메뉴 건너뛰기




Volumn 103, Issue 5, 2007, Pages 1785-1800

P2Y2 nucleotide receptors inhibit trauma-induced death of astrocytic cells

Author keywords

Apoptosis; Cell survival; Neuroprotection; Purinergic receptors

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE; CASPASE 9; DNA FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 9; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEOTIDE; P2Y2 NUCLEOTIDE RECEPTOR; PD 1693; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SURAMIN; UNCLASSIFIED DRUG; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PURINERGIC P2 RECEPTOR; PURINERGIC P2Y2 RECEPTOR;

EID: 36248932131     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04872.x     Document Type: Article
Times cited : (30)

References (85)
  • 1
    • 0028329654 scopus 로고
    • Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum
    • Abbrachio M. P., Saffrey M. J., Hopker V. Burnstock G. (1994) Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum. Neurosci. 59, 67 76.
    • (1994) Neurosci. , vol.59 , pp. 67-76
    • Abbrachio, M.P.1    Saffrey, M.J.2    Hopker, V.3    Burnstock, G.4
  • 2
    • 0035146929 scopus 로고    scopus 로고
    • Life-or-death decisions by the Bcl-2 protein family
    • Adams J. M. Cory S. (2001) Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci. 26, 61 66.
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 61-66
    • Adams, J.M.1    Cory, S.2
  • 3
    • 0034093306 scopus 로고    scopus 로고
    • Stretch-induced injury alters mitochondrial membrane potential and cellular ATP in cultured astrocytes and neurons
    • Ahmed S. M., Rzigalinski B. A., Willoughby K. A., Sitterding H. A. Ellis E. F. (2000) Stretch-induced injury alters mitochondrial membrane potential and cellular ATP in cultured astrocytes and neurons. J. Neurochem. 74, 1951 1960.
    • (2000) J. Neurochem. , vol.74 , pp. 1951-1960
    • Ahmed, S.M.1    Rzigalinski, B.A.2    Willoughby, K.A.3    Sitterding, H.A.4    Ellis, E.F.5
  • 4
    • 30044441160 scopus 로고    scopus 로고
    • 2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation
    • 2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. Proc. Natl Acad. Sci. USA 102, 19138 19143.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 19138-19143
    • Arthur, D.B.1    Akassoglou, K.2    Insel, P.A.3
  • 6
    • 1542317747 scopus 로고    scopus 로고
    • Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotection
    • Bambrick L., Kristian T. Fiskum G. (2004) Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotection. Neurochem. Res. 29, 601 608.
    • (2004) Neurochem. Res. , vol.29 , pp. 601-608
    • Bambrick, L.1    Kristian, T.2    Fiskum, G.3
  • 7
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248 254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 8
    • 10844280686 scopus 로고    scopus 로고
    • Mitochondria and neuronal death/survival signaling pathways in cerebral ischemia
    • Chan P. H. (2004) Mitochondria and neuronal death/survival signaling pathways in cerebral ischemia. Neurochem. Res. 29, 1943 1949.
    • (2004) Neurochem. Res. , vol.29 , pp. 1943-1949
    • Chan, P.H.1
  • 9
    • 0037203537 scopus 로고    scopus 로고
    • Apoptotic signaling pathways: Caspases and stress-activated protein kinases
    • Cho S. G. Choi E. J. (2002) Apoptotic signaling pathways: caspases and stress-activated protein kinases. J. Biochem. Mol. Biol. 35, 24 27.
    • (2002) J. Biochem. Mol. Biol. , vol.35 , pp. 24-27
    • Cho, S.G.1    Choi, E.J.2
  • 11
    • 33845420318 scopus 로고    scopus 로고
    • Stretch-Activated signaling pathways responsible for early response gene expression in fetal lung epithelial cells
    • Copland I. B. Post M. (2007) Stretch-Activated signaling pathways responsible for early response gene expression in fetal lung epithelial cells. J. Cell. Physiol. 210, 133 143.
    • (2007) J. Cell. Physiol. , vol.210 , pp. 133-143
    • Copland, I.B.1    Post, M.2
  • 12
    • 1542498425 scopus 로고    scopus 로고
    • Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons
    • Dai Y., Fukuoka T., Wang H., Yamanaka H., Obata K., Tokunaga A. Noguchi K. (2004) Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons. Pain 108, 258 266.
    • (2004) Pain , vol.108 , pp. 258-266
    • Dai, Y.1    Fukuoka, T.2    Wang, H.3    Yamanaka, H.4    Obata, K.5    Tokunaga, A.6    Noguchi, K.7
  • 13
    • 0037063692 scopus 로고    scopus 로고
    • The role of extracellular signal regulated kinase in cognitive and motor deficits following experimental traumatic brain injury
    • Dash P. K., Mach S. A. Moore A. N. (2002) The role of extracellular signal regulated kinase in cognitive and motor deficits following experimental traumatic brain injury. Neurosci. 114, 755 767.
    • (2002) Neurosci. , vol.114 , pp. 755-767
    • Dash, P.K.1    MacH, S.A.2    Moore, A.N.3
  • 15
    • 33746364197 scopus 로고    scopus 로고
    • Bcl-2 phosphorylation by p38 MAPK: Identification of target sites and biological consequences
    • De Chiara G., Marcocci M. E., Torcia M. et al. (2006) Bcl-2 phosphorylation by p38 MAPK: identification of target sites and biological consequences. J. Biol. Chem. 281, 21353 21361.
    • (2006) J. Biol. Chem. , vol.281 , pp. 21353-21361
    • De Chiara, G.1    Marcocci, M.E.2    Torcia, M.3
  • 16
    • 0029151874 scopus 로고
    • A new model for rapid stretch-induced injury of cells in culture: Characterization of the model using astrocytes
    • Ellis E. F., Mckinney J. S., Willoughby K. A., Liang S. Povlishock J. T. (1995) A new model for rapid stretch-induced injury of cells in culture: characterization of the model using astrocytes. J. Neurotrauma 12, 325 339.
    • (1995) J. Neurotrauma , vol.12 , pp. 325-339
    • Ellis, E.F.1    McKinney, J.S.2    Willoughby, K.A.3    Liang, S.4    Povlishock, J.T.5
  • 17
    • 0028987857 scopus 로고
    • 2U purinoreceptors: Positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity
    • 2U purinoreceptors: positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity. J. Biol. Chem. 270, 4185 4188.
    • (1995) J. Biol. Chem. , vol.270 , pp. 4185-4188
    • Erb, L.1    Garrad, R.A.2    Wang, Y.3    Quinn, T.4    Turner, J.T.5    Weisman, G.A.6
  • 20
    • 0033782296 scopus 로고    scopus 로고
    • Mitochondrial participation in ischemic and traumatic neural cell death
    • Fiskum G. (2000) Mitochondrial participation in ischemic and traumatic neural cell death. J. Neurotrauma 17, 843 855.
    • (2000) J. Neurotrauma , vol.17 , pp. 843-855
    • Fiskum, G.1
  • 23
    • 0000064578 scopus 로고    scopus 로고
    • Altered expression of bcl-2, bcl-X, bax, and c-fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats
    • Gillardon F., Lenz C., Waschke K. F., Krajewski S., Reed J. C., Zimmermann M. Kuschinsky W. (1996) Altered expression of bcl-2, bcl-X, bax, and c-fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats. Brain Res. Mol. Brain Res. 40, 254 260.
    • (1996) Brain Res. Mol. Brain Res. , vol.40 , pp. 254-260
    • Gillardon, F.1    Lenz, C.2    Waschke, K.F.3    Krajewski, S.4    Reed, J.C.5    Zimmermann, M.6    Kuschinsky, W.7
  • 24
    • 0022629214 scopus 로고
    • Extracellular ATP: Effects, sources, and fate
    • Gordon J. L. (1986) Extracellular ATP: effects, sources, and fate. Biochem. J. 233, 309 319.
    • (1986) Biochem. J. , vol.233 , pp. 309-319
    • Gordon, J.L.1
  • 25
    • 0032861127 scopus 로고    scopus 로고
    • Extracellular-signal-regulated kinase signalling in neurons
    • Grewal S. S., York R. D. Stork P. J. S. (1999) Extracellular-signal- regulated kinase signalling in neurons. Curr. Opin. Neurobiol. 9, 544 553.
    • (1999) Curr. Opin. Neurobiol. , vol.9 , pp. 544-553
    • Grewal, S.S.1    York, R.D.2    Stork, P.J.S.3
  • 26
    • 0033179760 scopus 로고    scopus 로고
    • Bcl-2 family members and the mitochondria in apoptosis
    • Gross A., McDonnell J. M. Korsmeyer S. J. (1999) Bcl-2 family members and the mitochondria in apoptosis. Genes Dev. 13, 1899 1911.
    • (1999) Genes Dev. , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 27
    • 10244229166 scopus 로고    scopus 로고
    • Mitochondrial impairment in the developing brain after hypoxia-ischemia
    • Hagberg H. (2004) Mitochondrial impairment in the developing brain after hypoxia-ischemia. J. Bioenerg. Biomembr. 36, 369 373.
    • (2004) J. Bioenerg. Biomembr. , vol.36 , pp. 369-373
    • Hagberg, H.1
  • 28
    • 0037336296 scopus 로고    scopus 로고
    • Glial neuronal signaling in the central nervous system
    • Hannson E. Ronnback L. (2003) Glial neuronal signaling in the central nervous system. FASEB J. 17, 341 348.
    • (2003) FASEB J. , vol.17 , pp. 341-348
    • Hannson, E.1    Ronnback, L.2
  • 29
    • 30344484510 scopus 로고    scopus 로고
    • Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo
    • Harada C., Nakamura K., Namekata K. et al. (2006) Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. Am. J. Pathol. 168, 261 269.
    • (2006) Am. J. Pathol. , vol.168 , pp. 261-269
    • Harada, C.1    Nakamura, K.2    Namekata, K.3
  • 30
    • 0035033952 scopus 로고    scopus 로고
    • Signalling for survival and death in neurons: The role of stress-activated kinases, JNK and p38
    • Harper S. J. LoGrasso P. (2001) Signalling for survival and death in neurons: the role of stress-activated kinases, JNK and p38. Cell. Signal. 13, 299 310.
    • (2001) Cell. Signal. , vol.13 , pp. 299-310
    • Harper, S.J.1    Lograsso, P.2
  • 31
    • 0033566291 scopus 로고    scopus 로고
    • Concurrent loss and proliferation of astrocytes following lateral fluid percussion brain injury in the adult rat
    • Hill-Felberg S. J., McIntosh T. K., Oliver D. L. Raghupathi R. Barbarese E. (1999) Concurrent loss and proliferation of astrocytes following lateral fluid percussion brain injury in the adult rat. J. Neurosci. Res. 57, 271 279.
    • (1999) J. Neurosci. Res. , vol.57 , pp. 271-279
    • Hill-Felberg, S.J.1    McIntosh, T.K.2    Oliver, D.L.3    Raghupathi, R.4    Barbarese, E.5
  • 32
    • 0033807228 scopus 로고    scopus 로고
    • Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling
    • Housley M. D. Kolch W. (2000) Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling. Mol. Pharmacol. 58, 659 668.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 659-668
    • Housley, M.D.1    Kolch, W.2
  • 33
    • 23944479376 scopus 로고    scopus 로고
    • Molecular mechanisms of apoptosis induced by mechanical forces
    • Hsieh M. H. Nguyen H. T. (2005) Molecular mechanisms of apoptosis induced by mechanical forces. Int. Rev. Cytol. 245, 45 90.
    • (2005) Int. Rev. Cytol. , vol.245 , pp. 45-90
    • Hsieh, M.H.1    Nguyen, H.T.2
  • 34
    • 0037025261 scopus 로고    scopus 로고
    • 2+ signalling in glial cell pathology in the central nervous system
    • 2+ signalling in glial cell pathology in the central nervous system. Eur. J. Pharmacol. 447, 247 260.
    • (2002) Eur. J. Pharmacol. , vol.447 , pp. 247-260
    • James, G.1    Butt, A.M.2
  • 35
    • 33751079649 scopus 로고    scopus 로고
    • 2 purinergic receptors in facial motoneurons after nerve lesions in rodents and correlation with motoneuron degeneration
    • 2 purinergic receptors in facial motoneurons after nerve lesions in rodents and correlation with motoneuron degeneration. Neurobiol. Dis. 25, 121 133
    • (2007) Neurobiol. Dis. , vol.25 , pp. 121-133
    • Kassa, R.M.1    Bentivoglio, M.2    Mariotti, R.3
  • 36
    • 33646550833 scopus 로고    scopus 로고
    • Inflammatory and apoptotic signaling after spinal cord injury
    • Keane R. W., Davis A. R. Dietrich W. D. (2006) Inflammatory and apoptotic signaling after spinal cord injury. J. Neurotrauma 23, 335 344.
    • (2006) J. Neurotrauma , vol.23 , pp. 335-344
    • Keane, R.W.1    Davis, A.R.2    Dietrich, W.D.3
  • 37
    • 0034235663 scopus 로고    scopus 로고
    • Role of p38 mitogen-activated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cell
    • Kikuchi M., Tenneti L. Lipton S. A. (2000) Role of p38 mitogen-activated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cell. J. Neurosci. 20, 5037 5044.
    • (2000) J. Neurosci. , vol.20 , pp. 5037-5044
    • Kikuchi, M.1    Tenneti, L.2    Lipton, S.A.3
  • 38
    • 0037203546 scopus 로고    scopus 로고
    • Akt: Versatile mediator of cell survival and beyond
    • Kim D. Chung J. (2002) Akt: Versatile mediator of cell survival and beyond. J. Biochem. Mol. Biol. 35, 106 115.
    • (2002) J. Biochem. Mol. Biol. , vol.35 , pp. 106-115
    • Kim, D.1    Chung, J.2
  • 39
    • 33746379603 scopus 로고    scopus 로고
    • JNK- and p38 kinase-mediated phosphorylation of bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells
    • Kim B., Ryu S. Song B. (2006) JNK- and p38 kinase-mediated phosphorylation of bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J. Biol. Chem. 281, 21256 21265.
    • (2006) J. Biol. Chem. , vol.281 , pp. 21256-21265
    • Kim, B.1    Ryu, S.2    Song, B.3
  • 42
    • 0018628641 scopus 로고
    • Fibrillary astrocytes proliferate in response to brain injury: A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine
    • Latov N., Nilaver G., Zimmerman E. A., Johnson W. G., Silverman A. J., Defendini R. Cote L. (1979) Fibrillary astrocytes proliferate in response to brain injury: a study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine. Dev. Biol. 72, 381 384.
    • (1979) Dev. Biol. , vol.72 , pp. 381-384
    • Latov, N.1    Nilaver, G.2    Zimmerman, E.A.3    Johnson, W.G.4    Silverman, A.J.5    Defendini, R.6    Cote, L.7
  • 43
    • 0030882314 scopus 로고    scopus 로고
    • Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation
    • Lazarowski E. R., Homoloya L., Boucher R. C. Harden T. K. (1997) Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation. J. Biol. Chem. 272, 24348 24354.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24348-24354
    • Lazarowski, E.R.1    Homoloya, L.2    Boucher, R.C.3    Harden, T.K.4
  • 47
    • 0033965412 scopus 로고    scopus 로고
    • Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins
    • Lutz R. J. (2000) Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins. Biochem. Soc. Trans. 28, 51 56.
    • (2000) Biochem. Soc. Trans. , vol.28 , pp. 51-56
    • Lutz, R.J.1
  • 48
    • 0034954305 scopus 로고    scopus 로고
    • Mechanical trauma induces rapid astroglial activation of ERK/MAP kinase: Evidence for a paracrine signal
    • Mandell J. W., Gocan N. C. Vandenberg S. R. (2001) Mechanical trauma induces rapid astroglial activation of ERK/MAP kinase: evidence for a paracrine signal. Glia 34, 283 295.
    • (2001) Glia , vol.34 , pp. 283-295
    • Mandell, J.W.1    Gocan, N.C.2    Vandenberg, S.R.3
  • 49
    • 33749679450 scopus 로고    scopus 로고
    • Key regulators in bee venom-induced apoptosis are bcl-2 and caspase-3 in human leukemic U937 cells through down-regulation of ERK and Akt
    • Moon D. O., Park S. Y., Heo M. S., Kim K. C., Park C., Ko W. S., Choi Y. H. Kim G. Y. (2006) Key regulators in bee venom-induced apoptosis are bcl-2 and caspase-3 in human leukemic U937 cells through down-regulation of ERK and Akt. Int. Immunopharmacol. 6, 1796 1807.
    • (2006) Int. Immunopharmacol. , vol.6 , pp. 1796-1807
    • Moon, D.O.1    Park, S.Y.2    Heo, M.S.3    Kim, K.C.4    Park, C.5    Ko, W.S.6    Choi, Y.H.7    Kim, G.Y.8
  • 51
    • 0037401763 scopus 로고    scopus 로고
    • Activation of P2Y2 receptor induces c-fos protein through a pathway involving mitogen-activated protein kinases and phosphoinositide 3-kinases in HeLa cells
    • Muscella A., Elia M. G., Graco S., Storelli C. Marsigliante S. (2003) Activation of P2Y2 receptor induces c-fos protein through a pathway involving mitogen-activated protein kinases and phosphoinositide 3-kinases in HeLa cells. J. Cell. Physiol. 195, 234 240.
    • (2003) J. Cell. Physiol. , vol.195 , pp. 234-240
    • Muscella, A.1    Elia, M.G.2    Graco, S.3    Storelli, C.4    Marsigliante, S.5
  • 52
    • 33749508895 scopus 로고    scopus 로고
    • Essential protective roles of reactive astrocytes in traumatic brain injury
    • Myer D. J., Gurkoff G. G., Lee S. M., Hovda D. A. Sofroniew M. V. (2006) Essential protective roles of reactive astrocytes in traumatic brain injury. Brain 129, 2761 2772.
    • (2006) Brain , vol.129 , pp. 2761-2772
    • Myer, D.J.1    Gurkoff, G.G.2    Lee, S.M.3    Hovda, D.A.4    Sofroniew, M.V.5
  • 53
    • 0032895885 scopus 로고    scopus 로고
    • Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: Possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis
    • Nakahara S., Yone K., Sakou T., Wada S., Nagamine T., Niiyama T. Ichijo H. (1999) Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis. J. Neuropathol. Exp. Neurol. 58, 442 450.
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 442-450
    • Nakahara, S.1    Yone, K.2    Sakou, T.3    Wada, S.4    Nagamine, T.5    Niiyama, T.6    Ichijo, H.7
  • 54
    • 28844455030 scopus 로고    scopus 로고
    • Protein kinase signaling cascades in CNS trauma
    • Neary J. T. (2005) Protein kinase signaling cascades in CNS trauma. IUBMB Life 57, 711 718.
    • (2005) IUBMB Life , vol.57 , pp. 711-718
    • Neary, J.T.1
  • 56
    • 24644471872 scopus 로고    scopus 로고
    • Signaling from P2 nucleotide receptors to protein kinase cascades induced by CNS injury: Implications for reactive gliosis and neurodegeneration
    • Neary J. T. Kang Y. (2005) Signaling from P2 nucleotide receptors to protein kinase cascades induced by CNS injury: implications for reactive gliosis and neurodegeneration. Mol. Neurobiol. 31, 95 103.
    • (2005) Mol. Neurobiol. , vol.31 , pp. 95-103
    • Neary, J.T.1    Kang, Y.2
  • 57
    • 33746888712 scopus 로고    scopus 로고
    • P2 purinergic receptors signal to glycogen synthase kinase-3b in astrocytes
    • Neary J. T. Kang Y. (2006) P2 purinergic receptors signal to glycogen synthase kinase-3b in astrocytes. J. Neurosci. Res. 84, 515 524.
    • (2006) J. Neurosci. Res. , vol.84 , pp. 515-524
    • Neary, J.T.1    Kang, Y.2
  • 58
    • 0028123312 scopus 로고
    • Extracellular ATP induces stellation and increases glial fibrillary acidic protein content and DNA synthesis in primary astocyte cultures
    • Neary J. T., Baker L., Jorgensen S. L. Norenberg M. D. (1994a) Extracellular ATP induces stellation and increases glial fibrillary acidic protein content and DNA synthesis in primary astocyte cultures. Acta Neurpathol. 87, 8 13.
    • (1994) Acta Neurpathol. , vol.87 , pp. 8-13
    • Neary, J.T.1    Baker, L.2    Jorgensen, S.L.3    Norenberg, M.D.4
  • 59
    • 0027936235 scopus 로고
    • Synergistic activation of DNA synthesis in astrocytes by fibroblast growth factors and extracellular ATP
    • Neary J. T., Whittermore S. R., Zhu Q. Norenberg M. D. (1994b) Synergistic activation of DNA synthesis in astrocytes by fibroblast growth factors and extracellular ATP. J. Neurochem. 63, 490 494.
    • (1994) J. Neurochem. , vol.63 , pp. 490-494
    • Neary, J.T.1    Whittermore, S.R.2    Zhu, Q.3    Norenberg, M.D.4
  • 60
    • 0037444676 scopus 로고    scopus 로고
    • Activation of ERK by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors
    • Neary J. T., Kang Y., Willoughby K. A. Ellis E. F. (2003) Activation of ERK by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors. J. Neurosci. 23, 2348 2356.
    • (2003) J. Neurosci. , vol.23 , pp. 2348-2356
    • Neary, J.T.1    Kang, Y.2    Willoughby, K.A.3    Ellis, E.F.4
  • 61
    • 17844388314 scopus 로고    scopus 로고
    • Traumatic injury activates protein kinase B/Akt in cultured astrocytes: Role of extracellular ATP and P2 purinergic receptors
    • Neary J. T., Kang Y., Tran M. Feld J. (2005) Traumatic injury activates protein kinase B/Akt in cultured astrocytes: role of extracellular ATP and P2 purinergic receptors. J. Neurotrauma 22, 491 500.
    • (2005) J. Neurotrauma , vol.22 , pp. 491-500
    • Neary, J.T.1    Kang, Y.2    Tran, M.3    Feld, J.4
  • 62
    • 30644468596 scopus 로고    scopus 로고
    • JNK/SAPK and p38/SAPK-2 mediate mechanical stretch-induced apoptosis via caspase-3 and -9 in NRK-52E renal epithelial cells
    • Nguyen H. T., Hsieh M. H., Gaborro A., Tinloy B., Phillips C. Adam R. M. (2006) JNK/SAPK and p38/SAPK-2 mediate mechanical stretch-induced apoptosis via caspase-3 and -9 in NRK-52E renal epithelial cells. Nephron Exp. Nephrol. 102, 49 61.
    • (2006) Nephron Exp. Nephrol. , vol.102 , pp. 49-61
    • Nguyen, H.T.1    Hsieh, M.H.2    Gaborro, A.3    Tinloy, B.4    Phillips, C.5    Adam, R.M.6
  • 63
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with conserved homolog, bax, that accelerates programmed cell death
    • Oltvai Z. N., Milliman C. L. Korsmeyer S. J. (1993) Bcl-2 heterodimerizes in vivo with conserved homolog, bax, that accelerates programmed cell death. Cell 74, 609 619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 64
    • 0036197012 scopus 로고    scopus 로고
    • Differential activation of mitogen-activated protein kinase pathways after traumatic brain injury in the rat hippocampus
    • Otani N., Nawashiro H., Fukui S., Nomura N., Yano A., Miyazawa T. Shima K. (2002) Differential activation of mitogen-activated protein kinase pathways after traumatic brain injury in the rat hippocampus. J. Cereb. Blood Flow Metab. 22, 327 334.
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 327-334
    • Otani, N.1    Nawashiro, H.2    Fukui, S.3    Nomura, N.4    Yano, A.5    Miyazawa, T.6    Shima, K.7
  • 65
    • 10744222950 scopus 로고    scopus 로고
    • Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8 and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells
    • Park M., Choi J., Kim M. et al. (2003) Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8 and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. J. Biol. Chem. 278, 50624 50634.
    • (2003) J. Biol. Chem. , vol.278 , pp. 50624-50634
    • Park, M.1    Choi, J.2    Kim, M.3
  • 67
    • 29044432341 scopus 로고    scopus 로고
    • The anti-apoptotic effect of leukotriene B4 in neutrophils: A role for phosphatidylinositol 3-kinase, extracellular siganl-regulated kinase and Mcl-1
    • Petrin D., Turcotte S., Gilbert A. K., Rola-Pleszczynski M. Stankova J. (2006) The anti-apoptotic effect of leukotriene B4 in neutrophils: a role for phosphatidylinositol 3-kinase, extracellular siganl-regulated kinase and Mcl-1. Cell. Signal. 18, 479 487.
    • (2006) Cell. Signal. , vol.18 , pp. 479-487
    • Petrin, D.1    Turcotte, S.2    Gilbert, A.K.3    Rola-Pleszczynski, M.4    Stankova, J.5
  • 69
    • 0034320568 scopus 로고    scopus 로고
    • Mechanisms of apoptosis
    • Reed J. C. (2000) Mechanisms of apoptosis. Am. J. Pathol. 157, 1415 1430.
    • (2000) Am. J. Pathol. , vol.157 , pp. 1415-1430
    • Reed, J.C.1
  • 70
    • 20744449939 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 applied to the optic nerve after axotomy increases bcl-2 and decreases bax in ganglion cells by activating the extracellular signal-regulated kinase signaling pathway
    • Ríos-Muñoz W., Soto I., Duprey-Díaz M. V., Blagburn J. Blanco R. E. (2005) Fibroblast growth factor 2 applied to the optic nerve after axotomy increases bcl-2 and decreases bax in ganglion cells by activating the extracellular signal-regulated kinase signaling pathway. J. Neurochem. 93, 1422 1433.
    • (2005) J. Neurochem. , vol.93 , pp. 1422-1433
    • Ríos-Muñoz, W.1    Soto, I.2    Duprey-Díaz, M.V.3    Blagburn, J.4    Blanco, R.E.5
  • 71
    • 10244227953 scopus 로고    scopus 로고
    • Mitochondrial dysfunction contributes to cell death following traumatic brain injury in adult and immature animals
    • Robertson C. L. (2004) Mitochondrial dysfunction contributes to cell death following traumatic brain injury in adult and immature animals. J. Bioenerg. Biomembr. 36, 363 368.
    • (2004) J. Bioenerg. Biomembr. , vol.36 , pp. 363-368
    • Robertson, C.L.1
  • 73
    • 0033844429 scopus 로고    scopus 로고
    • Expression of genes involved in initiation, regulation, and execution of apoptosis in human neutrophils and during neutrophil differentiation of HL-60 cells
    • Santos-Beneit A. M. Mollinedo F. (2000) Expression of genes involved in initiation, regulation, and execution of apoptosis in human neutrophils and during neutrophil differentiation of HL-60 cells. J. Leukoc. Biol. 67, 712 724.
    • (2000) J. Leukoc. Biol. , vol.67 , pp. 712-724
    • Santos-Beneit, A.M.1    Mollinedo, F.2
  • 74
    • 0032935664 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
    • Schaeffer H. J. Weber M. J. (1999) Mitogen-activated protein kinases: Specific messages from ubiquitous messengers. Mol. Cell. Biol. 19, 2435 2444.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2435-2444
    • Schaeffer, H.J.1    Weber, M.J.2
  • 78
    • 16244373077 scopus 로고    scopus 로고
    • Biomechanical stress-induced signaling in smooth muscle cells: An update
    • Shaw A. Xu Q. (2003) Biomechanical stress-induced signaling in smooth muscle cells: an update. Curr. Vasc. Pharmacol. 1, 41 58.
    • (2003) Curr. Vasc. Pharmacol. , vol.1 , pp. 41-58
    • Shaw, A.1    Xu, Q.2
  • 79
    • 0035890085 scopus 로고    scopus 로고
    • The expanding role of mitochondria in apoptosis
    • Wang X. (2001) The expanding role of mitochondria in apoptosis. Genes Dev. 15, 2922 2933.
    • (2001) Genes Dev. , vol.15 , pp. 2922-2933
    • Wang, X.1
  • 80
    • 4043079197 scopus 로고    scopus 로고
    • P2X7 receptor inhibition improves recovery after spinal cord injury
    • Wang X., Arcuino G., Takano T. et al. (2004) P2X7 receptor inhibition improves recovery after spinal cord injury. Nat. Med. 10, 821 827.
    • (2004) Nat. Med. , vol.10 , pp. 821-827
    • Wang, X.1    Arcuino, G.2    Takano, T.3
  • 81
    • 0037364149 scopus 로고    scopus 로고
    • Characterization of bax and bcl-2 in apoptosis after experimental traumatic brain injury in the rat
    • Wennersten A., Holmin S. Mathiesen T. (2003) Characterization of bax and bcl-2 in apoptosis after experimental traumatic brain injury in the rat. Acta Neurpathol. 105, 281 288.
    • (2003) Acta Neurpathol. , vol.105 , pp. 281-288
    • Wennersten, A.1    Holmin, S.2    Mathiesen, T.3
  • 82
    • 16644401532 scopus 로고    scopus 로고
    • Cellular injury induces activation of MAPK via P2Y receptors
    • Yang L., Cranson D. Trinkaus-Randall V. (2004) Cellular injury induces activation of MAPK via P2Y receptors. J. Cell. Biochem. 91, 938 950.
    • (2004) J. Cell. Biochem. , vol.91 , pp. 938-950
    • Yang, L.1    Cranson, D.2    Trinkaus-Randall, V.3
  • 83
    • 19644367000 scopus 로고    scopus 로고
    • Activation and signaling of the p38 MAP kinase pathway
    • Zarubin T. Han J. (2005) Activation and signaling of the p38 MAP kinase pathway. Cell Res. 15, 11 18.
    • (2005) Cell Res. , vol.15 , pp. 11-18
    • Zarubin, T.1    Han, J.2
  • 84
    • 33750058573 scopus 로고    scopus 로고
    • Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK
    • Zhou Y., Wang Q., Mark Evers B. Chung D. H. (2006) Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK. Biochem. Biophys. Res. Commun. 350, 860 865.
    • (2006) Biochem. Biophys. Res. Commun. , vol.350 , pp. 860-865
    • Zhou, Y.1    Wang, Q.2    Mark Evers, B.3    Chung, D.H.4
  • 85
    • 33745750361 scopus 로고    scopus 로고
    • Nucleotide signaling in the nervous system development
    • Zimmermann H. (2006) Nucleotide signaling in the nervous system development. Pflugers Arch. Eur. J. Physiol. 452, 573 588.
    • (2006) Pflugers Arch. Eur. J. Physiol. , vol.452 , pp. 573-588
    • Zimmermann, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.