-
1
-
-
34547667231
-
Treatment for chronic myelogenous leukemia: the long road to imatinib
-
Hunter T. Treatment for chronic myelogenous leukemia: the long road to imatinib. J Clin Invest 2007, 117:2036-2043.
-
(2007)
J Clin Invest
, vol.117
, pp. 2036-2043
-
-
Hunter, T.1
-
2
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty K.T., Puzanov I., Kim K.B., Ribas A., McArthur G.A., Sosman J.A., O'Dwyer P.J., Lee R.J., Grippo J.F., Nolop K., et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010, 363:809-819.
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
Ribas, A.4
McArthur, G.A.5
Sosman, J.A.6
O'Dwyer, P.J.7
Lee, R.J.8
Grippo, J.F.9
Nolop, K.10
-
3
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag G., Hirth P., Tsai J., Zhang J., Ibrahim P.N., Cho H., Spevak W., Zhang C., Zhang Y., Habets G., et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 2010, 467:596-599.
-
(2010)
Nature
, vol.467
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
Zhang, J.4
Ibrahim, P.N.5
Cho, H.6
Spevak, W.7
Zhang, C.8
Zhang, Y.9
Habets, G.10
-
4
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., et al. Patterns of somatic mutation in human cancer genomes. Nature 2007, 446:153-158.
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
Dalgliesh, G.L.4
Hunter, C.5
Bignell, G.6
Davies, H.7
Teague, J.8
Butler, A.9
Stevens, C.10
-
5
-
-
55949117661
-
Kinase requirements in human cells. I. Comparing kinase requirements across various cell types
-
Grueneberg D.A., Degot S., Pearlberg J., Li W., Davies J.E., Baldwin A., Endege W., Doench J., Sawyer J., Hu Y., et al. Kinase requirements in human cells. I. Comparing kinase requirements across various cell types. Proc Natl Acad Sci U S A 2008, 105:16472-16477.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16472-16477
-
-
Grueneberg, D.A.1
Degot, S.2
Pearlberg, J.3
Li, W.4
Davies, J.E.5
Baldwin, A.6
Endege, W.7
Doench, J.8
Sawyer, J.9
Hu, Y.10
-
6
-
-
55949096610
-
Kinase requirements in human cells. IV. Differential kinase requirements in cervical and renal human tumor cell lines
-
Grueneberg D.A., Li W., Davies J.E., Sawyer J., Pearlberg J., Harlow E. Kinase requirements in human cells. IV. Differential kinase requirements in cervical and renal human tumor cell lines. Proc Natl Acad Sci U S A 2008, 105:16490-16495.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16490-16495
-
-
Grueneberg, D.A.1
Li, W.2
Davies, J.E.3
Sawyer, J.4
Pearlberg, J.5
Harlow, E.6
-
7
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S., Zhang X., Parsons D.W., Lin J.C., Leary R.J., Angenendt P., Mankoo P., Carter H., Kamiyama H., Jimeno A., et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008, 321:1801-1806.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
Mankoo, P.7
Carter, H.8
Kamiyama, H.9
Jimeno, A.10
-
8
-
-
66149125644
-
Challenges and opportunities in defining the essential cancer kinome
-
Manning B.D. Challenges and opportunities in defining the essential cancer kinome. Sci Signal 2009, 2:15.
-
(2009)
Sci Signal
, vol.2
, pp. 15
-
-
Manning, B.D.1
-
9
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
Wood L.D., Parsons D.W., Jones S., Lin J., Sjoblom T., Leary R.J., Shen D., Boca S.M., Barber T., Ptak J., et al. The genomic landscapes of human breast and colorectal cancers. Science 2007, 318:1108-1113.
-
(2007)
Science
, vol.318
, pp. 1108-1113
-
-
Wood, L.D.1
Parsons, D.W.2
Jones, S.3
Lin, J.4
Sjoblom, T.5
Leary, R.J.6
Shen, D.7
Boca, S.M.8
Barber, T.9
Ptak, J.10
-
10
-
-
77955464738
-
Kinase requirements in human cells. V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3
-
Baldwin A., Grueneberg D.A., Hellner K., Sawyer J., Grace M., Li W., Harlow E., Munger K. Kinase requirements in human cells. V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3. Proc Natl Acad Sci U S A 2010, 107:12463-12468.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 12463-12468
-
-
Baldwin, A.1
Grueneberg, D.A.2
Hellner, K.3
Sawyer, J.4
Grace, M.5
Li, W.6
Harlow, E.7
Munger, K.8
-
11
-
-
55949124308
-
Kinase requirements in human cells. II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells
-
Baldwin A., Li W., Grace M., Pearlberg J., Harlow E., Munger K., Grueneberg D.A. Kinase requirements in human cells. II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells. Proc Natl Acad Sci U S A 2008, 105:16478-16483.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16478-16483
-
-
Baldwin, A.1
Li, W.2
Grace, M.3
Pearlberg, J.4
Harlow, E.5
Munger, K.6
Grueneberg, D.A.7
-
12
-
-
55949101858
-
Kinase requirements in human cells. III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen
-
Bommi-Reddy A., Almeciga I., Sawyer J., Geisen C., Li W., Harlow E., Kaelin W.G., Grueneberg D.A. Kinase requirements in human cells. III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen. Proc Natl Acad Sci U S A 2008, 105:16484-16489.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16484-16489
-
-
Bommi-Reddy, A.1
Almeciga, I.2
Sawyer, J.3
Geisen, C.4
Li, W.5
Harlow, E.6
Kaelin, W.G.7
Grueneberg, D.A.8
-
13
-
-
0038670241
-
Mutational analysis of the tyrosine kinome in colorectal cancers
-
Bardelli A., Parsons D.W., Silliman N., Ptak J., Szabo S., Saha S., Markowitz S., Willson J.K., Parmigiani G., Kinzler K.W., et al. Mutational analysis of the tyrosine kinome in colorectal cancers. Science 2003, 300:949.
-
(2003)
Science
, vol.300
, pp. 949
-
-
Bardelli, A.1
Parsons, D.W.2
Silliman, N.3
Ptak, J.4
Szabo, S.5
Saha, S.6
Markowitz, S.7
Willson, J.K.8
Parmigiani, G.9
Kinzler, K.W.10
-
14
-
-
77955660663
-
Diverse somatic mutation patterns and pathway alterations in human cancers
-
Kan Z., Jaiswal B.S., Stinson J., Janakiraman V., Bhatt D., Stern H.M., Yue P., Haverty P.M., Bourgon R., Zheng J., et al. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 2010, 466:869-873.
-
(2010)
Nature
, vol.466
, pp. 869-873
-
-
Kan, Z.1
Jaiswal, B.S.2
Stinson, J.3
Janakiraman, V.4
Bhatt, D.5
Stern, H.M.6
Yue, P.7
Haverty, P.M.8
Bourgon, R.9
Zheng, J.10
-
15
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y., Wang Z., Bardelli A., Silliman N., Ptak J., Szabo S., Yan H., Gazdar A., Powell S.M., Riggins G.J., et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004, 304:554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
-
16
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
Sjoblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006, 314:268-274.
-
(2006)
Science
, vol.314
, pp. 268-274
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
Parsons, D.W.4
Lin, J.5
Barber, T.D.6
Mandelker, D.7
Leary, R.J.8
Ptak, J.9
Silliman, N.10
-
17
-
-
20044381123
-
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
-
Stephens P., Edkins S., Davies H., Greenman C., Cox C., Hunter C., Bignell G., Teague J., Smith R., Stevens C., et al. A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 2005, 37:590-592.
-
(2005)
Nat Genet
, vol.37
, pp. 590-592
-
-
Stephens, P.1
Edkins, S.2
Davies, H.3
Greenman, C.4
Cox, C.5
Hunter, C.6
Bignell, G.7
Teague, J.8
Smith, R.9
Stevens, C.10
-
18
-
-
33749151698
-
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers
-
Wood L.D., Calhoun E.S., Silliman N., Ptak J., Szabo S., Powell S.M., Riggins G.J., Wang T.L., Yan H., Gazdar A., et al. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Hum Mutat 2006, 27:1060-1061.
-
(2006)
Hum Mutat
, vol.27
, pp. 1060-1061
-
-
Wood, L.D.1
Calhoun, E.S.2
Silliman, N.3
Ptak, J.4
Szabo, S.5
Powell, S.M.6
Riggins, G.J.7
Wang, T.L.8
Yan, H.9
Gazdar, A.10
-
19
-
-
33646830138
-
A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer
-
Delfino F.J., Stevenson H., Smithgall T.E. A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer. J Biol Chem 2006, 281:8829-8835.
-
(2006)
J Biol Chem
, vol.281
, pp. 8829-8835
-
-
Delfino, F.J.1
Stevenson, H.2
Smithgall, T.E.3
-
20
-
-
66149091940
-
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
-
Luo J., Emanuele M.J., Li D., Creighton C.J., Schlabach M.R., Westbrook T.F., Wong K.K., Elledge S.J. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 2009, 137:835-848.
-
(2009)
Cell
, vol.137
, pp. 835-848
-
-
Luo, J.1
Emanuele, M.J.2
Li, D.3
Creighton, C.J.4
Schlabach, M.R.5
Westbrook, T.F.6
Wong, K.K.7
Elledge, S.J.8
-
21
-
-
65849111219
-
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
-
Scholl C., Frohling S., Dunn I.F., Schinzel A.C., Barbie D.A., Kim S.Y., Silver S.J., Tamayo P., Wadlow R.C., Ramaswamy S., et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 2009, 137:821-834.
-
(2009)
Cell
, vol.137
, pp. 821-834
-
-
Scholl, C.1
Frohling, S.2
Dunn, I.F.3
Schinzel, A.C.4
Barbie, D.A.5
Kim, S.Y.6
Silver, S.J.7
Tamayo, P.8
Wadlow, R.C.9
Ramaswamy, S.10
-
22
-
-
38549141939
-
Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer
-
Iorns E., Turner N.C., Elliott R., Syed N., Garrone O., Gasco M., Tutt A.N., Crook T., Lord C.J., Ashworth A. Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer. Cancer Cell 2008, 13:91-104.
-
(2008)
Cancer Cell
, vol.13
, pp. 91-104
-
-
Iorns, E.1
Turner, N.C.2
Elliott, R.3
Syed, N.4
Garrone, O.5
Gasco, M.6
Tutt, A.N.7
Crook, T.8
Lord, C.J.9
Ashworth, A.10
-
23
-
-
77957154710
-
Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)
-
Carter H., Samayoa J., Hruban R.H., Karchin R. Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM). Cancer Biol Ther 2010, 10:582-587.
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 582-587
-
-
Carter, H.1
Samayoa, J.2
Hruban, R.H.3
Karchin, R.4
-
24
-
-
38049097938
-
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
-
McDermott U., Sharma S.V., Dowell L., Greninger P., Montagut C., Lamb J., Archibald H., Raudales R., Tam A., Lee D., et al. Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A 2007, 104:19936-19941.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19936-19941
-
-
McDermott, U.1
Sharma, S.V.2
Dowell, L.3
Greninger, P.4
Montagut, C.5
Lamb, J.6
Archibald, H.7
Raudales, R.8
Tam, A.9
Lee, D.10
-
25
-
-
20444419344
-
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
-
MacKeigan J.P., Murphy L.O., Blenis J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 2005, 7:591-600.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 591-600
-
-
MacKeigan, J.P.1
Murphy, L.O.2
Blenis, J.3
-
26
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J., Yen C., Liaw D., Podsypanina K., Bose S., Wang S.I., Puc J., Miliaresis C., Rodgers L., McCombie R., et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275:1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
-
27
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T., Dixon J.E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998, 273:13375-13378.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
28
-
-
20444374445
-
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
-
Samuels Y., Diaz L.A., Schmidt-Kittler O., Cummins J.M., Delong L., Cheong I., Rago C., Huso D.L., Lengauer C., Kinzler K.W., et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 2005, 7:561-573.
-
(2005)
Cancer Cell
, vol.7
, pp. 561-573
-
-
Samuels, Y.1
Diaz, L.A.2
Schmidt-Kittler, O.3
Cummins, J.M.4
Delong, L.5
Cheong, I.6
Rago, C.7
Huso, D.L.8
Lengauer, C.9
Kinzler, K.W.10
-
29
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten J.D., Faber A.L., Horn C., Donoho G.P., Briggs S.L., Robbins C.M., Hostetter G., Boguslawski S., Moses T.Y., Savage S., et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 2007, 448:439-444.
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savage, S.10
-
30
-
-
77953957633
-
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
-
Poliseno L., Salmena L., Zhang J., Carver B., Haveman W.J., Pandolfi P.P. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 2010, 465:1033-1038.
-
(2010)
Nature
, vol.465
, pp. 1033-1038
-
-
Poliseno, L.1
Salmena, L.2
Zhang, J.3
Carver, B.4
Haveman, W.J.5
Pandolfi, P.P.6
-
31
-
-
74049107249
-
PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality
-
López-Knowles E., O'Toole S.A., McNeil C.M., Millar E.K., Qiu M.R., Crea P., Daly R.J., Musgrove E.A., Sutherland R.L. PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality. Int J Cancer 2010, 126:1121-1131.
-
(2010)
Int J Cancer
, vol.126
, pp. 1121-1131
-
-
López-Knowles, E.1
O'Toole, S.A.2
McNeil, C.M.3
Millar, E.K.4
Qiu, M.R.5
Crea, P.6
Daly, R.J.7
Musgrove, E.A.8
Sutherland, R.L.9
-
32
-
-
34247391898
-
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo
-
Calleja V., Alcor D., Laguerre M., Park J., Vojnovic B., Hemmings B.A., Downward J., Parker P.J., Larijani B. Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol 2007, 5:e95.
-
(2007)
PLoS Biol
, vol.5
-
-
Calleja, V.1
Alcor, D.2
Laguerre, M.3
Park, J.4
Vojnovic, B.5
Hemmings, B.A.6
Downward, J.7
Parker, P.J.8
Larijani, B.9
-
33
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
-
Guertin D.A., Stevens D.M., Thoreen C.C., Burds A.A., Kalaany N.Y., Moffat J., Brown M., Fitzgerald K.J., Sabatini D.M. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 2006, 11:859-871.
-
(2006)
Dev Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
Brown, M.7
Fitzgerald, K.J.8
Sabatini, D.M.9
-
34
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov D.D., Guertin D.A., Ali S.M., Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307:1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
35
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson T.R., Laplante M., Thoreen C.C., Sancak Y., Kang S.A., Kuehl W.M., Gray N.S., Sabatini D.M. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 2009, 137:873-886.
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
Gray, N.S.7
Sabatini, D.M.8
-
36
-
-
47249105677
-
PHLiPPing the switch on Akt and protein kinase C signaling
-
Brognard J., Newton A.C. PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab 2008, 19:223-230.
-
(2008)
Trends Endocrinol Metab
, vol.19
, pp. 223-230
-
-
Brognard, J.1
Newton, A.C.2
-
37
-
-
67649386534
-
Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C
-
Brognard J., Niederst M., Reyes G., Warfel N., Newton A.C. Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. J Biol Chem 2009, 284:15215-15223.
-
(2009)
J Biol Chem
, vol.284
, pp. 15215-15223
-
-
Brognard, J.1
Niederst, M.2
Reyes, G.3
Warfel, N.4
Newton, A.C.5
-
38
-
-
69249144030
-
Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms
-
Hirano I., Nakamura S., Yokota D., Ono T., Shigeno K., Fujisawa S., Shinjo K., Ohnishi K. Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms. J Biol Chem 2009, 284:22155-22165.
-
(2009)
J Biol Chem
, vol.284
, pp. 22155-22165
-
-
Hirano, I.1
Nakamura, S.2
Yokota, D.3
Ono, T.4
Shigeno, K.5
Fujisawa, S.6
Shinjo, K.7
Ohnishi, K.8
-
39
-
-
60549099721
-
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
-
Liu J., Weiss H.L., Rychahou P., Jackson L.N., Evers B.M., Gao T. Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. Oncogene 2009, 28:994-1004.
-
(2009)
Oncogene
, vol.28
, pp. 994-1004
-
-
Liu, J.1
Weiss, H.L.2
Rychahou, P.3
Jackson, L.N.4
Evers, B.M.5
Gao, T.6
-
40
-
-
69249228672
-
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt
-
Pei H., Li L., Fridley B.L., Jenkins G.D., Kalari K.R., Lingle W., Petersen G., Lou Z., Wang L. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell 2009, 16:259-266.
-
(2009)
Cancer Cell
, vol.16
, pp. 259-266
-
-
Pei, H.1
Li, L.2
Fridley, B.L.3
Jenkins, G.D.4
Kalari, K.R.5
Lingle, W.6
Petersen, G.7
Lou, Z.8
Wang, L.9
-
41
-
-
33947203621
-
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
-
Brognard J., Sierecki E., Gao T., Newton A.C. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 2007, 25:917-931.
-
(2007)
Mol Cell
, vol.25
, pp. 917-931
-
-
Brognard, J.1
Sierecki, E.2
Gao, T.3
Newton, A.C.4
-
42
-
-
15944406764
-
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
Gao T., Furnari F., Newton A.C. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005, 18:13-24.
-
(2005)
Mol Cell
, vol.18
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
43
-
-
69549116880
-
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
-
Yang W.L., Wang J., Chan C.H., Lee S.W., Campos A.D., Lamothe B., Hur L., Grabiner B.C., Lin X., Darnay B.G., et al. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 2009, 325:1134-1138.
-
(2009)
Science
, vol.325
, pp. 1134-1138
-
-
Yang, W.L.1
Wang, J.2
Chan, C.H.3
Lee, S.W.4
Campos, A.D.5
Lamothe, B.6
Hur, L.7
Grabiner, B.C.8
Lin, X.9
Darnay, B.G.10
-
44
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
Harrington L.S., Findlay G.M., Gray A., Tolkacheva T., Wigfield S., Rebholz H., Barnett J., Leslie N.R., Cheng S., Shepherd P.R., et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 2004, 166:213-223.
-
(2004)
J Cell Biol
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
Rebholz, H.6
Barnett, J.7
Leslie, N.R.8
Cheng, S.9
Shepherd, P.R.10
-
45
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly K.E., Rojo F., She Q.B., Solit D., Mills G.B., Smith D., Lane H., Hofmann F., Hicklin D.J., Ludwig D.L., et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006, 66:1500-1508.
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
Lane, H.7
Hofmann, F.8
Hicklin, D.J.9
Ludwig, D.L.10
-
46
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um S.H., Frigerio F., Watanabe M., Picard F., Joaquin M., Sticker M., Fumagalli S., Allegrini P.R., Kozma S.C., Auwerx J., et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004, 431:200-205.
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
-
47
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov D.D., Ali S.M., Sengupta S., Sheen J.H., Hsu P.P., Bagley A.F., Markhard A.L., Sabatini D.M. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 2006, 22:159-168.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
48
-
-
33947538050
-
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
-
Wan X., Harkavy B., Shen N., Grohar P., Helman L.J. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 2007, 26:1932-1940.
-
(2007)
Oncogene
, vol.26
, pp. 1932-1940
-
-
Wan, X.1
Harkavy, B.2
Shen, N.3
Grohar, P.4
Helman, L.J.5
-
49
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J., Woffendin H., Garnett M.J., Bottomley W., et al. Mutations of the BRAF gene in human cancer. Nature 2002, 417:949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
-
50
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan P.T., Garnett M.J., Roe S.M., Lee S., Niculescu-Duvaz D., Good V.M., Jones C.M., Marshall C.J., Springer C.J., Barford D., et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 2004, 116:855-867.
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
Jones, C.M.7
Marshall, C.J.8
Springer, C.J.9
Barford, D.10
-
51
-
-
50649090571
-
Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway
-
Sebolt-Leopold J.S. Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway. Clin Cancer Res 2008, 14:3651-3656.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3651-3656
-
-
Sebolt-Leopold, J.S.1
-
52
-
-
77949685981
-
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
-
Hatzivassiliou G., Song K., Yen I., Brandhuber B.J., Anderson D.J., Alvarado R., Ludlam M.J., Stokoe D., Gloor S.L., Vigers G., et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010, 464:431-435.
-
(2010)
Nature
, vol.464
, pp. 431-435
-
-
Hatzivassiliou, G.1
Song, K.2
Yen, I.3
Brandhuber, B.J.4
Anderson, D.J.5
Alvarado, R.6
Ludlam, M.J.7
Stokoe, D.8
Gloor, S.L.9
Vigers, G.10
-
53
-
-
74849109743
-
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
-
Heidorn S.J., Milagre C., Whittaker S., Nourry A., Niculescu-Duvas I., Dhomen N., Hussain J., Reis-Filho J.S., Springer C.J., Pritchard C., et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 2010, 140:209-221.
-
(2010)
Cell
, vol.140
, pp. 209-221
-
-
Heidorn, S.J.1
Milagre, C.2
Whittaker, S.3
Nourry, A.4
Niculescu-Duvas, I.5
Dhomen, N.6
Hussain, J.7
Reis-Filho, J.S.8
Springer, C.J.9
Pritchard, C.10
-
54
-
-
77949732073
-
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
-
Poulikakos P.I., Zhang C., Bollag G., Shokat K.M., Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010, 464:427-430.
-
(2010)
Nature
, vol.464
, pp. 427-430
-
-
Poulikakos, P.I.1
Zhang, C.2
Bollag, G.3
Shokat, K.M.4
Rosen, N.5
-
55
-
-
0023607638
-
A novel putative tyrosine kinase receptor encoded by the eph gene
-
Hirai H., Maru Y., Hagiwara K., Nishida J., Takaku F. A novel putative tyrosine kinase receptor encoded by the eph gene. Science 1987, 238:1717-1720.
-
(1987)
Science
, vol.238
, pp. 1717-1720
-
-
Hirai, H.1
Maru, Y.2
Hagiwara, K.3
Nishida, J.4
Takaku, F.5
-
56
-
-
77649114060
-
Eph receptors and ephrins in cancer: bidirectional signalling and beyond
-
Pasquale E.B. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer 2010, 10:165-180.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 165-180
-
-
Pasquale, E.B.1
-
57
-
-
70350780571
-
Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression
-
Genander M., Halford M.M., Xu N.J., Eriksson M., Yu Z., Qiu Z., Martling A., Greicius G., Thakar S., Catchpole T., et al. Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell 2009, 139:679-692.
-
(2009)
Cell
, vol.139
, pp. 679-692
-
-
Genander, M.1
Halford, M.M.2
Xu, N.J.3
Eriksson, M.4
Yu, Z.5
Qiu, Z.6
Martling, A.7
Greicius, G.8
Thakar, S.9
Catchpole, T.10
-
58
-
-
0032168781
-
Selective loss of substrate recognition induced by the tumour-associated D294G point mutation in protein kinase Calpha
-
Prevostel C., Alvaro V., Vallentin A., Martin A., Jaken S., Joubert D. Selective loss of substrate recognition induced by the tumour-associated D294G point mutation in protein kinase Calpha. Biochem J 1998, 334(Pt 2):393-397.
-
(1998)
Biochem J
, vol.334
, Issue.2 PART
, pp. 393-397
-
-
Prevostel, C.1
Alvaro, V.2
Vallentin, A.3
Martin, A.4
Jaken, S.5
Joubert, D.6
-
59
-
-
0035032583
-
A single point mutation in the V3 region affects protein kinase Calpha targeting and accumulation at cell-cell contacts
-
Vallentin A., Lo T.C., Joubert D. A single point mutation in the V3 region affects protein kinase Calpha targeting and accumulation at cell-cell contacts. Mol Cell Biol 2001, 21:3351-3363.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3351-3363
-
-
Vallentin, A.1
Lo, T.C.2
Joubert, D.3
-
60
-
-
19644364146
-
The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals
-
Zhu Y., Dong Q., Tan B.J., Lim W.G., Zhou S., Duan W. The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals. Cancer Res 2005, 65:4520-4524.
-
(2005)
Cancer Res
, vol.65
, pp. 4520-4524
-
-
Zhu, Y.1
Dong, Q.2
Tan, B.J.3
Lim, W.G.4
Zhou, S.5
Duan, W.6
-
61
-
-
23044464191
-
RACK1 mediates activation of JNK by protein kinase C [corrected]
-
Lopez-Bergami P., Habelhah H., Bhoumik A., Zhang W., Wang L.H., Ronai Z. RACK1 mediates activation of JNK by protein kinase C [corrected]. Mol Cell 2005, 19:309-320.
-
(2005)
Mol Cell
, vol.19
, pp. 309-320
-
-
Lopez-Bergami, P.1
Habelhah, H.2
Bhoumik, A.3
Zhang, W.4
Wang, L.H.5
Ronai, Z.6
-
62
-
-
65549140324
-
Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells
-
Leroy C., Fialin C., Sirvent A., Simon V., Urbach S., Poncet J., Robert B., Jouin P., Roche S. Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells. Cancer Res 2009, 69:2279-2286.
-
(2009)
Cancer Res
, vol.69
, pp. 2279-2286
-
-
Leroy, C.1
Fialin, C.2
Sirvent, A.3
Simon, V.4
Urbach, S.5
Poncet, J.6
Robert, B.7
Jouin, P.8
Roche, S.9
-
63
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 2007, 131:1190-1203.
-
(2007)
Cell
, vol.131
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
Possemato, A.4
Yu, J.5
Haack, H.6
Nardone, J.7
Lee, K.8
Reeves, C.9
Li, Y.10
-
64
-
-
67749111502
-
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
-
Shackelford D.B., Shaw R.J. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 2009, 9:563-575.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
65
-
-
77953653569
-
New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion
-
Zagorska A., Deak M., Campbell D.G., Banerjee S., Hirano M., Aizawa S., Prescott A.R., Alessi D.R. New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci Signal 2010, 3:ra25.
-
(2010)
Sci Signal
, vol.3
-
-
Zagorska, A.1
Deak, M.2
Campbell, D.G.3
Banerjee, S.4
Hirano, M.5
Aizawa, S.6
Prescott, A.R.7
Alessi, D.R.8
-
66
-
-
54549088877
-
Rac activation and inactivation control plasticity of tumor cell movement
-
Sanz-Moreno V., Gadea G., Ahn J., Paterson H., Marra P., Pinner S., Sahai E., Marshall C.J. Rac activation and inactivation control plasticity of tumor cell movement. Cell 2008, 135:510-523.
-
(2008)
Cell
, vol.135
, pp. 510-523
-
-
Sanz-Moreno, V.1
Gadea, G.2
Ahn, J.3
Paterson, H.4
Marra, P.5
Pinner, S.6
Sahai, E.7
Marshall, C.J.8
-
67
-
-
0032550225
-
Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase
-
Fukata Y., Kimura K., Oshiro N., Saya H., Matsuura Y., Kaibuchi K. Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase. J Cell Biol 1998, 141:409-418.
-
(1998)
J Cell Biol
, vol.141
, pp. 409-418
-
-
Fukata, Y.1
Kimura, K.2
Oshiro, N.3
Saya, H.4
Matsuura, Y.5
Kaibuchi, K.6
-
68
-
-
43049101715
-
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
-
Yamashiro S., Yamakita Y., Totsukawa G., Goto H., Kaibuchi K., Ito M., Hartshorne D.J., Matsumura F. Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev Cell 2008, 14:787-797.
-
(2008)
Dev Cell
, vol.14
, pp. 787-797
-
-
Yamashiro, S.1
Yamakita, Y.2
Totsukawa, G.3
Goto, H.4
Kaibuchi, K.5
Ito, M.6
Hartshorne, D.J.7
Matsumura, F.8
-
69
-
-
77951880868
-
Activating ROCK1 somatic mutations in human cancer
-
Lochhead P.A., Wickman G., Mezna M., Olson M.F. Activating ROCK1 somatic mutations in human cancer. Oncogene 2010, 29:2591-2598.
-
(2010)
Oncogene
, vol.29
, pp. 2591-2598
-
-
Lochhead, P.A.1
Wickman, G.2
Mezna, M.3
Olson, M.F.4
-
70
-
-
78049429691
-
Crizotinib-latest champion in the cancer wars?
-
Hallberg B., Palmer R.H. Crizotinib-latest champion in the cancer wars?. N Engl J Med 2010, 363:1760-1762.
-
(2010)
N Engl J Med
, vol.363
, pp. 1760-1762
-
-
Hallberg, B.1
Palmer, R.H.2
-
71
-
-
25144496606
-
PMUT: a web-based tool for the annotation of pathological mutations on proteins
-
Ferrer-Costa C., Gelpi J.L., Zamakola L., Parraga I., de la Cruz X., Orozco M. PMUT: a web-based tool for the annotation of pathological mutations on proteins. Bioinformatics 2005, 21:3176-3178.
-
(2005)
Bioinformatics
, vol.21
, pp. 3176-3178
-
-
Ferrer-Costa, C.1
Gelpi, J.L.2
Zamakola, L.3
Parraga, I.4
de la Cruz, X.5
Orozco, M.6
-
72
-
-
34547566118
-
CanPredict: a computational tool for predicting cancer-associated missense mutations
-
Kaminker J.S., Zhang Y., Watanabe C., Zhang Z. CanPredict: a computational tool for predicting cancer-associated missense mutations. Nucleic Acids Res 2007, 35:W595-598.
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Kaminker, J.S.1
Zhang, Y.2
Watanabe, C.3
Zhang, Z.4
-
73
-
-
33846650692
-
Distinguishing cancer-associated missense mutations from common polymorphisms
-
Kaminker J.S., Zhang Y., Waugh A., Haverty P.M., Peters B., Sebisanovic D., Stinson J., Forrest W.F., Bazan J.F., Seshagiri S., et al. Distinguishing cancer-associated missense mutations from common polymorphisms. Cancer Res 2007, 67:465-473.
-
(2007)
Cancer Res
, vol.67
, pp. 465-473
-
-
Kaminker, J.S.1
Zhang, Y.2
Waugh, A.3
Haverty, P.M.4
Peters, B.5
Sebisanovic, D.6
Stinson, J.7
Forrest, W.F.8
Bazan, J.F.9
Seshagiri, S.10
-
74
-
-
72849127628
-
Kinase mutations in human disease: interpreting genotype-phenotype relationships
-
Lahiry P., Torkamani A., Schork N.J., Hegele RA Kinase mutations in human disease: interpreting genotype-phenotype relationships. Nat Rev Genet 2010, 11:60-74.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 60-74
-
-
Lahiry, P.1
Torkamani, A.2
Schork, N.J.3
Hegele, R.A.4
|