Activation of endogenous GABAA channels on airway smooth muscle potentiates isoproterenol-mediated relaxation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 295, Issue 6, 2008, Pages

  Gallos, George ^a   Gleason, Neil R ^a   Zhang, Yi ^a   Pak, Sang Woo ^a   Sonett, J R ^a   Yang, Jay ^a   Emala, Charles W ^a  

^a College of Physicians and Surgeons of Columbia University ^*  (United States)

Author keywords

Gabazine; Guinea pig; Muscimol; Organ bath

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; ISOPRENALINE; MUSCIMOL; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ACETYLCHOLINE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (CALCIUM POTASSIUM); BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; IBERIOTOXIN; NEUROKININ A; NEUROKININ A (4 10), BETA ALA(8); NEUROKININ A (4-10), BETA-ALA(8)-; PEPTIDE; PEPTIDE FRAGMENT; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; CELL ACTIVATION; CONTROLLED STUDY; DRUG EFFECT; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; GUINEA PIG; HUMAN; METABOLISM; MUSCLE RELAXATION; ORGAN CULTURE TECHNIQUE; SMOOTH MUSCLE; TRACHEA;

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATASES; ADRENERGIC BETA-AGONISTS; ANIMALS; BRONCHOCONSTRICTION; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA ANTAGONISTS; GUINEA PIGS; HUMANS; ISOPROTERENOL; MUSCLE RELAXATION; MUSCLE, SMOOTH; NEUROKININ A; ORGAN CULTURE TECHNIQUES; PEPTIDE FRAGMENTS; PEPTIDES; PYRIDAZINES; RECEPTORS, GABA-A; TRACHEA; VASODILATOR AGENTS;

EID: 57149090713     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90330.2008     Document Type: Article

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