메뉴 건너뛰기




Volumn 58, Issue 2, 2011, Pages 178-190

Identification and characterization of anesthetic targets by mouse molecular genetics approaches

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA3; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA4; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; ALFAXALONE; AMPA RECEPTOR; ANESTHETIC AGENT; DESFLURANE; DIAZEPAM; ENFLURANE; ETOMIDATE; HALOTHANE; ISOFLURANE; KAINIC ACID RECEPTOR; KETAMINE; METABOTROPIC RECEPTOR; MIDAZOLAM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITROUS OXIDE; PENTOBARBITAL; PROPOFOL;

EID: 79951726995     PISSN: 0832610X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12630-010-9414-1     Document Type: Review
Times cited : (18)

References (100)
  • 1
    • 0033567181 scopus 로고    scopus 로고
    • General anaesthetic actions on ligand-gated ion channels
    • DOI 10.1007/s000180050371
    • Krasowski MD, Harrison NL. General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci 1999; 55: 1278-303. (Pubitemid 29410747)
    • (1999) Cellular and Molecular Life Sciences , vol.55 , Issue.10 , pp. 1278-1303
    • Krasowski, M.D.1    Harrison, N.L.2
  • 2
    • 0033592682 scopus 로고    scopus 로고
    • Benzodiazepine actions mediated by specific gamma-aminobutyric acidA receptor sub-types
    • Rudolph U, Crestani F, Benke D, et al. Benzodiazepine actions mediated by specific gamma-aminobutyric acidA receptor sub-types. Nature 1999; 401: 796-800.
    • (1999) Nature , vol.401 , pp. 796-800
    • Rudolph, U.1    Crestani, F.2    Benke, D.3
  • 4
    • 0036754319 scopus 로고    scopus 로고
    • A receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem
    • DOI 10.1016/S0028-3908(02)00174-0, PII S0028390802001740
    • Kralic JE, O'Buckley TK, Khisti RT, Hodge CW, Homanics GE, Morrow AL. GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem. Neuropharmacol 2002; 43: 685-94. (Pubitemid 35279576)
    • (2002) Neuropharmacology , vol.43 , Issue.4 , pp. 685-694
    • Kralic, J.E.1    O'Buckley, T.K.2    Khisti, R.T.3    Hodge, C.W.4    Homanics, G.E.5    Morrow, A.L.6
  • 7
    • 0035804244 scopus 로고    scopus 로고
    • Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
    • DOI 10.1038/35051086
    • Brickley SG, Revilla V, Cull-Candy SG, Wisden W, Farrant M. Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature 2001; 409: 88-92. (Pubitemid 32098630)
    • (2001) Nature , vol.409 , Issue.6816 , pp. 88-92
    • Brickley, S.G.1    Revilla, V.2    Cull-Candy, S.G.3    Wisden, W.4    Farrant, M.5
  • 8
    • 1342344806 scopus 로고    scopus 로고
    • A Receptor Function and Dissection of the Pharmacology of Benzodiazepines and General Anesthetics Through Mouse Genetics
    • DOI 10.1146/annurev.pharmtox.44.101802.121429
    • Rudolph U, Moehler H. Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annu Rev Pharmacol Toxicol 2004; 44: 475-98. (Pubitemid 38263850)
    • (2004) Annual Review of Pharmacology and Toxicology , vol.44 , pp. 475-498
    • Rudolph, U.1    Mohler, H.2
  • 9
    • 4344574333 scopus 로고    scopus 로고
    • Molecular and neuronal substrates for general anaesthetics
    • DOI 10.1038/nrn1496
    • Rudolph U, Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci 2004; 5: 709-20. (Pubitemid 39150142)
    • (2004) Nature Reviews Neuroscience , vol.5 , Issue.9 , pp. 709-720
    • Rudolph, U.1    Antkowiak, B.2
  • 10
    • 42349089480 scopus 로고    scopus 로고
    • General anaesthesia: From molecular targets to neuronal pathways of sleep and arousal
    • DOI 10.1038/nrn2372, PII NRN2372
    • Franks NP. General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 2008; 9: 370-86. (Pubitemid 351556044)
    • (2008) Nature Reviews Neuroscience , vol.9 , Issue.5 , pp. 370-386
    • Franks, N.P.1
  • 11
    • 33645564153 scopus 로고    scopus 로고
    • A receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate
    • A receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate. J Neurosci 2006; 26: 3713-20.
    • (2006) J Neurosci , vol.26 , pp. 3713-3720
    • Cheng, V.Y.1    Martin, L.J.2    Elliott, E.M.3
  • 13
    • 33847795712 scopus 로고    scopus 로고
    • Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions
    • Zeller A, Arras M, Jurd R, Rudolph U. Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions. BMC Pharmacol 2007; 7: 2.
    • (2007) BMC Pharmacol , vol.7 , pp. 2
    • Zeller, A.1    Arras, M.2    Jurd, R.3    Rudolph, U.4
  • 18
    • 0031936716 scopus 로고    scopus 로고
    • Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma- Aminobutyric acid type A receptor
    • DOI 10.1097/00000542-199803000-00030
    • Quinlan JJ, Homanics GE, Firestone LL. Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma-aminobutyric acid type A receptor. Anesthesiology 1998; 88: 775-80. (Pubitemid 28120213)
    • (1998) Anesthesiology , vol.88 , Issue.3 , pp. 775-780
    • Quinlan, J.J.1    Homanics, G.E.2    Firestone, L.L.3
  • 19
    • 0034716487 scopus 로고    scopus 로고
    • Awareness during anaesthesia: A prospective case study
    • Sandin RH, Enlund G, Samuelsson P, Lennmarken C. Awareness during anaesthesia: a prospective case study. Lancet 2000; 355: 707-11. (Pubitemid 30107626)
    • (2000) Lancet , vol.355 , Issue.9205 , pp. 707-711
    • Sandin, R.H.1    Enlund, G.2    Samuelsson, P.3    Lennmarken, C.4
  • 21
    • 38349098244 scopus 로고    scopus 로고
    • Awareness during anesthesia
    • Orser BA, Mazer CD, Baker AJ. Awareness during anesthesia. CMAJ 2008; 178: 185-8.
    • (2008) CMAJ , vol.178 , pp. 185-188
    • Orser, B.A.1    Mazer, C.D.2    Baker, A.J.3
  • 23
    • 70350442441 scopus 로고    scopus 로고
    • Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade
    • Martin LJ, Oh GH, Orser BA. Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade. Anesthesiology 2009; 111: 1025-35.
    • (2009) Anesthesiology , vol.111 , pp. 1025-1035
    • Martin, L.J.1    Oh, G.H.2    Orser, B.A.3
  • 25
    • 70349684954 scopus 로고    scopus 로고
    • Amnestic concentrations of etomidate modulate GABAA, slow synaptic inhibition in hippocampus
    • Dai S, Perouansky M, Pearce RA. Amnestic concentrations of etomidate modulate GABAA, slow synaptic inhibition in hippocampus. Anesthesiology 2009; 111: 766-73.
    • (2009) Anesthesiology , vol.111 , pp. 766-773
    • Dai, S.1    Perouansky, M.2    Pearce, R.A.3
  • 26
    • 4143077106 scopus 로고    scopus 로고
    • A conductances in anesthetic suppression of intrinsic neuronal excitibility
    • A conductances in anesthetic suppression of intrinsic neuronal excitibility. J Neurophysiol 2004; 92: 1658-67.
    • (2004) J Neurophysiol , vol.92 , pp. 1658-1667
    • Bieda, M.C.1    MacIver, M.B.2
  • 28
    • 64749100839 scopus 로고    scopus 로고
    • GABAA receptor alpha5 subunits contribute to GABAA, slow synaptic inhibition in mouse hippocampus
    • Zarnowska ED, Keist R, Rudolph U, Pearce RA. GABAA receptor alpha5 subunits contribute to GABAA, slow synaptic inhibition in mouse hippocampus. J Neurophysiol 2009; 101: 1179-91.
    • (2009) J Neurophysiol , vol.101 , pp. 1179-1191
    • Zarnowska, E.D.1    Keist, R.2    Rudolph, U.3    Pearce, R.A.4
  • 29
    • 73949111037 scopus 로고    scopus 로고
    • Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane
    • Rau V, Iyer SV, Oh I, et al. Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane. Anesth Analg 2009; 109: 1816-22.
    • (2009) Anesth Analg , vol.109 , pp. 1816-1822
    • Rau, V.1    Iyer, S.V.2    Oh, I.3
  • 31
    • 33749009598 scopus 로고    scopus 로고
    • An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: Characterization in heterologous systems and production of knockin mice
    • Borghese CM, Werner DF, Topf N, et al. An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice. J Pharmacol Exp Ther 2006; 319: 208-18.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 208-218
    • Borghese, C.M.1    Werner, D.F.2    Topf, N.3
  • 32
    • 33845949948 scopus 로고    scopus 로고
    • Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane
    • DOI 10.1097/00000542-200701000-00019, PII 0000054220070100000019
    • Sonner JM, Werner DF, Elsen FP, et al. Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology 2007; 106: 107-13. (Pubitemid 46035410)
    • (2007) Anesthesiology , vol.106 , Issue.1 , pp. 107-113
    • Sonner, J.M.1    Werner, D.F.2    Elsen, F.P.3    Xing, Y.4    Liao, M.5    Harris, R.A.6    Harrison, N.L.7    Fanselow, M.S.8    Eger II, E.I.9    Homanics, G.E.10
  • 34
    • 0029998302 scopus 로고    scopus 로고
    • Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes
    • Belelli D, Callachan H, Hill-Venning C, Peters JA, Lambert JJ. Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes. Br J Pharmacol 1996; 118: 563-76. (Pubitemid 26180968)
    • (1996) British Journal of Pharmacology , vol.118 , Issue.3 , pp. 563-576
    • Belelli, D.1    Callachan, H.2    Hill-Venning, C.3    Peters, J.A.4    Lambert, J.J.5
  • 35
    • 0031897215 scopus 로고    scopus 로고
    • The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor
    • DOI 10.1038/sj.bjp.0701787
    • McGurk KA, Pistis M, Belelli D, Hope AG, Lambert JJ. The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor. Br J Pharmacol 1998; 124: 13-20. (Pubitemid 28210037)
    • (1998) British Journal of Pharmacology , vol.124 , Issue.1 , pp. 13-20
    • McGurk, K.A.1    Pistis, M.2    Belelli, D.3    Hope, A.G.4    Lambert, J.J.5
  • 36
    • 0030895793 scopus 로고    scopus 로고
    • Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor
    • Hill-Venning C, Belelli D, Peters JA, Lambert JJ. Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor. Br J Pharmacol 1997; 120: 749-56.
    • (1997) Br J Pharmacol , vol.120 , pp. 749-756
    • Hill-Venning, C.1    Belelli, D.2    Peters, J.A.3    Lambert, J.J.4
  • 37
    • 0030932375 scopus 로고    scopus 로고
    • Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at gamma,-aminobutyric acid type A receptors expressed in Xenopus laevis oocytes
    • Sanna E, Murgia A, Casula A, Biggio G. Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at gamma-aminobutyric acid type A receptors expressed in Xenopus laevis oocytes. Mol Pharmacol 1997; 51: 484-90. (Pubitemid 27118485)
    • (1997) Molecular Pharmacology , vol.51 , Issue.3 , pp. 484-490
    • Sanna, E.1    Murgia, A.2    Casula, A.3    Biggio, G.4
  • 38
    • 0030922807 scopus 로고    scopus 로고
    • The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid
    • Belelli D, Lambert JJ, Peters JA, Wafford K, Whiting PJ. The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. Proc Natl Acad Sci USA 1997; 94: 11031-6.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11031-11036
    • Belelli, D.1    Lambert, J.J.2    Peters, J.A.3    Wafford, K.4    Whiting, P.J.5
  • 39
    • 0033557760 scopus 로고    scopus 로고
    • 3gamma(2L)) and Drosophila (RDL) GABA receptors by a single amino acid residue
    • Pistis M, Belelli D, McGurk K, Peters JA, Lambert JJ. Complementary regulation of anaesthetic activation of human (alpha6beta3gamma2L) and Drosophila (RDL) GABA receptors by a single amino acid residue. J Physiol 1999; 515: 3-18. (Pubitemid 29092616)
    • (1999) Journal of Physiology , vol.515 , Issue.1 , pp. 3-18
    • Pistis, M.1    Belelli, D.2    McGurk, K.3    Peters, J.A.4    Lambert, J.J.5
  • 40
    • 0036270371 scopus 로고    scopus 로고
    • Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)-gamma(2)gamma-aminobutyric acid(A) receptors
    • Siegwart R, Jurd R, Rudolph U. Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)-gamma(2)gamma-aminobutyric acid(A) receptors. J Neurochem 2002; 80: 140-8.
    • (2002) J Neurochem , vol.80 , pp. 140-148
    • Siegwart, R.1    Jurd, R.2    Rudolph, U.3
  • 42
    • 2542486282 scopus 로고    scopus 로고
    • Gamma-aminobutyric acid type A receptor beta2 subunit mediates the hypothermic effect of etomidate in mice
    • DOI 10.1097/00000542-200406000-00016
    • Cirone J, Rosahl TW, Reynolds DS, et al. Gamma-aminobutyric acid type A receptor beta 2 subunit mediates the hypothermic effect of etomidate in mice. Anesthesiology 2004; 100: 1438-45. (Pubitemid 38679313)
    • (2004) Anesthesiology , vol.100 , Issue.6 , pp. 1438-1445
    • Cirone, J.1    Rosahl, T.W.2    Reynolds, D.S.3    Newman, R.J.4    O'Meara, G.F.5    Hutson, P.H.6    Wafford, K.A.7
  • 43
    • 0037315741 scopus 로고    scopus 로고
    • General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit
    • Jurd R, Arras M, Lambert S, et al. General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J 2003; 17: 250-2.
    • (2003) FASEB J , vol.17 , pp. 250-252
    • Jurd, R.1    Arras, M.2    Lambert, S.3
  • 44
    • 26444471375 scopus 로고    scopus 로고
    • Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol
    • DOI 10.1096/fj.04-3443fje
    • Zeller A, Arras M, Lazaris A, Jurd R, Rudolph U. Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol. FASEB J 2005; 19: 1677-9. (Pubitemid 41429527)
    • (2005) FASEB Journal , vol.19 , Issue.12 , pp. 1677-1679
    • Zeller, A.1    Arras, M.2    Lazaris, A.3    Jurd, R.4    Rudolph, U.5
  • 45
    • 11944265824 scopus 로고
    • Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies
    • Fritschy JM, Benke D, Mertens S, Oertel WH, Bachi T, Mohler H. Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies. Proc Natl Acad Sci USA 1992; 89: 6726-30.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6726-6730
    • Fritschy, J.M.1    Benke, D.2    Mertens, S.3    Oertel, W.H.4    Bachi, T.5    Mohler, H.6
  • 46
    • 33847139828 scopus 로고    scopus 로고
    • Identification of a molecular target mediating the general anesthetic actions of pentobarbital
    • DOI 10.1124/mol.106.030049
    • Zeller A, Arras M, Jurd R, Rudolph U. Identification of a molecular target mediating the general anesthetic actions of pentobarbital. Mol Pharmacol 2007; 71: 852-9. (Pubitemid 46294097)
    • (2007) Molecular Pharmacology , vol.71 , Issue.3 , pp. 852-859
    • Zeller, A.1    Arras, M.2    Jurd, R.3    Rudolph, U.4
  • 47
    • 20344403728 scopus 로고    scopus 로고
    • A receptors
    • DOI 10.1016/j.ejphar.2005.04.030, PII S0014299905004127
    • Lambert S, Arras M, Vogt KE, Rudolph U. Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors. Eur J Pharmacol 2005; 516: 23-7. (Pubitemid 40780114)
    • (2005) European Journal of Pharmacology , vol.516 , Issue.1 , pp. 23-27
    • Lambert, S.1    Arras, M.2    Vogt, K.E.3    Rudolph, U.4
  • 49
    • 0034663286 scopus 로고    scopus 로고
    • Membrane and synaptic actions of halothane on rat hippocampal pyramidal neurons and inhibitory interneurons
    • Nishikawa K, MacIver MB. Membrane and synaptic actions of halothane on rat hippocampal pyramidal neurons and inhibitory interneurons. J Neurosci 2000; 20: 5915-23. (Pubitemid 30658382)
    • (2000) Journal of Neuroscience , vol.20 , Issue.16 , pp. 5915-5923
    • Nishikawa, K.-I.1    MacIver, M.B.2
  • 51
    • 27744500994 scopus 로고    scopus 로고
    • Subunit arrangement and function in NMDA receptors
    • DOI 10.1038/nature04089, PII N04089
    • Furukawa H, Singh SK, Mancusso R, Gouaux E. Subunit arrangement and function in NMDA receptors. Nature 2005; 438: 185-92. (Pubitemid 41599865)
    • (2005) Nature , vol.438 , Issue.7065 , pp. 185-192
    • Furukawa, H.1    Singh, S.K.2    Mancusso, R.3    Gouaux, E.4
  • 52
    • 0028810883 scopus 로고
    • Structure and function of the NMDA receptor channel
    • Mori H, Mishina M. Structure and function of the NMDA receptor channel. Neuropharmacology 1995; 34: 1219-37.
    • (1995) Neuropharmacology , vol.34 , pp. 1219-1237
    • Mori, H.1    Mishina, M.2
  • 53
    • 0028810181 scopus 로고
    • Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain
    • Sucher NJ, Akbarian S, Chi CL, et al. Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. J Neurosci 1995; 15: 6509-20.
    • (1995) J Neurosci , vol.15 , pp. 6509-6520
    • Sucher, N.J.1    Akbarian, S.2    Chi, C.L.3
  • 54
    • 0031924075 scopus 로고    scopus 로고
    • A serious target for laughing gas
    • DOI 10.1038/nm0498-383
    • Franks NP, Lieb WR. A serious target for laughing gas. Nat Med 1998; 4: 383-4. (Pubitemid 28212743)
    • (1998) Nature Medicine , vol.4 , Issue.4 , pp. 383-384
    • Franks, N.P.1    Lieb, W.R.2
  • 56
    • 14644439228 scopus 로고    scopus 로고
    • 1 subunit gene disruption of the action of general anesthetic drugs in mice
    • DOI 10.1097/00000542-200503000-00013
    • Sato Y, Kobayashi E, Murayama T, Mishina M, Seo N. Effect of N-methyl-D-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology 2005; 102: 557-61. (Pubitemid 40315145)
    • (2005) Anesthesiology , vol.102 , Issue.3 , pp. 557-561
    • Sato, Y.1    Kobayashi, E.2    Murayama, T.3    Mishina, M.4    Seo, N.5
  • 57
    • 0031763592 scopus 로고    scopus 로고
    • AMPA receptors: Molecular and functional diversity
    • Borges K, Dingledine R. AMPA receptors: molecular and functional diversity. Prog Brain Res 1998; 116: 153-70. (Pubitemid 28526934)
    • (1998) Progress in Brain Research , vol.116 , pp. 153-170
    • Borges, K.1    Dingledine, R.2
  • 58
    • 0032728760 scopus 로고    scopus 로고
    • Blockade of glutamate receptors and barbiturate anesthesia: Increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in Glur2 null mutant mice
    • DOI 10.1097/00000542-199911000-00025
    • Joo DT, Xiong Z, MacDonald JF, et al. Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice. Anesthesiology 1999; 91: 1329-41. (Pubitemid 29506096)
    • (1999) Anesthesiology , vol.91 , Issue.5 , pp. 1329-1341
    • Joo, D.T.1    Xiong, Z.2    MacDonald, J.F.3    Jia, Z.4    Roder, J.5    Sonner, J.6    Orser, B.A.7
  • 59
    • 0035092443 scopus 로고    scopus 로고
    • Blockade of AMPA receptors and volatile anesthetics. Reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration
    • Joo DT, Gong D, Sonner JM, et al. Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration. Anesthesiology 2001; 94: 478-88. (Pubitemid 32198458)
    • (2001) Anesthesiology , vol.94 , Issue.3 , pp. 478-488
    • Joo, D.T.1    Gong, D.2    Sonner, J.M.3    Jia, Z.4    MacDonald, J.F.5    Eger II, E.I.6    Orser, B.A.7
  • 61
    • 33645877403 scopus 로고    scopus 로고
    • The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists
    • Linden AM, Aller MI, Leppa E, et al. The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists. J Pharmacol Exp Ther 2006; 317: 615-26.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 615-626
    • Linden, A.M.1    Aller, M.I.2    Leppa, E.3
  • 64
    • 13244254005 scopus 로고    scopus 로고
    • A receptor-mediated inhibition
    • DOI 10.1111/j.1460-9568.2004.03843.x
    • Hentschke H, Schwarz C, Antkowiak B. Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor-mediated inhibition. Eur J Neurosci 2005; 21: 93-102. (Pubitemid 40193878)
    • (2005) European Journal of Neuroscience , vol.21 , Issue.1 , pp. 93-102
    • Hentschke, H.1    Schwarz, C.2    Antkowiak, B.3
  • 65
    • 0034736184 scopus 로고    scopus 로고
    • GABA(A) receptors: Immunocytochemical distribution of 13 subunits in the adult rat brain
    • Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G. GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 2000; 101: 815-50.
    • (2000) Neuroscience , vol.101 , pp. 815-850
    • Pirker, S.1    Schwarzer, C.2    Wieselthaler, A.3    Sieghart, W.4    Sperk, G.5
  • 66
    • 0027136076 scopus 로고
    • Exaggerated anesthetic requirements in the preferentially anesthetized brain
    • Antognini JF, Schwartz K. Exaggerated anesthetic requirements in the preferentially anesthetized brain. Anesthesiology 1993; 79: 1244-9. (Pubitemid 24005771)
    • (1993) Anesthesiology , vol.79 , Issue.6 , pp. 1244-1249
    • Antognini, J.F.1    Schwartz, K.2
  • 67
    • 0027467413 scopus 로고
    • Anesthetic potency (MAC) is independent of forebrain structures in the rat
    • Rampil IJ, Mason P, Singh H. Anesthetic potency (MAC) is independent of forebrain structures in the rat. Anesthesiology 1993; 78: 707-12. (Pubitemid 23110045)
    • (1993) Anesthesiology , vol.78 , Issue.4 , pp. 707-712
    • Rampil, I.J.1    Mason, P.2    Singh, H.3
  • 68
    • 34748872025 scopus 로고    scopus 로고
    • Neurons in the ventral spinal cord are more depressed by isoflurane, halothane, and propofol than are neurons in the dorsal spinal cord
    • DOI 10.1213/01.ane.0000280483.17854.56, PII 0000053920071000000021
    • Kim J, Yao A, Atherley R, Carsten E, Jinks SL, Antognini JF. Neurons in the ventral spinal cord are more depressed by isoflurane, halothane, and propofol than are neurons in the dorsal spinal cord. Anesth Analg 2007; 105: 1020-6. (Pubitemid 47479316)
    • (2007) Anesthesia and Analgesia , vol.105 , Issue.4 , pp. 1020-1026
    • Kim, J.1    Yao, A.2    Atherley, R.3    Carstens, E.4    Jinks, S.L.5    Antognini, J.F.6
  • 69
    • 45149115876 scopus 로고    scopus 로고
    • Volatile anesthetic effects on midbrain-elicited locomotion suggest that the locomotor network in the ventral spinal cord is the primary site for immobility
    • Jinks SL, Bravo M, Hayes SG. Volatile anesthetic effects on midbrain-elicited locomotion suggest that the locomotor network in the ventral spinal cord is the primary site for immobility. Anesthesiology 2008; 108: 1016-24.
    • (2008) Anesthesiology , vol.108 , pp. 1016-1024
    • Jinks, S.L.1    Bravo, M.2    Hayes, S.G.3
  • 70
    • 0029670846 scopus 로고    scopus 로고
    • Distribution of immunoreactivity for the beta 2 and beta 3 subunits of the GABAA receptor in the mammalian spinal cord
    • Alvarez FJ, Taylor-Blake B, Fyffe RE, De Blas AL, Light AR. Distribution of immunoreactivity for the beta 2 and beta 3 subunits of the GABAA receptor in the mammalian spinal cord. J Comp Neurol 1996; 365: 392-412.
    • (1996) J Comp Neurol , vol.365 , pp. 392-412
    • Alvarez, F.J.1    Taylor-Blake, B.2    Fyffe, R.E.3    De Blas, A.L.4    Light, A.R.5
  • 71
    • 0019725433 scopus 로고
    • Organotypic monolayer cultures of nervous tissue
    • DOI 10.1016/0165-0270(81)90003-0
    • Gahwiler BH. Organotypic monolayer cultures of nervous tissue. J Neurosci Methods 1981; 4: 329-42. (Pubitemid 12084147)
    • (1981) Journal of Neuroscience Methods , vol.4 , Issue.4 , pp. 329-342
    • Gahwiler, B.H.1
  • 73
    • 0037450353 scopus 로고    scopus 로고
    • A receptor clusters of cultured hippocampal pyramidal cells
    • DOI 10.1002/cne.10535
    • Christie SB, De Blas AL. GABAergic and glutamatergic axons innervate the axon initial segment and organize GABA(A) receptor clusters of cultured hippocampal pyramidal cells. J Comp Neurol 2003; 456: 361-74. (Pubitemid 36120242)
    • (2003) Journal of Comparative Neurology , vol.456 , Issue.4 , pp. 361-374
    • Christie, S.B.1    De, B.A.L.2
  • 74
    • 0037185248 scopus 로고    scopus 로고
    • Intact sorting, targeting, and clustering of gamma-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro
    • DOI 10.1002/cne.10102
    • Brunig I, Scotti E, Sidler C, Fritschy JM. Intact sorting, targeting, and clustering of gamma-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro. J Comp Neurol 2002; 443: 43-55. (Pubitemid 34027568)
    • (2002) Journal of Comparative Neurology , vol.443 , Issue.1 , pp. 43-55
    • Brunig, I.1    Scotti, E.2    Sidler, C.3    Fritschy, J.-M.4
  • 75
    • 7044222044 scopus 로고    scopus 로고
    • Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs
    • DOI 10.1038/nn1334
    • Di Cristo G, Wu C, Chattopadhyaya B, et al. Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. Nat Neurosci 2004; 7: 1184-6. (Pubitemid 39426235)
    • (2004) Nature Neuroscience , vol.7 , Issue.11 , pp. 1184-1186
    • Di, C.G.1    Wu, C.2    Chattopadhyaya, B.3    Ango, F.4    Knott, G.5    Welker, E.6    Svoboda, K.7    Huang, Z.J.8
  • 76
    • 9744244185 scopus 로고    scopus 로고
    • Determination of diffusion and partition coefficients of propofol in rat brain tissue: Implications for studies of drug action in vitro
    • DOI 10.1093/bja/aeh272
    • Gredell JA, Turnquist PA, Maciver MB, Pearce RA. Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro. Br J Anaesth 2004; 93: 810-7. (Pubitemid 39585612)
    • (2004) British Journal of Anaesthesia , vol.93 , Issue.6 , pp. 810-817
    • Gredell, J.A.1    Turnquist, P.A.2    MacIver, M.B.3    Pearce, R.A.4
  • 77
    • 33845942409 scopus 로고    scopus 로고
    • Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: Implications for in vitro studies
    • DOI 10.1097/00000542-200701000-00020, PII 0000054220070100000020
    • Benkwitz C, Liao M, Laster MJ, Sonner JM, Eger EI 2nd, Pearce RA. Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies. Anesthesiology 2007; 106: 114-23. (Pubitemid 46035411)
    • (2007) Anesthesiology , vol.106 , Issue.1 , pp. 114-123
    • Benkwitz, C.1    Liao, M.2    Laster, M.J.3    Sonner, J.M.4    Eger II, E.I.5    Pearce, R.A.6
  • 78
    • 0036068932 scopus 로고    scopus 로고
    • In vitro networks: Cortical mechanisms of anaesthetic action
    • Antkowiak B. In vitro networks: cortical mechanisms of anaesthetic action. Br J Anaesth 2002; 89: 102-11.
    • (2002) Br J Anaesth , vol.89 , pp. 102-111
    • Antkowiak, B.1
  • 80
  • 81
    • 13244268681 scopus 로고    scopus 로고
    • Opposing actions of etomidate on cortical theta oscillations are mediated by different gamma-aminobutyric acid type A receptor subtypes
    • DOI 10.1097/00000542-200502000-00017
    • Drexler B, Roether CL, Jurd R, Rudolph U, Antkowiak B. Opposing actions of etomidate on cortical theta oscillations are mediated by different gamma-aminobutyric acid type A receptor subtypes. Anesthesiology 2005; 102: 346-52. (Pubitemid 40189083)
    • (2005) Anesthesiology , vol.102 , Issue.2 , pp. 346-352
    • Drexler, B.1    Roether, C.L.2    Jurd, R.3    Rudolph, U.4    Antkowiak, B.5
  • 82
    • 0016760562 scopus 로고
    • Etomidate, a new water-soluble non-barbiturate intravenous induction agent
    • Morgan M, Lumley J, Whitwam JG. Etomidate, a new water-soluble non-barbiturate intravenous induction agent. Lancet 1975; 1: 955-6.
    • (1975) Lancet , vol.1 , pp. 955-956
    • Morgan, M.1    Lumley, J.2    Whitwam, J.G.3
  • 83
    • 0029095877 scopus 로고
    • The comparative effects of methohexital, propofol, and etomidate for electroconvulsive therapy
    • Avramov MN, Husain MM, White PF. The comparative effects of methohexital, propofol, and etomidate for electroconvulsive therapy. Anesth Analg 1995; 81: 596-602.
    • (1995) Anesth Analg , vol.81 , pp. 596-602
    • Avramov, M.N.1    Husain, M.M.2    White, P.F.3
  • 84
    • 10344260172 scopus 로고    scopus 로고
    • Etomidate versus propofol for electroconvulsive therapy in patients with schizophrenia
    • DOI 10.1097/00124509-200412000-00007
    • Gazdag G, Kocsis N, Tolna J, Ivanyi Z. Etomidate versus propofol for electroconvulsive therapy in patients with schizophrenia. J ECT 2004; 20: 225-9. (Pubitemid 39628468)
    • (2004) Journal of ECT , vol.20 , Issue.4 , pp. 225-229
    • Gazdag, G.1    Kocsis, N.2    Tolna, J.3    Ivanyi, Z.4
  • 85
    • 0041323342 scopus 로고    scopus 로고
    • Pharmacologic and physiologic influences affecting sensory evoked potentials: Implications for perioperative monitoring
    • DOI 10.1097/00000542-200309000-00029
    • Banoub M, Tetzlaff JE, Schubert A. Pharmacologic and physiologic influences affecting sensory evoked potentials: implications for perioperative monitoring. Anesthesiology 2003; 99: 716-37. (Pubitemid 37051989)
    • (2003) Anesthesiology , vol.99 , Issue.3 , pp. 716-737
    • Banoub, M.1    Tetzlaff, J.E.2    Schubert, A.3
  • 86
    • 0031815007 scopus 로고    scopus 로고
    • Anesthetic effects on electrophysiologic recordings
    • DOI 10.1097/00004691-199805000-00005
    • Sloan TB. Anesthetic effects on electrophysiologic recordings. J Clin Neurophysiol 1998; 15: 217-26. (Pubitemid 28376422)
    • (1998) Journal of Clinical Neurophysiology , vol.15 , Issue.3 , pp. 217-226
    • Sloan, T.B.1
  • 87
    • 68749100597 scopus 로고    scopus 로고
    • Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors
    • Drexler B, Jurd R, Rudolph U, Antkowiak B. Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors. Neuropharmacology 2009; 57: 446-55.
    • (2009) Neuropharmacology , vol.57 , pp. 446-455
    • Drexler, B.1    Jurd, R.2    Rudolph, U.3    Antkowiak, B.4
  • 89
    • 58549100304 scopus 로고    scopus 로고
    • Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms
    • Ying SW, Werner DF, Homanics GE, Harrison NL, Goldstein PA. Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms. Neuropharmacology 2009; 56: 438-47.
    • (2009) Neuropharmacology , vol.56 , pp. 438-447
    • Ying, S.W.1    Werner, D.F.2    Homanics, G.E.3    Harrison, N.L.4    Goldstein, P.A.5
  • 90
    • 0036785886 scopus 로고    scopus 로고
    • The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway
    • Nelson LE, Guo TZ, Lu J, Saper CB, Franks NP, Maze M. The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci 2002; 5: 979-84.
    • (2002) Nat Neurosci , vol.5 , pp. 979-984
    • Nelson, L.E.1    Guo, T.Z.2    Lu, J.3    Saper, C.B.4    Franks, N.P.5    Maze, M.6
  • 91
    • 60849097577 scopus 로고    scopus 로고
    • The involvement of hypothalamic sleep pathways in general anesthesia: Testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse
    • Zecharia AY, Nelson LE, Gent TC, et al. The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. J Neurosci 2009; 29: 2177-87.
    • (2009) J Neurosci , vol.29 , pp. 2177-2187
    • Zecharia, A.Y.1    Nelson, L.E.2    Gent, T.C.3
  • 92
    • 34548329110 scopus 로고    scopus 로고
    • A receptors limits the immobilizing actions of GABAergic anesthetics
    • DOI 10.1124/mol.107.037648
    • Grasshoff C, Jurd R, Rudolph U, Antkowiak B. Modulation of presynaptic beta3-containing GABAA receptors limits the immobilizing actions of GABAergic anesthetics. Mol Pharmacol 2007; 72: 780-7. (Pubitemid 47347313)
    • (2007) Molecular Pharmacology , vol.72 , Issue.3 , pp. 780-787
    • Grasshoff, C.1    Jurd, R.2    Rudolph, U.3    Antkowiak, B.4
  • 93
    • 76249121803 scopus 로고    scopus 로고
    • Organotypic cultures of spinal cord ventral horn are valuable tools for investigating immobility-related mechanisms in vitro
    • Grasshoff C, Antkowiak B. Organotypic cultures of spinal cord ventral horn are valuable tools for investigating immobility-related mechanisms in vitro. Anesth Analg 110: 638.
    • Anesth Analg , vol.110 , pp. 638
    • Grasshoff, C.1    Antkowiak, B.2
  • 94
    • 0032615671 scopus 로고    scopus 로고
    • Dual actions of volatile anesthetics on GABA(A) IPSCs: Dissociation of blocking and prolonging effects
    • Banks MI, Pearce RA. Dual actions of volatile anesthetics on GABA(A) IPSCs: dissociation of blocking and prolonging effects. Anesthesiology 1999; 90: 120-34.
    • (1999) Anesthesiology , vol.90 , pp. 120-134
    • Banks, M.I.1    Pearce, R.A.2
  • 95
    • 33746632113 scopus 로고    scopus 로고
    • 3(N265M) point mutation
    • DOI 10.1097/00000542-200608000-00012, PII 0000054220060800000012
    • Drexler B, Jurd R, Rudolph U, Antkowiak B. Dual actions of enflurane on postsynaptic currents abolished by the gamma-aminobutyric acid type A receptor beta3(N265M) point mutation. Anesthesiology 2006; 105: 297-304. (Pubitemid 44148174)
    • (2006) Anesthesiology , vol.105 , Issue.2 , pp. 297-304
    • Drexler, B.1    Jurd, R.2    Rudolph, U.3    Antkowiak, B.4
  • 96
    • 77950557636 scopus 로고    scopus 로고
    • Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors
    • Li GD, Chiara DC, Cohen JB, Olsen RW. Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors. J Biol Chem 2010; 285: 8615-20.
    • (2010) J Biol Chem , vol.285 , pp. 8615-8620
    • Li, G.D.1    Chiara, D.C.2    Cohen, J.B.3    Olsen, R.W.4
  • 97
    • 33645311284 scopus 로고    scopus 로고
    • The GABA(A) receptor family: Possibilities for the development of better anesthetics
    • German
    • Drexler B, Grasshoff C, Rudolph U, Unertl K, Antkowiak B. The GABA(A) receptor family: possibilities for the development of better anesthetics (German). Anaesthesist 2006; 55: 287-95.
    • (2006) Anaesthesist , vol.55 , pp. 287-295
    • Drexler, B.1    Grasshoff, C.2    Rudolph, U.3    Unertl, K.4    Antkowiak, B.5
  • 99
    • 36649032770 scopus 로고    scopus 로고
    • A receptor subunits in the adult C57 mouse as assessed with in situ hybridization
    • DOI 10.1016/j.neuroscience.2007.09.008, PII S0306452207011086
    • Heldt SA, Ressler KJ. Forebrain and midbrain distribution of major benzodiazepine-sensitive GABAA receptor subunits in the adult C57 mouse as assessed with in situ hybridization. Neuroscience 2007; 150: 370-85. (Pubitemid 350198707)
    • (2007) Neuroscience , vol.150 , Issue.2 , pp. 370-385
    • Heldt, S.A.1    Ressler, K.J.2
  • 100
    • 58049133111 scopus 로고    scopus 로고
    • GABA A receptors: Subtypes provide diversity of function and pharmacology
    • Olsen RW, Sieghart W. GABA A receptors: subtypes provide diversity of function and pharmacology. Neuropharmacology 2009; 56: 141-8.
    • (2009) Neuropharmacology , vol.56 , pp. 141-148
    • Olsen, R.W.1    Sieghart, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.