Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 7, 1999, Pages 1339-1347

  Baures, Paul W ^a   Oza, Vibha B ^a   Peterson, Scott A ^a   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Amyloid fibril; Inhibition; NSAID; Screening; Transthyretin

Indexed keywords

AMYLOID; ANTHRANILIC ACID DERIVATIVE; FLUFENAMIC ACID; FLUFENAMIC ACID DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PREALBUMIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS;

AMYLOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; DIFLUNISAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FLUFENAMIC ACID; HUMANS; LIGHT; NIFLUMIC ACID; PREALBUMIN; SCATTERING, RADIATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULINDAC; TOLMETIN;

EID: 0032970177     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00066-8     Document Type: Article

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