Extracellular nucleotides activate the p38-stress-activated protein kinase cascade in glomerular mesangial cells

British Journal of Pharmacology

Volumn 129, Issue 3, 2000, Pages 612-618

  Huwiler, Andrea ^a   Wartmann, Markus ^b   Van Den Bosch, Henk ^c   Pfeilschifter, Josef ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Mitogen activated protein kinase; MKK3; Nucleotide receptor; p38 MAPK; Renal mesangial cell

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; ADENOSINE; ADENOSINE 5' O (3 THIOTRIPHOSPHATE); ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; BETA,GAMMA METHYLENEADENOSINE TRIPHOSPHATE; NUCLEOTIDE; PURINE P2Y RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; SURAMIN; TRANSCRIPTION FACTOR; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GLOMERULUS; HUMAN; HUMAN CELL; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

EID: 0033966107     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703077     Document Type: Article

References (44)

1. BARNARD, E.A., BURNSTOCK, G. & WEBB, T.E. (1994). G‐protein‐coupled receptors for ATP and other nucleotides: a new receptor family. Trends Pharmacol. Sci., 15, 67–70.
2. BOARDER, M.R. & HOURANI, S.M. (1998). The regulation of vascular function by P2 receptors: multiple sites and multiple receptors. Trends Pharmacol. Sci., 19, 99–107.
3. BOGDANOV, Y.D., WILDMAN, S.S., CLEMENTS, M.P., KING, B.F. & BURNSTOCK, G. (1998). Molecular cloning and characterization of rat P2Y4 nucleotide receptor. Br. J. Pharmacol., 124, 428–430.
4. BRINER, V.A. & KERN, F. (1994). ATP stimulates Ca 2+ mobilization by a nucleotide receptor in glomerular endothelial cells. Am. J. Physiol., 266, (Renal Fluid Electrol. Physiol., 35), F210–F217.
5. CANO, E. & MAHADEVAN, L.C. (1995). Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci., 20, 117–122.
6. CHAN, C.M., UNWIN, R.J. & BURNSTOCK, G. (1998). Potential functional roles of extracellular ATP in kidney and urinary tract. Exp. Nephrol., 6, 200–207.
7. COMMUNI, D. & BOEYNAEMS, J.‐M. (1997). Receptors responsive to extracellular pyrimidine nucleotides. Trends Pharmacol. Sci., 18, 83–86.
8. CUENDA, A., ROUSE, J., DOZA, Y.N., MEIER, R., COHEN, P., GALLAGHER, T.F., YOUNG, P.R. & LEE, J.C. (1995). SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1. FEBS Lett., 364, 229–233.
9. DUNN, P.M. & BLAKELEY, A.G. (1988). A reversible P2‐purinoceptor antagonist in the mouse vas deferens. Br. J. Pharmacol., 93, 243–245.
10. GUPTA, S., CAMPBELL, D., DERIJARD, B. & DAVIS, R.J. (1995). Transcription factor ATF 2 regulation by the JNK signal transduction pathway. Science, 267, 389–393.
11. GUTIERREZ, A.M., LOU, X., ERIK, A., PERSSON, G. & RING, A. (1999). Ca 2+ response of rat mesangial cells to ATP analogues. Eur. J. Pharmacol., 369, 107–112.
12. HARPER, S., WEBB, T.E., CHARLTON, S.J., NG, L.L. & BOARDER, M.R. (1998). Evidence that P2Y4 nucleotide receptors are involved in the regulation of rat aortic smooth muscle cells by UTP and ATP. Br. J. Pharmacol., 124, 703–710.
13. HUBER‐LANG, M., FISCHER, K.G., GLOY, J., SCHOLLMEYER, P., KRAMER‐GUTH, A., GREGER, R. & PAVENSTÄDT, H. (1997). UTP and ATP induce different membrane voltage responses in rat mesangial cells. Am. J. Physiol., 272, F704–F711.
14. HUWILER, A. & PFEILSCHIFTER, J. (1994). Stimulation by extracellular ATP and UTP of the mitogen‐activated protein kinase cascade and proliferation of rat renal mesangial cells. Br. J. Pharmacol., 113, 1455–1463.
15. HUWILER, A. & PFEILSCHIFTER, J. (1999). Nitric oxide stimulates the stress‐activated protein kinase p38 in rat renal mesangial cells. J. Exp. Biol., 202, 655–660.
16. HUWILER, A., BRINER, V.A., FABBRO, D. & PFEILSCHIFTER, J. (1997b). Feedback regulation of extracellular ATP‐stimulated phosphoinositide hydrolysis by protein kinase C‐α in bovine glomerular endothelial cells. Kidney Int., 52, 329–337.
17. HUWILER, A. & PFEILSCHIFTER, J. (1994). Stimulation by extracellular ATP and UTP of the mitogen‐activated protein kinase cascade and proliferation of rat renal mesangial cells. Br. J. Pharmacol., 113, 1455–1463.
18. HUWILER, A. & PFEILSCHIFTER, J. (1999). Nitric oxide stimulates the stress‐activated protein kinase p38 in rat renal mesangial cells. J. Exp. Biol., 202, 655–660.
19. HUWILER, A., STABEL, S., FABBRO, D. & PFEILSCHIFTER, J. (1995). Platelet‐derived growth factor and angiotensin II stimulate the mitogen‐activated protein kinase cascade in rat renal mesangial cells. Biochem. J., 305, 777–784.
20. HUWILER, A., VAN ROSSUM, G., WARTMANN, M. & PFEILSCHIFTER, J. (1997a). Stimulation by extracellular ATP and UTP of the stress‐activated protein kinase cascade in rat renal mesangial cells. Br. J. Pharmacol., 120, 807–812.
21. INSCHO, E.W., MITCHELL, K.D. & NAVAR, L.G. (1994). Extracellular ATP in the regulation of renal microvascular function. FASEB J., 8, 319–328.
22. JIANG, Y., GRAM, H., ZHAO, M., NEW, L., GU, J., FENG, L., DIPADOVA, F., ULEVITCH, R.J. & HAN, J. (1997). Characterization of the structure and function of the fourth member of p38 group mitogen‐activated protein kinases, p38δ. J. Biol. Chem., 272, 30122–30128.
23. KING, B.F., TOWNSEND‐NICHOLSON, A. & BURNSTOCK, G. (1998). Metabotropic receptors for ATP and UTP: exploring the correspondence between native and recombinant nucleotide receptors. Trends Pharmacol. Sci., 19, 506–514.
24. LUSTIG, K.D., SHIAU, A.K., BRAKE, A.J. & JULIUS, D. (1993). Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc. Natl. Acad. Sci. U.S.A., 90, 5113–5117.
25. MESSMER, U.K., LAPETINA, E.G. & BRÜNE, B. (1994). Nitric oxide‐induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C‐ and protein kinase A‐activating compounds. Mol. Pharmacol., 47, 757–765.
26. MOHAUPT, M.G., FISCHER, T., SCHWÖBEL, J., STERZEL, R.B. & SCHULZE‐LOHOFF, E. (1998). Activation of purinergic P2Y2 receptors inhibits inducible NO synthase in cultured rat mesangial cells. Am. J. Physiol., 275, F103–F110.
27. NICHOLAS, R.A., LAZAROWSKI, E.R., WATT, W.C., LI, Q., BOYER, J. & HARDEN, T.K. (1996a). Pharmacological and second messenger signalling selectivities of cloned P2Y receptors. J. Auton. Pharmacol., 16, 319–323.
28. NICHOLAS, R.A., WATT, W.C., LAZAROWSKI, E.R., LI, Q. & HARDEN, K. (1996b). Uridine nucleotide selectivity of three phospholipase C‐activating P2 receptors: identification of a UDP‐selective, a UTP‐selective, and an ATP‐ and UTP‐specific receptor. Mol. Pharmacol., 50, 224–229.
29. PARR, C.E., SULLIVAN, D.M., PARADISO, A.M., LAZAROWSKI, E.R., BURCH, L.H., OLSEN, J.C., ERB, L., WEISMAN, G.A., BOUCHER, R.C. & TURNER, J.T. (1994). Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc. Natl. Acad. Sci. U.S.A., 91, 3275–3279.
30. PAVENSTÄDT, H., GLOY, J., LEIPZIGER, J., KLAER, B., PFEILSCHIFTER, J., SCHOLLMEYER, P. & GREGER, R. (1993). Effect of extracellular ATP on contraction, cytosolic calcium activity, membrane voltage and ion currents of rat mesangial cells in primary culture. Br. J. Pharmacol., 109, 953–959.
31. PFEILSCHIFTER, J. (1990a). Extracellular ATP stimulates polyphosphoinositide hydrolysis and prostaglandin synthesis in rat renal mesangial cells. Involvement of a pertussis toxin‐sensitive guanine nucleotide binding protein and feedback inhibition by protein kinase C. Cell. Signalling, 2, 129–138.
32. PFEILSCHIFTER, J. (1990b). Comparison of extracellular ATP and UTP signalling in rat renal mesangial cells. No indications for the involvement of separate purino‐ and pyrimidino‐ceptors. Biochem. J., 272, 469–472.
33. PFEILSCHIFTER, J. & HUWILER, A. (1996). Regulatory functions of protein kinase C isoenzymes in purinoceptor signalling in mesangial cells. J. Auton. Pharmacol., 16, 315–318.
34. PFEILSCHIFTER, J. & MERRIWEATHER, C. (1993). Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C‐ε in rat renal mesangial cells. Br. J. Pharmacol., 110, 847–853.
35. PFEILSCHIFTER, J. & VOSBECK K. (1991). Transforming growth factor‐β2 inhibits interleukin 1 β‐ and tumor necrosis factor α‐induction of nitric oxide synthase in rat renal mesangial cells. Biochem. Biophys. Res. Commun., 175, 372–379.
36. POELSTRA, K., BROUWER, E., BALLER, J.F.W., HARDONK, M.J. & BAKKER, W.W. (1993). Attenuation of anti‐Thy 1 glomerulonephritis in the rat by anti‐inflammatory platelet‐inhibiting agents. Am. J. Pathol., 142, 441–450.
37. POELSTRA, K., HEYNEN, E.R., BALLER, J.F.W., HARDONK, M.J. & BAKKER, W.W. (1992). Modulation of anti‐Thy 1 nephritis in the rat by adenine nucleotides. Lab. Invest., 66, 555–563.
38. RAINGEAUD, J., GUPTA, S., ROGERS, J.S., DICKENS, M., HAN, J., ULEVITCH, R.J. & DAVIS, R.J. (1995). Pro‐inflammatory cytokines and environmental stress cause p38 mitogen‐activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem., 270, 7420–7426.
39. RAINGEAUD, J., WHITMARSH, A.J., BARRETT, T., DERIJARD, B. & DAVIS, R.J. (1996). MKK3‐ and MKK6‐regulated gene expression is mediated by the p38 mitogen‐activated protein kinase signal transduction pathway. Mol. Cell Biol., 16, 1247–1255.
40. RALEVIC, V. & BURNSTOCK, G. (1998). Receptors for purines and pyrimidines. Pharmacol. Rev., 50, 413–492.
41. SCHULZE‐LOHOFF, E., ZANNER, S., OGILVIE, A. & STERZEL, R.B. (1992). Extracellular ATP stimulates proliferation of cultured mesangial cells via P 2 ‐purinergic receptors. Am. J. Physiol., 263, F374–F383.
42. SPIELMAN, W.S. & AREND, L.J. (1991). Adenosine receptors and signalling in the kidney. Hypertension, 17, 117–130.
43. WANG, X.S., DIENER, K., MANTHEY, C.L., WANG, S., ROSENZWEIG, B., BRAY, J., DELANEY, J., COLE, C.N., CHAN‐HUI, P.‐Y., MANTIO, N., LICHENSTEIN, H.S., ZUKOWSKI, M. & YAO, Z. (1997). Molecular cloning and characterization of a novel p38 mitogen‐activated protein kinase. J. Biol. Chem., 272, 23668–23674.
44. YOUNG, P.R., MCLAUGHLIN, M.M., KUMAR, S., KASSIS, S., DOYLE, M.L., MCNULTY, D., GALLAGHER, T.F., FISHER, S., MCDONNELL, P.C., CARR, S.A., HUDDLESTON, M.J., SEIBEL, G., PORTER, T.G., LIVI, G.P., ADAMS, J.L. & LEE, J.C. (1997). Pyridinyl imidazole inhibitors of p38 mitogen‐activated protein kinase bind in the ATP site. J. Biol. Chem., 272, 12116–12121.