Do SCFA have a role in appetite regulation?

Proceedings of the Nutrition Society

Volumn 70, Issue 1, 2011, Pages 119-128

  Darzi, Julia ^a,c   Frost, Gary S ^b   Robertson, M Denise ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Acetate; Acetic acid; Inulin; Oligofructose; Propionate; Propionic acid; Satiety; SCFA

Indexed keywords

ACETIC ACID; BUTYRIC ACID; CARBOHYDRATE; FREE FATTY ACID RECEPTOR 2; FREE FATTY ACID RECEPTOR 3; FRUCTAN; FRUCTOSE OLIGOSACCHARIDE; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1; INULIN; INULIN TYPE FRUCTAN; LEPTIN; PEPTIDE YY; PROPIONIC ACID; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; VINEGAR;

ADIPOCYTE; CIDER; COLON FLORA; CONFERENCE PAPER; DIETARY FIBER; FERMENTATION; FOOD INTAKE; HOMEOSTASIS; HORMONE RELEASE; HUMAN; HUNGER; L CELL; MEAL; PALATABILITY; PROTEIN LOCALIZATION; SATIETY; VISUAL ANALOG SCALE;

APPETITE REGULATION; COLON; DIETARY FATS; DIETARY FIBER; FATTY ACIDS, VOLATILE; GASTROINTESTINAL HORMONES; HUMANS; PREBIOTICS; SATIATION; TASTE;

EID: 79951743069     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665110004039     Document Type: Conference Paper

References (74)

1. Foresight. Tackling Obesities: Future Choices - Project Report: Government Office for Science; 2007. 2nd ed.
2. Blundell JE & Halford JC (1994) Regulation of nutrient supply: the brain and appetite control. Proc Nutr Soc 53, 407-418.
3. Cummings DE & Overduin J (2007) Gastrointestinal regulation of food intake. J Clin Invest 117, 13-23. (Pubitemid 46048445)
4. Burton-Freeman B (2000) Dietary fiber and energy regulation. J Nutr 130, 272S-275S. (Pubitemid 30073727)
5. Delzenne NM & Cani PD (2005) A place for dietary fibre in the management of the metabolic syndrome. Curr Opin Clin Nutr Metab Care 8, 636-640. (Pubitemid 41586005)
6. Howarth NC, Saltzman E & Roberts SB (2001) Dietary fiber and weight regulation. Nutr Rev 59, 129-139. (Pubitemid 32494625)
7. Koh-Banerjee P, Franz MV, Sampson L et al. (2004) Changes in whole-grain, bran, and cereal fiber consumption in relation to 8-y weight gain among men. Am J Clin Nutr 80, 1237-1245. (Pubitemid 41350684)
8. Koh-Banerjee P & Rimm EB (2003) Whole grain consumption and weight gain: a review of the epidemiological evidence, potential mechanisms and opportunities for future research. Proc Nutr Soc 62, 25-29. (Pubitemid 36569803)
9. Melanson KJ, Angelopoulos TJ, Nguyen VT et al. (2006) Consumption of whole-grain cereals during weight loss: Effects on dietary quality, dietary fiber, magnesium, vitamin B-6, and obesity. J Am Diet Assoc 106, 1380-1388. (Pubitemid 44331735)
10. Pereira MA & Ludwig DS (2001) Dietary fiber and bodyweight regulation. Observations and mechanisms. Pediatr Clin North Am 48, 969-980. (Pubitemid 32718105)
11. Slavin JL (2005) Dietary fiber and body weight. Nutrition 21, 411-418. (Pubitemid 40387943)
12. Harland JI & Garton LE (2008) Whole-grain intake as a marker of healthy body weight and adiposity. Public Health Nutr 11, 554-563. (Pubitemid 351693808)
13. Good CK, Holschuh N, Albertson AM et al. (2008) Whole grain consumption and body mass index in adult women: an analysis of NHANES 1999-2000 and the USDA pyramid servings database. J Am Coll Nutr 27, 80-87. (Pubitemid 351600526)
14. McKeown NM, Yoshida M, Shea MK et al. (2009) Whole-grain intake and cereal fiber are associated with lower abdominal adiposity in older adults. J Nutr 139, 1950-1955.
15. Rose N, Hosig K, Davy B et al. (2007) Whole-grain intake is associated with body mass index in college students. J Nutr Educ Behav 39, 90-94. (Pubitemid 46341984)
16. Lutsey PL, Jacobs DRJ, Kori S et al. (2007) Whole grain intake and its cross-sectional association with obesity, insulin resistance, inflammation, diabetes and subclinical CVD: The MESA Study. Br J Nutr 98, 397-405. (Pubitemid 47091382)
17. Cummings JH, Pomare EW, Branch WJ et al. (1987) Shortchain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28, 1221-1227. (Pubitemid 17156038)
18. Topping DL & Clifton PM (2001) Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides. Physiol Rev 81, 1031-1064. (Pubitemid 32611227)
19. Dass NB, John AK, Bassil AK et al. (2007) The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation. Neurogastroenterol Motil 19, 66-74. (Pubitemid 44952780)
20. Cummings JH & Englyst HN (1987) Fermentation in the human large intestine and the available substrates. Am J Clin Nutr 45, 1243-1255. (Pubitemid 17081922)
21. Brown AJ, Goldsworthy SM, Barnes AA et al. (2003) The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 278, 11312-11319. (Pubitemid 36792688)
22. Le Poul E, Loison C, Struyf S et al. (2003) Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 278, 25481-15489.
23. Nilsson NE, Kotarsky K, Owman C et al. (2003) Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun 303, 1047-1052. (Pubitemid 36390250)
24. Stoddart LA, Smith NJ & Milligan G (2008) International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, - 2, and - 3: pharmacology and pathophysiological functions. Pharmacol Rev 60, 405-417.
25. Tazoe H, Otomo Y, Kaji I et al. (2008) Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J Physiol Pharmacol 59, 251-262.
26. Xiong Y, Miyamoto N, Shibata K et al. (2004) Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci USA 101, 1045-1050. (Pubitemid 38160581)
27. Covington DK, Briscoe CA, Brown AJ et al. (2006) The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing. Biochem Soc Trans 34, 770-773. (Pubitemid 44796417)
28. Karaki S, Mitsui R, Hayashi H et al. (2006) Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res 324, 353-360. (Pubitemid 43673476)
29. Karaki S, Tazoe H, Hayashi H et al. (2008) Expression of the short-chain fatty acid receptor, GPR43, in the human colon. J Mol Histol 39, 135-142. (Pubitemid 351422023)
30. Tazoe H, Otomo Y, Karaki S et al. (2009) Expression of short-chain fatty acid receptor GPR41 in the human colon. Biomed Res 30, 149-156.
31. Plaisancié P, Dumoulin V, Chayvialle JA et al. (1996) Luminal peptide YY-releasing factors in the isolated vascularly perfused rat colon. J Endocrinol 151, 421-429. (Pubitemid 26405590)
32. Plaisancié P, Dumoulin V, Chayvialle JA et al. (1995) Luminal glucagon-like peptide-1(7-36) amide-releasing factors in the isolated vascularly perfused rat colon. J Endocrinol 145, 521-526.
33. Cherbut C, Ferrier L, Rozé C et al. (1998) Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat. Am J Physiol 275, G1415-1422.
34. Cuche G & Malbert CH (2000) Ileal short-chain fatty acids inhibit gastric motility by a humoral pathway. Am J Physiol 279, G925-G930.
35. Hlebowicz J, Lindstedt S, Björgell O et al. (2008) The botanical integrity of wheat products influences the gastric distention and satiety in healthy subjects. Nutr J 7, 12-19.
36. Mettler S, Schwarz I & Colombani PC (2009) Additive postprandial blood glucose-attenuating and satietyenhancing effect of cinnamon and acetic acid. Nutr Res 29, 723-727.
37. Ostman E, Granfeldt Y, Persson L et al. (2005) Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects. Eur J Clin Nutr 59, 983-988. (Pubitemid 43118157)
38. Kondo T, Kishi M, Fushimi T et al. (2009) Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. Biosci Biotechnol Biochem 73, 1837-1843.
39. Frost GS, Brynes AE, Dhillo WS et al. (2003) The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal. Eur J Clin Nutr 57, 293-298. (Pubitemid 36240482)
40. Liljeberg HGM & Bjorck IME (1996) Delayed gastric emptying rate as a potential mechanism for lowered glycemia after eating sourdough bread: Studies in humans and rats using test products with added organic acids or an organic salt. Am J Clin Nutr 64, 886-893.
41. Liljeberg HGM, Lonner CH & Bjorck IME (1995) Sourdough fermentation or addition of organic acids or corresponding salts to bread improves nutritional properties of starch in healthy humans. J Nutr 125, 1503-1511.
42. Darzi J, Frost GS & Robertson MD (2008) The acute effects of a propionate-rich sourdough bread on appetite and metabolic response. Proc Nutr Soc 67, E317.
43. Sørensen LB, Møller P, Flint A et al. (2003) Effect of sensory perception of foods on appetite and food intake: a review of studies on humans. Int J Obes 27, 1152-1162.
44. Yeomans MR (2007) Chapter 10: The role of palatability in control of human appetite: Implications for understanding and treating obesity. In Appetite and Body Weight: Integrative Systems and The Development of Anti-obesity drugs. pp. 247-269. Liverpool: Elsevier Ltd.
45. Berti C, Riso P, Brusamolino A et al. (2005) Effect on appetite control of minor cereal and pseudocereal products. Br J Nutr 94, 850-858. (Pubitemid 41672393)
46. Roberfroid MB (2005) Introducing inulin-type fructans. Br J Nutr 93, S13-S25. (Pubitemid 43073402)
47. Kelly G (2008) Inulin-type prebiotics: a review (Part 1). Altern Med Rev 13, 315-329.
48. Niness KR (1999) Inulin and oligofructose: what are they? J Nutr 129, 1402S-1406S. (Pubitemid 29302766)
49. Cani PD, Knauf C, Iglesias MA et al. (2006) Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes 55, 1484-1490. (Pubitemid 44195391)
50. Cani PD, Dewever C & Delzenne NM (2004) Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr 92, 521-526. (Pubitemid 40277074)
51. Cani PD, Hoste S, Guiot Y et al. (2007) Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats. Br J Nutr 98, 32-37. (Pubitemid 47272144)
52. Daubioul C, Rousseau N, Demeure R et al. (2002) Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats. J Nutr 132, 967-973. (Pubitemid 34493561)
53. Kok NN, Morgan LM, Williams CM et al. (1998) Insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin-like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats. J Nutr 128, 1099-1103. (Pubitemid 28317672)
54. Cani PD, Neyrinck AM, Maton N et al. (2005) Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like peptide-1. Obes Res 13, 1000-1007.
55. Peters HP, Boers HM, Haddeman E et al. (2009) No effect of added beta-glucan or of fructooligosaccharide on appetite or energy intake. Am J Clin Nutr 89, 58-63.
56. Archer BJ, Johnson SK, Devereux HM et al. (2004) Effect of fat replacement by inulin or lupin-kernel fibre on sausage patty acceptability, post-meal perceptions of satiety and food intake in men. Br J Nutr 91, 591-599. (Pubitemid 38584783)
57. Perrigue MM, Monsivais P & Drewnowski A (2009) Added soluble fiber enhances the satiating power of low-energy-density liquid yogurts. J Am Diet Assoc 109, 1862-1868.
58. Cani PD, Joly E, Horsmans Y et al. (2006) Oligofructose promotes satiety in healthy human: a pilot study. Eur J Clin Nutr 60, 567-572. (Pubitemid 43922875)
59. Antal M, Regöly-Mérei A, Biró L et al. (2008) Effects of oligofructose containing diet in obese persons. Orv Hetil 149, 1989-1995.
60. Parnell JA & Reimer RA (2009) Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr 89, 1751-1759.
61. Flint A, Raben A, Blundell JE et al. (2000) Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 24, 38-48. (Pubitemid 30098877)
62. Piche T, des Varannes SB, Sacher-Huvelin S et al. (2003) Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease. Gastroenterology 124, 894-902. (Pubitemid 36389791)
63. Cani PD, Lecourt E, Dewulf EM et al. (2009) Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am J Clin Nutr 90, 1236-1243.
64. Whelan K, Efthymiou L, Judd PA et al. (2006) Appetite during consumption of enteral formula as a sole source of nutrition: the effect of supplementing pea-fibre and fructooligosaccharides. Br J Nutr 96, 350-356. (Pubitemid 46470103)
65. Alles MS, de Roos NM, Bakx JC et al. (1999) Consumption of fructooligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes. Am J Clin Nutr 69, 64-69. (Pubitemid 29031252)
66. Giacco R, Clemente G, Luongo D et al. (2004) Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals. Clin Nutr 23, 331-340. (Pubitemid 38811670)
67. Pedersen AM, Sandstorm B & Van Amelsvoort JMM (1997) The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr 78, 215-222.
68. Forcheron F & Beylot M (2007) Long-term administration of inulin-type fructans has no significant lipid-lowering effect in normolipidemic humans. Metabolism 56, 1093-1098. (Pubitemid 47021174)
69. Davidson MH, Maki KC, Synecki C et al. (1998) Effects of dietary inulin on serum lipids in men and women with hypercholesterolemia. Nutr Res 18, 503-517. (Pubitemid 28145098)
70. Jackson KG, Taylor GRJ, Clohessy AM et al. (1999) The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women. Br J Nutr 82, 23-30. (Pubitemid 29377972)
71. Luo J, Rizkalla SW, Alamowitch C et al. (1996) Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism. Am J Clin Nutr 63, 939-945. (Pubitemid 26172384)
72. Luo J, Van Yperselle N, Rizkalla SW et al. (2000) Chronic consumption of short-chain fructooligosacchrarides does not affect basal hepatic glucose production or insulin resistance in type 2 diabetics. J Nutr 130, 1572-1577. (Pubitemid 30340705)
73. Fernandes J, Rao AV & Wolever TM (2000) Different substrates and methane producing status affect short-chain fatty acid profiles produced by In vitro fermentation of human feces. J Nutr 130, 1932-1936. (Pubitemid 30497523)
74. Vogt JA, Pencharz PB & Wolever MS (2004) L-Rhamose increases serum propionate in humans. Am J Clin Nutr 80, 89-94. (Pubitemid 41115560)