Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

Clinical Science

Volumn 120, Issue 5, 2011, Pages 195-206

  Keane, Deirdre C ^a   Takahashi, Hilton K ^b   Dhayal, Shalinee ^c   Morgan, Noel G ^c   Curi, Rui ^b   Newsholme, Philip ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c PLYMOUTH UNIVERSITY PENINSULA SCHOOLS OF MEDICINE AND DENTISTRY   (United Kingdom)

Author keywords

Arachidonic acid; Lipotoxicity; Palmitic acid; Pancreatic cell; Reactive oxygen species; Type 2 diabetes mellitus

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE PROTEIN 4; ARACHIDONIC ACID; CYCLOOXYGENASE 1; FATTY ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOXYGENASE; ONCOPROTEIN; PALMITIC ACID; PROTEIN P47; REACTIVE OXYGEN METABOLITE; SATURATED FATTY ACID; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CLONE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; INSULIN RELEASE; MICROARRAY ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ARACHIDONIC ACID; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION REGULATION; GLUTATHIONE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; LIPOXYGENASE INHIBITORS; NITRITES; OXIDATIVE STRESS; PALMITATES; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79251614060     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20100282     Document Type: Article

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