메뉴 건너뛰기




Volumn 42, Issue 1, 2011, Pages 55-72

CCR2/CCL2-mediated inflammation protects photoreceptor cells from amyloid-β-induced apoptosis

Author keywords

Age related macular degeneration; Alzheimer's disease; Inflammation; Microglial cells; Oxidative stress; Retina

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CHEMOKINE RECEPTOR CCR2; MONOCYTE CHEMOTACTIC PROTEIN 1; RECOVERIN; RHODOPSIN; SYNAPTOPHYSIN;

EID: 79751533971     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.01.004     Document Type: Article
Times cited : (28)

References (82)
  • 1
    • 0000063816 scopus 로고
    • Preparation, enrichment and growth of purified cultures of neurons and photoreceptors from chick embryos and from normal and mutant mice
    • Adler R. Preparation, enrichment and growth of purified cultures of neurons and photoreceptors from chick embryos and from normal and mutant mice. Meth. Neurosciences. 1990, 2:134-150.
    • (1990) Meth. Neurosciences. , vol.2 , pp. 134-150
    • Adler, R.1
  • 2
    • 77954888689 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and brain inflammation: effects on microglial functions
    • Ajmone-Cat M.A., Bernardo A., Greco A., Minghetti L. Non-steroidal anti-inflammatory drugs and brain inflammation: effects on microglial functions. Pharmaceuticals 2010, 3:1949-1965.
    • (2010) Pharmaceuticals , vol.3 , pp. 1949-1965
    • Ajmone-Cat, M.A.1    Bernardo, A.2    Greco, A.3    Minghetti, L.4
  • 4
    • 0036741098 scopus 로고    scopus 로고
    • A role of local inflammation in the formation of drusen in the aging eye
    • Anderson D.H., Mullins R.F., Hageman G.S., Johnson L.V. A role of local inflammation in the formation of drusen in the aging eye. Am. J. Ophthalmol. 2002, 134:411-431.
    • (2002) Am. J. Ophthalmol. , vol.134 , pp. 411-431
    • Anderson, D.H.1    Mullins, R.F.2    Hageman, G.S.3    Johnson, L.V.4
  • 5
    • 0345760069 scopus 로고    scopus 로고
    • Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration
    • Anderson D.H., Talaga K.C., Rivest A.J., Barron E., Hageman G.S., Johnson L.V. Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp. Eye Res. 2004, 78:243-256.
    • (2004) Exp. Eye Res. , vol.78 , pp. 243-256
    • Anderson, D.H.1    Talaga, K.C.2    Rivest, A.J.3    Barron, E.4    Hageman, G.S.5    Johnson, L.V.6
  • 6
    • 0030038809 scopus 로고    scopus 로고
    • Scavenging of Alzheimer's amyloid beta-protein by microglia in culture
    • Ard M.D., Cole G.M., Wei J., Mehrle A.P., Fratkin J.D. Scavenging of Alzheimer's amyloid beta-protein by microglia in culture. J. Neurosci. Res. 1996, 43:190-202.
    • (1996) J. Neurosci. Res. , vol.43 , pp. 190-202
    • Ard, M.D.1    Cole, G.M.2    Wei, J.3    Mehrle, A.P.4    Fratkin, J.D.5
  • 7
    • 27744447179 scopus 로고    scopus 로고
    • Amyloid-beta causes apoptosis of neuronal cells via caspase cascade, which can be prevented by amyloid-beta-derived short peptides
    • Awasthi A., Matsunaga Y., Yamada T. Amyloid-beta causes apoptosis of neuronal cells via caspase cascade, which can be prevented by amyloid-beta-derived short peptides. Exp. Neurol. 2005, 196:282-289.
    • (2005) Exp. Neurol. , vol.196 , pp. 282-289
    • Awasthi, A.1    Matsunaga, Y.2    Yamada, T.3
  • 8
    • 0033795036 scopus 로고    scopus 로고
    • The role of oxidative stress in the pathogenesis of age-related macular degeneration
    • Beatty S., Koh H., Phil M., Henson D., Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv. Ophthalmol. 2000, 45:115-134.
    • (2000) Surv. Ophthalmol. , vol.45 , pp. 115-134
    • Beatty, S.1    Koh, H.2    Phil, M.3    Henson, D.4    Boulton, M.5
  • 9
    • 0034595821 scopus 로고    scopus 로고
    • Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia
    • Brazil M.I., Chung H., Maxfield F.R. Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia. J. Biol. Chem. 2000, 275:16941-16947.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16941-16947
    • Brazil, M.I.1    Chung, H.2    Maxfield, F.R.3
  • 10
    • 34748868594 scopus 로고    scopus 로고
    • Steroidal and nonsteroidal antiinflammatory medications can improve photoreceptor survival after laser retinal photocoagulation
    • Brown J., Hacker H., Schuschereba S., Zwick H., Lund D., Stuck B. Steroidal and nonsteroidal antiinflammatory medications can improve photoreceptor survival after laser retinal photocoagulation. Ophthalmology 2007, 114:1876-1883.
    • (2007) Ophthalmology , vol.114 , pp. 1876-1883
    • Brown, J.1    Hacker, H.2    Schuschereba, S.3    Zwick, H.4    Lund, D.5    Stuck, B.6
  • 11
    • 63549133336 scopus 로고    scopus 로고
    • Amyloid beta (1-42) alters structure and function of retinal pigmented epithelial cells
    • Bruban J., Dinet V., Sennlaub E., Jonet L., Mascarelli F. Amyloid beta (1-42) alters structure and function of retinal pigmented epithelial cells. Aging Cell 2009, 8:162-177.
    • (2009) Aging Cell , vol.8 , pp. 162-177
    • Bruban, J.1    Dinet, V.2    Sennlaub, E.3    Jonet, L.4    Mascarelli, F.5
  • 12
    • 0029949082 scopus 로고    scopus 로고
    • Bcl-2 overexpression reduces apoptotic receptor cell death in three different retinal degenerations
    • Chen J., Flannery J.G., LaVail M.M., Steinberg R.H., Xu J., Simon M.I. Bcl-2 overexpression reduces apoptotic receptor cell death in three different retinal degenerations. Proc. Natl Acad. Sci. USA 1996, 93:7042-7047.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 7042-7047
    • Chen, J.1    Flannery, J.G.2    LaVail, M.M.3    Steinberg, R.H.4    Xu, J.5    Simon, M.I.6
  • 14
    • 33750198829 scopus 로고    scopus 로고
    • Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds
    • Czirr E., Weggen S. Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds. Neurodegener. Dis. 2006, 3:298-304.
    • (2006) Neurodegener. Dis. , vol.3 , pp. 298-304
    • Czirr, E.1    Weggen, S.2
  • 15
    • 0037975774 scopus 로고    scopus 로고
    • Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas
    • Dentchev T., Milam A.H., Lee V.M., Trojanowski J.Q., Dunaief J.L. Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Mol. Vis. 2003, 9:184-190.
    • (2003) Mol. Vis. , vol.9 , pp. 184-190
    • Dentchev, T.1    Milam, A.H.2    Lee, V.M.3    Trojanowski, J.Q.4    Dunaief, J.L.5
  • 16
    • 38749112528 scopus 로고    scopus 로고
    • Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model
    • Ding J.D., Lin J., Mace B.E., Herrmann R., Sullivan P., Bowes Rickman C. Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model. Vis. Res. 2008, 48:339-345.
    • (2008) Vis. Res. , vol.48 , pp. 339-345
    • Ding, J.D.1    Lin, J.2    Mace, B.E.3    Herrmann, R.4    Sullivan, P.5    Bowes Rickman, C.6
  • 17
    • 33144459399 scopus 로고    scopus 로고
    • The role of inflammation in the pathogenesis of age-related macular degeneration
    • Donoso L.A., Kim D., Frost A., Callahan A., Hageman G. The role of inflammation in the pathogenesis of age-related macular degeneration. Surv. Ophthalmol. 2006, 51:137-152.
    • (2006) Surv. Ophthalmol. , vol.51 , pp. 137-152
    • Donoso, L.A.1    Kim, D.2    Frost, A.3    Callahan, A.4    Hageman, G.5
  • 21
    • 56349166514 scopus 로고    scopus 로고
    • Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications
    • El Khoury J., Luster A.D. Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol. Sci. 2008, 29:626-632.
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 626-632
    • El Khoury, J.1    Luster, A.D.2
  • 22
    • 34147115541 scopus 로고    scopus 로고
    • Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
    • El Khoury J., Toft M., Hickman S.E., Means T.K., Terada K., Geula C., Luster A.D. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat. Med. 2007, 13:432-438.
    • (2007) Nat. Med. , vol.13 , pp. 432-438
    • El Khoury, J.1    Toft, M.2    Hickman, S.E.3    Means, T.K.4    Terada, K.5    Geula, C.6    Luster, A.D.7
  • 23
    • 0035128064 scopus 로고    scopus 로고
    • Risk factors for age-related macular degeneration
    • Evans J.R. Risk factors for age-related macular degeneration. Prog. Retin. Eye Res. 2001, 20:227-253.
    • (2001) Prog. Retin. Eye Res. , vol.20 , pp. 227-253
    • Evans, J.R.1
  • 24
    • 1042265187 scopus 로고    scopus 로고
    • Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
    • Ferrer I., Boada Rovira M., Sánchez Guerra M.L., Rey M.J., Costa-Jussá F. Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Brain Pathol. 2004, 1:11-20.
    • (2004) Brain Pathol. , vol.1 , pp. 11-20
    • Ferrer, I.1    Boada Rovira, M.2    Sánchez Guerra, M.L.3    Rey, M.J.4    Costa-Jussá, F.5
  • 26
    • 33344463679 scopus 로고    scopus 로고
    • Common mechanisms of amyloid oligomer pathogenesis in degenerative disease
    • Glabe C.G. Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol. Aging 2006, 27:570-575.
    • (2006) Neurobiol. Aging , vol.27 , pp. 570-575
    • Glabe, C.G.1
  • 28
    • 0033520641 scopus 로고    scopus 로고
    • Histopathology of age-related macular degeneration
    • Green W.R. Histopathology of age-related macular degeneration. Mol. Vis. 1999, 3:27-33.
    • (1999) Mol. Vis. , vol.3 , pp. 27-33
    • Green, W.R.1
  • 30
    • 0037375042 scopus 로고    scopus 로고
    • Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration
    • Gupta N., Brown K.E., Milam A.H. Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration. Ex. Eye Res. 2003, 76:463-471.
    • (2003) Ex. Eye Res. , vol.76 , pp. 463-471
    • Gupta, N.1    Brown, K.E.2    Milam, A.H.3
  • 34
    • 40349111175 scopus 로고    scopus 로고
    • Therapeutic potential of gamma-secretase inhibitors and modulators
    • Imbimbo B.P. Therapeutic potential of gamma-secretase inhibitors and modulators. Curr. Top. Med. Chem. 2008, 8:54-61.
    • (2008) Curr. Top. Med. Chem. , vol.8 , pp. 54-61
    • Imbimbo, B.P.1
  • 35
    • 0037015020 scopus 로고    scopus 로고
    • The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
    • Johnson L.V., Leitner W.P., Rivest A.J., Staples M.K., Radeke M.J., Anderson D.H. The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc. Natl Acad. Sci. USA 2002, 99:11830-11835.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 11830-11835
    • Johnson, L.V.1    Leitner, W.P.2    Rivest, A.J.3    Staples, M.K.4    Radeke, M.J.5    Anderson, D.H.6
  • 37
    • 33644799775 scopus 로고    scopus 로고
    • Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen
    • Johnson P.T., Brown M.N., Pulliam B.C., Anderson D.H., Johnson L.V. Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen. Invest Ophthalmol Vis Sci. 2005, 46:4788-4795.
    • (2005) Invest Ophthalmol Vis Sci. , vol.46 , pp. 4788-4795
    • Johnson, P.T.1    Brown, M.N.2    Pulliam, B.C.3    Anderson, D.H.4    Johnson, L.V.5
  • 38
    • 46149121003 scopus 로고    scopus 로고
    • Cerebral and peripheral amyloid phagocytes-an old liaison with a new twist
    • Jucker M., Heppner F.L. Cerebral and peripheral amyloid phagocytes-an old liaison with a new twist. Neuron 2008, 59:8-10.
    • (2008) Neuron , vol.59 , pp. 8-10
    • Jucker, M.1    Heppner, F.L.2
  • 40
    • 0026681119 scopus 로고
    • Prevalence of age-related maculopathy. The Beaver Dam Eye Study
    • Klein R., Klein B.E., Linton K.L. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology 1992, 99:933-943.
    • (1992) Ophthalmology , vol.99 , pp. 933-943
    • Klein, R.1    Klein, B.E.2    Linton, K.L.3
  • 43
    • 7744235869 scopus 로고    scopus 로고
    • Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism
    • Koenigsknecht J., Landreth G. Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism. J. Neurosci. 2004, 24:9838-9846.
    • (2004) J. Neurosci. , vol.24 , pp. 9838-9846
    • Koenigsknecht, J.1    Landreth, G.2
  • 46
    • 0037375044 scopus 로고    scopus 로고
    • Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration
    • Liang F.Q., Godley B.F. Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp. Eye Res. 2003, 76:397-403.
    • (2003) Exp. Eye Res. , vol.76 , pp. 397-403
    • Liang, F.Q.1    Godley, B.F.2
  • 47
    • 0028833332 scopus 로고
    • Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina
    • Loffler K.U., Edward D.P., Tso M.O. Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina. Invest Ophthalmol Vis Sci. 1995, 36:24-31.
    • (1995) Invest Ophthalmol Vis Sci. , vol.36 , pp. 24-31
    • Loffler, K.U.1    Edward, D.P.2    Tso, M.O.3
  • 49
    • 32444450909 scopus 로고    scopus 로고
    • Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers
    • Luibl V., Isas J.M., Kayed R., Glabe C.G., Langen R., Chen J. Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J. Clin. Invest. 2006, 116:378-385.
    • (2006) J. Clin. Invest. , vol.116 , pp. 378-385
    • Luibl, V.1    Isas, J.M.2    Kayed, R.3    Glabe, C.G.4    Langen, R.5    Chen, J.6
  • 50
    • 37549048032 scopus 로고    scopus 로고
    • Review of genetics in aged-related macular degeneration
    • Montezuma S.R., Sobrin L., Seddon J.M. Review of genetics in aged-related macular degeneration. Semin. Ophthalmol. 2007, 22:229-240.
    • (2007) Semin. Ophthalmol. , vol.22 , pp. 229-240
    • Montezuma, S.R.1    Sobrin, L.2    Seddon, J.M.3
  • 52
    • 0037192392 scopus 로고    scopus 로고
    • Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria
    • Morais Cardoso S., Swerdlow R.H., Oliveira C.R. Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria. Brain Res. 2002, 931:117-125.
    • (2002) Brain Res. , vol.931 , pp. 117-125
    • Morais Cardoso, S.1    Swerdlow, R.H.2    Oliveira, C.R.3
  • 53
    • 24644438615 scopus 로고    scopus 로고
    • Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics
    • Morgan D., Gordon M.N., Tan J., Wilcock D., Rojiani A.M. Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. J. Neuropathol. Exp. Neurol. 2005, 64:743-753.
    • (2005) J. Neuropathol. Exp. Neurol. , vol.64 , pp. 743-753
    • Morgan, D.1    Gordon, M.N.2    Tan, J.3    Wilcock, D.4    Rojiani, A.M.5
  • 54
    • 3042662255 scopus 로고    scopus 로고
    • MGLuR5 activation reduces β-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor
    • Movsesyan V.A., Stoica B.A., Faden A.I. MGLuR5 activation reduces β-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor. J. Neurochem. 2004, 89:1528-1536.
    • (2004) J. Neurochem. , vol.89 , pp. 1528-1536
    • Movsesyan, V.A.1    Stoica, B.A.2    Faden, A.I.3
  • 55
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report
    • Nicoll J.A., Wilkinson D., Holmes C., Steart P., Markham H., Weller R.O. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat. Med. 2003, 4:448-452.
    • (2003) Nat. Med. , vol.4 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 56
    • 56149088067 scopus 로고    scopus 로고
    • Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease
    • Ning A., Cui J., To E., Ashe K.H., Matsubara J. Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease. Invest Ophthalmol Vis Sci. 2008, 49:5136-5143.
    • (2008) Invest Ophthalmol Vis Sci. , vol.49 , pp. 5136-5143
    • Ning, A.1    Cui, J.2    To, E.3    Ashe, K.H.4    Matsubara, J.5
  • 58
    • 0030248270 scopus 로고    scopus 로고
    • Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
    • Paresce D.M., Ghosh R.N., Maxfield F.R. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron 1997, 17:553-565.
    • (1997) Neuron , vol.17 , pp. 553-565
    • Paresce, D.M.1    Ghosh, R.N.2    Maxfield, F.R.3
  • 60
    • 59449092729 scopus 로고    scopus 로고
    • Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease
    • Perez S.E., Lumayag S., Kovacs B., Mufson E.J., Xu S. Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease. Invest Ophthalmol Vis Sci 2009, 50:793-800.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 793-800
    • Perez, S.E.1    Lumayag, S.2    Kovacs, B.3    Mufson, E.J.4    Xu, S.5
  • 61
    • 0027447286 scopus 로고
    • Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state
    • Pike C.J., Burdick D., Walencewicz A.J., Glabe C.G., Cotman C.W. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J. Neurosci. 1993, 13:1676-1687.
    • (1993) J. Neurosci. , vol.13 , pp. 1676-1687
    • Pike, C.J.1    Burdick, D.2    Walencewicz, A.J.3    Glabe, C.G.4    Cotman, C.W.5
  • 63
    • 48949116059 scopus 로고    scopus 로고
    • Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells
    • Raoul W., Keller N., Rodéro M., Behar-Cohen F., Sennlaub F., Combadière C. Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells. J. Neuroimmunol. 2008, 198:56-61.
    • (2008) J. Neuroimmunol. , vol.198 , pp. 56-61
    • Raoul, W.1    Keller, N.2    Rodéro, M.3    Behar-Cohen, F.4    Sennlaub, F.5    Combadière, C.6
  • 64
    • 0033620899 scopus 로고    scopus 로고
    • Retina-derived microglial cells induce photoreceptor cell death in vitro
    • Roque R.S., Rosales A.A., Jingjing L., Agarwal N., Al-Ubaidi M.R. Retina-derived microglial cells induce photoreceptor cell death in vitro. Brain Res. 1999, 836:110-119.
    • (1999) Brain Res. , vol.836 , pp. 110-119
    • Roque, R.S.1    Rosales, A.A.2    Jingjing, L.3    Agarwal, N.4    Al-Ubaidi, M.R.5
  • 65
    • 0036753448 scopus 로고    scopus 로고
    • The role of microglia in Alzheimer's disease: friend or foe?
    • Schenk D.B., Yednock T. The role of microglia in Alzheimer's disease: friend or foe?. Neurobiol. Aging 2002, 23:677-679.
    • (2002) Neurobiol. Aging , vol.23 , pp. 677-679
    • Schenk, D.B.1    Yednock, T.2
  • 66
    • 33645902493 scopus 로고    scopus 로고
    • Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
    • Serbina N.V., Pamer E.G. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 2006, 7:311-317.
    • (2006) Nat. Immunol. , vol.7 , pp. 311-317
    • Serbina, N.V.1    Pamer, E.G.2
  • 69
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • Simard A., Soulet D., Gowing G., Julien J.-P., Rivest S. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 2006, 94:489-502.
    • (2006) Neuron , vol.94 , pp. 489-502
    • Simard, A.1    Soulet, D.2    Gowing, G.3    Julien, J.-P.4    Rivest, S.5
  • 70
    • 0036934466 scopus 로고    scopus 로고
    • Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain
    • Su J.H., Kesslak J.P., Head E., Cotman C.W. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol. 2002, 104:1-6.
    • (2002) Acta Neuropathol. , vol.104 , pp. 1-6
    • Su, J.H.1    Kesslak, J.P.2    Head, E.3    Cotman, C.W.4
  • 72
    • 0037382957 scopus 로고    scopus 로고
    • H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK
    • Tamagno E., Robino G., Obbili A., Bardini P., Aragno M., Parola M., Danni O. H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK. Exp. Neurol. 2003, 180:144-155.
    • (2003) Exp. Neurol. , vol.180 , pp. 144-155
    • Tamagno, E.1    Robino, G.2    Obbili, A.3    Bardini, P.4    Aragno, M.5    Parola, M.6    Danni, O.7
  • 73
    • 0034802625 scopus 로고    scopus 로고
    • CD40 signaling and Alzheimer's disease pathogenesis
    • Town T., Tan J., Mullan M. CD40 signaling and Alzheimer's disease pathogenesis. Neurochem. Int. 2001, 39:371-380.
    • (2001) Neurochem. Int. , vol.39 , pp. 371-380
    • Town, T.1    Tan, J.2    Mullan, M.3
  • 75
    • 25444505871 scopus 로고    scopus 로고
    • Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases
    • Walker D.G., Lue L.F. Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases. J. Neurosci. Res. 2005, 81:412-425.
    • (2005) J. Neurosci. Res. , vol.81 , pp. 412-425
    • Walker, D.G.1    Lue, L.F.2
  • 80
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: driving force, bystander or beneficial response
    • Wyss-Coray T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response. Nat. Med. 2006, 12:1005-1015.
    • (2006) Nat. Med. , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 82
    • 1842478123 scopus 로고    scopus 로고
    • Current concepts in the pathogenesis of age-related macular degeneration
    • Zarbin A.M. Current concepts in the pathogenesis of age-related macular degeneration. Arch. Ophthalmol. 2004, 122:598-614.
    • (2004) Arch. Ophthalmol. , vol.122 , pp. 598-614
    • Zarbin, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.