Egr-1-A Ca2+-regulated transcription factor

Cell Calcium

Volumn 47, Issue 5, 2010, Pages 397-403

  Thiel, Gerald ^a   Mayer, Sabine I ^a   Müller, Isabelle ^a   Stefano, Luisa ^a,b   Rössler, Oliver G ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

Author keywords

Calcineurin; Calcium channel; Egr 1; G protein coupled receptors; NMDA receptor; Transcription

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; CARBACHOL; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR; GLUCOSE; GLUTAMIC ACID; GONADORELIN; GROWTH DIFFERENTIATION FACTOR; HORMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IONOTROPIC RECEPTOR; NEUROTRANSMITTER; THROMBIN; TRANSCRIPTION FACTOR EGR 1; TRANSCRIPTION FACTOR NFAT; VOLTAGE GATED CALCIUM CHANNEL;

CALCIUM CELL LEVEL; GENETIC TRANSCRIPTION; HUMAN; INTRACELLULAR SIGNALING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TRANSCRIPTION REGULATION; UPREGULATION;

EID: 77952943076     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceca.2010.02.005     Document Type: Review

References (72)

1. Sukhatme V.P., Cao X., Chang L.C., Tsai-Morris C.-H., Stamenkovich D., Ferreira P.C.P., Cohen D.R., Edwards S.A., Shows T.B., Curran T., Le Beau M.M., Adamson E.D. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 1988, 53:37-43.
2. Christy B., Lau L.F., Nathans D. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with " zinc finger" sequences. Proc. Natl. Acad. Sci. U.S.A. 1988, 85:7857-7861.
3. Milbrandt J. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 1987, 238:797-799.
4. Lemaire P., Revelant O., Bravo R., Charnay P. Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc. Natl. Acad. Sci. U.S.A. 1988, 85:4691-4695.
5. Lim R.W., Varnum B.C., Herschman H.R. Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant. Oncogene 1987, 1:263-270.
6. Thiel G., Cibelli G. Regulation of life and death by the zinc finger transcription factor Egr-1. J. Cell. Physiol. 2002, 193:287-292.
7. Rössler O.G., Stefano L., Bauer I., Thiel G. Stimulus-transcription coupling in the nervous system-The zinc finger protein Egr-1. Transcription Factors in the Nervous System-Development, Brain Function, and Disease 2006, 379-395. Wiley-VCH, Weinheim, Germany. G. Thiel (Ed.).
8. Jones M.W., Errington M.L., French P.J., Fine P.J., Bliss T.V.P., Garel S., Charney P., Bozon B., Laroche S., Davis S. A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat. Neurosci. 2001, 4:289-296.
9. Bozon B., Davis S., Laroche S. A requirement for the immediate early gene zif268 in reconsolidation of recognition after retrieval. Neuron 2003, 40:695-701.
10. Lee J.L., Everitt B.J., Thomas K.L. Independent cellular processes for hippocampal memory consolidation and reconsolidation. Science 2004, 304:839-843.
11. Malkani S., Wallace K.J., Donley M.P., Rosen J.B. An egr-1 (zif268) antisense oligonucleotide infused into the amygdala disrupts fear conditioning. Learn. Mem. 2004, 11:617-624.
12. Khachigian L.M., Lindner V., Williams A.J., Collins T. Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science 1996, 271:1427-1431.
13. Lee S., Sadovsky Y., Swirnoff A.H., Polish J.A., Goda P., Gavrilina G., Milbrandt J. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (egr-1). Science 1996, 273:1219-1221.
14. Topilko P., Schneider-Maunoury S., Levi G., Trembleau A., Gourji D., Driancourt M.-A., Rao C.V., Charnay P. Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice. Mol. Endocrinol. 1997, 12:107-122.
15. Yan S.-F., Fujita T., Lu J., Okada K., Zou Y.S., Mackman N., Pinsky D.J., Stern D.M. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat. Med. 2000, 6:1355-1361.
16. Liu C., Rangnekar V.M., Adamson E., Mercola D. Suppression of growth and transformation and induction of apoptosis by Egr-1. Cancer Gene Ther. 1998, 5:3-28.
17. Virolle T., Adamson E.D., Baron D., Mercola D., Mustelin T., de Belle I I. The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat. Cell. Biol. 2001, 3:1124-1128.
18. Mayer S.I., Rössler O.G., Endo T., Charnay P., Thiel G. Epidermal growth factor-induced proliferation of astrocytes requires Egr transcription factors. J. Cell Sci. 2009, 122:3340-3350.
19. Cole A.J., Saffen D.W., Baraban J.M., Worley P.F. Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature 1989, 340:474-476.
20. Wisden W., Errington M.L., Williams S., Dunnett S.B., Waters C., Hitchcock D., Evan G., Bliss T.V., Hunt S.P. Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron 1990, 4:603-614.
21. Szekely A.M., Costa E., Grayson D.R. Transcriptional program coordination by N-methyl-d-aspartate-sensitive glutamate receptor stimulation in primary cultures of cerebellar neurons. Mol. Pharmacol. 1990, 38:624-633.
22. Vaccario F.M., Hayward M.D., Nestler E.J., Duman R.S., Tallmann J.F. Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons. Brain Res. Mol. Brain. Res. 1992, 12:233-241.
23. Condorelli D.F., Dellalbani P., Amico C., Lukasiuk K., Kaczmarek L., Giuffrida-Stella A.M. Glutamate receptor-driven activation of transcription factors in primary neuronal cultures. Neurochem. Res. 1994, 19:489-499.
24. Bading H., Segal M.M., Sucher N.J., Dudek H., Lipton S.A., Greenberg M.E. N-methyl-d-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons. Neuroscience 1995, 64:653-664.
25. 2+ rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1. J. Cell. Physiol. 2007, 213:36-44.
26. Khakh B.S., North R.A. P2X receptors as cell-surface ATP sensors in health and disease. Nature 2006, 442:527-532.
27. Surprenant A., North R.A. Signaling at purinergic P2X receptors. Annu. Rev. Physiol. 2009, 71:333-359.
28. Chessell I.P., Hatcher J.P., Bountra C., Michel A.D., Hughes J.P., Green P., Egerton J., Murfin M., Richardson J., Peck W.L., Grahames C.B., Casula M.A., Yiangou Y., Birch R., Anand P., Buell G.N. Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 2005, 114:386-396.
29. Sheng M., Kim M.J. Postsynaptic signaling and plasticity mechanisms. Science 2002, 298:776-780.
30. Waxman E.A., Lynch D.R. N-Methyl-d-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease. Neuroscientist 2005, 11:37-49.
31. Thomas G.M., Huganir R.L. MAPK cascade signalling and synaptic plasticity. Nat. Rev. Neurosci. 2004, 5:173-183.
32. Wang J.Q., Fibuch E.E., Mao L. Regulation of mitogen-activated protein kinases by glutamate receptors. J. Neurochem. 2007, 100:1-11.
33. Beckmann A.M., Wilce P.A. Egr transcription factors in the nervous system. Neurochem. Int. 1997, 31:477-510.
34. Majdan M., Schatz C.J. Effects of visual experience on activity-dependent gene regulation in cortex. Nat. Neurosci. 2006, 5:650-659.
35. Wei F., Xu Z.C., Qu Z., Milbrandt J., Zhuo M. Role of EGR1 in hippocampal synaptic enhancement induced by tetanic stimulation and amputation. J. Cell. Biol. 2000, 149:1325-1333.
36. Mokin M., Keifer J. Expression of the immediate-early gene-encoded protein Egr-1 (zif268) during in vitro classical conditioning. Learn. Mem. 2005, 12:144-149.
37. Mayer S.I., Willars G.B., Nishida E., Thiel G. Elk-1, CREB, and MKP-1 regulate Egr-1 expression in gonadotropin-releasing hormone stimulated gonadotrophs. J. Cell. Biochem. 2008, 105:1267-1278.
38. Rössler O.G., Henß I., Thiel G. Transcriptional response to muscarinic acetylcholine receptor stimulation: regulation of Egr-1 biosynthesis by ERK, Elk-1, MKP-1, and calcineurin in carbachol-stimulated human neuroblastoma cells. Arch. Biochem. Biophys. 2008, 470:93-102.
39. 2+ concentration, phosphorylation of ERK and activation of ternary complex factor. BMC Mol. Biol. 2009, 10:40.
40. Mackie E.J., Pagel C.N., Smith R., de Niese M.R., Song S.J., Pike R.N. Protease-activated receptors: a means of converting extracellular proteolysis into intracellular signals. IUBMB Life 2002, 53:277-281.
41. Lacinová L. Voltage-dependent calcium channels. Gen. Physiol. Biophys. 2005, 24(Suppl. 1):1-78.
42. Flavell S.W., Kim T.K., Gray J.M., Harmin D.A., Hemberg M., Hong E.J., Markenscoff-Papadimitriou E., Bear D.M., Greenberg M.E. Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation side selection. Neuron 2008, 60:1022-1038.
43. Josefsen K., Sorensen L.R., Buschard K., Birkenbach M. Glucose induces early growth response gene (Egr-1) expression in pancreatic beta cells. Diabetologia 1999, 42:195-203.
44. Bernal-Mizrachi E., Wice B., Inoue H., Permutt M.A. Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet β-cells. J. Biol. Chem. 2000, 275:25681-25689.
45. Mayer S.I., Thiel G. Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB. Eur. J. Cell. Biol. 2009, 88:19-33.
46. 2+ channel null mice. EMBO J. 2003, 22:3844-3854.
47. Vignali S., Leiss V., Karl R., Hofmann F., Welling A. Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells. J. Physiol. 2006, 572:691-706.
48. Khoo S., Gibson T.B., Arnette D., Lawrence M., January B., McGlynn K., Vanderbilt C.A., Griffen S.C., German M.S., Cobb M.H. MAP kinases and their roles in pancreatic β-cells. Cell. Biochem. Biophys. 2004, 40:191-200.
49. Benes C., Roisin M.P., Van Tan H., Creuzet C., Miyazaki J.-i., Fagard R. Rapid activation and nuclear translocation of mitogen-activated protein kinases in response to physiological concentration of glucose in the MIN6 pancreatic β cell line. J. Biol. Chem. 1998, 273:15507-15513.
50. Arnette D., Gibson T.B., Lawrence M.C., January B., Khoo S., McGlynn K., Vanderbilt C.A., Cobb M.H. Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic β cells. J. Biol. Chem. 2003, 278:32517-32525.
51. Al Sarraj J., Vinson C., Hai J., Thiel G. Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors. J. Cell. Biochem. 2005, 96:1003-1020.
52. Bauer I., Hohl M., Al-Sarraj A., Vinson C., Thiel G. Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase. Arch. Biochem. Biophys. 2005, 438:36-52.
53. Hardinham G.E., Chawla S., Johnson C.M., Bading H. Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature 1997, 385:260-265.
54. Hardingham G.E., Arnold F.J., Bading H. Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Nat. Neurosci. 2001, 4:261-267.
55. Bading H., Greenberg M.E. Stimulation of protein tyrosine phosphorylation by NMDA receptor activation. Science 1991, 253:912-914.
56. Rosen L.B., Greenberg M.E. Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:1113-1118.
57. Xia Z., Dudek H., Miranti C.K., Greenberg M.E. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. J. Neurosci. 1996, 16:5425-5436.
58. Dolmetsch R.E., Pajvani U., Fife K., Spotts J.M., Greenberg M.E. Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science 2001, 294:333-339.
59. Kaufmann K., Bach K., Thiel G. Extracellular signal-regulated protein kinases Erk1/Erk2 stimulate expression and biological activity of the transcriptional regulator Egr-1. Biol. Chem. 2001, 382:1077-1081.
60. Deak M., Clifton A.D., Lucocq J.M., Alessi D.R. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998, 17:4426-4441.
61. Arthur J.S., Cohen P. MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells. FEBS Lett. 2000, 482:44-48.
62. Arthur J.S., Fong A.L., Dwyer J.M., Davare M., Reese E., Obrietan K., Impey S. Mitogen-and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins. J. Neurosci. 2004, 24:4324-4332.
63. Wu G.-Y., Deisseroth K., Tsien R.W. Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:2808-2813.
64. Sugimoto T., Stewart S., Guan K.-L. The calcium/calmodulin-dependent protein phosphatase calcineurin is the major Elk-1 phosphatase. J. Biol. Chem. 1997, 272:29415-29418.
65. Tian J., Karin M. Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinase is negatively regulated by protein phosphatase 2B (calcineurin). J. Biol. Chem. 1999, 274:15173-15180.
66. Lam B.Y.H., Zhang W., Enticknap N., Haggis E., Cader M.Z., Chawla S. Inverse regulation of plasticity-related immediate early genes by calcineurin in hippocampal neurons. J. Biol. Chem. 2009, 284:12562-12571.
67. Eder A., Bading H. Calcium signals can freely cross the nuclear envelope in hippocampal neurons: somatic calcium increases generate nuclear calcium transient. BMC Neurosci. 2007, 8:57.
68. 2+ cycling facilitates activation of the transcription factor NFAT in sensory neurons. J. Neurosci. 2009, 29:12101-12114.
69. Murphy T.H., Worley P.F., Baraban J.M. L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes. Neuron 1991, 7:625-635.
70. Rengarajan J., Mittelstadt P.R., Mages H.W., Gerth A.J., Kroczek R.A., Ashwell J.D., Glimcher L.H. Sequential involvement of NFAT and Egr transcription factors in FasL regulation. Immunity 2000, 12:293-300.
71. Collins S., Lutz M.A., Zarek P.E., Anders R.A., Kersh G.J., Powell J.D. Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. Eur. J. Immunol. 2008, 38:528-536.
72. Kao C., Wu H., Xie J., Chang C.-P., Ranish J.A., Graef I.A., Crabtree G.R. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science 2009, 323:651-654.