ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation

Nature

Volumn 405, Issue 6783, 2000, Pages 195-200

  Kawasaki, Hiroaki ^a,b   Schiltz, Lou ^c   Chiu, Robert ^d   Itakura, Kellchi ^e   Taira, Kazunari ^b,f   Nakatani, Yoshihiro ^c,g   Yokoyama, Kazunari K ^a  

^a RIKEN TSUKUBA INSTITUTE   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^f UNIVERSITY OF TOKYO   (Japan)

^g DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE ACETYLTRANSFERASE;

ARTICLE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSCRIPTION REGULATION; ULTRAVIOLET IRRADIATION;

ACETYLTRANSFERASES; ACTIVATING TRANSCRIPTION FACTOR 2; AMINO ACID SEQUENCE; ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENZYME ACTIVATION; HELA CELLS; HISTONE ACETYLTRANSFERASES; HISTONES; HUMANS; LUCIFERASES; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RECOMBINANT FUSION PROTEINS; RESPONSE ELEMENTS; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034636554     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35012097     Document Type: Article

References (29)

1. Hai, T., Liu, F., Coukos, W. J. & Green, M. R. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 3, 2083-2090 (1989).
2. Maekawa, T. et al. Leucine zipper structure of the protein CRE-BP 1 binding to the cyclic AMP-response element in brain. EMRO J. 8, 2023-2028 (1989).
3. Ptashne, M. & Gann, A. Transcriptional activation by recruitment. Nature 386, 569-573 (1997).
4. Brownell, J. E. et al. Tetrahymena histone acetyltransferase A: a homolog of yeast Gcn5p linking histone acetylation to gene activation. Cell 84, 843-851 (1996).
5. Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H. & Nakatani, Y. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87, 953-959 (1996).
6. Bannister, A. J. & Kouzarides, T. The CBP co-activator is a histone acetyltransferase. Nature 384, 641-643 (1996).
7. Yang X. J., Ogryzko, V. V., Nishikawa, J., Howard, B. H. & Nakatani, Y. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A, Nature 382, 319-324 (1996).
8. Chen, H. et al. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90, 569-580 (1997).
9. Spencer, T. E. et al. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389, 194-198 (1997).
10. Imhof, A. et al. Acetylation of general transcription factors by histone acetyltransferases. Curr. Biol. 7, 689-692 (1997).
11. Torchia, J. et al. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387, 677-684 (1997).
12. Struhl, K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12, 599-606 (1998).
13. Brown, C. E., Lechner, T., Howe, L. & Workman, J. L. The many HATs of transcription coactivators. Trends Biochem. Sci. 25, 15-19 (2000).
14. Kawasaki, H. et al. p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells. Genes Dev. 12, 233-245 (1998).
15. Liu, F. & Green, M. A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1A protein. Cell 61, 1217-1224 (1990).
16. Schiltz, R. L. et al. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosome substrates. J. Biol Chem. 274, 1189-1192 (1999).
17. Martinez-Balbas, M. A. et al. The acetyltransferase activity of CBP stimulates transcription. EMBO J. 17, 2886-2893 (1998).
18. Dutnall, R. N., Tafrov, S. T., Stermglanz, R. & Ramakrishnam, V. Structure of the histone acetyltranscferase Hatl: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell 94, 427-438 (1998).
19. Eckner, R., Yao, T. -S., Oldread, E. & Livingston, D. M. Molecular cloning and functional analysis of the adenovirus EJA-associaled 300-kDa protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8, 869-884 (1994).
20. Herrlich, P., Blattner, C., Knebel, A., Bender, K. & Rahmsdorf, H. J. Nuclear and non-nuclear targets of genotoxic agents in the induction of gene expression. Shared principles in yeast, rodents, man and plants. Biol. Chem. 378, 1217-1229 (1997).
21. van Dam, H. et al. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-Jun induction in response to genotoxic agents. EMBO J. 14, 1798-1811 (1995).
22. Livingston, C., Patel, G. & Jones, N. C. ATF-2 contains a phospborylation-dependent transcriptional activation domain. EMBO J. 14, 1785-1797 (1995).
23. Luger, K., Mader, A. W., Richmond, R. K., Sargent, D. P. & Richmond, T. J. X-ray structure of the nucleosome core particle at 2.8Å resolution. Nature 389, 251-259 (1997).
24. Gu, W. & Roeder, R. G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606 (1997).
25. Zhang, W. & Bicker, J. J. Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc. Natl Acad. Sci. USA 95, 9855-9860 (1998).
26. Boyes, J., Byfield, P., Nakatani, Y. & Ogryzko, V. V. Regulation of activity of the transcription factor GATA-1 by acetylation. Nature 396, 594-598 (1998).
27. Kawasaki, H. et al. Distinct roles of the co-activators p300 and CBP in retinoic acid-induced F9-cell differentiation. Nature 393, 284-289 (1998).
28. Montminy, M. R. & Beiezikjian, J. M. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature 328, 175-178 (1987).
29. Bender, K., Gottlicher, M., Whiteside, S., Rahmsdorf, H. J. & Herrlich, P. Sequential DNA damage-independent and -dependent activation of NF-kB by ultraviolet. EMBO J. 17, 5710-5181 (1998).