A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 4, 2011, Pages 1505-1514

  Choi, Sungwook ^a   Kelly, Jeffery W ^b  

^a Chungnam National University   (South Korea)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

High throughput screening; Transthyretin; TTR kinetic stabilizer; TTR (stilbene) n 2 fluorescent conjugate

Indexed keywords

AMYLOID; AMYLOIDOGENESIS INHIBITOR; PREALBUMIN; PROTEIN INHIBITOR; STILBENE DERIVATIVE; THYROXINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; COVALENT BOND; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE ANALYSIS; HUMAN; STOICHIOMETRY;

AMYLOID; HUMANS; KINETICS; MODELS, MOLECULAR; PREALBUMIN; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, QUATERNARY; SPECTROMETRY, FLUORESCENCE; STILBENES;

EID: 79951554447     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.12.050     Document Type: Article

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