Carotenoids and their isomers: Color pigments in fruits and vegetables

Molecules

Volumn 16, Issue 2, 2011, Pages 1710-1738

  Khoo, Hock Eng ^a   Prasad, K Nagendra ^a   Kong, Kin Weng ^a   Jiang, Yueming ^b   Ismail, Amin ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b SOUTH CHINA INSTITUTE OF BOTANY   (China)

Author keywords

Carotene; Cryptoxanthin; Fruit; Lutein; Lycopene; Vegetables; Zeaxanthin

Indexed keywords

ANTIOXIDANT; CAROTENOID;

CHEMICAL STRUCTURE; CHEMISTRY; COLOR; FOOD HANDLING; FRUIT; FUNCTIONAL FOOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOMERISM; METHODOLOGY; REVIEW; VEGETABLE;

ANTIOXIDANTS; CAROTENOIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLOR; FOOD HANDLING; FRUIT; FUNCTIONAL FOOD; HUMANS; ISOMERISM; MOLECULAR STRUCTURE; VEGETABLES;

EID: 79952123580     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules16021710     Document Type: Review

References (119)

1. WHO. Fruit, Vegetables and NCD Disease Prevention; World Health Organization: Geneva, Switzerland, 2003; http://www.who.int/hpr/NPH/fruit-and- vegetables/fruit-vegetables-fs.pdf, (accessed on 3 May 2010).
2. Cooper, D.A. Carotenoids in health and disease: Recent scientific evaluations, research recommendations and the consumer. J. Nutr. 2004, 134, 221S-224S. (Pubitemid 38057453)
3. Young, C.Y.F.; Yuan, H.Q.; He, M.L.; Zhang, J.Y. Carotenoids and prostate cancer risk. Mini- Rev. Med. Chem. 2008, 8, 529-537.
4. Shahidi, F. Nutraceuticals and functional foods: Whole versus processed foods. Trends Food Sci. Technol. 2009, 20, 376-387.
5. Bartley, G.E.; Scolnik, P.A. Plant carotenoids: Pigments for photoprotection, visual attraction, and human health. Plant Cell 1995, 7, 1027-1038.
6. Janik, E.; Grudzinski, W.; Gruszecki, W.I.; Krupa, Z. The xanthophyll cycle pigments in Secale cereale leaves under combined Cd and high light stress conditions. J. Photochem. Photobiol. B 2008, 90, 47-52.
7. Lancaster, J.E.; Lister, C.E.; Reay, P.F.; Triggs, C.M. Influence of pigment composition on skin color in a wide range of fruit and vegetables. J. Am. Soc. Hortic. Sci. 1997, 122, 594-598. (Pubitemid 27433813)
8. Rodriguez-Amaya, D.B.; Kimura, M. HarvestPlus Handbook for Carotenoid Analysis. In HarvestPlus Technical Monograph, Series 2; International Food Policy Research Institute and International Center for Tropical Agriculture: Washington, DC, USA, 2004.
9. Rodriguez-Amaya, D.B. A Guide to Carotenoid Analysis in Foods; International Life Sciences Institute, ILSI Press: Washington, DC, USA, 2001.
10. Hornero-Méndez, D.; Mínguez-Mosquera, M.I. Xanthophyll esterification accompanying carotenoid overaccumulation in chromoplast of Capsicum annuum ripening fruits is a constitutive process and useful for ripeness index. J. Agric. Food Chem. 2000, 48, 1617-1622. (Pubitemid 30331498)
11. Minguez-Mosquera, M.I.; Hornero-Mendez, D. Changes in carotenoid esterification during the fruit ripening of Capsicum annuum Cv. Bola. J. Agric. Food Chem. 1994, 42, 640-644.
12. Schieber, A.; Carle, R. Occurrence of carotenoid cis-isomers in food: Technological, analytical, and nutritional implications. Trends Food Sci. Technol. 2005, 16, 416-422. (Pubitemid 41207991)
13. Mertz, C.; Brat, P.; Caris-Veyrat, C.; Gunata, Z. Characterization and thermal lability of carotenoids and vitamin C of tamarillo fruit (Solanum betaceum Cav.). Food Chem. 2010, 119, 653-659.
14. Zepka, L.Q.; Mercadante, A.Z. Degradation compounds of carotenoids formed during heating of a simulated cashew apple juice. Food Chem. 2009, 117, 28-34.
15. Shi, J.; Yi, C.; Ye, X.; Xue, S.; Jiang, Y.; Ma, Y.; Liu, D. Effects of supercritical CO2 fluid parameters on chemical composition and yield of carotenoids extracted from pumpkin. LWT - Food Sci. Technol. 2010, 43, 39-44.
16. Niedzwiedzki, D.M.; Sandberg, D.J.; Cong, H.; Sandberg, M.N.; Gibson, G.N.; Birge, R.R.; Frank, H.A. Ultrafast time resolved absorption spectroscopy of geometric isomers of carotenoids. Chem. Phys. 2009, 357, 4-16.
17. Qiu, D.; Chen, Z.-R.; Li, H.-R. Effect of heating on solid β-carotene. Food Chem. 2009, 112, 344-349.
18. Liu, R.S.H.; Asato, A.E. The primary process of vision and the structure of bathorhodopsin: A mechanism for photoisomerization of polyenes. Proc. Natl. Acad. Sci. USA 1985, 82, 259-263. (Pubitemid 15128249)
19. Britton, G. Overview of carotenoid biosynthesis. In Carotenoids: Biosynthesis and Metabolism; Britton, G., Liaaen-Jensen, S., Pfander, H., Eds.; Birkhäuser Verlag: Basel, Switzerland, 1998; pp. 13-147.
20. Vásquez-Caicedo, A.L.; Sruamsiri, P.; Carle, R.; Neidhart, S. Accumulation of all-trans-β- carotene and its 9-cis and 13-cis stereoisomers during postharvest ripening of nine Thai mango cultivars. J. Agric. Food Chem. 2005, 53, 4827-4835. (Pubitemid 40937605)
21. Aman, R.; Schieber, A.; Carle, R. Effects of heating and illumination on trans-cis isomerization and degradation of β-carotene and lutein in isolated spinach chloroplasts. J. Agric. Food Chem. 2005, 53, 9512-9518. (Pubitemid 41784158)
22. Rickman, J.C.; Bruhn, C.M.; Barrett, D.M. Nutritional comparison of fresh, frozen, and canned fruits and vegetables II. Vitamin A and carotenoids, vitamin E, minerals and fiber. J. Sci. Food Agric. 2007, 87, 1185-1196. (Pubitemid 46729208)
23. Parker, R. Absorption, metabolism, and transport of carotenoids. FASEB J. 1996, 10, 542-551.
24. De Rigal, D.; Gauillard, F.; Richard-Forget, F. Changes in the carotenoid content of apricot (Prunus armeniaca, var Bergeron) during enzymatic browning: β-carotene inhibition of chlorogenic acid degradation. J. Sci. Food Agric. 2000, 80, 763-768. (Pubitemid 30208602)
25. Bohm, V.; Puspitasari-Nienaber, N.L.; Ferruzzi, M.G.; Schwartz, S.J. Trolox equivalent antioxidant capacity of different geometrical isomers of a-carotene, β-carotene, lycopene, and zeaxanthin. J. Agric. Food Chem. 2002, 50, 221-226. (Pubitemid 34038535)
26. Chen, B.H.; Tang, Y.C. Processing and stability of carotenoid powder from carrot pulp waste. J. Agric. Food Chem. 1998, 46, 2312-2318. (Pubitemid 128491151)
27. Goula, A.M.; Adamopoulos, K.G.; Chatzitakis, P.C.; Nikas, V.A. Prediction of lycopene degradation during a drying process of tomato pulp. J. Food Eng. 2006, 74, 37-46. (Pubitemid 41653154)
28. Mordi, R.C.; Walton, J.C.; Burton, G.W.; Hughes, L.; Keith, I.U.; David, L.A.; Douglas, M.J. Oxidative degradation of β-carotene and β-apo-8'-carotenal. Tetrahedron 1993, 49, 911-928.
29. Wacheä, Y.; Bosser-Deratuld, A.L.; Lhuguenot, J.-C.; Belin, J.-M. Effect of cis/trans isomerism of β-carotene on the ratios of volatile compounds produced during oxidative degradation. J. Agric. Food Chem. 2003, 51, 1984-1987.
30. Lin, C.H.; Chen, B.H. Determination of carotenoids in tomato juice by liquid Chromatography. J. Chromatogr. A 2003, 1012, 103-109. (Pubitemid 37101029)
31. Britton, G. UV/Visible Spectroscopy. In Carotenoids Spectroscopy; Brotton, G., Liaaen-Jensen, S., Pfander, H., Eds.; Birkhäuser Verlag: Basel, Switzerland, 1995; Volume 1B, pp. 57-61.
32. Krinsky, N.I. Carotenoid protection against oxidation. Pure Appl. Chem. 1979, 51, 649-660.
33. Di Mascio, P.; Kaiser, S.; Sies, H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch. Biochem. Biophys. 1989, 274, 532-538. (Pubitemid 19261144)
34. Marx, M.; Schieber, A.; Carle, R. Quantitative determination of carotene stereoisomers in carrot juices and vitamin supplemented (ATBC) drinks. Food Chem. 2000, 70, 403-408. (Pubitemid 30421120)
35. Khoo, H.-E.; Prasad, K.N.; Ismail, A.; Mohd-Esa, N. Carotenoids from Mangifera pajang and their antioxidant capacity. Molecules 2010, 15, 6699-6712.
36. De Faria, A.F.; Hasegawa, P.N.; Chagas, E.A.; Pio, R.; Purgatto, E.; Mercadante, A.Z. Cultivar influence on carotenoid composition of loquats from Brazil. J. Food Compos. Anal. 2009, 22, 196-203.
37. Chen, J.P.; Tai, C.Y.; Chen, B.H. Improved liquid chromatographic method for determination of carotenoids in Taiwanese mango (Mangifera indica L.). J. Chromatogr. A 2004, 1054, 261-268. (Pubitemid 39445828)
38. Chen, J.P.; Tai, C.Y.; Chen, B.H. Effects of different drying treatments on the stability of carotenoids in Taiwanese mango (Mangifera indica L.). Food Chem. 2007, 100, 1005-1010. (Pubitemid 44062179)
39. Lessin, W.J.; Schwartz, S.J. Quantification of cis-trans isomers of provitamin A carotenoids in fresh and processed fruits and vegetables. J. Agric. Food Chem. 1997, 45, 3728-3732. (Pubitemid 127485661)
40. Li, F.; Murillo, C.; Wurtzel, E.T. Maize Y9 encodes a product essential for 15-cis-?-carotene isomerization. Plant Physiol. 2007, 144, 1181-1189. (Pubitemid 46950626)
41. Hulshof, P.J.M.; Kosmeijer-Schuil, T.; West, C.E.; Hollman, P.C.H. Quick screening of maize kernels for provitamin A content. J. Food Compos. Anal. 2007, 20, 655-661. (Pubitemid 47233396)
42. Rodriguez-Amaya, D.B. Carotenoids and Food Preparation. In The Retention of Provitamin A Carotenoids in Prepared, Processed, and Stored Foods; John Snow Inc: Rio de Janeiro, Brazil, 1997.
43. During, A.; Smith, M.K.; Piper, J.B.; Smith, J.C. β-Carotene 15,15'-dioxygenase activity in human tissues and cells: Evidence of an iron dependency. J. Nutr. Biochem. 2001, 12, 640-647. (Pubitemid 33035936)
44. Holden, J.M.; Eldridge, A.L.; Beecher, G.R.; Buzzard, I.M.; Bhagwat, A.S.; Davis, C.S.; Douglass, L.W.; Gebhardt, E.S.; Haytowitz, D.; Schakel, S. Carotenoid content of U.S. foods: An update of the database. J. Food Compos. Anal. 1999, 12, 169-196. (Pubitemid 129567869)
45. Guo, W.-H.; Tu, C.-Y.; Hu, C.-H. Cis-trans isomerizations of β-carotene and lycopene: A theoretical study. J. Phys. Chem. 2008, 112, 12158-12167.
46. ESA. Carotenoid Isomers. ESA Application Note, 5600A; ESA Inc: Chelmsford, MA, USA, 2009; http://www.esainc.com (accessed on 7 October 2009).
47. Kuki, M.; Koyama, Y.; Nagae, H. Triplet-sensitized and thermal isomerization of all-trans, 7-cis, 9-cis, 13-cis and 15-cis isomers of β-carotene: Configurational dependence of the quantum yield of isomerization via the T1 state. J. Phys. Chem. 1991, 95, 7171-7180.
48. Vásquez-Caicedo, A.L.; Schilling, S.; Carle, R.; Neidhart, S. Effects of thermal processing and fruit matrix on beta-carotene stability and enzyme inactivation during transformation of mangoes into purée and nectar. Food Chem. 2007, 102, 1172-1186. (Pubitemid 46178478)
49. Lozano-Alejo, N.; Carrillo, G.V.; Pixley, K.; Palacios-Rojas, N. Physical properties and carotenoid content of maize kernels and its nixtamalized snacks. Innov. Food Sci. Emerg. Technol. 2007, 8, 385-389. (Pubitemid 47061519)
50. Tang, Y.C; Chen, B.H. Pigment change of freeze-dried carotenoid powder during storage. Food Chem. 2000, 69, 11-17. (Pubitemid 30050568)
51. Chen, B.H.; Huang, J.H. Degradation and isomerization of chlorophyll a and β-carotene as affected by various heating and illumination treatments. Food Chem. 1998, 62, 299-307. (Pubitemid 28369413)
52. Marx, M.; Stuparic, M.; Schieber, A.; Carle, R. Effects of thermal processing on trans-cisisomerization of β-carotene in carrot juices and carotene-containing preparations. Food Chem. 2003, 83, 609-617. (Pubitemid 37162815)
53. Breitenbach, J.; Sandmann, G. ?-Carotene cis isomers as products and substrates in the plant polycis carotenoid biosynthetic pathway to lycopene. Planta 2005, 220, 785-793. (Pubitemid 40393793)
54. Castenmiller, J.J.M.; West, C.E. Bioavailability and bioconversion of carotenoids. Annu. Rev. Nutr. 1998, 18, 19-38. (Pubitemid 28366859)
55. Rao, A.V.; Rao, L.G. Carotenoids and human health. Pharmacol. Res. 2007, 55, 207-216. (Pubitemid 46518154)
56. Boileau, T.W.M.; Boileau, A.C.; Erdman, J.W., Jr. Bioavailability of all-trans and cis-isomers of lycopene. Exp. Biol. Med. 2002, 227, 914-919. (Pubitemid 35340347)
57. Schulz, H.; Baranska, M.; Baranski, R. Potential of NIR-FT-Raman spectroscopy in natural carotenoid analysis. Biopolymers 2005, 77, 212-221. (Pubitemid 40432487)
58. Kong, K.-W.; Khoo, H.-E; Prasad, K.N.; Ismail, A.; Tan, C.-P.; Rajab, N.F. Revealing the power of the natural red pigment lycopene. Molecules 2010, 15, 959-987.
59. Blanquet-Diot, S.; Soufi, M.; Rambeau, M.; Rock, E.; Alric, M. Digestive stability of xanthophylls exceeds that of carotenes as studied in a dynamic in vitro gastrointestinal system. J. Nutr. 2009, 139, 876-883.
60. Failla, M.L.; Chitchumroonchokchai, C.; Ishida, B.K. In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene. J. Nutr. 2008, 138, 482-486. (Pubitemid 351355244)
61. Shi, J.; Maguer, M.L.; Bryan, M. Lycopene from Tomatoes. In Functional Food: Biochemical &Processing Aspects; Shi, J.; Mazza, G., Maguer, M.L., Eds.; CRC Press LCC: Danvers, MA, USA, 2002; Volume 2, pp. 135-167.
62. Moraru, C.; Lee, T.-C. Lycopene isomerization at gastric pH. In Nutraceuticals &Functional Foods Session of IFT Annual Meeting, Las Vegas, NV, USA, 12-16 July 2004.
63. Lee, M.T.; Chen, B.H. Stability of lycopene during heating and illumination in a model system. Food Chem. 2002, 78, 425-432. (Pubitemid 36153172)
64. Tyssandier, V.; Reboul, E.; Dumas, J.-F.; Bouteloup-Demange, C.; Armand, M.; Marcand, J.; Sallas, M.; Borel, P. Processing of vegetable-borne carotenoids in the human stomach and duodenum. Am. J. Physiol-Gastr. L. 2003, 284, G913-G923. (Pubitemid 36597333)
65. Tee, E.-S.; Lim, C.-L. Carotenoid composition and content of Malaysian vegetables and fruits by the AOAC and HPLC methods. Food Chem. 1991, 41, 309-339.
66. Losso, J.N.; Khachatryan, A.; Ogawa, M.; Godber, J.S.; Shih, F. Random centroid optimization of phosphatidylglycerol stabilized lutein-enriched oil-in-water emulsions at acidic pH. Food Chem. 2005, 92, 737-744. (Pubitemid 40544819)
67. Matsuno, T.; Hirono, T.; Ikuno, Y.; Maoka, T.; Shimizu, M.; Komori, T. Isolation of three new carotenoids and proposed metabolic pathways of carotenoids in hen's egg yolk. Comp. Biochem. Physiol. B 1986, 84, 477-481.
68. Handelman, G.J. The evolving role of carotenoids in human biochemistry. Nutrition 2001, 17, 818-822. (Pubitemid 33001647)
69. 30 stationary phase to resolve cis-trans carotenoid isomers in reversed-phase liquid chromatography. J. Chromatogr. A 1995, 707, 205-216.
70. 30 stationary phases for the analysis of food by liquid chromatography. J. Chromatogr. A 2000, 880, 189-202. (Pubitemid 30317303)
71. 40-carotenoids. Phytochem. 1981, 20, 2411-2415.
72. Meléndez-Martínez, A.J.; Vicario, I.M.; Heredia, F.J. Geometrical isomers of violaxanthin in orange juice. Food Chem. 2007, 104, 169-175. (Pubitemid 46561112)
73. Gross, J. Pigments in Fruits: Food Science and Technology; Academic Press: Orlando, FL, USA, 1987.
74. Meléndez-Martínez, A.J.; Britton, G.; Vicario, I.M.; Heredi, F.J. HPLC analysis of geometrical isomers of lutein epoxide isolated from dandelion (Taraxacum officinale F. Weber ex Wiggers). Phytochemistry 2006, 67, 771-777.
75. Milanowska, J.; Gruszecki, W.I. Heat-induced and light-induced isomerization of the xanthophyll pigment zeaxanthin. J. Photochem. Photobiol. B. 2005, 80, 178-186. (Pubitemid 41150646)
76. Kishimoto, S.; Maoka, T.; Nakayama, M.; Ohmiya, A. Carotenoid composition in petals of chrysanthemum (Dendranthema grandiflorum (Ramat.) Kitamura). Phytochemistry 2004, 65, 2781-2787. (Pubitemid 39330176)
77. Yahia, E.M.; Ornelas-Paz, J.J.; Gardea, A. Extraction, separation and partial identification of 'Ataulfo' mango fruit carotenoids. Acta Hortic. 2006, 712, 333-338. (Pubitemid 44483639)
78. Furr, H.C.; Clark, R.M. Intestinal absorption and tissue distribution of carotenoids. J. Nutr. Biochem. 1997, 8, 364-377. (Pubitemid 27344876)
79. Scott, K.J.; Thurnham, D.I.; Hart, D.J.; Bingham, S.A.; Day, K. The correlation between the intake of lutein, lycopene and β-carotene from vegetables and fruits, and blood plasma concentrations in a group of women aged 50-65 years in the UK. Brit. J. Nutr. 1996, 75, 409-418. (Pubitemid 26097781)
80. Krinsky, N.I.; Johnson, E.J. Carotenoid actions and their relation to health and disease. Mol. Aspects Med. 2005, 26, 459-516. (Pubitemid 41741836)
81. Simpson, K.L. Chemical Changes in Natural Food Pigments. In Chemical Changes in Food during Processing; Richardson, T.; Finley, J.W., Eds.; Van Nostrand Reinhold Company, Inc.: New York, NY, USA, 1985; pp. 409-437.
82. Minguez-Mosquera, M.I.; Gandul-Rojas, B.; Garrido-Fernandez, J.; Gallardo-Guerrero, L. Pigments present in virgin olive oil. J. Am. Oil Chem. Soc. 1990, 67, 192-196. (Pubitemid 20670499)
83. Takyi, E.E.K. Bioavailability of Carotenoids from Vegetables versus Supplements. In Vegetables, Fruits, and Herbs in Health Promotion; Watson, R.R., Ed.; CRC Press LCC: Danvers, MA, USA, 2001; pp. 19-31.
84. Marín, A.; Ferreres, F.; Tomas-Barberan, F.A.; Gil, M.I. Characterization and quantitation of antioxidant constituents of sweet pepper (Capsicum annuum L.). J. Agric. Food Chem. 2004, 52, 3861-3869.
85. Markus, F.; Daood, H.G.; Kapitany, J.; Biacs, P.A. Change in the carotenoid and antioxidant content of spice red pepper (paprika) as a function of ripening and some technological factors. J. Agric. Food Chem. 1999, 47, 100-107. (Pubitemid 29179630)
86. Wieruszewski, J.B. Astaxanthin bioavailabity, retention efficiency and kinetics in Atlantic salmon (Salmo salar) as influenced by pigment concentration and method of administration (kinetics only). Master Thesis, Simon Fraser University, Ottawa, Canada, 2002.
87. De Pee, S.; West, C.E.; Permaesih, D.; Martuti, S.; Muhilal; Hautvast, J.G.A.J. Increasing intake of orange fruits is more effective than increasing intake of dark-green leafy vegetables in increasing serum concentrations of retinol and β-carotene in schoolchildren in Indonesia. Am. J. Clin. Nutr. 1998, 68, 1058-1067. (Pubitemid 28493967)
88. Muzhingi, T.; Yeum, K.J.; Russell, R.M.; Johnson, E.J.; Qin, J.; Tang, G. Determination of carotenoids in yellow maize, the effects of saponification and food preparations. Intl. J. Vit. Nutr. Res. 2008, 78, 112-120.
89. Rajyalakshmi, P.; Venkatalaxmi, K.; Venkatalakshmamma, K.; Jyothsna, Y.; Devi, K.B.; Suneetha, V. Total carotenoid and beta-carotene contents of forest green leafy vegetables consumed by tribals of south India. Plant Food Hum. Nutr. 2001, 56, 225-238. (Pubitemid 32575653)
90. Bhaskarachary, K.; Rao, D.S.S.; Deosthale, Y.G.; Reddy, V. Carotene content of some common and less familiar foods of plant origin. Food Chem. 1995, 54, 189-193.
91. Setiawan, B.; Sulaeman, A.; Giraud, D.W.; Driskell, J.A. Carotenoid content of selected Indonesian fruits. J. Food Compos. Anal. 2001, 14, 169-176. (Pubitemid 33664858)
92. Hulshof, P.J.M.; Chao, X.; Van De Bovenkamp, P.; Muhilal; West, C.E. Application of a validated method for the determination of provitamin A carotenoids in Indonesia foods of different maturity and origin. J. Agric. Food Chem. 1997, 45, 1174-1179. (Pubitemid 127476887)
93. Yano, M.; Kato, M.; Ikoma, Y.; Kawasaki, A.; Fukazawa, Y.; Sugiura, M.; Matsumoto, H.; Oohara, Y.; Nagao, A.; Ogawa, K. Quantitation of carotenoids in raw and processed fruits in Japan. Food Sci. Technol. Res. 2005, 11, 13-18. (Pubitemid 43062058)
94. Lako, J.; Trenerry, V.C.; Wahlqvist, M.; Wattanapenpaiboon, N.; Sotheeswaran, S.; Premier, R. Phytochemical flavonols, carotenoids and the antioxidant properties of a wide selection of Fijian fruit, vegetables and other readily available foods. Food Chem. 2007, 101, 1727-1741. (Pubitemid 44466216)
95. Bramley, P.M. Is lycopene beneficial to human health? Phytochem. 2000, 54, 233-236. (Pubitemid 30353698)
96. Charoensiri, R.; Kongkachuichai, R.; Suknicom, S.; Sungpuag, P. Beta-carotene, lycopene, and alpha-tocopherol contents of selected Thai fruits. Food Chem. 2009, 113, 202-207.
97. Granado-Lorencio, F.; Olmedilla-Alonso, B.; Herrero-Barbudo, C.; Blanco-Navarro, I.; Pérez- Sacristán, B.; Blázquez- García, S. In vitro bioaccessibility of carotenoids and tocopherols from fruits and vegetables. Food Chem. 2007, 102, 641-648. (Pubitemid 46111043)
98. Levy, A.; Harel, S.; Palevitch, D.; Akiri, B.; Menagem, E.; Kanner, J. Carotenoid pigments and β- carotene in paprika fruits (Capsicum spp.) with different genotypes. J. Agric. Food Chem. 1995, 43, 362-366.
99. Dias, M.G.; Filomena, M.; Camões, G.F.C.; Oliveira, L. Carotenoids in traditional Portuguese fruits and vegetables. Food Chem. 2009, 113, 808-815.
100. Gil, M.I.; Tomás-Barberán, F.A.; Hess-Pierce, B.; Kader, A.A. Antioxidant capacities, phenolic compounds, carotenoids, and vitamin C contents of nectarine, peach, and plum cultivars from California. J. Agric. Food Chem. 2002, 50, 4976-4982. (Pubitemid 34856177)
101. Speek, A.J.; Speek-Saichua, S.; Schreurs, W.H.P. Total carotenoids and β-carotene contents of Thai vegetables and effects of processing. Food Chem. 1988, 27, 245-251.
102. Begum, A.; Pereira, S.M. The β-carotene content of Indian edible green leaves. Trop. Geogr. Med. 1977, 29, 47-50. (Pubitemid 8095183)
103. Lakshminarayana, R.; Raju, M.; Krishnakantha, T.P.; Baskaran, V. Determination of major carotenoids in a few Indian leafy vegetables by high-performance liquid chromatography. J. Agric. Food Chem. 2005, 53, 2838-2842. (Pubitemid 40525241)
104. Singh, J.; Upadhyay, A.K.; Prasad, K.; Bahadur, A.; Rai, M. Variability of carotenes, vitamin C, E and phenolics in Brassica vegetables. J. Food Compos. Anal. 2007, 20, 106-112. (Pubitemid 44774665)
105. Murkovic, M.U.; Mülleder, U.; Neunteufl, H. Carotenoid content in different varieties of pumpkins. J. Food Comp. Anal. 2002, 15, 633-638. (Pubitemid 35446539)
106. Pandey, S.; Singh, J.; Upadhyay, A.K.; Ram, D.; Rai, M. Ascorbate and carotenoid content in an Indian collection of pumpkin (Cucurbita moschata Duch. Ex Poir.). Cucurbit Gen. Coop. Rep. 2003, 26, 51-53.
107. Aruna, G.; Mamatha, B.S.; Baskaran, V. Lutein content of selected Indian vegetables and vegetable oils determined by HPLC. J. Food Compos. Anal. 2009, 22, 632-636.
108. Khoo, H.E.; Ismail, A.; Mohd-Esa, N.; Idris, S. Carotenoid content of underutilized fruits. Plant Food Hum. Nutr. 2008, 63, 170-175.
109. Yuan, J.-M.; Gao, Y.-T.; Ong, C.-N.; Ross, R.K.; Yu, M.C. Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma. J. Natl. Cancer I. 2006, 98, 482-490.
110. Homnava, A.; Payne, J.; Koehler, P.; Eitenmiller, R. Provitamin A (alpha-carotene, beta-carotene and beta-cryptoxanthin) and ascorbic acid content of Japanese and American persimmons. J. Food Quality 1990, 13, 85-95.
111. Xianquan, S.; Shi, J.; Kakuda, Y.; Yueming, J. Stability of lycopene during food processing and storage. J. Med. Food 2005, 8, 413-422. (Pubitemid 43121891)
112. USDA database. USDA National Nutrient Database for Standard Reference, Release 23; Agricultural Research Service, United States Department of Agriculture: Washington, DC, USA, 2011; http://www.ars.usda.gov (accessed on 20 January 2011).
113. Camara, B.; Hugueney, P.; Bouvier, F.; Kuntz, M.; Monéger, R.; Kwang, W.J.; Jonathan, J. Biochemistry and molecular biology of chromoplast development. Int. Rev. Cytol. 1995, 163, 175-247. (Pubitemid 26013690)
114. Bouvier, F.; d'Harlingue, A.; Hugueney, P.; Marin, E.; Marion-Poll, A.; Camara, B. Xanthophyll biosynthesis. J. Biol. Chem. 1996, 271, 28861-28867.
115. Prasad, K. N.; Lyee, C.; Khoo, H.E.; Bao. Y.; Azlan, A.; Amin. I. Carotenoids and antioxidant capacities from Canarium odontophyllum Miq. fruits. Food Chem. 2011, 124, 1549-1555.
116. Tanaka, Y. Flower colour and cytochromes P450. Phytochem. Rev. 2006, 5, 283-291. (Pubitemid 44900349)
117. Bakker, J.; Timberlake, C.F. Isolation, identification, and characterization of new color-stable anthocyanins occurring in some red wines. J. Agric. Food Chem. 1997, 45, 35-43. (Pubitemid 127485749)
118. Ben-Amotz, A.; Fishler, R. Analysis of carotenoids with emphasis on 9-cis β-carotene in vegetables and fruits commonly consumed in Israel. Food Chem. 1998, 62, 515-520. (Pubitemid 28398499)
119. Levin, I.; De Vos, C.H.R.; Tadmor, Y.; Bovy, A.; Lieberman, M.; Oren-Shamir, M.; Segev, O.; Kolotilin, I.; Keller, M.; Ovadia, R. High pigment tomato mutants-more than just lycopene (a review). Isr. J. Plant Sci. 2006, 54, 179-190. (Pubitemid 46917580)