Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 31, 2010, Pages 13912-13917

  Larsson, H Peter ^a   Wang, Xiaoyu ^a   Lev, Bogdan ^b   Baconguis, Isabelle ^c   Caplan, David A ^b,d   Vyleta, Nicholas P ^c   Koch, Hans P ^a   Diez Sampedro, Ana ^a   Noskov, Sergei Y ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Excitatory amino acid transporters; Fluorescence; Simulations; The sodium aspartate symporter from Pyrococcus horikoshii (GltPh)

Indexed keywords

CARRIER PROTEIN; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMATE TRANSPORTER; PROTEIN GLTPH; SODIUM; UNCLASSIFIED DRUG; CATION; SLC1A1 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; COMPUTER SIMULATION; MOLECULAR DYNAMICS; MONTE CARLO METHOD; PRIORITY JOURNAL; PROTEIN STRUCTURE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; MUTATION; OOCYTE; PROTEIN TERTIARY STRUCTURE; XENOPUS LAEVIS;

BACTERIA (MICROORGANISMS); PYROCOCCUS HORIKOSHII;

ANIMALS; BINDING SITES; CATIONS; COMPUTER SIMULATION; EXCITATORY AMINO ACID TRANSPORTER 3; HUMANS; MODELS, MOLECULAR; MONTE CARLO METHOD; MUTATION; OOCYTES; PROTEIN STRUCTURE, TERTIARY; SODIUM; SUBSTRATE SPECIFICITY; XENOPUS LAEVIS;

EID: 77956362466     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1006289107     Document Type: Article

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