Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition

Cellular Physiology and Biochemistry

Volumn 26, Issue 2, 2010, Pages 125-134

  Yaguchi, Takahiro ^a   Saito, Masaru ^a   Yasuda, Yoshiyuki ^a   Kanno, Takeshi ^a   Nakano, Takashi ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

ATP; Caco 2 cell; Mitogen activated protein kinase; Proliferation; Protein kinase C

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ADENOSINE TRIPHOSPHATE; CASPASE INHIBITOR; HOE 33342; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; PROPIDIUM IODIDE; PROTEIN ANTIBODY; PROTEIN KINASE C; PURINERGIC P2 RECEPTOR; SURAMIN;

ARTICLE; CELL CYCLE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN CACO 2; CELL VIABILITY; CONCENTRATION RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 78049330168     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000320518     Document Type: Article

References (29)

1. Communi D, Janssens R, Suarez-Huerta N, Robaye B, Boeynaems JM: Advances in signalling by extracellular nucleotides. The role and transduction mechanisms of P2Y receptors. Cell Signal 2000;12:351-360.
2. North RA: Molecular physiology of P2X receptors. Physiol Rev 2002;82:1013-1067.
3. Aihara H, Fujiwara S, Mizuta I, Tada H, Kanno T, Tozaki T, Nagai K, Yajima Y, Inoue K, Kondoh T, Motooka Y, Nishizaki T: Adenosine triphosphate accelerates recovery from hypoxic/ hypoglycemic perturbation of guinea pig hippocampal neurotransmission via a P2 receptor. Brain Res 2002;952:31-37.
4. Inoue K, Koizumi S, Ueno S, Kita A, Tsuda M: The functions of AT P receptors in the synaptic transmission in the hippocampus. Prog Brain Res 1999;120:193-206.
5. Pankratov Y, Castro E, Miras-Portugal MT, Krishtal O: A purinergic component of the excitatory postsynaptic current mediated by P2X receptors in the CA1 neurons of the rat hippocampus. Eur J Neurosci 1998;10:3898-3902.
6. Yamazaki Y, Kaneko K, Fujii S, Kato H, Ito K: Long-term potentiation and long-term depression induced by local application of ATP to hippocampal CA1 neurons of the guinea pig. Hippocampus 2003;13:81-92.
7. Koizumi S, Saito Y, Nakazawa K, Nakajima K, Sawada JI, Kohsaka S, Illes P, Inoue K: Spatial and temporal aspects of Ca2+ signaling mediated by P2Y receptors in cultured rat hippocampal astrocytes. Life Sci 2002;72:431-442.
8. Koizumi S, Fujishita K, Tsuda M, Shigemoto-Mogami Y, Inoue K: Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived AT P in hippocampal cultures. Proc Natl Acad Sci USA 2003;100:11023-11028.
9. Chizh BA, Illes P: P2X receptors and nociception. Pharmacol Rev 2001;53:553-568.
10. Brake AJ, Wagenbach MJ, Julius D: New structural motif for ligand gated ion channels defined by an ionotropic ATP receptor. Nature 1994;371:519-523.
11. Janssens R, Boeynaems JM: Effects of extracellular nucleotides and nucleosides on prostate carcinoma cells. Br J Pharmacol 2001;132:536-546.
12. Maaser K, Höpfner M, Kap H, Sutter AP, Barthel B, von Lampe B, Zeitz M, Scherübl H: Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y2-receptors. Br J Cancer 2002;86:636-644.
13. Katzur AC, Koshimizu T, Tomiæ M, Schultze-Mosgau A, Ortmann O, Stojilkovic SS: Expression and responsiveness of P2Y2 receptors in human en-dometrial cancer cell lines. J Clin Endocrinol Metab 1999;84:4085-4091.
14. Schultze-Mosgau A, Katzur AC, Arora KK, Stojilkovic SS, Diedrich K, Ortmann O: Characterization of calcium-mobilizing, purinergic P2Y2 receptors in human ovarian cancer cells. Mol Hum Reprod 2000;6:435-442.
15. Höpfner M, Lemmer K, Jansen A, Hanski C, Riecken EO, Gavish M, Mann B, Buhr H, Glassmeier G, Scherübl H: Expression of functional P2-purinergic receptors in primary cultures of human colorectal carcinoma cells. Biochem Biophys Res Commun 1998;251:811-817.
16. Höpfner M, Maaser K, Barthel B, von Lampe B, Hanski C, Riecken EO, Zeitz M, Scherübl H: Growth inhibition and apoptosis induced by P2Y2 receptors in human colorectal carcinoma cells: involvement of intracellular calcium and cyclic adenosine monophosphate. Int J Colorectal Dis 2001;16:154-166.
17. Hofmann J: Protein kinase C isozymes as potential targets for anticancer therapy. Curr Cancer Drug Targets 2004;4:125-146.
18. Nishizuka Y: Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 1995;9:484-496.
19. Abbracchio MP, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Miras-Portu-gal MT, King BF, Gachet C, Jacobson KA, Weisman GA, Burnstock G: Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol Sci 2003;24:52-55.
20. Dorsam RT, Kunapuli SP: Central role of the P2Y12 receptor in platelet activation. J Clin Invest 2004;113:340-345.
21. Lee SY, O'Grady SM: Modulation of ion channel function by P2Y receptors. Cell Biochem Biophys 2003;39:75-88.
22. Yasuda Y, Saito M, Yamamura T, Yaguchi T, Nishizaki T. Extracellular adenosine induces apoptosis in Caco-2 human co-lonic cancer cells by activating caspase-9/-3 via A2a adenosine receptors. J Gastroenterol 2009;44:56-65.
23. Kanno T, Yamamoto H, Yaguchi T, Hi R, Mukasa T, Fujikawa H, Nagata T, Yamamoto S, Tanaka A, Nishizaki T: The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site. J Lipid Res 2006;47:1146-1156.
24. Coutinho-Silva R, Stahl L, Cheung KK, de Campos NE, de Oliveira Souza C, Ojcius DM, Burnstock G: P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: effects of extracellular nucleotides on apoptosis and cell proliferation. Am J Physiol Gastrointest Liver Physiol 2005;288:G1024-1035.
25. Bradford MD, Soltoff SP: P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C. Biochem J 2002;366:745-755.
26. Oury C, Toth-Zsamboki E, Vermylen J, Hoylaerts MF: P2X1-mediated activation of extracellular signal-regulated ki-nase 2 contributes to platelet secretion and aggregation induced by collagen. Blood 2002;100:2499-2505.
27. Seetulsingh-Goorah SP, Stewart BW: Growth inhibition of HL-60 cells by extracellular ATP: concentration-dependent involvement of a P2 receptor and adenosine generation. Biochem Biophys Res Commun 1998;250:390-396.
28. Schönwasser DC, Marais RM, Marshall CJ, Parker PJ: Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein ki-nase C isotypes. Mol Cell Biol 1998;18:790-798.
29. Buzzi N, Bilbao PS, Boland R, de Boland AR: Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line. Biochim Biophys Acta 2009;1790:1651-1659.