Role of extracellular ATP in cell fate determination

Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry

Volumn 11, Issue 1, 2011, Pages 48-58

  Bilbao, Paola Scodelaro ^a   Katz, Sebastián ^a   Boland, Ricardo ^a  

^a UNIVERSIDAD NACIONAL DEL SUR   (Argentina)

Author keywords

Apoptosis; Differentiation; Extracellular ATP; MAPKs; PI3K Akt; Proliferation

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; CALCIUM ION; CALSENILIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE 4; DIACYLGLYCEROL; EPIDERMAL GROWTH FACTOR RECEPTOR; FOCAL ADHESION KINASE 2; INOSITOL TRISPHOSPHATE; INOSITOL TRISPHOSPHATE 3 KINASE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL KINASE; PHOSPHOLIPASE C; PURINERGIC P2 RECEPTOR; PURINERGIC P2X RECEPTOR; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y11 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; SYNAPTOPHYSIN; UNINDEXED DRUG; URIDINE TRIPHOSPHATE;

APOPTOSIS; CARCINOMA CELL; CELL DEATH; CELL DIFFERENTIATION; CELL FATE; CELL GROWTH; CELL LINE; CELL MEMBRANE; CELL PROLIFERATION; ESOPHAGUS CANCER; HUMAN; MITOGENESIS; REVIEW; SIGNAL TRANSDUCTION;

EID: 79951706912     PISSN: 18715222     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152211794519467     Document Type: Review

References (118)

1. Burnstock, G. The past, present and future of purine nucleotides assignaling molecules. Neuropharmacology, 1997, 36(9), 1127-1139.
2. Burnstock, G. Purine and pyrimidine receptors. Cell. Mol. Life Sci., 2007, 64(12), 1471-1483.
3. Nandigama, R.; Padmasekar, M.; Wartenberg, M.; Sauer, H. Feedforward cycle of hypotonic stress-induced ATP release, purinergicreceptor activation, and growth stimulation of prostate cancer cells.J. Biol. Chem., 2006, 281(9), 5686-5693.
4. Di Virgilio, F.; Ferrari, D.; Adinolfi, E. P2X7: a growth-promotingreceptor-implications for cancer. Purinergic Signal., 2009, 5(2), 251-256.
5. White, N.; Burnstock, G. P2 receptors and cancer. Trends Pharmacol. Sci., 2006, 27(4), 211-217.
6. Erb, L.; Liao, Z.; Seye, C.I.; Weisman, G.A. P2 receptors: intracellularsignaling. Pflugers Arch., 2006, 452(5), 552-562.
7. Van Kolen, K.; Slegers, H. Atypical PKCzeta is involved in RhoAdependentmitogenic signaling by the P2Y12 receptor in C6 cells.FEBS J., 2006, 273(8), 1843-1854.
8. Ratchford, A.M.; Baker, O.J.; Camden, J.M.; Rikka, S.; Petris, M.J.; Seye, C.I.; Erb, L.; Weisman, G.A. P2Y2 nucleotide receptorsmediate metalloprotease-dependent phosphorylation of epidermalgrowth factor receptor and ErbB3 in human salivary glandcells. J. Biol. Chem., 2010, 285(10), 7545-7555.
9. Rumjahn, S.M.; Baldwin, K.A.; Buxton, I.L. P2Y receptormediatedangiogenesis via vascular endothelial growth factor receptor2 signaling. Proc. West Pharmacol. Soc., 2007, 50, 58-60.
10. Abbracchio, M.P.; Burnstock, G. Purinergic signaling: pathophysiologicalroles. Jpn. J. Pharmacol., 1998, 78(2), 113-145.
11. Burnstock, G. Purinergic signaling--an overview. Novartis Found. Symp., 2006, 276, 26-48.
12. Burnstock, G. Purinergic signaling. Br. J. Pharmacol., 2006, 147(1), S172-181.
13. Abbracchio, M.P.; Burnstock, G.; Boeynaems, J.M.; Barnard, E.A.; Boyer, J.L.; Kennedy, C.; Knight, G.E.; Fumagalli, M.; Gachet, C.; Jacobson, K.A.; Weisman, G.A. International Union of PharmacologyLVIII: update on the P2Y G protein-coupled nucleotide receptors:from molecular mechanisms and pathophysiology to therapy. Pharmacol. Rev., 2006, 58(3), 281-341.
14. Katz, S.; Boland, R.; Santillán, G. Modulation of ERK 1/2 and p38MAPK signaling pathways by ATP in osteoblasts: involvement ofmechanical stress-activated calcium influx, PKC and Src activation. Int. J. Biochem. Cell. Biol., 2006, 38(12), 2082-2091.
15. 2+ release, stress activated and Lvoltage-dependent calcium influx, PKC and Src kinases. Arch. Biochem. Biophys., 2008, 477(2), 244-252.
16. 2+ in breast cancer (MCF-7) cells. Arch. Biochem. Biophys., 2007, 466(1), 15-23.
17. Buzzi, N.; Bilbao, P.S.; Boland, R.; de Boland, A.R. ExtracellularATP activates MAP kinase cascades through a P2Y purinergic receptorin the human intestinal Caco-2 cell line. Biochim. Biophys. Acta, 2009, 1790(12), 1651-1659.
18. Turjanski, A.G.; Vaqué, J.P.; Gutkind, J.S. MAP kinases and thecontrol of nuclear events. Oncogene, 2007, 26(22), 3240-3253.
19. Goldsmith, Z.G.; Dhanasekaran, D.N. G protein regulation ofMAPK networks. Oncogene, 2007, 26(22), 3122-3142.
20. Wada, T.; Penninger, J.M. Mitogen-activated protein kinases inapoptosis regulation. Oncogene, 2004, 23(16), 2838-2849.
21. Huwiler, A.; Rölz, W.; Dorsch, S.; Ren, S.; Pfeilschifter, J. ExtracellularATP and UTP activate the protein kinase B/Akt cascade via the P2Y2 purinoceptor in renal mesangial cells. Br. J. Pharmacol., 2002, 136(4), 520-529.
22. Heo, J.S.; Han, H.J. ATP stimulates mouse embryonic stem cellproliferation via protein kinase C, phosphatidylinositol 3-kinase/Akt, and mitogen-activated protein kinase signaling pathways. Stem Cells, 2006, 24(12), 2637-2648.
23. Burgos, M.; Neary, J.T.; González, F.A. P2Y2 nucleotide receptorsinhibit trauma-induced death of astrocytic cells. J. Neurochem., 2007, 103(5), 1785-1800.
24. Scodelaro Bilbao, P.; Santillán, G.; Boland, R. ATP stimulates theproliferation of MCF-7 cells through the PI3K/Akt signaling pathway. Arch. Biochem. Biophys., 2010, 499(1-2), 40-48.
25. Montiel, M.; de la Blanca, E.P.; Jiménez, E. P2Y receptors activateMAPK/ERK through a pathway involving PI3K/PDK1/PKC-zetain human vein endothelial cells. Cell. Physiol. Biochem., 2006, 18(1-3), 123-134.
26. Hanada, M.; Feng, J.; Hemmings, B.A. Structure, regulation andfunction of PKB/AKT--a major therapeutic target. Biochim. Biophys. Acta, 2004, 1697(1-2), 3-16.
27. Liu, W.; Bagaitkar, J.; Watabe, K. Roles of AKT signal in breastcancer. Front. Biosci., 2007, 12, 4011-4019.
28. Fresno Vara, J.A.; Casado, E.; de Castro, J.; Cejas, P.; Belda-Iniesta, C.; González-Barón, M. PI3K/Akt signaling pathway andcancer. Cancer Treat. Rev., 2004, 30(2), 193-204.
29. Soltoff, S.P.; Avraham, H.; Avraham, S.; Cantley, L.C. Activationof P2Y2 receptors by UTP and ATP stimulates mitogen-activatedkinase activity through a pathway that involves related adhesionfocal tyrosine kinase and protein kinase C. J. Biol. Chem., 1998, 273(5), 2653-2660.
30. 2+]i elevation can substitute for receptor activation.J. Biol. Chem., 1998, 273(36), 23110-23117.
31. Schmitt, J.M.; Stork, P.J. beta 2-adrenergic receptor activates extracellularsignal-regulated kinases (ERKs) via the small G proteinrap1 and the serine/threonine kinase B-Raf. J. Biol. Chem., 2000, 275(33), 25342-25350.
32. 2+, and calmodulin. Cell. Signal., 2002, 14(8), 649-654.
33. Gutkind, J.S. Regulation of mitogen-activated protein kinase signalingnetworks by G protein-coupled receptors. Sci. STKE, 2000,(40), re1.
34. Neary, J.T.; McCarthy, M.; Kang, Y.; Zuniga, S. Mitogenic signalingfrom P1 and P2 purinergic receptors to mitogen-activated proteinkinase in human fetal astrocyte cultures. Neurosci. Lett., 1998, 242(3), 159-162.
35. Vázquez-Cuevas, F.G.; Zárate-Díaz, E.P.; Garay, E.; Arellano, R.O. Functional expression and intracellular signaling of UTPsensitiveP2Y receptors in theca-interstitial cells. Reprod. Biol. Endocrinol., 2010, 8, 88.
36. Yu, S.M.; Chen, S.F.; Lau, Y.T.; Yang, C.M.; Chen, J.C. Mechanismof extracellular ATP-induced proliferation of vascular smoothmuscle cells. Mol. Pharmacol., 1996, 50(4), 1000-1009.
37. Tu, M.T.; Luo, S.F.; Wang, C.C.; Chien, C.S.; Chiu, C.T.; Lin, C.C.; Yang, C.M. P2Y2 receptor-mediated proliferation of C6glioma cells via activation of Ras/Raf/MEK/MAPK pathway. Br. J. Pharmacol., 2000, 129(7), 1481-1489.
38. 2+ signaling andproliferative responses in pulmonary artery vasa vasorum endothelialcells. Am. J. Physiol. Cell. Physiol., 2010 [Epub ahead of print].
39. Burnstock, G. Physiology and pathophysiology of purinergic neurotransmission. Physiol. Rev., 2007, 87(2), 659-797.
40. Sanches, G.; de Alencar, L.S.; Ventura, A.L. ATP induces proliferationof retinal cells in culture via activation of PKC and extracellularsignal-regulated kinase cascade. Int. J. Dev. Neurosci., 2002, 20(1), 21-27.
41. Nunes, P.H.; Calaza Kda, C.; Albuquerque, L.M.; Fragel-Madeira, L.; Sholl-Franco, A.; Ventura, A.L. Signal transduction pathwaysassociated with ATP-induced proliferation of cell progenitors in theintact embryonic retina. Int. J. Dev. Neurosci., 2007, 25(8), 499-508.
42. Thevananther, S.; Sun, H.; Li, D.; Arjunan, V.; Awad, S.S.; Wyllie, S.; Zimmerman, T.L.; Goss, J.A.; Karpen, S.J. Extracellular ATPactivates c-jun N-terminal kinase signaling and cell cycle progressionin hepatocytes. Hepatology, 2004, 39(2), 393-402.
43. Huwiler, A.; Pfeilschifter, J. Stimulation by extracellular ATP andUTP of the mitogen-activated protein kinase cascade and proliferationof rat renal mesangial cells. Br. J. Pharmacol., 1994, 113(4), 1455-1463.
44. Huwiler, A.; van Rossum, G.; Wartmann, M.; Pfeilschifter, J. Stimulation by extracellular ATP and UTP of the stress-activatedprotein kinase cascade in rat renal mesangial cells. Br. J. Pharmacol., 1997, 120(5), 807-812.
45. Huwiler, A.; Wartmann, M.; van den Bosch, H.; Pfeilschifter, J. Extracellular nucleotides activate the p38-stress-activated proteinkinase cascade in glomerular mesangial cells. Br. J. Pharmacol., 2000, 129(3), 612-618.
46. Buzzi, N.; Boland, R.; de Boland, A.R. Signal transduction pathwaysassociated with ATP-induced proliferation of colon adenocarcinomacells. Biochim. Biophys. Acta, 2010, 1800(9), 946-955.
47. Yaguchi, T.; Saito, M.; Yasuda, Y.; Kanno, T.; Nakano, T.; Nishizaki, T. Higher concentrations of extracellular ATP suppress proliferationof Caco-2 human colonic cancer cells via an unknown receptorinvolving PKC inhibition. Cell. Physiol. Biochem., 2010, 26(2), 125-134.
48. Neary, J.T.; Zhu, Q.; Kang, Y.; Dash, P.K. Extracellular ATP inducesformation of AP-1 complexes in astrocytes via P2 purinoceptors. Neuroreport., 1996, 7(18), 2893-2896.
49. Scodelaro Bilbao, P.; Boland, R.; Santillán, G. ATP modulatestranscription factors through P2Y2 and P2Y4 receptors viaPKC/MAPKs and PKC/Src pathways in MCF-7 cells. Arch. Biochem. Biophys., 2010, 494(1), 7-14.
50. Schäfer, R.; Hartig, R.; Sedehizade, F.; Welte, T.; Reiser, G. Adeninenucleotides inhibit proliferation of the human lung adenocarcinomacell line LXF-289 by activation of nuclear factor kappaB1and mitogen-activated protein kinase pathways. FEBS J., 2006, 273(16), 3756-3767.
51. Chang, S.J.; Tzeng, C.R.; Lee, Y.H.; Tai, C.J. Extracellular ATPactivates the PLC/PKC/ERK signaling pathway through the P2Y2purinergic receptor leading to the induction of early growth response1 expression and the inhibition of viability in human endometrialstromal cells. Cell. Signal., 2008, 20(7), 1248-1255.
52. Yang, L.; Cranson, D.; Trinkaus-Randall, V. Cellular injury inducesactivation of MAPK via P2Y receptors. J. Cell. Biochem., 2004, 91(5), 938-950.
53. Gerasimovskaya, E.V.; Ahmad, S.; White, C.W.; Jones, P.L.; Carpenter, T.C.; Stenmark, K.R. Extracellular ATP is anautocrine/paracrine regulator of hypoxia-induced adventitial fibroblastgrowth. Signaling through extracellular signal-regulatedkinase-1/2 and the Egr-1 transcription factor. J. Biol. Chem., 2002, 277(47), 44638-44650.
54. Neary, J.T.; Baker, L.; Jorgensen, S.L.; Norenberg, M.D. ExtracellularATP induces stellation and increases glial fibrillary acidicprotein content and DNA synthesis in primary astrocyte cultures. Acta Neuropathol., 1994, 87(1), 8-13.
55. Lee, Y.J.; Han, H.J. Role of ATP in DNA synthesis of renal proximaltubule cells: involvement of calcium, MAPKs, and CDKs. Am.J. Physiol. Renal Physiol., 2006, 291(1), F98-106.
56. Budagian, V.; Bulanova, E.; Brovko, L.; Orinska, Z.; Fayad, R.; Paus, R.; Bulfone-Paus, S. Signaling through P2X7 receptor in humanT cells involves p56lck, MAP kinases, and transcription factorsAP-1 and NF-kappa B. J. Biol. Chem., 2003, 278(3), 1549-1560.
57. Yu, T.; Junger, W.G.; Yuan, C.; Jin, A.; Zhao, Y.; Zheng, X.; Zeng, Y.; Liu, J. Shockwaves increase T-cell proliferation and IL-2 expressionthrough ATP release, P2X7 receptors, and FAK activation. Am. J. Physiol. Cell. Physiol., 2010, 298(3), C457-464.
58. Mairet-Coello, G.; Tury, A.; DiCicco-Bloom, E. Insulin-likegrowth factor-1 promotes G1/S cell cycle progression through bidirectionalregulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developingrat cerebral cortex. J. Neurosci., 2009, 29(3), 775-788.
59. Peltier, J.; O'Neill, A.; Schaffer, D.V. PI3K/Akt and CREB regulateadult neural hippocampal progenitor proliferation and differentiation. Dev. Neurobiol., 2007, 67(10), 1348-1361.
60. Moon, S.W.; Chung, E.J.; Jung, S.A.; Lee, J.H. PDGF stimulationof Müller cell proliferation: Contributions of c-JNK and thePI3K/Akt pathway. Biochem. Biophys. Res. Commun., 2009, 388(1), 167-171.
61. Milenkovic, I.; Weick, M.; Wiedemann, P.; Reichenbach, A.; Bringmann, A. P2Y receptor-mediated stimulation of Müller glialcell DNA synthesis: dependence on EGF and PDGF receptor transactivation. Invest. Ophthalmol. Vis. Sci., 2003, 44(3), 1211-1220.
62. Ornelas, I.M.; Ventura, A.L. Involvement of the PI3K/AKT pathwayin ATP-induced proliferation of developing retinal cells in culture. Int. J. Dev. Neurosci., 2010, 28(6), 503-511.
63. Gerasimovskaya, E.V.; Tucker, D.A.; Weiser-Evans, M.; Wenzlau, J.M.; Klemm, D.J.; Banks, M.; Stenmark, K.R. Extracellular ATPinducedproliferation of adventitial fibroblasts requires phosphoinositide3-kinase, Akt, mammalian target of rapamycin, and p70 S6kinase signaling pathways. J. Biol. Chem., 2005, 280(3), 1838-1848.
64. Gerasimovskaya, E.V.; Tucker, D.A.; Stenmark, K.R. Activation ofphosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycinis necessary for hypoxia-induced pulmonary artery adventitialfibroblast proliferation. J. Appl. Physiol., 2005, 98(2), 722-731.
65. Ryu, J.K.; Choi, H.B.; Hatori, K.; Heisel, R.L.; Pelech, S.L.; McLarnon, J.G.; Kim, S.U. Adenosine triphosphate induces proliferationof human neural stem cells: Role of calcium and p70 ribosomalprotein S6 kinase. J. Neurosci. Res., 2003, 72(3), 352-362.
66. Muscella, A.; Elia, M.G.; Greco, S.; Storelli, C.; Marsigliante, S. Activation of P2Y2 receptor induces c-FOS protein through apathway involving mitogen-activated protein kinases and phosphoinositide3-kinases in HeLa cells. J. Cell. Physiol., 2003, 195(2), 234-240.
67. Wilden, P.A.; Agazie, Y.M.; Kaufman, R.; Halenda, S.P. ATPstimulatedsmooth muscle cell proliferation requires independentERK and PI3K signaling pathways. Am. J. Physiol., 1998, 275(4 Pt2), H1209-1215.
68. Gao, L.; Cao, L.; Qiu, Y.; Su, Z.; Burnstock, G.; Xiang, Z.; He, C. Blocking P2X receptors can inhibit the injury-induced proliferationof olfactory epithelium progenitor cells in adult mouse. Int. J. Pediatr. Otorhinolaryngol., 2010, 74(7), 747-751.
69. Jacques-Silva, M.C.; Rodnight, R.; Lenz, G.; Liao, Z.; Kong, Q.; Tran, M.; Kang, Y.; Gonzalez, F.A.; Weisman, G.A.; Neary, J.T.P2X7 receptors stimulate AKT phosphorylation in astrocytes. Br. J. Pharmacol., 2004, 141(7), 1106-1117.
70. Luke, T.M.; Hexum, T.D. UTP and ATP increase extracellularsignal-regulated kinase 1/2 phosphorylation in bovine chromaffincells through epidermal growth factor receptor transactivation. Purinergic Signal., 2008, 4(4), 323-330.
71. Neary, J.T.; Whittemore, S.R.; Zhu, Q.; Norenberg, M.D. Synergisticactivation of DNA synthesis in astrocytes by fibroblast growthfactors and extracellular ATP. J. Neurochem., 1994, 63(2), 490-494.
72. Hengartner, M.O. The biochemistry of apoptosis. Nature, 2000, 407(6805), 770-776.
73. Van Delft, M.F.; Huang, D.C. How the Bcl-2 family of proteinsinteract to regulate apoptosis. Cell. Res., 2006, 16(2), 203-213.
74. Franke, H.; Illes, P. Involvement of P2 receptors in the growth andsurvival of neurons in the CNS. Pharmacol. Ther., 2006, 109(3), 297-324.
75. Lin, A.; Dibling, B. The true face of JNK activation in apoptosis. Aging Cell, 2002, 1(2), 112-116.
76. Song, Y.H.; Godard, M.; Li, Y.; Richmond, S.R.; Rosenthal, N.; Delafontaine, P. Insulin-like growth factor I-mediated skeletalmuscle hypertrophy is characterized by increased mTOR-p70S6Ksignaling without increased Akt phosphorylation. J. Investig. Med., 2005, 53(3), 135-142.
77. Elliott, M.R.; Chekeni, F.B.; Trampont, P.C.; Lazarowski, E.R.; Kadl, A.; Walk, S.F.; Park, D.; Woodson, R.I.; Ostankovich, M.; Sharma, P.; Lysiak, J.J.; Harden, T.K.; Leitinger, N.; Ravichandran, K.S. Nucleotides released by apoptotic cells act as afind-me signal to promote phagocytic clearance. Nature, 2009, 461(7261), 282-286.
78. Tamajusuku, A.S.; Villodre, E.S.; Paulus, R.; Coutinho-Silva, R.; Battasstini, A.M.; Wink, M.R.; Lenz, G. Characterization of ATPinducedcell death in the GL261 mouse glioma. J. Cell. Biochem., 2010, 109(5), 983-991.
79. Adinolfi, E.; Pizzirani, C.; Idzko, M.; Panther, E.; Norgauer, J.; DiVirgilio, F.; Ferrari, D. P2X7 receptor: death or life? Purinergic Signal., 2005, 1(3), 219-227.
80. da Cruz, C.M.; Ventura, A.L.; Schachter, J.; Costa-Junior, H.M.; daSilva Souza, H.A.; Gomes, F.R.; Coutinho-Silva, R.; Ojcius, D.M.; Persechini, P.M. Activation of ERK1/2 by extracellular nucleotidesin macrophages is mediated by multiple P2 receptors independentlyof P2X7-associated pore or channel formation. Br. J. Pharmacol., 2006, 147(3), 324-334.
81. Dutot, M.; Liang, H.; Pauloin, T.; Brignole-Baudouin, F.; Baudouin, C.; Warnet, J.M.; Rat, P. Effects of toxic cellular stressesand divalent cations on the human P2X7 cell death receptor. Mol. Vis., 2008, 14, 889-897.
82. Kong, Q.; Wang, M.; Liao, Z.; Camden, J.M.; Yu, S.; Simonyi, A.; Sun, G.Y.; Gonzalez, F.A.; Erb, L.; Seye, C.I.; Weisman, G.A.P2X7 nucleotide receptors mediate caspase-8/9/3-dependent apoptosisin rat primary cortical neurons. Purinergic Signal., 2005, 1(4), 337-347.
83. Greig, A.V.; Linge, C.; Terenghi, G.; McGrouther, D.A.; Burnstock, G. Purinergic receptors are part of a functional signaling systemfor proliferation and differentiation of human epidermal keratinocytes.J. Invest. Dermatol., 2003, 120(6), 1007-1015.
84. Shabbir, M.; Burnstock, G. Purinergic receptor-mediated effects ofadenosine 5'-triphosphate in urological malignant diseases. Int. J. Urol., 2009, 16(2), 143-150.
85. Bulanova, E.; Budagian, V.; Orinska, Z.; Hein, M.; Petersen, F.; Thon, L.; Adam, D.; Bulfone-Paus, S. Extracellular ATP inducescytokine expression and apoptosis through P2X7 receptor in murinemast cells. J. Immunol., 2005, 174(7), 3880-3890.
86. Zhang, X.; Meng, L.; He, B.; Chen, J.; Liu, P.; Zhao, J.; Zhang, Y.; Li, M.; An, D. The role of P2X7 receptor in ATP-mediated humanleukemia cell death: calcium influx-independent. Acta Biochim. Biophys. Sin. (Shanghai), 2009, 41(5), 362-369.
87. Sellers, L.A.; Simon, J.; Lundahl, T.S.; Cousens, D.J.; Humphrey, P.P.; Barnard, E.A. Adenosine nucleotides acting at the humanP2Y1 receptor stimulate mitogen-activated protein kinases and induceapoptosis. J. Biol. Chem., 2001, 276(19), 16379-16390.
88. Orellano, E.A.; Rivera, O.J.; Chevres, M.; Chorna, N.E.; González, F.A. Inhibition of neuronal cell death after retinoic acid-induceddown-regulation of P2X7 nucleotide receptor expression. Mol. Cell. Biochem., 2010, 337(1-2), 83-99.
89. Ortega, F.; Pérez-Sen, R.; Delicado, E.G.; Miras-Portugal, M.T.P2X7 nucleotide receptor is coupled to GSK-3 inhibition and neuroprotectionin cerebellar granule neurons. Neurotox. Res., 2009, 15(3), 193-204.
90. Solini, A.; Cuccato, S.; Ferrari, D.; Santini, E.; Gulinelli, S.; Callegari, M.G.; Dardano, A.; Faviana, P.; Madec, S.; Di Virgilio, F.; Monzani, F. Increased P2X7 receptor expression and function inthyroid papillary cancer: a new potential marker of the disease?. Endocrinology, 2008, 149(1), 389-396.
91. Mamedova, L.K.; Gao, Z.G.; Jacobson, K.A. Regulation of deathand survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors. Biochem. Pharmacol., 2006, 72(8), 1031-1041.
92. Chorna, N.E.; Santiago-Pérez, L.I.; Erb, L.; Seye, C.I.; Neary, J.T.; Sun, G.Y.; Weisman, G.A.; González, F.A. P2Y receptors activateneuroprotective mechanisms in astrocytic cells. J. Neurochem., 2004, 91(1), 119-132.
93. Franke, H.; Sauer, C.; Rudolph, C.; Krügel, U.; Hengstler, J.G.; Illes, P. P2 receptor-mediated stimulation of the PI3-K/Aktpathway in vivo. Glia, 2009, 57(10), 1031-1045.
94. Elia, M.G.; Muscella, A.; Romano, S.; Greco, S.; Di Jeso, B.; Verri, T.; Storelli, C.; Marsigliante, S. Effects of extracellular nucleotidesin the thyroid: P2Y2 receptor-mediated ERK1/2 activationand c-Fos induction in PC Cl3 cells. Cell. Signal., 2005, 17(6), 739-749.
95. Arthur, D.B.; Georgi, S.; Akassoglou, K.; Insel, P.A. Inhibition ofapoptosis by P2Y2 receptor activation: novel pathways for neuronalsurvival. J. Neurosci., 2006, 26(14), 3798-3804.
96. Muscella, A.; Greco, S.; Elia, M.G.; Storelli, C.; Marsigliante, S. Differential signaling of purinoceptors in HeLa cells through theextracellular signal-regulated kinase and protein kinase C pathways.J. Cell. Physiol., 2004, 200(3), 428-439.
97. Santiago-Pérez, L.I.; Flores, R.V.; Santos-Berríos, C.; Chorna, N.E.; Krugh, B.; Garrad, R.C.; Erb, L.; Weisman, G.A.; González, F.A. P2Y2 nucleotide receptor signaling in human monocytic cells:activation, desensitization and coupling to mitogen-activated proteinkinases. J. Cell. Physiol., 2001, 187(2), 196-208.
98. Tan, C.; Salehi, A.; Svensson, S.; Olde, B.; Erlinge, D. ADP receptorP2Y13 induce apoptosis in pancreatic beta-cells. Cell. Mol. LifeSci., 2010, 67(3), 445-453.
99. Ahmad, S.; Ahmad, A.; White, C.W. Purinergic signaling andkinase activation for survival in pulmonary oxidative stress anddisease. Free Radic. Biol. Med., 2006, 41(1), 29-40.
100. Coutinho-Silva, R.; Stahl, L.; Cheung, K.K.; de Campos, N.E.; deOliveira Souza, C.; Ojcius, D.M.; Burnstock, G. P2X and P2Ypurinergic receptors on human intestinal epithelial carcinoma cells:effects of extracellular nucleotides on apoptosis and cell proliferation. Am. J. Physiol. Gastrointest. Liver Physiol., 2005, 288(5), G1024-G1035.
101. Yoon, M.J.; Lee, H.J.; Kim, J.H.; Kim, D.K. Extracellular ATPinduces apoptotic signaling in human monocyte leukemic cells, HL-60 and F-36P. Arch. Pharm. Res., 2006, 29(11), 1032-1041.
102. Maaser, K.; Höpfner, M.; Kap, H.; Sutter, A.P.; Barthel, B.; vonLampe, B.;, Zeitz, M.; Scherübl, H. Extracellular nucleotides inhibitgrowth of human oesophageal cancer cells via P2Y2-receptors. Br. J. Cancer, 2002, 86(4), 636-644.
103. Ryten, M.; Dunn, P.M.; Neary, J.T.; Burnstock, G. ATP regulatesthe differentiation of mammalian skeletal muscle by activation of aP2X5 receptor on satellite cells. J. Cell. Biol., 2002, 158(2), 345-355.
104. Humphreys, B.D.; Rice, J.; Kertesy, S.B.; Dubyak, G.R. Stressactivatedprotein kinase/JNK activation and apoptotic induction bythe macrophage P2X7 nucleotide receptor. J. Biol. Chem., 2000, 275(35), 26792-26798.
105. Gröschel-Stewart, U.; Bardini, M.; Robson, T.; Burnstock, G. Localisationof P2X5 and P2X7 receptors by immunohistochemistryin rat stratified squamous epithelia. Cell. Tissue Res., 1999, 296(3), 599-605.
106. Lassar, A.B.; Skapek, S.X.; Novitch, B. Regulatory mechanismsthat coordinate skeletal muscle differentiation and cell cycle withdrawal. Curr. Opin. Cell. Biol., 1994, 6(6), 788-794.
107. Walsh, K.; Perlman, H. Cell cycle exit upon myogenic differentiation. Curr. Opin. Genet. Dev., 1997, 7(5), 597-602.
108. Fodor, J.; Matta, C.; Juhász, T.; Oláh, T.; Gönczi, M.; Szíjgyártó, Z.; Gergely, P.; Csernoch, L.; Zákány, R. Ionotropic purinergic receptorP2X4 is involved in the regulation of chondrogenesis inchicken micromass cell cultures. Cell Calcium, 2009, 45(5) 421-430.
109. 2+/calmodulin-dependent kinase IIsignaling cascade mediates P2X7 receptor-dependent inhibition ofneuritogenesis in neuroblastoma cells. FEBS J., 2009, 276(18), 5307-5325.
110. 2+-regulated transcription factor. Cell Calcium, 2010, 47(5), 397-403.
111. 2+ rise, transactivation of the EGF receptor andphosphorylation of ERK and Elk-1. J. Cell. Physiol., 2007, 213(1), 36-44.
112. Cohen, J.E.; Douglas Fields, R. Activity-dependent neuron-glialsignaling by ATP and leukemiainhibitory factor promotes hippocampalglial cell development. Neuron Glia Biol., 2008, 4(1): 43-55.
113. Nishii, N.; Nejime, N.; Yamauchi, C.; Yanai, N.; Shinozuka, K.; Nakabayashi, T. Effects of ATP on the Intracellular Calcium Levelin the Osteoblastic TBR31-2 Cell Line. Biol. Pharm. Bull., 2009, 32(1), 18-23.
114. Wurm, A.; Erdmann, I.; Bringmann, A.; Reichenbach, A.; Pannicke, T. Expression and function of P2Y receptors on Müller cellsof the postnatal rat retina. Glia, 2009, 57(15), 1680-1690.
115. Meyer, M.P.; Swann, K.; Burnstock, G.; Clarke, J.D. The extracellularATP receptor, cP2Y1, inhibits cartilage formation in micromasscultures of chick limb mesenchyme. Dev. Dyn., 2001, 222(3), 494-505.
116. Conigrave, A.D.; Lee, J.Y.; van der Weyden, L.; Jiang, L.; Ward, P.; Tasevski, V.; Luttrell, B.M.; Morris, M.B. Pharmacological profileof a novel cyclic AMP-linked P2 receptor on undifferentiatedHL-60 leukemia cells. Br. J. Pharmacol., 1998, 124(7), 1580-1585.
117. Van Der Weyden, L.; Conigrave, A.D.; Morris, M.B. Signal transductionand white cell maturation via extracellular ATP and theP2Y11 receptor. Immunol. Cell Biol., 2000, 78(4), 369-374.
118. Communi, D.; Janssens, R.; Suarez-Huerta, N.; Robaye, B.; Boeynaems, J.-M. Advances in signaling by extracellular nucleotides:the role and transduction mechanisms of P2Y receptors. Cell. Signal., 2000, 12(6), 351-360.