 26033933)
8. W.S. Cook, and R.H. Unger Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity Dev. Cell 2 2002 385 387 (Pubitemid 34436568)
9. R. Coppari, M. Ichinose, C.E. Lee, A.E. Pullen, C.D. Kenny, R.A. McGovern, V. Tang, S.M. Liu, T. Ludwig, and S.C. Chua Jr. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity Cell Metab. 1 2005 63 72 (Pubitemid 43960588)
10. D. Cota, K. Proulx, K.A. Smith, S.C. Kozma, G. Thomas, S.C. Woods, and R.J. Seeley Hypothalamic mTOR signaling regulates food intake Science 312 2006 927 930 (Pubitemid 43727328)
11. D. Cota, E.K. Matter, S.C. Woods, and R.J. Seeley The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity J. Neurosci. 28 2008 7202 7208
12. M.A. Cowley, J.L. Smart, M. Rubinstein, M.G. Cerdán, S. Diano, T.L. Horvath, R.D. Cone, and M.J. Low Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus Nature 411 2001 480 484 (Pubitemid 32494394)
13. P.B. Daniel, W.H. Walker, and J.F. Habener Cyclic AMP signaling and gene regulation Annu. Rev. Nutr. 18 1998 353 383 (Pubitemid 28366872)
14. J. de Rooij, F.J. Zwartkruis, M.H. Verheijen, R.H. Cool, S.M. Nijman, A. Wittinghofer, and J.L. Bos Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP Nature 396 1998 474 477 (Pubitemid 28553318)
15. M. Delgado, and D. Ganea Inhibition of IFN-gamma-induced janus kinase-1-STAT1 activation in macrophages by vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide J. Immunol. 165 2000 3051 3057
16. J.K. Elmquist, R. Coppari, N. Balthasar, M. Ichinose, and B.B. Lowell Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis J. Comp. Neurol. 493 2005 63 71 (Pubitemid 41636188)
17. P.J. Enriori, A.E. Evans, P. Sinnayah, E.E. Jobst, L. Tonelli-Lemos, S.K. Billes, M.M. Glavas, B.E. Grayson, M. Perello, and E.A. Nillni Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons Cell Metab. 5 2007 181 194
18. J.M. Enserink, A.E. Christensen, J. de Rooij, M. van Triest, F. Schwede, H.G. Genieser, S.O. Døskeland, J.L. Blank, and J.L. Bos A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK Nat. Cell Biol. 4 2002 901 906 (Pubitemid 35331366)
19. M. Fasshauer, J. Klein, U. Lossner, and R. Paschke Isoproterenol is a positive regulator of the suppressor of cytokine signaling-3 gene expression in 3T3-L1 adipocytes J. Endocrinol. 175 2002 727 733 (Pubitemid 36054243)
20. J.S. Flier Neuroscience. Regulating energy balance: the substrate strikes back Science 312 2006 861 864 (Pubitemid 43727307)
21. R.C. Frederich, A. Hamann, S. Anderson, B. Löllmann, B.B. Lowell, and J.S. Flier Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action Nat. Med. 1 1995 1311 1314
22. J.M. Friedman Modern science versus the stigma of obesity Nat. Med. 10 2004 563 569 (Pubitemid 38796839)
23. P. Gaede, H. Lund-Andersen, H.H. Parving, and O. Pedersen Effect of a multifactorial intervention on mortality in type 2 diabetes N. Engl. J. Med. 358 2008 580 591 (Pubitemid 351214285)
24. S. Gasperini, L. Crepaldi, F. Calzetti, L. Gatto, C. Berlato, F. Bazzoni, A. Yoshimura, and M.A. Cassatella Interleukin-10 and cAMP-elevating agents cooperate to induce suppressor of cytokine signaling-3 via a protein kinase A-independent signal Eur. Cytokine Netw. 13 2002 47 53 (Pubitemid 34535571)
25. I. Gloaguen, P. Costa, A. Demartis, D. Lazzaro, A. Di Marco, R. Graziani, G. Paonessa, F. Chen, C.I. Rosenblum, and L.H. Van der Ploeg Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance Proc. Natl. Acad. Sci. USA 94 1997 6456 6461 (Pubitemid 27270706)
26. M. Gloerich, and J.L. Bos Epac: defining a new mechanism for cAMP action Annu. Rev. Pharmacol. Toxicol. 50 2010 355 375
27. J.W. Hill, K.W. Williams, C. Ye, J. Luo, N. Balthasar, R. Coppari, M.A. Cowley, L.C. Cantley, B.B. Lowell, and J.K. Elmquist Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice J. Clin. Invest. 118 2008 1796 1805 (Pubitemid 351632382)
28. J.K. Howard, B.J. Cave, L.J. Oksanen, I. Tzameli, C. Bjørbaek, and J.S. Flier Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3 Nat. Med. 10 2004 734 738 (Pubitemid 38937639)
29. P.D. Lambert, K.D. Anderson, M.W. Sleeman, V. Wong, J. Tan, A. Hijarunguru, T.L. Corcoran, J.D. Murray, K.E. Thabet, G.D. Yancopoulos, and S.J. Wiegand Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity Proc. Natl. Acad. Sci. USA 98 2001 4652 4657 (Pubitemid 32295031)
30. M. Maffei, M. Stoffel, M. Barone, B. Moon, M. Dammerman, E. Ravussin, C. Bogardus, D.S. Ludwig, J.S. Flier, and M. Talley Absence of mutations in the human OB gene in obese/diabetic subjects Diabetes 45 1996 679 682 (Pubitemid 26142808)
31. H. Mori, R. Hanada, T. Hanada, D. Aki, R. Mashima, H. Nishinakamura, T. Torisu, K.R. Chien, H. Yasukawa, and A. Yoshimura Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity Nat. Med. 10 2004 739 743 (Pubitemid 38937640)
32. H. Münzberg, J.S. Flier, and C. Bjørbaek Region-specific leptin resistance within the hypothalamus of diet-induced obese mice Endocrinology 145 2004 4880 4889 (Pubitemid 39551104)
33. M.G. Myers Jr., R.L. Leibel, R.J. Seeley, and M.W. Schwartz Obesity and leptin resistance: distinguishing cause from effect Trends Endocrinol. Metab. 21 2010 643 651
34. S.R. Neves, P.T. Ram, and R. Iyengar G protein pathways Science 296 2002 1636 1639 (Pubitemid 34579147)
35. L. Ozcan, A.S. Ergin, A. Lu, J. Chung, S. Sarkar, D. Nie, M.G. Myers Jr., and U. Ozcan Endoplasmic reticulum stress plays a central role in development of leptin resistance Cell Metab. 9 2009 35 51
36. L.E. Parton, C.P. Ye, R. Coppari, P.J. Enriori, B. Choi, C.Y. Zhang, C. Xu, C.R. Vianna, N. Balthasar, and C.E. Lee Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity Nature 449 2007 228 232 (Pubitemid 47402365)
37. G. Ramadori, C.E. Lee, A.L. Bookout, S. Lee, K.W. Williams, J. Anderson, J.K. Elmquist, and R. Coppari Brain SIRT1: anatomical distribution and regulation by energy availability J. Neurosci. 28 2008 9989 9996
38. A. Sahu, and A.S. Metlakunta Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion J. Neuroendocrinol. 17 2005 720 726 (Pubitemid 41568098)
39. W.A. Sands, H.D. Woolson, G.R. Milne, C. Rutherford, and T.M. Palmer Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells Mol. Cell. Biol. 26 2006 6333 6346 (Pubitemid 44277875)
40. M.M. Scott, J.L. Lachey, S.M. Sternson, C.E. Lee, C.F. Elias, J.M. Friedman, and J.K. Elmquist Leptin targets in the mouse brain J. Comp. Neurol. 514 2009 518 532
41. C.H. Serezani, M.N. Ballinger, D.M. Aronoff, and M. Peters-Golden Cyclic AMP: master regulator of innate immune cell function Am. J. Respir. Cell Mol. Biol. 39 2008 127 132
42. J. Stamler, O. Vaccaro, J.D. Neaton, and D. Wentworth Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial Diabetes Care 16 1993 434 444 (Pubitemid 23046633)
43. L.A. Tartaglia The leptin receptor J. Biol. Chem. 272 1997 6093 6096 (Pubitemid 27118072)
44. L.F. Van Gaal, I.L. Mertens, and C.E. De Block Mechanisms linking obesity with cardiovascular disease Nature 444 2006 875 880 (Pubitemid 46028447)
45. K.W. Williams, L.O. Margatho, C.E. Lee, M. Choi, S. Lee, M.M. Scott, C.F. Elias, and J.K. Elmquist Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons J. Neurosci. 30 2010 2472 2479
46. J.M. Zabolotny, K.K. Bence-Hanulec, A. Stricker-Krongrad, F. Haj, Y. Wang, Y. Minokoshi, Y.B. Kim, J.K. Elmquist, L.A. Tartaglia, B.B. Kahn, and B.G. Neel PTP1B regulates leptin signal transduction in vivo Dev. Cell 2 2002 489 495 (Pubitemid 34436576)
47. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425 432 (Pubitemid 24365442)
48. X. Zhang, G. Zhang, H. Zhang, M. Karin, H. Bai, and D. Cai Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity Cell 135 2008 61 73
49. A.Z. Zhao Control of food intake through regulation of cAMP Curr. Top. Dev. Biol. 67 2005 207 224 (Pubitemid 43588854)
50. A.Z. Zhao, K.E. Bornfeldt, and J.A. Beavo Leptin inhibits insulin secretion by activation of phosphodiesterase 3B J. Clin. Invest. 102 1998 869 873 (Pubitemid 28419231)
51. A.Z. Zhao, J.N. Huan, S. Gupta, R. Pal, and A. Sahu A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding Nat. Neurosci. 5 2002 727 728 (Pubitemid 34827588)