ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation

Nucleic Acids Research

Volumn 35, Issue 4, 2007, Pages 1312-1321

  Bruhat, Alain ^a   Chrérasse, Yoan ^a   Maurin, Anne Catherine ^a   Breitwieser, Wolfgang ^b   Parry, Laurent ^a   Deval, Christiane ^a   Jones, Nic ^b   Jousse, Céline ^b   Fafournoux, Pierre ^a  

^a INRA and University of Auvergne   (France)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID; CCAAT ENHANCER BINDING PROTEIN; HISTONE H2B; HISTONE H4; MESSENGER RNA;

ACETYLATION; ANIMAL CELL; ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; EMBRYO; FIBROBLAST; GENE CONTROL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; TIME; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ACETYLATION; ACTIVATING TRANSCRIPTION FACTOR 2; ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACIDS; ANIMALS; CELLS, CULTURED; HISTONES; MICE; PHOSPHORYLATION; RESPONSE ELEMENTS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR CHOP;

EID: 34047117344     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkm038     Document Type: Article

References (42)

1. Kilberg,M.S., Pan,Y.X., Chen,H. and Leung-Pineda,V. (2005) Nutrtional control of gene expression: How mammalian cells respond to amino acid limitation. Annu. Rev. Nutr., 25, 59-85.
2. Wek,R.C., Jiang,H.Y. and Anthony,T.G. (2006) Coping with stress: EIF2 kinases and translational control. Biochem. Soc. Trans., 34, 7-11.
3. Chen,H., Pan,Y.X., Dudenhausen,E.E. and Kilberg,M.S. (2004) Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation. J. Biol. Chem., 279, 50829-50839.
4. Averous,J., Bruhat,A., Jousse,C., Carraro,V., Thiel,G. and Fafournoux,P. (2004) Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. J. Biol. Chem., 279, 5288-5297.
5. Ron,D. and Habener,J.F. (1992) CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant- negative inhibitor of gene transcription. Genes Dev., 6, 439-453.
6. Luethy,J.D. and Holbrook,N.J. (1992) Activation of the gadd153 promoter by genotoxic agents: A rapid and specific response to DNA damage. Cancer Res., 52, 5-10.
7. Sylvester,S.L., ap Rhys,C.M., Luethy-Martindale,J.D. and Holbrook,N.J. (1994) Induction of GADD153, a CCAAT/enhancer-binding protein (C/ EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression [published erratum appears in J. Biol. Chem. (1995) 270, 14842]. J Biol. Chem., 269, 20119-20125.
8. Wang,X.Z. and Ron,D. (1996) Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science, 272, 1347-1349.
9. Bruhat,A., Jousse,C., Wang,X.Z., Ron,D., Ferrara,M. and Fafournoux,P. (1997) Amino acid limitation induces expression of CHOP, a CCAAT/ enhancer binding protein-related gene, at both transcriptional and post- transcriptional levels. J. Biol. Chem., 272, 17588-17593.
10. Bruhat,A., Jousse,C., Carraro,V., Reimold,A.M., Ferrara,M. and Fafournoux,P. (2000) Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter. Mol. Cell. Biol., 20, 7192-7204.
11. Zhong,C., Chen,C. and Kilberg,M.S. (2003) Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter. Biochem. J., 372, 603-609.
12. Pan,Y.X., Chen,H., Thiaville,M.M. and Kilberg,M.S. (2006) Activation of the ATF3 gene through a coordinated amino acidsensing response program that controls transcriptional regulation of responsive genes following amino acid limitation. Biochem. J., 401, 299-307.
13. Palii,S.S., Chen,H. and Kilberg,M.S. (2004) Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. J. Biol. Chem., 279, 3463-3471.
14. Lopez,A.B., Wang,C., Huang,C.C., Yaman,I., Li,Y., Chakravarty,K., Johnson,P.F., Chiang,C.M., Snider,M.D. et al. A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. Biochem. J., as Immediate Publication, 17 October 2006.
15. Wagner,E.F. (2001) AP-1-Introductory remarks. Oncogene, 20, 2334-2335.
16. Gupta,S., Campbell,D., Derijard,B. and Davis,R.J. (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science, 267, 389-393.
17. Karin,M., Liu,Z. and Zandi,E. (1997) AP-1 function and regulation. Curr. Opin. Cell. Biol., 9, 240-246.
18. Hayakawa,J., Mittal,S., Wang,Y., Korkmaz,K.S., Adamson,E., English,C., Ohmichi,M., McClelland,M. and Mercola,D. (2004) Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress. Mol. Cell, 16, 521-535.
19. Bhoumik,A., Takahashi,S., Breitweiser,W., Shiloh,Y., Jones,N. and Ronai,Z. (2005) ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol. Cell, 18, 577-587.
20. Livingstone,C., Patel,G. and Jones,N. (1995) ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO. J., 14, 1785-1797.
21. Ouwens,D.M., de Ruiter,N.D., van der Zon,G.C., Carter,A.P., Schouten,J., van der Burgt,C., Kooistra,K., Bos,J.L., Maassen,J.A. et al. (2002) Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. EMBO. J., 21, 3782-3793.
22. Harding,H.P., Zhang,Y., Zeng,H., Novoa,I., Lu,P.D., Calfon,M., Sadri,N., Yun,C., Popko,B. et al. (2003) An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell, 11, 619-633.
23. Bruhat,A., Averous,J., Carraro,V., Zhong,C., Reimold,A.M., Kilberg,M.S. and Fafournoux,P. (2002) Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response. J. Biol. Chem., 277, 48107-48114.
24. Marciniak,S.J., Yun,C.Y., Oyadomari,S., Novoa,I., Zhang,Y., Jungreis,R., Nagata,K., Harding,H.P. and Ron,D. (2004) CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev., 18, 3066-3077
25. Jiang,H.Y. and Wek,R.C. (2005) Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition. J. Biol. Chem., 280, 14189-14202.
26. Davis,R.J. (2000) Signal transduction by the JNK group of MAP kinases. Cell, 103, 239-252.
27. Chang,L. and Karin,M. (2001) Mammalian MAP kinase signalling cascades. Nat., 410, 37-40.
28. Kyriakis,J.M. and Avruch,J. (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev., 81, 807-869.
29. Franchi-Gazzola,R., Visigalli,R., Bussolati,O., Dall'Asta,V. and Gazzola,G.C. (1999) Adaptive increase of amino acid transport system A requires ERK1/2 activation. J. Biol. Chem., 274, 28922-28928.
30. Sharp,J.W., Ross-Inta,C.M., Hao,S., Rudell,J.B. and Gietzen,D.W. (2006) Co-localization of phosphorylated extracellular signal-regulated protein kinases 1/2 (ERK1/2) and phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha) in response to a threoninedevoid diet. J. Comp. Neurol., 494, 485-494.
31. Aubel,C., Dehez,S., Chabanon,H., Seva,C., Ferrara,M. and Brachet,P. (2001) Activation of c-Jun N-terminal kinase 1 (JNK-1) after amino acid deficiency in HeLa cells. Cell. Signal, 13, 417-423.
32. Kuo,M.H. and Allis,C.D. (1998) Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays, 20, 615-626.
33. Berger,S.L. (2002) Histone modifications in transcriptional regulation. Curr. Opin. Genet. Dev., 12, 142-148.
34. Sterner,D.E. and Berger,S.L. (2000) Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev., 64, 435-459.
35. Shogren-Knaak,M., Ishii,H., Sun,J.M., Pazin,M.J., Davie,J.R. and Peterson,C.L. (2006) Histone H4-K16 acetylation controls chromatin structure and protein interactions. Sci., 311, 844-847.
36. Thomson,S., Hollis,A., Hazzalin,C.A. and Mahadevan,L.C. (2004) Distinct stimulus-specific histone modifications at hsp70 chromatin targeted by the transcription factor heat shock factor-1. Mol. Cell, 15, 585-594.
37. Marmorstein,R. (2001) Structure of histone acetyltransferases. J. Mol. Biol., 311, 433-444.
38. Bannister,A.J. and Kouzarides,T. (1996) The CBP co-activator is a histone acetyltransferase. Nature, 384, 641-643.
39. Spencer,T.E., Jenster,G., Burcin,M.M., Allis,C.D., Zhou,J., Mizzen,C.A., McKenna,N.J., Onate,S.A., Tsai,S.Y. et al. (1997) Steroid receptor coactivator-1 is a histone acetyltransferase. Nature, 389, 194-198.
40. Yang,X.J., Ogryzko,V.V., Nishikawa,J., Howard,B.H. and Nakatani,Y. (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature, 382, 319-324.
41. Kawasaki,H., Schiltz,L., Chiu,R., Itakura,K., Taira,K., Nakatani,Y. and Yokoyama,K.K. (2000) ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. Nature, 405, 195-200.
42. Kawasaki,H., Song,J., Eckner,R., Ugai,H., Chiu,R., Taira,K., Shi,Y., Jones,N. and Yokoyama,K.K. (1998) p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells. Genes Dev., 12, 233-245.