Jun dimerization protein 2 controls senescence and differentiation via regulating histone modification

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Yokoyama, Kazunari K ^a,c,e   Huang, Yu Chang ^a   Hasegawa, Hitomi ^b   Wang, Shin Wei ^c   Ku, Chia Chen ^a   Lin, Ying Chu ^a,c   Chiou, Shyh Shin ^c   Hou, Ming Feng ^a,c   Wu, Deng Chyang ^c   Tsai, Eing Mei ^a,c   Saito, Shigeo ^a,d   Yamaguchi, Naoto ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b CHIBA UNIVERSITY   (Japan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d Saito Laboratory of Cell Technology   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; CCAAT ENHANCER BINDING PROTEIN DELTA; HISTONE ACETYLTRANSFERASE; HISTONE H3; POLYCOMB GROUP PROTEIN; POLYCOMB REPRESSIVE COMPLEX 1; POLYCOMB REPRESSIVE COMPLEX 2; PROTEIN P300; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR JDP2; UNCLASSIFIED DRUG; HISTONE; JDP2 PROTEIN, HUMAN; JUNDP2 PROTEIN, MOUSE; REPRESSOR PROTEIN;

ADIPOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL EVALUATION; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; GENE CONTROL; GENETIC TRANSCRIPTION; HISTONE ACETYLATION; HISTONE MODIFICATION; HUMAN; NONHUMAN; OXIDATIVE STRESS; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SENESCENCE; ANIMAL; CELL AGING; MOUSE; PHYSIOLOGY;

ANIMALS; CELL AGING; CELL DIFFERENTIATION; HISTONES; HUMANS; MICE; REPRESSOR PROTEINS;

EID: 79251543936     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/569034     Document Type: Review

References (120)

1. Kouzarides T., Chromatin modifications and their function Cell 2007 128 4 693 705
2. Shilatifard A., Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression Annual Review of Biochemistry 2006 75 243 269
3. Li B., Carey M., Workman J. L., The role of chromatin during transcription Cell 2007 128 4 707 719
4. Ekwall K., Genome-wide analysis of HDAC function Trends in Genetics 2005 21 11 608 615
5. Luger K., Mder A. W., Richmond R. K., Sargent D. F., Richmond T. J., Crystal structure of the nucleosome core particle at 2.8 resolution Nature 1997 389 6648 251 260
6. Andrews A. J., Chen X., Zevin A., The histone chaperone Nap1 promotes nucleosome assembly by eliminating nonnuclesomal histone DNA interactions Molecular Cell 2010 37 834 842
7. Ahmad K., Henikoff S., Epigenetic consequences of nucleosome dynamics Cell 2002 111 3 281 284
8. Ransom M., Dennehey B. K., Tyler J. K., Chaperoning histones during DNA replication and repair Cell 2010 140 2 183 195
9. Margueron R., Trojer P., Reinberg D., The key to development: interpreting the histone code? Current Opinion in Genetics and Development 2005 15 2 163 176
10. Svejstrup J. Q., Transcription, histones face the FACT Science 2003 301 5636 1053 1055
11. Workman J. L., Nucleosome displacement in transcription Genes and Development 2006 20 15 2009 2017
12. Akey C. W., Luger K., Histone chaperones and nucleosome assembly Current Opinion in Structural Biology 2003 13 1 6 14
13. Loyola A., Almouzni G., Histone chaperones, a supporting role in the limelight Biochimica et Biophysica Acta 2004 1677 13 3 11
14. Ray-Gallet D., Quivy J.-P., Scamps C., Martini E. M.-D., Lipinski M., Almouzni G., HIRA is critical for a nucleosome assembly pathway independent of DNA synthesis Molecular Cell 2002 9 5 1091 1100
15. Tagami H., Ray-Gallet D., Almouzni G., Nakatani Y., Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis Cell 2004 116 1 51 61
16. Aronheim A., Zandi E., Hennemann H., Elledge S. J., Karin M., Isolation of an AP-1 repressor by a novel method for detecting protein- protein interactions Molecular and Cellular Biology 1997 17 6 3094 3102
17. Jin C., Ugai H., Song J., Murata T., Nili F., Sun K., Horikoshi M., Yokoyama K. K., Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2 FEBS Letters 2001 489 1 34 41
18. Broder Y. C., Katz S., Aronheim A., The Ras recruitment system, a novel approach to the study of protein-protein interactions Current Biology 1998 8 20 1121 1124
19. Wardell S. E., Boonyaratanakornkit V., Adelman J. S., Aronheim A., Edwards D. P., Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator Molecular and Cellular Biology 2002 22 15 5451 5466
20. Pan J., Jin C., Murata T., Yokoyama K. K., Sequence specific transcription factor, JDP2 interacts with histone and inhibits p300-mediated histone acetylation Nucleic Acids Research. Supplement 2003 3 305 306
21. Katz S., Aronheim A., Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2 Biochemical Journal 2002 368 3 939 945
22. Katz S., Heinrich R., Aronheim A., The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase FEBS Letters 2001 506 3 196 200
23. Kimura M., IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription FEBS Letters 2008 582 19 2833 2837
24. Piu F., Aronheim A., Katz S., Karin M., AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation Molecular and Cellular Biology 2001 21 9 3012 3024
25. Blazek E., Wasmer S., Kruse U., Aronheim A., Aoki M., Vogt P. K., Partial oncogenic transformation of chicken embryo fibroblasts by Jun dimerization protein 2, a negative regulator of TRE- and CRE-dependent transcription Oncogene 2003 22 14 2151 2159
26. Holding C., JDP2a cell-cycle master switch? Trends in Biochemical Sciences 2002 27 12 603
27. Ostrovsky O., Bengal E., Aronheim A., Induction of terminal differentiation by the c-Jun dimerization protein JDP2 in C2 myoblasts and rhabdomyosarcoma cells Journal of Biological Chemistry 2002 277 42 40043 40054
28. Kawaida R., Ohtsuka T., Okutsu J., Takahashi T., Kadono Y., Oda H., Hikita A., Nakamura K., Tanaka S., Furukawa H., Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL Journal of Experimental Medicine 2003 197 8 1029 1035
29. Hwang H. C., Martins C. P., Bronkhorst Y., Randel E., Berns A., Fero M., Clurman B. E., Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis Proceedings of the National Academy of Sciences of the United States of America 2002 99 17 11293 11298
30. Heinrich R., Livne E., Ben-Izhak O., Aronheim A., The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene Journal of Biological Chemistry 2004 279 7 5708 5715
31. Jin C., Li H., Murata T., Sun K., Horikoshi M., Chiu R., Yokoyama K. K., JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells Molecular and Cellular Biology 2002 22 13 4815 4826
32. Jin C., Kato K., Chimura T., Yamasaki T., Nakade K., Murata T., Li H., Pan J., Zhao M., Sun K., Chiu R., Ito T., Nagata K., Horikoshi M., Yokoyama K. K., Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2 Nature Structural and Molecular Biology 2006 13 4 331 338
33. Nakade K., Pan J., Yoshiki A., Ugai H., Kimura M., Liu B., Li H., Obata Y., Iwama M., Itohara S., Murata T., Yokoyama K. K., JDP2 suppresses adipocyte differentiation by regulating histone acetylation Cell Death and Differentiation 2007 14 8 1398 1405
34. Yang X.-J., Ogryzko V. V., Nishikawa J.-I., Howard B. H., Nakatani Y., A p300/CPB-associated factor that competes with the adenoviral oncoprotein E1A Nature 1996 382 6589 319 324
35. Kawasaki H., Schiltz L., Chiu R., Itakura K., Taira K., Nakatani Y., Yokoyama K. K., ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation Nature 2000 405 6783 195 200
36. Karanam B., Wang L., Wang D., Liu X., Marmorstein R., Cotter R., Cole P. A., Multiple roles for acetylation in the interaction of p300 HAT with ATF-2 Biochemistry 2007 46 28 8207 8216
37. Bruhat A., Chrrasse Y., Maurin A.-C., Breitwieser W., Parry L., Deval C., Jones N., Jousse C., Fafournoux P., ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation Nucleic Acids Research 2007 35 4 1312 1321
38. Seo S.-B., McNamara P., Heo S., Turner A., Lane W. S., Chakravarti D., Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein Cell 2001 104 1 119 130
39. Seo S.-B., Macfarlan T., McNamara P., Hong R., Mukai Y., Heo S., Chakravarti D., Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex Journal of Biological Chemistry 2002 277 16 14005 14010
40. Nakade K., Pan J., Yamasaki T., Murata T., Wasylyk B., Yokoyama K. K., JDP2 (Jun dimerization protein 2)-deficient mouse embryonic fibroblasts are resistant to replicative senescene Journal of Biological Chemistry 2009 284 16 10808 10817
41. Kehat I., Hasin T., Aronheim A., The role of basic leucine zipper protein-mediated transcription in physiological and pathological myocardial hypertrophy Annals of the New York Academy of Sciences 2006 1080 97 109
42. Rajala M. W., Scherer P. E., Minireview: the adipocyteat the crossroads of energy homeostasis, inflammation, and atherosclerosis Endocrinology 2003 144 9 3765 3773
43. Kahn B. B., Flier J. S., Obesity and insulin resistance Journal of Clinical Investigation 2000 106 4 473 481
44. Rangwala S. M., Lazar M. A., Transcriptional control of adipogenesis Annual Review of Nutrition 2000 20 535 559
45. Rosen E. D., Spiegelman B. M., Molecular regulation of adipogenesis Annual Review of Cell and Developmental Biology 2000 16 145 171
46. Tanaka T., Yoshida N., Kishimoto T., Akira S., Defective adipocyte differentiation in mice lacking the C/EBP and/or C/EBP gene EMBO Journal 1997 16 24 7432 7443
47. Evans R. M., Barish G. D., Wang Y.-X., PPARs and the complex journey to obesity Nature Medicine 2004 10 4 355 361
48. Morrison R. F., Farmer S. R., Hormonal signaling and transcriptional control of adipocyte differentiation Journal of Nutrition 2000 130 12 3116S 3121S
49. Rosen E. D., Walkey C. J., Puigserver P., Spiegelman B. M., Transcriptional regulation of adipogenesis Genes and Development 2000 14 11 1293 1307
50. Lin F.-T., MacDougald O. A., Diehl A. M., Lane M. D., A 30-kDa alternative translation product of the CCAAT/enhancer binding protein message: transcriptional activator lacking antimitotic activity Proceedings of the National Academy of Sciences of the United States of America 1993 90 20 9606 9610
51. Christy R. J., Kaestner K. H., Geiman D. E., Lane M. D., CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes Proceedings of the National Academy of Sciences of the United States of America 1991 88 6 2593 2597
52. Wu Z., Xie Y., Bucher N. L. R., Farmer S. R., Conditional ectopic expression of C/EBP in NIH-3T3 cells induces PPAR and stimulates adipogenesis Genes and Development 1995 9 19 2350 2363
53. Fajas L., Schoonjans K., Gelman L., Kim J. B., Najib J., Martin G., Fruchart J.-C., Briggs M., Spiegelman B. M., Auwerx J., Regulation of peroxisome proliferator-activated receptor expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism Molecular and Cellular Biology 1999 19 8 5495 5503
54. Shao D., Lazar M. A., Peroxisome proliferator activated receptor, CCAAT/enhancer-binding protein, and cell cycle status regulate the commitment to adipocyte differentiation Journal of Biological Chemistry 1997 272 34 21473 21478
55. Schwarz E. J., Reginato M. J., Shao D., Krakow S. L., Lazar M. A., Retinoic acid blocks adipogenesis by inhibiting C/EBP γ-mediated transcription Molecular and Cellular Biology 1997 17 3 1552 1561
56. Wu Z., Rosen E. D., Brun R., Hauser S., Adelmant G., Troy A. E., McKeon C., Darlington G. J., Spiegelman B. M., Cross-regulation of C/EBP and PPAR controls the transcriptional pathway of adipogenesis and insulin sensitivity Molecular Cell 1999 3 2 151 158
57. Kang S., Bajnok L., Longo K. A., Petersen R. K., Hansen J. B., Kristiansen K., MacDougald O. A., Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1 Molecular and Cellular Biology 2005 25 4 1272 1282
58. Hansen J. B., Jrgensen C., Petersen R. K., Hallenborg P., De Matteis R., Bye H. A., Petrovic N., Enerbck S., Nedergaard J., Cinti S., Te Riele H., Kristiansen K., Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation Proceedings of the National Academy of Sciences of the United States of America 2004 101 12 4112 4117
59. Guan H.-P., Ishizuka T., Chui P. C., Lehrke M., Lazar M. A., Corepressors selectively control the transcriptional activity of PPAR in adipocytes Genes and Development 2005 19 4 453 461
60. Sherr C. J., Cancer cell cycles Science 1996 274 5293 1672 1674
61. Weinberg R. A., E2F and cell proliferation: a world turned upside down Cell 1996 85 4 457 459
62. Harbour J. W., Dean D. C., The Rb/E2F pathway: expanding roles and emerging paradigms Genes and Development 2000 14 19 2393 2409
63. Harbour J. W., Dean D. C., Rb function in cell-cycle regulation and apoptosis Nature Cell Biology 2000 2 4 E65 E67
64. Sherr C. J., Roberts J. M., CDK inhibitors: positive and negative regulators of G1-phase progression Genes and Development 1999 13 12 1501 1512
65. Pavletich N. P., Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors Journal of Molecular Biology 1999 287 5 821 828
66. Sharpless N. E., INK4a/ARF: a multifunctional tumor suppressor locus Mutation Research 2005 576 1-2 22 38
67. El-Deiry W. S., Tokino T., Velculescu V. E., Levy D. B., Parsons R., Trent J. M., Lin D., Mercer W. E., Kinzler K. W., Vogelstein B., WAF1, a potential mediator of p53 tumor suppression Cell 1993 75 4 817 825
68. Hermeking H., Lengauer C., Polyak K., He T.-C., Zhang L., Thiagalingam S., Kinzler K. W., Vogelstein B., 14-3-3 is a p53-regulated inhibitor of G2/M progression Molecular Cell 1997 1 1 3 11
69. Zhan Q., Chen I.-T., Antinore M. J., Fornace A. J. Jr., Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding Molecular and Cellular Biology 1998 18 5 2768 2778
70. Miyashita T., Reed J. C., Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Cell 1995 80 2 293 299
71. Nakano K., Vousden K. H., PUMA, a novel proapoptotic gene, is induced by p53 Molecular Cell 2001 7 3 683 694
72. Nagata S., Apoptosis by death factor Cell 1997 88 3 355 365
73. Wu G. S., Burns T. F., McDonald E. R. III, Jiang W., Meng R., Krantz I. D., Kao G., Gan D. D., Zhou J. Y., Muschel R., Hamilton S. R., Spinner N. B., Markowitz S., Wu G., el-Deiry W. S., KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene Nature Genetics 1997 17 2 141 143
74. Yu J., Zhang L., Hwang P. M., Kinzler K. W., Vogelstein B., PUMA induces the rapid apoptosis of colorectal cancer cells Molecular Cell 2001 7 3 673 682
75. Reisman D., Loging W. T., Transcriptional regulation of the p53 tumor suppressor gene Seminars in Cancer Biology 1998 8 5 317 324
76. Fu L., Benchimol S., Participation of the human p53 3′ UTR in translational repression and activation following -irradiation EMBO Journal 1997 16 13 4117 4125
77. Honda R., Tanaka H., Yasuda H., Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 FEBS Letters 1997 420 1 25 27
78. Perry M. E., Piette J., Zawadzki J. A., Harvey D., Levine A. J., The mdm-2 gene is induced in response to UV light in a p53-dependent manner Proceedings of the National Academy of Sciences of the United States of America 1993 90 24 11623 11627
79. Honda R., Yasuda H., Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53 EMBO Journal 1999 18 1 22 27
80. Shieh S.-Y., Ikeda M., Taya Y., Prives C., DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 Cell 1997 91 3 325 334
81. Mayo L. D., Turchi J. J., Berberich S. J., Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53 Cancer Research 1997 57 22 5013 5016
82. Khanna K. K., Keating K. E., Kozlov S., Scott S., Gatei M., Hobson K., Taya Y., Gabrielli B., Chan D., Lees-Miller S. P., Lavin M. F., ATM associates with and phosphorylates p53: mapping the region of interaction Nature Genetics 1998 20 4 398 400
83. Banin S., Moyal L., Shieh S.-Y., Taya Y., Anderson C. W., Chessa L., Smorodinsky N. I., Prives C., Reiss Y., Shiloh Y., Z Y. IV, Enhanced phosphorylation of p53 by ATM in response to DNA damage Science 1998 281 5383 1674 1677
84. Sherr C. J., Divorcing ARF and p53: an unsettled case Nature Reviews Cancer 2006 6 9 663 673
85. Van Maerken T., Vandesompele J., Rihani A., De Paepe A., Speleman F., Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14ARF-MDM2-p53 axis Cell Death and Differentiation 2009 16 12 1563 1572
86. Serrano M., Lee H.-W., Chin L., Cordon-Cardo C., Beach D., DePinho R. A., Role of the INK4a locus in tumor suppression and cell mortality Cell 1996 85 1 27 37
87. Bodnar A. G., Ouellette M., Frolkis M., Holt S. E., Chiu C.-P., Morin G. B., Harley C. B., Shay J. W., Lichtsteiner S., Wright W. E., Extension of life-span by introduction of telomerase into normal human cells Science 1998 279 5349 349 352
88. Lee H.-W., Blasco M. A., Gottlieb G. J., Horner J. W. II, Greider C. W., DePinho R. A., Essential role of mouse telomerase in highly proliferative organs Nature 1998 392 6676 569 574
89. Blasco M. A., Lee H.-W., Hande M. P., Samper E., Lansdorp P. M., DePinho R. A., Greider C. W., Telomere shortening and tumor formation by mouse cells lacking telomerase RNA Cell 1997 91 1 25 34
90. Garca-Cao I., Garca-Cao M., Toms-Loba A., Martn-Caballero J., Flores J. M., Klatt P., Blasco M. A., Serrano M., Increased p53 activity does not accelerate telomere-driven ageing EMBO Reports 2006 7 5 546 552
91. Ressler S., Bartkova J., Niederegger H., Bartek J., Scharffetter-Kochanek K., Jansen-Drr P., Wlaschek M., p16INK4A is a robust in vivo biomarker of cellular aging in human skin Aging Cell 2006 5 5 379 389
92. Efeyan A., Garcia-Cao I., Herranz D., Velasco-Miguel S., Serrano M., Tumour biology: policing of oncogene activity by p53 Nature 2006 443 7108 159
93. Mallette F. A., Gaumont-Leclerc M.-F., Ferbeyre G., The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence Genes and Development 2007 21 1 43 48
94. Helgadottir A., Thorleifsson G., Manolescu A., Gretarsdottir S., Blondal T., Jonasdottir A., Jonasdottir A., Sigurdsson A., Baker A., Palsson A., Masson G., Gudbjartsson D. F., Magnusson K. P., Andersen K., Levey A. I., Backman V. M., Matthiasdottir S., Jonsdottir T., Palsson S., Einarsdottir H., Gunnarsdottir S., Gylfason A., Vaccarino V., Hooper W. C., Reilly M. P., Granger C. B., Austin H., Rader D. J., Shah S. H., Quyyumi A. A., Gulcher J. R., Thorgeirsson G., Thorsteinsdottir U., Kong A., Stefansson K., A common variant on chromosome 9p21 affects the risk of myocardial infarction Science 2007 316 5830 1491 1493
95. Zeggini E., Weedon M. N., Lindgren C. M., Frayling T. M., Elliott K. S., Lango H., Timpson N. J., Perry J. R. B., Rayner N. W., Freathy R. M., Barrett J. C., Shields B., Morris A. P., Ellard S., Groves C. J., Harries L. W., Marchini J. L., Owen K. R., Knight B., Cardon L. R., Walker M., Hitman G. A., Morris A. D., Doney A. S. F., McCarthy M. I., Hattersley A. T., Bruce I. N., Donovan H., Eyre S., Gilbert P. D., Hider S. L., Hinks A. M., John S. L., Potter C., Silman A. J., Symmons D. P. M., Thomson W., Worthington J., Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes Science 2007 316 5829 1336 1341
96. Scott L. J., Mohlke K. L., Bonnycastle L. L., Willer C. J., Li Y., Duren W. L., Erdos M. R., Stringham H. M., Chines P. S., Jackson A. U., Prokunina-Olsson L., Ding C.-J., Swift A. J., N., Hu T., Pruim R., Xiao R., Li X.-Y., Conneely K. N., Riebow N. L., Sprau A. G., Tong M., White P. P., Hetrick K. N., Barnhart M. W., Bark C. W., Goldstein J. L., Watkins L., Xiang F., Saramies J., Buchanan T. A., Watanabe R. M., Valle T. T., Kinnunen L., Abecasis G. R., Pugh E. W., Doheny K. F., Bergman R. N., Tuomilehto J., Collins F. S., Boehnke M., A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants Science 2007 316 5829 1341 1345
97. Saxena R., Voight B. F., Lyssenko V., Burtt N. P., De Bakker P. I. W., Chen H., Roix J. J., Kathiresan S., Hirschhorn J. N., Daly M. J., Hughes T. E., Groop L., Altshuler D., Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 2007 316 5829 1331 1336
98. Melzer D., Frayling T. M., Murray A., Hurst A. J., Harries L. W., Song H., Khaw K., Luben R., Surtees P. G., Bandinelli S. S., Corsi A.-M., Ferrucci L., Guralnik J. M., Wallace R. B., Hattersley A. T., Pharoah P. D., A common variant of the p16INK4a genetic region is associated with physical function in older people Mechanisms of Ageing and Development 2007 128 5-6 370 377
99. McPherson R., Pertsemlidis A., Kavaslar N., Stewart A., Roberts R., Cox D. R., Hinds D. A., Pennacchio L. A., Tybjaerg-Hansen A., Folsom A. R., Boerwinkle E., Hobbs H. H., Cohen J. C., A common allele on chromosome 9 associated with coronary heart disease Science 2007 316 5830 1488 1491
100. Mason P. J., Bessler M., Heterozygous telomerase deficiency in mouse and man: when less is definitely not more Cell Cycle 2004 3 9 1127 1129
101. Vitolo J. M., Thiriet C., Hayes J. J., The H3-H4 N-terminal tail domains are the primary mediators of transcription factor IIIA access to 5S DNA within a nucleosome Molecular and Cellular Biology 2000 20 6 2167 2175
102. Yang Z., Zheng C., Thiriet C., Hayes J. J., The core histone N-terminal tail domains negatively regulate binding of transcription factor IIIA to a nucleosome containing a 5S RNA gene via a novel mechanism Molecular and Cellular Biology 2005 25 1 241 249
103. Li F., Macfarlan T., Pittman R. N., Chakravarti D., Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities Journal of Biological Chemistry 2002 277 47 45004 45012
104. Yu J., Li Y., Ishizuka T., A SANT motif in the SMRT corepressor in triplets the histone code and promotes histone acetylations The EMBO Journal 2003 22 3403 3410
105. Choi B., Ko J. K., Shin J., The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains Journal of Biological Chemistry 2004 279 49 50930 50941
106. Loven M. A., Muster N., Yates J. R., A novel estrogen receptor alpha-associated pasortien, template-activation factor I beta, inhibits acetylation and transactivation Molecular Endocrinology 2003 17 67 78
107. Loven M. A., Davis R. E., Curtis C. D., Muster N., Yates J. R., Nardulli A. M., A novel estrogen receptor -associated protein alters receptor- deoxyribonucleic acid interactions and represses receptor-mediated transcription Molecular Endocrinology 2004 18 11 2649 2659
108. Macfarlan T., Kutney S., Altman B., Montross R., Yu J., Chakravarti D., Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor Journal of Biological Chemistry 2005 280 8 7346 7358
109. Macfarlan T., Parker J. B., Nagata K., Chakravarti D., Thanatos-associated protein 7 associates with template activating factor-I and inhibits histone acetylation to repress transcription Molecular Endocrinology 2006 20 2 335 347
110. Hublitz P., Kunowska N., Mayer U. P., Mller J. M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I. W., Van Grunsven L. A., Potiers N., Van Dorsselaer A., Metzger E., Roemer K., Schle R., NIR is a novel INHAT repressor that modulates the transcriptional activity of p53 Genes and Development 2005 19 23 2912 2924
111. Hong W., Kim A. Y., Ky S., Rakowski C., Seo S.-B., Chakravarti D., Atchison M., Blobel G. A., Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1 Molecular and Cellular Biology 2002 22 11 3729 3743
112. Stopka T., Amanatullah D. F., Papetti M., Skoultchi A. I., PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure EMBO Journal 2005 24 21 3712 3723
113. Hong R., Chakravarti D., The human proliferating cell nuclear antigen regulates transcriptional coactivator p300 activity and promotes transcriptional repression Journal of Biological Chemistry 2003 278 45 44505 44513
114. Suzuki T., Muto S., Miyamoto S., Aizawa K., Horikoshi M., Nagai R., Functional interaction of the DNA-binding transcription factor Sp1 through its DNA-binding domain with the histone chaperone TAF-I Journal of Biological Chemistry 2003 278 31 28758 28764
115. Miyamoto S., Suzuki T., Muto S., Positive and negative regulation of the cardiovascular transcription actor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain Molecular and Cellular Biology 2003 23 8528 8541
116. Angelov D., Lenouvel F., Hans F., Mller C. W., Bouvet P., Bednar J., Moudrianakis E. N., Cadet J., Dimitrov S., The histone octamer is invisible when NF-κB binds to the nucleosome Journal of Biological Chemistry 2004 279 41 42374 42382
117. Mo X., Kowenz-Leutz E., Laumonnier Y., Xu H., Leutz A., Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain Genes and Development 2005 19 20 2447 2457
118. Maddox P. S., Hyndman F., Monen J., Oegema K., Desai A., Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin Journal of Cell Biology 2007 176 6 757 763
119. Agelopoulos M., Thanos D., Epigenetic determination of a cell-specific gene expression program by ATF-2 and the histone variant macroH2A EMBO Journal 2006 25 20 4843 4853
120. Pan J., Nakade K., Huang Y.-C., Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 Oncogene 2010