Purinergic signalling: Pathophysiological roles

Japanese Journal of Pharmacology

Volumn 78, Issue 2, 1998, Pages 113-145

  Abbracchio, Maria P ^a   Burnstock, Geoffrey ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Neurotransmission; P1 receptor; P2 receptor; Pathophysiology

Indexed keywords

ADENOSINE RECEPTOR; ADENOSINE TRIPHOSPHATE; GROWTH FACTOR; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; NUCLEOSIDE; NUCLEOTIDE; PURINE DERIVATIVE; PURINE P2 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; PYRIMIDINE DERIVATIVE; RECEPTOR SUBTYPE;

ANIMAL CELL; APOPTOSIS; CANCER; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL MATURATION; CELL PROLIFERATION; CELL REGENERATION; CHEMICAL STRUCTURE; DRUG DEPENDENCE; DRUG TOXICITY; EMBRYO; EMBRYO DEVELOPMENT; GLIA CELL; HORMONE RELEASE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INFLAMMATION; ISCHEMIA; NERVE FIBER GROWTH; NERVOUS SYSTEM; NEUROIMMUNOLOGY; NEUROTRANSMISSION; NONHUMAN; OSTEOLYSIS; PAIN; PATHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; WOUND HEALING;

EID: 0031770379     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.78.113     Document Type: Review

References (300)

1. Burnstock G: Purinergic nerves. Pharmacol Rev 24, 509-581 (1972)
2. Burnstock G: A basis for distinguishing two types of purinergic receptor. In Cell Membrane Receptors for Drugs and Hormones: A Multidisciplinary Approach, Edited by Straub RW and Bolis L, pp 107-118, Raven Press, New York (1978)
3. Abbracchio MP and Burnstock G: Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol Ther 64, 445-475 (1994)
4. Burnstock G: P2 purinoceptors: historical perspective and classification. In P2 Purinoceptors: Localization, Function and Transduction Mechanisms, Ciba Foundation Symposium, Vol 198, pp 1-29, John Wiley & Sons, Chichester (1996)
5. Evans RJ, Surprenant A and North RA: P2X receptors: cloned and expressed. In The P2 Nucleotide Receptors, Edited by Turner JT, Weisman GA and Fedan JS, pp43-61, Humana Press, Totowa (1997)
6. Weisman GA, Gonzalez FA, Erb L, Garrad RC and Turner JT: The cloning and expression of G protein-coupled P2Y nucleotide receptors. In The P2 Nucleotide Receptors, Edited by Turner JT, Weisman GA and Fedan JS, pp 63-79, Humana Press, Totowa (1997)
7. Burnstock G: Purinoceptors: ontogeny and phylogeny. Drug Dev Res 39, 204-242 (1996)
8. Abbracchio MP: P1 and P2 receptors in cell growth and differentiation. Drug Dev Res 39, 393-406 (1996)
9. DiVirgilio F, Ferrari D, Chiozzi P, Falzoni S, Sanz J, Dal Susino M, Mutini C, Hanau S and Baricordi OR: Purinoceptor function in the immune system. Drug Dev Res 39, 319-329 (1996)
10. Firestein GS: Anti-inflammatory effects of adenosine kinase inhibitors in acute and chronic inflammation. Drug Dev Res 39, 371-376 (1996)
11. Fisette PL, Denlinger LC, Proctor RA and Bertics PJ: Modulation of macrophage function by P2Y-purinergic receptors. Drug Dev Res 39, 377-387 (1996)
12. Drury AN and Szent-Gyorgyi A: The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J Physiol (Lond) 68, 213-237 (1929)
13. Holton P: The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol (Lond) 145, 494-504 (1959)
14. Burnstock G, Campbell G and Rand MJ: The inhibitory innervation of the taenia of the guinea pig caecum. J Physiol (Lond) 182, 504-526 (1966)
15. Burnstock G, Campbell G, Satchell D and Smythe A: Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol 40, 668-688 (1970)
16. Burnstock G: Purinergic receptors. J Theor Biol 62, 491-503 (1976)
17. Williams M: Receptors nomenclature: How, what and when? Trends Pharmacol Sci 8, 251-252 (1987)
18. Burnstock G: Overview (purinergic receptors). In Role of Adenosine and Adenine Nucleotides in the Biological System, Edited by Imai S and Nakazawa M, pp 3-16, Elsevier Science, Amsterdam (1991)
19. Abbracchio MP, Cattabeni F, Fredholm BB and Williams M: Purinoceptor nomenclature: a status report. Drug Dev Res 28, 207-213 (1993).
20. Fredholm, BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P and Williams M: VI. Nomenclature and classification of purinoceptors. Pharmacol Rev 46, 143-156 (1994)
21. Fredholm, BB, Abbracchio MP, Burnstock G, Dubyak GR, Harden TK, Jacobson KA, Schwabe U and Williams M: Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmacol Sci 18, 79-82 (1997)
22. Burnstock G and King BF: Numbering of cloned P2 purinoceptors. Drug Dev Res 38, 67-71 (1996)
23. Burnstock G and Kennedy C: Is there a basis for distinguishing two types of P2-purinoceptor? Gen Pharmacol 16, 433-440 (1985)
24. Gordon JL: Extracellular ATP: effects, sources and fate. Biochem J 233, 309-319 (1986)
25. Pintor J and Miras-Portugal MT: Diadenosine polyphosphates (ApXA) as new neurotransmitters. Drug Dev Res 28, 259-262 (1993)
26. O'Connor SE, Dainty IA and Leff P: Further subclassification of ATP receptors based on agonist studies. Trends Pharmacol Sci 12, 127-141 (1991)
27. 2-purinergic receptors for extracellular ATP. Am J Respir Cell Biol 4, 295-300 (1991)
28. Burnstock G: Noradrenaline and ATP: Cotransmitters and neuromodulators. J Physiol Pharmacol 46, 365-384 (1995)
29. North RA: P2X purinoceptor plethora. Semin Neurosci 8, 187-194 (1996)
30. 7). Science 272, 735-738 (1996)
31. Edwards FA, Gibb AJ and Colquhoun D: ATP receptor-mediated synaptic currents in the central nervous system. Nature 359, 144-145 (1992)
32. 2 purinoceptor from human erythroleukemic cells. J Biol Chem 271, 18363-18367 (1996)
33. 4 that mediates chemotaxis. Nature 387, 337-352 (1996)
34. Bogdanov YD, Dale L, King BF, Whittock N and Burnstock G: Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos. J Biol Chem 272, 12583-12590 (1997)
35. Barnard EA, Burnstock G and Webb TE: G-protein coupled receptors for ATP and other nucleotides: a new receptor family. Trends Pharmacol Sci 15, 67-70 (1994)
36. Harden, TK, Nicholas RA, Schachter JR, Lazarowski ER and Boyer JL: Pharmacological selectivities of molecularly defined subtypes of P2Y receptors. In The P2 Nucleotide Receptors, Edited by Turner JT, Weisman GA and Fedan JS, pp 109-134, Humana Press, Totowa (1997)
37. Burnstock G: Do some nerve cells release more than one transmitter? Neuroscience 1, 239-248 (1976)
38. Burnstock G: Co-trasmission. The fifth Heymans Lecture-Ghent, February 17, 1990. Arch Int Pharmacodyn Ther 304, 7-33 (1990)
39. Burnstock G: Purinergic neurotrasmission. Semin Neurosci 8, 171-257 (1996)
40. Kupferman I: Functional studies of cotransmission. Physiol Rev 71, 683-711 (1991)
41. Kennedy C, Mclaren GJ, Westfall TD and Sneddon P: ATP as a co-transmitter with noradrenaline in sympathetic nerves-function and fate. In P2 Purinoceptors: Localization, Function and Transduction Mechanisms, Ciba Foundation Symposium, Vol 198, pp 223-235, John Wiley & Sons, Chichester (1996)
42. von Kügelgen I and Starke K: Release of noradrenaline and ATP by electrical stimulation and nicotine in guinea pig vas deferens. Naunyn Schmiedebergs Arch Pharmacol 344, 419-429 (1991)
43. Evans RJ and Kennedy C: Characterization of P2-purinoceptors in the smooth muscle of the rat tail artery: a comparison between contractile and electro-physiological responses. Br J Pharmacol 113, 853-860 (1994)
44. Starke K, von Kügelgen I, Driessen B and Bultmann R: ATP release and its prejunctional modulation. In P2 Purinoceptors: Localization, Function and Transduction Mechanisms, Ciba Foundation Symposium, Vol 198, pp 239-259, John Wiley & Sons, Chichester (1996)
45. Taylor EM and Parsons ME: Adrenergic and purinergic neurotransmission in arterial resistance vessels of the cat intestinal circulation. Eur J Pharmacol 164, 23-33 (1989)
46. Schwartz DD and Malik KU: Renal periarterial nerve stimulation-induced vasoconstriction at low frequencies is primarily due to release of a purinergic transmitter in the rat. J Pharmacol Exp Ther 250, 764-771 (1989)
47. Bulloch JM and McGrath JC: Blockade of vasopressor and vas deferens responses by α,β-methylene ATP in the pithed rat. Br J Pharmacol 94, 103-108 (1988)
48. 2X receptors in the pithed rat. J Auton Pharmacol 9, 371-380 (1989)
49. Lagercrantz H: On the composition and function of large dense-cored vesicles in symphathetic nerves. Neuroscience 1, 81-92 (1976)
50. Trachte GT: Angiotensin effects on vas deferens adrenergic and purinergic neurotransmission. Eur J Pharmacol 146, 261-269 (1988)
51. Ellis JL and Burnstock G: Angiotensin neuromodulation of adrenergic and purinergic co-transmission in the guinea pig vas deferens. Br J Pharmacol 97, 1157-1164 (1989)
52. Ellis JL and Burnstock G: Modulation of neurotransmission in the guinea pig vas deferens by capsaicin: involvement of calcitonin gene-related peptide and substance P. Br J Pharmacol 98, 707-713 (1989)
53. Gonçalves J, Bultmann R and Driessen B: Opposite modulation of cotransmitter release in guinea pig vas deferens: increase of noradrenaline and decrease of ATP release by activation of prejunctional β-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol 353, 184-192 (1996)
54. Zimmermann H: Signalling via ATP in the nervous system. Trends Neurosci 17, 420-426 (1994)
55. Inoue T and Kannan MS: Nonadrenergic and noncholinergic excitatory neurotransmission in rat intrapulmonary artery. Am J Physiol 254, H1142-H1148 (1988)
56. Saffrey MJ, Hassall CJS, Hoyle CHV, Belai A, Moss J, Schmidt HHHW, Förstermann U, Murad F and Burnstock G: Nitric oxide synthase and NADPH diaphorase activity in cultured myenteric neurones. Neuroreport 3, 333-336 (1992)
57. Jahr CE and Jessell TM: ATP excites a sub-population of dorsal horn neurons. Nature 304, 730-733 (1983)
58. Salt TE and Hill RG: Excitation of single sensory neurones in the rat caudal trigeminal nucleus by iontophoretically applied adenosine 5′-triphosphate. Neurosci Lett 35, 53-57 (1983)
59. Krishtal OA, Marchenko SM and Obukhov AG: Cationic channels activated by extracellular ATP in rat sensory neurons. Neuroscience 27, 995-1000 (1988)
60. Burnstock G: Autonomic neuroeffector junctions-reflex vasodilatation of the skin. J Invest Dermatol 69, 47-57 (1977)
61. Hoyle CHV and Burnstock G: Neuromuscular transmission in the gastrointestinal tract. In Handbook of Physiology, Section 6: The Gastrointestinal System, Vol 1, Motility and Circulation, Edited by Wood JD, pp 435-464, American Physiological Society, Bethesda (1989)
62. Rand MJ: Nitrergic transmission: nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission. Clin Exp Pharmacol Physiol 19, 147-169 (1992)
63. Sanders KM and Ward SM: Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am J Physiol 262, G379-G392 (1992)
64. Song ZM, Brookes SJ, Neild TO and Costa M: Immunohistochemical and electrophysiological characterization of submucous neurons from the guinea pig small intestine in organ culture. J Auton Nerv Syst 63, 161-171 (1997)
65. Uemura S, Popolo S, Furness JB and Hardy KJ: Nitric oxide synthase in neurons of the human gall-bladder and its colocalization with neuropeptides. J Gastroenterol Hepatol 12, 257-265 (1997)
66. Boucher RC, Knowles MR, Olivier KN, Bennet W, Mason SJ and Stutts MJ: Mechanisms and therapeutic actions of uridine triphosphate in the lung. In Adenosine and Adenine Nucleotides: from Molecular Biology to Integrative Physiology, Edited by Belardinelli L and Pelleg A, pp 525-532, Kluwer, Norwell (1995)
67. Gil-Rodrigo CE, Galdiz B, Gandarias JM, Gomez R and Ainz LF: Characterization of the effects of adenosine, adenosine 5′-triphosphate and related purines on acid secretion in isolated rabbit gastric glands. Pharmacol Res 22, 103-113 (1990)
68. Sasaki T and Gallacher DV: Extracellular ATP activates receptor-operated cation channels in mouse lacrimal acinar cells to promote calcium influx in the absence of phosphoinositide metabolism. FEBS Lett 264, 130-134 (1990)
69. Soltoff SP, McMillian MK and Talamo BR: ATP activates a cation-permeable pathway in rat parotid acinar cells. Am J Physiol 262, C934-C940 (1992)
70. Vincent P: Cationic channels sensitive to extracellular ATP in rat lacrimal cells. J Physiol (Lond) 449, 313-331 (1992)
71. De Mey JG and Vanhoutte PM: Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J Physiol (Lond) 316, 347-355 (1981)
72. 2 purinoceptors on vascular endothelial cells: physiological significance and transduction mechanisms. Trends Pharmacol Sci 11, 34-37 (1990)
73. Burnstock G: Dual control of local blood flow by purines. In Biological Actions of Extracellular ATP, Edited by Dubyak GR and Fedan JA, Vol 603, pp 31-45, New York Academy of Sciences, New York (1990)
74. Natori Y, Moriguchi M, Fujiwara S, Takeshita I, Fukui M, Iwaki T and Kanaide H: Effects of L-NMMA and L-NNA on the selective ATP-induced enhancement of intratumoral blood flow. J Cereb Blood Flow Metab 12, 120-127 (1992)
75. Natori Y, T Baba, Moriguchi M, Takeshita I and Fukui M: Effects of theophylline on the selective increases in intratumoral blood flow induced by intracarotid infusion of adenosine and adenosine triphosphate in C6 glioma-transplanted rat brains. Surg Neurol 37, 8-14 (1992)
76. Berne RM: Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am J Physiol 204, 317-322 (1963)
77. Burnstock G: Development and perspectives of the purinoceptor concept. J Auton Pharmacol 16, 295-302 (1996)
78. 2 purinoceptor agonists: new insulin secretagogues potentially useful in the treatment of non-insulin-dependent diabetes mellitus. In Purinergic Approaches in Experimental Therapeutics, Edited by Jacobson KA and Jarvis MF, pp 253-260, Wiley-Liss, New York (1997)
79. Davidson JS, Wakefield IK, Sohnius U, van der Merwe PA and Millar RP: A novel extracellular nucleotide receptor coupled to phosphoinositidase-C in pituitary cells. Endocrinolology 126, 80-87 (1990)
80. Chen Z-P, Kratzmeier M, Poch A, Xu S, Mcardle CA, Levy A, Mukhopadhyay AK and Lightman SL: Effects of extracellular nucleotides in the pituitary: adenosine triphosphate receptor-mediated intracellular responses in gonadotrope-derived αT3-1 cells. Endocrinology 137, 248-256 (1996)
81. Diverse-Pierluissi M, Dunlap K and Westhead EW: Multiple actions of extracellular ATP on calcium currents in cultured bovine chromamn cells. Proc Natl Acad Sci USA 88, 1261-1265 (1991)
82. 2Y purinoceptor in adrenal chromaffin cells. Br J Pharmacol 106, 833-837 (1992)
83. Gandia L, Garcia AG and Morad M: ATP modulation of calcium channels in chromaffin cells. J Physiol (Lond) 470, 55-72 (1993)
84. 2Y agonists on adenosine transport in cultured chromaffin cells. J Neurochem 60, 613-619 (1993)
85. Houchi H, Okuno M, Yoshizumi M and Oka M: Regulatory mechanism of calcium efflux from cultured bovine adrenal chromaffin cells induced by extracellular ATP. Neurosci Lett 198, 177-180 (1995)
86. Lin LF, Bott MC, Kao L-S and Westhead EW: ATP stimulated catecholamine secretion: response in perfused adrenal glands and a subpopulation of cultured chromaffin cells. Neurosci Lett 183, 147-150 (1995)
87. Otsuguro K-I, Asano T, Ohta T, Ito S and Nakazato Y: ATP-evoked membrane current in guinea pig adrenal chromaffin cells. Neurosci Lett 187, 145-148 (1995)
88. Filippov AK and Brown DA: Activation of nucleotide receptors inhibits high-treshold calcium currents in NG108-15 neuronal hybrid cells. Eur J Neurosci 8, 1149-1155 (1996)
89. 2+ influx and catecholamine release from neuronal cells. News Physiol Sci 7, 56-59 (1992)
90. De Souza LR, Moore H, Raha S and Reed JK: Purine and pyrimidine nucleotides activate distinct signalling pathways in PC12 cells. J Neurosci Res 41, 753-763 (1995)
91. Yakushi Y, Watanabe A, Murayama T and Nomura Y: P2 purinoceptor-mediated stimulation of adenylyl cyclase in PC12 cells. Eur J Pharmacol 314, 243-248 (1996)
92. Nakamura Y and Ohtaki S: Extracellular ATP-induced production of hydrogen peroxide in porcine thyroid cells. J Endocrinol 126, 283-287 (1990)
93. Sato K, Okajima F and Kondo Y: Extracellular ATP stimulates three different receptor-signal transduction systems in FRTL-5 thyroid cells. Biochem J 283, 281-287 (1992)
94. 2. Am J Physiol 267, E323-E330 (1994)
95. Tornquist K, Ekokoski E and Dugue B: Purinergic agonist ATP is a comitogen in thyroid FRTL-5 cells. J Cell Physiol 166, 241-248 (1996)
96. 2-purinoceptors on human and porcine granulosa cells. J Clin Endocrinol Metabol 78, 650-656 (1994)
97. Soodak LK, Macdonald GJ and Behrman HR: Luteolysis is linked to luteinizing hormone-induced depletion of adenosine triphosphate in vivo. Endocrinology 122, 187-193 (1988)
98. 2-purinergic receptors: modulation of follicle-stimulating hormone responses. Endocrinology 134, 1537-1545 (1994)
99. Neary JT, Rathbone MP, Cattabeni F, Abbracchio MP and Burnstock G: Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells. Trends Neurosci 19, 13-18 (1996)
100. 2+ release from InsP3-sensitive stores in mammalian oligodendrocytes. J Physiol (Lond) 483, 41-57 (1995)
101. Kirischuk S, Moller T, Voitenko N, Kettenmann H and Verkhratsky A: ATP-induced cytoplasmic calcium mobilization in Bergmann glial cells. J Neurosci 15, 7861-7871 (1995)
102. Amédéé T and Despeyroux S: ATP activates cationic and anionic conductances in Schwann cells cultured from dorsal root ganglia of the mouse. Proc R Soc Lond B 259, 277-284 (1995)
103. Ansselin AD, Davey DF and Alien DG: Extracellular ATP increases intracellular calcium in cultured adult Schwann cells. Neuroscience 76, 947-955 (1997)
104. Kettenmann H, Banati R and Walz W: Electrophysiological behavior of microglia. Glia 7, 93-101 (1993)
105. Priller J, Haas CA, Reddington M and Kreutzberg GW: Calcitonin gene-related peptide and ATP induce immediate early gene expression in cultured rat microglial cells. Glia 15, 447-457 (1995)
106. Ferrari D, Villalba M, Chiozzi P, Falzoni S, Ricciardi-Castagnoli P and Di Virgilio F: Mouse microglial cells express a plasma membrane pore gated by extracellular ATP. J Immunol 156, 1531-1539 (1996)
107. Yeung CH: Temporary inhibition of the initiation of motility of demembranated hamster sperm by high concentrations of ATP. Int J Androl 9, 359-370 (1986)
108. Foresta C, Rossato M and Di Virgilio F: Extracellular ATP is a trigger for the acrosome reaction in human spermatozoa. J Biol Chem 267, 19443-19447 (1992)
109. + channel involved in sperm-induced fertilization. Science 261, 484-486 (1993)
110. 2+-mobilizing receptors of gastrulating chick embryo. Comp Biochem Physiol [C] 97, 1-12 (1990)
111. Hilfer SR, Palmatier BY and Fithian EM: Precocious evagination of the embryonic chick thyroid in ATP-containing medium. J Embryol Exp Morphol 42, 163-175 (1977)
112. Smuts MS: Rapid nasal pit formation in mouse embryos stimulated by ATP-containing medium. J Exp Zool 216, 409-414 (1981)
113. Wells DG, Zawisa MJ and Hume RI: Changes in responsiveness to extracellular ATP in chick skeletal muscle during development and upon denervation. Dev Biol 172, 585-590 (1995)
114. 2+ responses to ATP via purinoceptors in the early embryonic chick retina. J Physiol (Lond) 493, 855-863 (1996)
115. 1-purinoceptors on rat duodenum and urinary bladder. Br J Pharmacol 105, 639-642 (1992)
116. Petrungaro S, Salustri A and Siracusa G: Adenosine potentiates the delaying effect of dbcAMP on meiosis resumption in denuded mouse oocytes. Cell Biol Int Rep 10, 993 (1986)
117. X/+mutant limb outgrowth by adenosine deaminase. Differentiation 33, 270-279 (1987)
118. Wakade TD, Palmer KC, McCauley R, Przywara DA and Wakade AR: Adenosine-induced apoptosis in chick embryonic sympathetic neurons: A new physiological role for adenosine. J Physiol (Lond) 488, 123-138 (1995)
119. Crossland WJ, Kulkarni J and Wakade AR: The effects of adenosine and 2-deoxyadenosine on chick embryo sympathetic ganglion cells in vivo. In Proceedings of Society for Neuroscience 26th Annual Meeting, Washington, DC, November 16-21, Abstracts part 1, p 44 (1996)
120. Rozengurt E: Adenosine receptor activation in quiescent Swiss 3T3 cells: Enhancement of cAMP levels, DNA synthesis and cell division. Exp Cell Res 139, 71-78 (1982)
121. 2Y purinoceptor with covalently bound 3′-O-(4-benzoyl)-benzoyl-adenosine 5′-triphosphate. Proc Natl Acad Sci USA 87, 9717-9721 (1990)
122. Sandberg G and Fredholm BB: Regulation of thymocyte proliferation: effects of L-alanine, adenosine and cyclic AMP in vitro. Thymus 3, 63-75 (1981)
123. Pospisil M, Hofer M, Netikova J, Pipalova I, Vacek A, Bartonickova A and Volenec K: Elevation of extracellular adenosine induces radioprotective effects in mice. Radiat Res 134, 323-330 (1993)
124. Wang D-J, Huang N-N and Heppel L: Extracellular ATP and ADP stimulate proliferation of porcine aortic smooth muscle cells. J Cell Physiol 153, 221-233 (1992)
125. Malam-Souley R, Campan M, Gadeau A-P and Desgranges C: Exogenous ATP induces limited cell cycle progression of arterial smooth muscle cells. Am J Physiol 264, C783-C788 (1993)
126. Yu S-M, Chen S-F, LAU Y-T, YANG C-M and Chen J-C: Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells. Mol Pharmacol 50, 1000-1009 (1996)
127. 1 phase in vascular smooth muscle cells in primary culture. Biochem Biophys Res Commun 222, 652-658 (1996)
128. Dusseau JW and Hutchins PM: Hypoxia-induced angiogenesis in chick chorioallantoic membranes: a role for adenosine. Respir Physiol 71, 33-44 (1988)
129. Huang N, Wang D and Heppel LA: Extracellular ATP is a mitogen for 3T3, 3T6, and A431 cells and acts synergistically with other growth factors. Proc Natl Acad Sci USA 86, 7904-7908 (1989)
130. Gonzales FA, Bonapace E, Belzer I, Friedberg l and Heppel LA: Two distinct receptors for ATP can be distinguished in swiss 3T6 mouse fibroblasts by their desensitization. Biochem Biophys Res Commun 164, 706-713 (1989)
131. Rapaport E: Treatment of human tumor cells with ADP or ATP yield arrest of growth in the S phase of the cell cycle. J Cell Physiol 114, 279-283 (1983)
132. Weisman GA, Lustig KD, Lane E, Huang N, Blezer I and Friedberg I: Growth inhibition of transformed mouse fibroblasts by adenine nucleotides occurs via generation of extracellular adenosine. J Biol Chem 263, 12367-12372 (1988)
133. Belzer I and Friedberg I: ATP-resistant variants of transformed mouse fibroblasts. J Cell Physiol 140, 524-529 (1989)
134. Friedberg I, Belzer I, Oged-Plesz O and Kuebler D: Activation of cell growth inhibitor by ectoprotein kinase-mediated phosphorylation in transformed mouse fibroblasts. J Biol Chem 270, 20560-20567 (1995)
135. Rapaport E, Fishman RF and Cercel C: Growth inhibition of human tumor cells in soft-agar cultures by treatment with low levels of adenosine 5′-triphosphate. Cancer Res 43, 4402-4406 (1983)
136. Spungin B and Friedberg I: Growth inhibition of breast cancer cells induced by exogenous ATP. J Cell Physiol 157, 502-508 (1993)
137. 3 receptor. Pathophysiological significance and therapeutic implications for neurodegenerative disorders. Ann NY Acad Sci 825, 11-22 (1997)
138. 2+ transients are not required for platelet-derived growth factor to induce cell cycle progression of vascular smooth muscle cells in primary culture. Actions of tyrosine kinase. J Biol Chem 269, 9011-9018 (1994)
139. Neary JT: Trophic actions of extracellular ATP on astrocytes, synergistic interactions with fibroblast growth factors and underlying signal transduction mechanisms. In P2 Purinoceptors: Localization, Function and Transduction Mechanisms, Ciba Foundation Symposium, Vol 198, pp 130-141, John Wiley & Sons, Chichester (1996)
140. mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. Mol Endocrinol 5, 845-854 (1992)
141. Hatten ME, Liem RKH, Shelanski ML and Mason CA: Astroglia in CNS injury. Glia 4, 233-243 (1991)
142. Abbracchio MP: ATP in brain function. In Purinergic Approaches in Experimental Therapeutics, Edited by Jacobson KA and Jarvis MF, pp 383-404, Wiley-Liss, New York (1997)
143. Abbracchio MP, Ceruti S, Bolego C, Puglisi L, Burnstock G and Cattabeni F: Trophic roles of P2 purinoceptors in central nervous system astroglial cells. In P2 Purinoceptors: Localization, Function and Transduction Mechanisms, Ciba Foundation Symposium, Vol 198, pp 142-148, John Wiley & Sons, Chichester (1996)
144. Neary JT, Whittemore SR, Zhu Q and Norenberg MD: Synergistic activation of DNA synthesis in astrocytes by fibroblast growth factor and extracellular ATP. J Neurochem 63, 490-494 (1994)
145. Abbracchio MP, Ceruti S, Langfelder R, Cattabeni F, Saffrey MJ and Burnstock G: Effects of ATP analogues and basic fibroblast growth factor on astroglial cell differentiation in primary cultures of rat striatum. Int J Dev Neurosci 13, 685-693 (1995)
146. Bolego C, Ceruti S, Brambilla R, Puglisi L, Cattabeni F, Burnstock G and Abbracchio MP: Characterization of the signalling pathways involved in ATP and basic fibroblast growth factor-induced astrogliosis. Br J Pharmacol 121, 1692 -1699 (1997)
147. Gysbers JW and MP Rathbone: GTP and guanosine synergistically enhance NGF-induced neurite outgrowth from PC12 cells. Int J Dev Neurosci 14, 19-34 (1996)
148. 2B-receptors mediate an increase in IL-6 mRNA and IL-6 protein synthesis in human astroglioma cells (abstract). Drug Dev Res 37, 174 (1996)
149. + conductance in cultured microglial cells from mouse brain. J Neurosci 13, 4403-4411 (1993)
150. Langosch JM, Gebicke-Haerter PJ, Nornberg W and Illes P: Characterization and transduction mechanisms of purinoceptors in activated rat microglia. Br J Pharmacol 113, 29-34 (1994)
151. Jacobson MD and Evan GI: Breaking the ICE. Curr Biol 4, 337-340 (1994)
152. Herman MA, Schulz CA and Claude P: Responses to cAMP depend on stage of neuronal differentiation of NGF-treated adrenal chromaffin cells. Dev Biol 161, 477-489 (1994)
153. Tigyi G, Fischer DJ, Sebok A, Marshall F, Dyer DL and Miledi R: Lysophosphatidic acid-induced neurite retraction in PC12 cells: neurite-protective effects of cyclic AMP signaling. J Neurochem 66, 549-558 (1996)
154. Lamoureux P, Altun-Gultekin ZF, Lin C, Wagner JA and Heidemann SR: Rac is required for growth cone function but not neurite assembly. J Cell Sci 110, 635-641 (1997)
155. Abbracchio MP, Cattabeni F, Clementi F and Sher E: Adenosine receptors linked to adenylate cyclase activity in human neuroblastoma cells: modulation during cell differentiation. Neuroscience 30, 819-825 (1989)
156. Guroff G, Dickens G, End D and Londos C: The action of adenosine analogs on PC12 cells. J Neurochem 37, 1431-1439 (1981)
157. 2 antagonists. Neuroreport 2, 661-664 (1991)
158. Gysbers JW and Rathbone MP: Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells. Neuroreport 3, 977-1000 (1992)
159. Glasky AJ, Ritzmann RF, Melchoir CL, Hindley S, Gysbers JW and Rathbone MP: Effect of AIT-082 on neuritogenesis in vitro and working memory in vivo. Soc Neurosci Abstr 20, 38 (1993)
160. Baumann N, Jacque C and Dupouey P: Astrocyte modifications in neurological mutations of the mouse. In Astrocytes: Cell Biology and Pathology of Astrocytes, Edited by Federoff S and Vernadakis A, Vol 3, pp 325-336, Academic Press, Orlando (1986)
161. Gysbers JW and MP Rathbone: Neurite outgrowth in PC12 cells is enhanced by guanosine through both cAMP-dependent and -independent mechanisms. Neurosci Lett 220, 175-178 (1996)
162. Svensson B, Biessels GJ and Ekstrom AR: Detection of a purine analogue-sensitive kinase in frog sciatic nerves-possible involvement in nerve regeneration. Eur J Neurosci 5, 1017-1023 (1993)
163. Edstrom A, Edbladh M and Ekstrom P: Adenosine inhibition of the regeneration in vitro of adult frog sciatic sensory axons. Brain Res 570, 35-41 (1992)
164. Rudge JS: Astrocyte-derived neurotrophic factors. In Astrocytes: Pharmacology and Function, Edited by Murphy S, pp 267-305, Academic Press, San Diego (1993)
165. Zafra F, Lindholm D, Castris E, Hartikka J and Thoenen H: Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes. J Neurosci 12, 4793-4799 (1992)
166. Barde Y-A: Trophic factors and neuronal survival. Neuron 2, 1525-1534 (1989)
167. Lindsay RM, Altar CA, Cedarbaum JM, Hyman C and Wiegand SJ: The therapeutic potential of neurotrophic factors in the treatment of Parkinson's Disease. Exp Neurol 124, 103-118 (1993)
168. Middlemiss PJ, Gysbers JW and Rathbone MP: Extracellular guanosine and guanosine-5′-triphosphate increase: NGF synthesis and release from cultured mouse neopallial astrocytes. Brain Res 677, 152-156 (1995)
169. Neary JT, Baker L, Jorgensen SL and Norenberg MD: Extracellular ATP induces stellation and increases glial fibrillary acidic protein content and DNA synthesis in primary astrocytic cultures. Acta Neuropathol 87, 8-13 (1994)
170. Wang D-J, Huang N-N and Heppel L: Extracellular ATP shows synergistic enhancement of DNA synthesis when combined with agents that are active in wound healing or as neurotransmitters. Biochem Biophys Res Commun 166, 251-258 (1990)
171. Neary JT and Zhu Q: Signalling by ATP receptors in astrocytes. Neuroreport 5, 1617-1620 (1994)
172. TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358, 414-417 (1992)
173. Erlinge D, Yoo H, Edvinsson L, Reis DJ and Wanlestedt C: Mitogenic effects of ATP on vascular smooth muscle cells vs other growth factors and sympathetic cotransmitters. Am J Physiol 265, H1089-H1097 (1993)
174. Schäfer K-H, Saffrey MJ and Burnstock G: Trophic actions of 2-chloroadenosine and bFGF on cultured myenteric neurones. Neuroreport 6, 937-941 (1995)
175. Rapaport E: Experimental cancer therapy in mice by adenine nucleotides. Eur J Cancer Clin Oncol 24, 1491-1497 (1988)
176. Rapaport E: Anticancer activities of adenine nucleotides in tumor bearing hosts. Drug Dev Res 28, 428-431 (1993)
177. Rapaport E and Fontaine J: Generation of extracellular ATP in blood and its mediated inhibition of host weight loss in tumor-bearing mice. Biochem Pharmacol 38, 4261-4266 (1989)
178. Rapaport E: Treatment of advanced cancer with ATP infusions: purinoceptors in cancer. Drug Dev Res 37, 174 (1996)
179. 2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells. J Clin Invest 89, 191-196 (1992)
180. 2Z receptors in ATP-mediated killing of tumor necrosis factor-sensitive and tumor necrosis factor-resistant L929 fibroblasts. J Immunol 149, 3372-3378 (1992)
181. Kitagawa T and Akamatsu Y: Control of passive permeability of chinese hamster ovary cells by external and intracellular ATP. Biochim Biophys Acta 649, 76-82 (1981)
182. Rozengurt E, Heppel LA and Friedberg I: Effect of exogenous ATP on the permeability properties of transformed cultures of mouse cell lines. J Biol Chem 262, 4584-4590 (1977)
183. Heppel LA, Weisman GA and Friedberg I: Permeabilization of transformed cells in culture by external ATP. J Membr Biol 86, 189-196 (1985)
184. Correale P, Caraglia M, Procopio A, Marinetti MR, Guarrasi R, Fabbrocini A, Bianco AR and Tagliaferri P: Transmembrane ion flux modifiers verapamil and ouabain modulate cytotoxic effects of extracellular ATP on human tumor cells in
185. Mure T, Sano K and Kitagawa T: Modulation of membrane permeability, cell proliferation and cytotoxicity of antitumor agents by external ATP in mouse tumor cells. Jpn J Cancer Res 83, 121-126 (1992)
186. King KL and Cidlowski JA: Cell cycle and apoptosis: common pathways to life and death. J Cell Biochem 58, 175-180 (1995)
187. 2Z purinoceptor: an intriguing role in immunity, inflammation and cell death. Immunol Today 16, 524-528 (1995)
188. Di Virgilio, F, Pizzo P, Zanovello P, Bronte V and Collavo D: Extracellular ATP as a possible mediator of cell-mediated cytotoxicity. Immunol Today 11, 274-277 (1990)
189. Murgia M, Pizzo P, Steinberg TH and Di Virgilio F: Characterization of the cytotoxic effect of extracellular ATP in J774 macrophages. Biochem J 288, 897-901 (1992)
190. Zheng LM, Zychlinsky A, Liu C-C, Ojeius DM and Young JD-E: Extracellular ATP as a trigger for apoptosis or programmed cell death. J Cell Biol 112, 279-288 (1991)
191. + in dissipation of the mitochondrial membrane potential and cell death induced by extracellular ATP in hepatocytes. Biochem J 208, 207-213 (1992)
192. Hosoi K and Edidin M: Exogenous ATP and other nucleoside phosphates modulate epidermal growth factor receptors of A-431 epidermoid carcinoma cells. Proc Natl Acad Sci USA 86, 4510-4514 (1989)
193. Hosoi K, Fujishita M, Sugita K, Kurihara K, Atsumi T, Murai T and Ueha T: P2 purinergic receptors and cellular calcium metabolism in A431 human epidermoid carcinoma cells. Am J Physiol 263, C635-C643 (1992)
194. Kinzer D and Lehmann V: Extracellular ATP and adenosine modulate tumor necrosis factor-induced lysis of L929 cells in the presence of actinomycin D. J Immunol 146, 2708-2711 (1991)
195. Bronte V, Zanovello P, Rosato A, Zambon A, Mandruzzato S, Pizzo P, Di Virgilio F and Collavo D: Synergistic effect of extracellular adenosine 5′-triphosphate and tumor necrosis factor on DNA degradation. Cell Immunol 152, 110-119 (1993)
196. Taylor CW and Yeoman LC: Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine. Anti-Cancer Drugs 3, 485-491 (1992)
197. Henriksson T: Inhibition of natural killing by adenosine ribonucleotides. Immun Lett 7, 171-176 (1983)
198. Priebe, T, Platsoucas CD and Nelson JA: Adenosine receptors and modulation of natural killer cell activity by purine nucleosides. Cancer Res 50, 4328-4331 (1990)
199. Baba T, Fukui M, Sakata S, Tashima T, Takeshita I, Nakamura T and Inoue T: Selective enhancement of intratumoural blood flow in malignant gliomas: experimental study in rats by intracarotid administration of adenosine or adenosine triphosphate. Acta Neurochir 101, 66-74 (1989)
200. Baba T, Fukui M, Takeshita I, Ichiya Y, Kuwabara Y and Hasuo K: Selective enhancement of intratumoral blood flow in malignant gliomas using intra-arterial adenosine triphosphate. J Neurosurg 72, 907-911 (1990)
201. Gil M, Skopinska-Rosewska E, Radomska D, Demkow U, Skurzak H, Rochowska M, Beuth J and Roszkowski K: Effect of purinergic receptor antagonsits suramin and theobromine on tumor-induced angiogenesis in BALB/C mice. Folia Biol (Praha) 39, 63 (1993)
202. Phillis JW and Wu PH: Adenosine may regulate the vascular supply and thus the growth and spread of neoplastic tissues: a proposal. Gen Pharmacol 12, 309-310 (1981)
203. Bodin P and Burnstock G: Synergistic effect of acute hypoxia on flow-induced release of ATP from cultured endothelial cells. Experientia 51, 256-259 (1995)
204. Bodin P and Burnstock G: ATP-stimulated release of ATP by human endothelial cells. J Cardiovasc Pharmacol 27, 872-875 (1996)
205. Hamann M and Attwell D: Non-synaptic release of ATP by electrical stimulation in slices of rat hippocampus, cerebellum and habenula. Eur J Neurosci 8, 1510-1515 (1996)
206. Petruzzi E, Orlando C, Pinzani P, Sestini R, Del Rosso A, Dini G, Tanganelli E, Buggiani A and Pazzagli M: Adenosine triphosphate release by osmotic shock and hemoglobin A1C in diabetic subjects erythrocytes. Metabolism 43, 435-440 (1994)
207. Li BY, Li WH and Bai Y: Relationship between platelet density and platelet aggregation, ATP release, and cytosolic-free calcium mobilization in rabbits. Acta Pharmacol Sin 16, 367-372 (1995)
208. Uemura Y, Miller JM, Matson WR and Beal MF: Neurochemical analysis of focal ischemia in rats. Stroke 22, 1548-1553 (1991)
209. Rudolphi KA and Schubert P: Adenosine and brain ischemia. In Adenosine and Adenine Nucleotides: from Molecular Biology to Integrative Physiology, Edited by Belardinelli L and Pelleg A, pp 391-397, Kluwer, Norwell (1995)
210. Stella N, Estelles A, Siciliano J, Tence M, Desagher S, Piomelli D, Glowinski J and Premont J: Interleukin-1 enhances the ATP-evoked release of arachidonic acid from mouse astrocytes. J Neurosci 17, 2939-2946 (1997)
211. Phillis JW and O'Regan MH: Prevention of ischemic brain injury by adenosine receptor activation. Drug Dev Res 28, 390-394 (1993)
212. Lasley RD and Mentzer RM: Myocardial protection: the adenosine story. Drug Dev Res 39, 314-318 (1996)
213. Liu G-S, Downey JM and Cohen MV: Adenosine, ischemia and preconditioning. In Purinergic Approaches in Experimental Therapeutics, Edited by Jacobson KA and Jarvis MF, pp 153-172, Wiley-Liss, New York (1997)
214. 2 following prolonged ischemia improves myocardial performance. J Surg Res 43, 114-117 (1987)
215. Muralidharan S, Rambaran H, Laub GW, Chen C, GU J and McGrath LB: Effect of adenosine triphosphate on the postischemic left ventricular function of the immature myocardium. Chest 102, 577-580 (1992)
216. Reibel, DK and Rovetto MJ: Myocardial adenosine salvage rates and restoration of ATP content following ischemia. Am J Physiol 237, H247-H252 (1979)
217. Boiling, SF, Bies LE and Bove EL: Effect of ATP synthesis promoters on postischemic myocardial recovery. J Surg Res 49, 205-211 (1990)
218. Kim J-K, Rathbone MP, Middlemiss PJ, Hughes DW and Smith RW: Purinergic stimulation of astroblast proliferation: guanosine and its nucleotides stimulate cell division in chick astroblasts. J Neurosci Res 28, 442-455 (1991)
219. Rathbone MP, Christjanson L, DeForge S, DeLuca B, Gysbers JW, Hindley S, Jovetich M, Middlemiss P and Takhal S: Extracellular purine nucleosides stimulate cell division and morphogenesis: pathological and physiological implications. Med Hypotheses 37, 232-240 (1992)
220. Neary JT and Norenberg MD: Signalling by extracellular ATP: Physiological and pathological considerations in neuronalastrocytic interactions. Prog Brain Res 94, 145-151 (1992)
221. Abbracchio MP, Saffrey MJ, Hopker V and Burnstock G: Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum. Neuroscience 59, 67-76 (1994)
222. Abbracchio MP, Ceruti S, Burnstock G and Cattabeni F: Purinoceptors on glial cells of the central nervous system: functional and pathological implications. In Adenosine and Adenine Nucleotides: from Molecular Biology to Integrative Physiology, Edited by Belardinelli L and Pelleg A, pp 271-280, Kluwer, Norwell (1995)
223. Ciccarelli R, Di Iorio P, Ballerini P, Ambrosini G, Giuliani P, Tiboni GM and Caciagli F: Effects of exogenous ATP and related analogues on the proliferation rate of dissociated primary cultures of rat astrocytes. J Neurosci Res 39, 556-566 (1994)
224. Ceruti S, Barbieri D, Veronese E, Cattabeni F, Cossarizza A, Giammarioli AM, Malorni W, Franceschi C and Abbracchio MP: Different pathways of apoptosis revealed by 2-chloroadenosine and deoxy-D-ribose in mammalian astroglial cells. J Neurosci Res 47, 372-383 (1997)
225. Fischer S, Sharma HS, Karliczek GF and Schaper W: Expression of vascular permeability factor/vascular endothelial growth factor in pig cerebral microvascular endothelial cells and its upregulation by adenosine. Mol Brain Res 28, 141-148 (1995)
226. Ziada AMAR, Hudlicka O, Tyler KR and Wright AJA: The effect of long-term vasodilatation on capillary growth and performance in rabbit heart and skeletal muscle. Cardiovasc Res 18, 724-732 (1984)
227. Picano E and Michelassi C: Chronic oral dipyridamole as a novel antianginal drug: the collateral hypothesis. Cardiovasc Res 33, 666-670 (1997)
228. Diener HC, Cunha L, Forbes C, Sivenius J, Smets P and Lowenthal A: European stroke prevention study 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 143, 1-13 (1996)
229. Fitzgerald GA: Dipyridamole. N Engl J Med 316, 1247-1257 (1987)
230. Picano E and Abbracchio MP: European stroke prevention study-2 results: serendipitous demonstration of neuroprotection induced by endogenous adenosine accumulation? Trends Pharmacol Sci 19, 14-16 (1998)
231. Namiot Z, Marcinkiewicz M, Jaroszewicz W, Stasiewicz J and Gorski J: Mucosal adenosine deaminase activity and gastric ulcer healing. Eur J Pharmacol 243, 301-303 (1993)
232. Sponsel HT, Breckon R and Anderson RJ: Adenine nucleotide and protein kinase C regulation of renal tubular epithelial cell wound healing. Kidney Int 48, 85-92 (1995)
233. Frame MK and de Feijter AW: Propagation of mechanically induced intercellular calcium waves via gap junctions and ATP receptors in rat liver epithelial cells. Exp Cell Res 230, 197-207 (1997)
234. Vaes G: Cellular biology and biochemical mechanism of bone resorption. Clin Orthop 231, 239-271 (1988)
235. Zaidi M, Alam AS, Shankar VS, Bax BE, Bax CM, Moonga BS, Bevis PJ, Stevens C, Blake DR and Pazianas M: Cellular biology of bone resorption. Biol Rev Cambridge Philosophic Soc 68, 197-264 (1993)
236. 4-: elimination of osteoclasts, macrophages, and their precursors from isolated bone cell populations and fetal bone rudiments. Calcif Tissue Int 55, 141-150 (1994)
237. Nijweide PJ, Modderman WE and Hagenaars CE: Extracellular adenosine triphosphate: A shock to hemopoietic cells. Clin Orthop 313, 92-102 (1995)
238. Yu H and Ferrier J: Osteoblast-like cells have a variable mixed population of purino/nucleotide receptors. FEBS Lett 328, 209-214 (1993)
239. Yu H and Ferrier J: Osteoclast ATP receptor activation leads to a transient decrease in intracellular pH. J Cell Sci 108, 3051-3058 (1995)
240. 2-purinoceptors at the surface of human articular chondrocytes in monolayer culture. Biochim Biophys Acta 1074, 151-158 (1991)
241. Leong WS, Russell GG and Caswell AM: Induction of enhanced responsiveness of human articular chondrocytes to extracellular ATP by tumour necrosis factor-α. Clin Sci 85, 569-575 (1993)
242. Hatori M, Teixeira CC, Debolt K, Pacifici M and Shapiro IM: Adenine nucleotide metabolism by chondrocytes in vitro: role of ATP in chondrocyte maturation and matrix mineralization. J Cell Physiol 165, 468-474 (1995)
243. Kumagai H, Sakamoto H, Guggino S, Filburn CR and Sacktor B: Neurotransmitter regulation of cytosolic calcium in osteoblast-like bone cells. Calcif Tissue Int 45, 251-254 (1989)
244. 2-purinoceptors on human osteoblast-like cells. J Bone Min Res 7, 485-491 (1992)
245. i in rat osteoblastic cells by interaction with two receptor subtypes. Am J Physiol 23, C1040-C1048 (1992)
246. 2U purinergic receptors with similar second messenger signaling pathways in UMR-106 osteoblasts. J Pharmacol Exp Ther 269, 1049-1061 (1994)
247. 2U purinoceptor present in osteoclastoma, bone, and osteoblasts. J Bone Miner Res 10, 1137-1145 (1995)
248. Sistare FD, Rosenzweig BA and Contrera JG: P2 purinergic receptors potentiate parathyroid hormone receptor-mediated increases in intracellular calcium and inositol trisphosphate in UMR-106 rat osteoblasts. Endocrinology 136, 4489-4497 (1995)
249. Grant GA, Barlow JA and Leach KE: Modification of survival of gamma irradiated mice by adenosine nucleotides. Strahlentherapie (Sonderb) 152, 285-291 (1976)
250. Senagore AJ, Milsom JW, Walshaw RK, Mostoskey U, Dunstan R and Chaudry IH: Adenosine triphosphate-magnesium chloride in radiation injury. Surgery 112, 933-939 (1992)
251. 2. 1. Effects on the cis-diamminedichloroplatinum-treated isolated perfused kidneys. J Surg Res 38, 429-437 (1985)
252. Gao W, Hijiofca T, Lindert KA, Caldwell-Kenkel JC, Lemasters JJ and Thurman RG: Evidence that adenosine is a key component in carolina rinse responsible for reducing graft failure after orthotopic liver transplantation in the rat. Transplantation 52, 992-998 (1991)
253. 2 and dipyridamole pretreatment in renal preservation. J Surg Res 32, 70-74 (1982)
254. 1-purinoceptors. Arch Int Pharmacodyn Ther 264, 180-186 (1983)
255. Wang YJ and Borkan SC: Prior heat stress enhances survival of renal epithelial cells after ATP depletion. Am J Physiol 270, F1057-F1065 (1996)
256. Borkan SC, Wang YH, Lieberthal W, Burke PR and Schwartz JH: Heat stress ameliorates ATP depletion-induced sublethal injury in mouse proximal tubule cells. Am J Physiol 272, F347-F355 (1997)
257. Proctor, RA, Denlinger LC, Leventhal PS, Daugherty SK, Van de Loo J-W, Tanke T, Firestein GS and Bertics PJ: Protection of mice from endotoxic death by 2-methylthio-ATP. Proc Natl Acad Sci USA 91, 6017-6020 (1994)
258. Ali A, Goldberg RN, Suguthara C, Huang J, Martinez O, Feuer W and Bancalari E: Effects of ATP-Magnesium chloride on the cardiopulmonary manifestations of Group B streptococcal sepsis in the piglet. Pediatr Res 39, 609-615 (1996)
259. Cronstein BN, Bouma MG and Becker BF: Purinergic mechanisms in inflammation. Drug Dev Res 39, 426-435 (1996)
260. Denlinger, LC, Fisette PL, Garis KA, Kwon G, Vazquez-Torres A, Simon AD, Nguyen B, Proctor RA, Berics PJ and Corbett JA: Regulation of inducible nitric oxide synthase expression by macrophage purinoceptors and calcium. J Biol Chem 271, 337-342 (1996)
261. Verghese MV, Kneisler TB and Boucheron JA: P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells. J Biol Chem 271, 15597-15601 (1996)
262. Green PG, Luo J, Heller P and Levine JD: Modulation of bradykinin-induced plasma extravasation in the rat knee joint by sympathetic co-transmitters. Neuroscience 52, 451-458 (1993)
263. Ziganshina, LE, Ziganshin AU, Hoyle CH and Burnstock G: Acute paw oedema formation induced by ATP: re-evaluation of the mechanisms involved. Inflamm Res 45, 96-102 (1996)
264. Cheng Y, Chen M, James-Kracke M, Wixom P and Sun AY: Enhanced lipid peroxidation by extracellular ATP in PC12 cells. Neurochem Res 21, 27-33 (1996)
265. Hourani S, Di Virgilio F and Loubatieres-Mariani M-M: Physiological roles for P2 receptors in platelets, visceral smooth muscle, and the immune and endocrine systems. In The P2 Nucleotide Receptors, Edited by Turner JT, Weisman GA and Fedan JS, pp 361-411, Humana Press, Totowa (1997)
266. 2-purinergic receptors for extracellular ATP and other nucleotides. Am J Physiol 265, C577-C606 (1993)
267. Di Virgilio F, Bronte V, Collavo D and Zanovello P: Responses of mouse lymphocytes to extracellular adenosine 5′-triphosphate (ATP). Lymphocytes with cytotoxic activity are resistant to the permeabilizing effects of ATP. J Immunol 143, 1955-1960 (1989)
268. Chiozzi P, Murgia M, Falzoni S, Ferrari D and Di Virgilio F: Role of the purinergic P2Z receptor in spontaneous cell death in J774 macrophage cultures. Biochem Biophys Res Commun 218, 176-181 (1996)
269. Falzoni S, Munerati M, Ferrari D, Spisani S, Moretti S and Di Virgilio F: The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role. J Clin Invest 95, 1207-1216 (1995)
270. Jamieson GP, Snook MB, Thurlow PJ and Wiley JS: Extracellular ATP causes loss of L-selectin from human lymphocytes via occupancy of P2Z purinoceptors. J Cell Physiol 166, 637-642 (1996)
271. Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineau SM, Weidner JR, Aunins J, Elliston KO, Ayala JM, Casano FJ, Chin J, Ding GJ-F, Egger LA, Gaffney EP, Limjuco G, Palyha OC, Raja SM, Rolando AM, Salley JP, Yamin T-T, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA and Tocci MJ: A novel heterodimeric cystein protease is required for interleukin-1β processing in monocytes. Nature 356, 768-774 (1992)
272. 2+-mediated mechanisms. Biochem J 304, 877-885 (1994)
273. Szondy Z: The 2-chloro-deoxyadenosine-induced cell death signalling pathway in human thymocytes is different from that induced by 2-chloroadenosine. Biochem J 311, 585-588 (1995)
274. Giblett ET, Anderson JR, Cohen F, Pollara B and Meuwissen HJ: Adenosine deaminase deficiency in two patients with severely impaired cellular immunity. Lancet 2, 1067-1069 (1972)
275. Cohen A, Hirschhorn R, Horowitz SD, Rubinstein A, Palmar SH, Hong R and Martin DW Jr: Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency. Proc Natl Acad Sci USA 75, 471-476 (1978)
276. Burnstock G: A unifying purinergic hypothesis for the initiation of pain. Lancet 347, 1604-1605 (1996)
277. Chen C-C, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G and Wood JN: A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377, 428-431 (1995)
278. 3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377, 432-435 (1995)
279. Burnstock G and Wood JN: Purinergic receptors: their role in nociception and primary afferent neurotransmission. Curr Opin Neurobiol 6, 526-532 (1996)
280. Cook SP, Vulchanova L, Hargreaves KM, Elde R and McCleskey EW: Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature 387, 505-508 (1997)
281. 2 receptor by neurotransmitters and related substances. Br J Pharmacol 120, 221-224 (1997)
282. Kennedy C and Leff P: Painful connection for ATP. Nature 377, 385 (1995)
283. Salter J, De Koninck Y and Henry JL: Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn. Prog Neurobiol 41, 125-156 (1993)
284. Bardoni R, Goldstein PA, Lee CJ, Gu JG and Macdermott AB: ATP P2X receptors mediate fast synaptic transmission in the dorsal horn of the rat spinal cord. J Neurosci 17, 5297-5304 (1997)
285. 2 purinoceptor to ATP revealed by changing extracellular pH. Br J Pharmacol 117, 1371-1373 (1996)
286. Li C, Peoples RW and Weight FF: Acid pH augments excitatory action of ATP on a dissociated mammalian sensory neuron. Neuroreport 7, 2151-2154 (1996)
287. Levine JD, Fye K, Heller P, Basbaum AI and Whiting-O'Keefe Q: Clinical response to regional intravenous guanethidine in patients with rheumatoid arthritis. J Rheumatol 13, 1040-1043 (1986)
288. Crowe R and Whitear M: Quinacrine fluorescence of Merkel cells in Xenopus laevis. Cell Tissue Res 190, 273-283 (1978)
289. Malinovsky L and Pac L: Is the Merkel cell a secondary sensory cell? Z Mikrosk Anat Forsch 99, 119-128 (1985)
290. Burnstock G: Pathophysiology of migraine: a new hypothesis. Lancet 1, 1397-1399 (1981)
291. Crea F, Pupita G, Galassi AR, El-Tamimi H, Kaski JC, Davies G and Maseri A: Role of adenosine in pathogenesis of anginal pain. Circulation 81, 164-172 (1990)
292. Kindgen-Milles D and Holthusen H: Nociception from blood vessels is independent of the sympathetic nervous system under physiological conditions in humans. Eur J Pharmacol 328, 41-44 (1997)
293. Maehara Y, Kusumoto H, Anai H, Kusumoto T and Sugimachi K: Human tumor tissues have higher ATP contents than normal tissues. Clin Chim Acta 169, 341-344 (1987)
294. Siems WG, Grune T, Schmidt H, Tikhonov YV and Pimenov AM: Purine nucleotide levels in host tissues of Ehrlich ascites tumor-bearing mice in different growth phases of the tumor. Cancer Res 53, 5143-5147 (1993)
295. Janig W: Neurophysiological mechanisms of cancer pain. Recent Cancer Res 89, 45-58 (1984)
296. Driessen B, Reimann W, Selve N, Friderichs E and Bultmann R: Antinociceptive effect of intrathecally administered P2-purinoceptor antagonists in rats. Brain Res 666, 182-188 (1994)
297. Collier, HOJ and Tucker JF: Novel form of drug-dependence on adenosine in guinea pig ileum. Nature 302, 618-621 (1983)
298. Salem A and Hope W: Effect of adenosine receptor agonists and antagonists on the expression of opiate withdrawal in rats. Pharmacol Biochem Behav 57, 671-679 (1997)
299. Malec D, Michalska E and Pikulicka J: Influence of adenosinergic drugs on ethanol withdrawal syndrome in rats. Pol J Pharmacol 48, 583-588 (1996)
300. 1 receptor agonist, suppresses ethanol withdrawal syndrome in rats. Alcohol Alcohol 29, 261-264 (1994)