Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C

Journal of Biological Chemistry

Volumn 284, Issue 22, 2009, Pages 15215-15223

  Brognard, John ^a   Niederst, Matthew ^a   Reyes, Gloria ^a   Warfel, Noel ^a   Newton, Alexandra C ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT PHOSPHORYLATION; APOPTOSIS; BREAST CANCER; BREAST CANCER CELLS; HYDROPHOBIC MOTIFS; IN-CELL; IN-VITRO; LEUCINE-RICH REPEATS; OBSERVED RETENTION; PHOSPHATASE ACTIVITY; PROTEIN KINASE C; PROTEIN KINASE C ACTIVITIES; PROTEIN PHOSPHATASE; TUMOR CELL LINES;

AMINES; AMINO ACIDS; CELL CULTURE; CELL DEATH; LAWS AND LEGISLATION; ORGANIC ACIDS;

POLYMORPHISM;

LEUCINE; PHLPP2 PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE C; SERINE; UNCLASSIFIED DRUG; MUTANT PROTEIN; PHLPP2 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CHROMOSOME 16Q; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METASTASIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE; ALLELE; BREAST TUMOR; DRUG POTENTIATION; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR CELL LINE;

ALLELES; AMINO ACID SUBSTITUTION; BASE SEQUENCE; BREAST NEOPLASMS; CELL LINE, TUMOR; DNA MUTATIONAL ANALYSIS; HUMANS; LEUCINE; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; SERINE;

EID: 67649386534     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M901468200     Document Type: Article

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