메뉴 건너뛰기




Volumn 10, Issue 1, 2011, Pages 9-15

Notch signaling pathway as a therapeutic target in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO N [4 CHLORO 3 (2 PYRIDINYL)PHENYL] 4 METHANESULFONYLBENZAMIDE; ADAM PROTEIN INHIBITOR; ANTIESTROGEN; BEVACIZUMAB; DOCETAXEL; GAMMA SECRETASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR; LETROZOLE; MK 0752; NOTCH RECEPTOR; PROTEIN INHIBITOR; PROTEIN KINASE B; RO 4929097; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 78751557260     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-10-0677     Document Type: Review
Times cited : (126)

References (83)
  • 2
    • 1642382833 scopus 로고    scopus 로고
    • Notch signaling: Control of cell communication and cell fate
    • Lai EC. Notch signaling: control of cell communication and cell fate. Development 2004;131:965-73.
    • (2004) Development , vol.131 , pp. 965-973
    • Lai, E.C.1
  • 3
    • 0028670620 scopus 로고
    • Delta-notch signaling and Drosophila cell fate choice
    • Muskavitch MA. Delta-notch signaling and Drosophila cell fate choice. Dev Biol 1994;166:415-30.
    • (1994) Dev Biol , vol.166 , pp. 415-430
    • Muskavitch, M.A.1
  • 4
    • 0142259346 scopus 로고    scopus 로고
    • The role of notch in tumorigenesis: Oncogene or tumour suppressor?
    • Radtke F, Raj K. The role of notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 2003;3:756-67.
    • (2003) Nat Rev Cancer , vol.3 , pp. 756-767
    • Radtke, F.1    Raj, K.2
  • 5
    • 34548542102 scopus 로고    scopus 로고
    • The intracellular region of Notch ligands: Does the tail make the difference?
    • Pintar A, De Biasio A, Popovic M, Ivanova N, Pongor S. The intracellular region of Notch ligands: does the tail make the difference? Biol Direct 2007;2:19.
    • (2007) Biol Direct , vol.2 , pp. 19
    • Pintar, A.1    De Biasio, A.2    Popovic, M.3    Ivanova, N.4    Pongor, S.5
  • 6
    • 0001395691 scopus 로고    scopus 로고
    • Fringe is a glycosyltransferase that modifies Notch
    • Moloney DJ, Panin VM, Johnston SH, et al. Fringe is a glycosyltransferase that modifies Notch. Nature 2000;406:369-75.
    • (2000) Nature , vol.406 , pp. 369-375
    • Moloney, D.J.1    Panin, V.M.2    Johnston, S.H.3
  • 7
    • 20444472743 scopus 로고    scopus 로고
    • Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
    • Zhang YW, Luo WJ, Wang H, et al. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. J Biol Chem 2005;280:17020-6.
    • (2005) J Biol Chem , vol.280 , pp. 17020-17026
    • Zhang, Y.W.1    Luo, W.J.2    Wang, H.3
  • 8
    • 0027738465 scopus 로고
    • Notch: Neurogenesis is only part of the picture
    • Fortini ME, Artavanis-Tsakonas S. Notch: neurogenesis is only part of the picture. Cell 1993;75:1245-7.
    • (1993) Cell , vol.75 , pp. 1245-1247
    • Fortini, M.E.1    Artavanis-Tsakonas, S.2
  • 9
    • 0029085935 scopus 로고
    • Signalling downstreamof activated mammalian Notch
    • Jarriault S, Brou C, Logeat F, et al. Signalling downstreamof activated mammalian Notch. Nature 1995;377:355-8.
    • (1995) Nature , vol.377 , pp. 355-358
    • Jarriault, S.1    Brou, C.2    Logeat, F.3
  • 10
    • 0030063909 scopus 로고    scopus 로고
    • Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
    • Hsieh JJ, Henkel T, Salmon P, et al. Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol Cell Biol 1996;16:952-9.
    • (1996) Mol Cell Biol , vol.16 , pp. 952-959
    • Hsieh, J.J.1    Henkel, T.2    Salmon, P.3
  • 11
    • 0034669031 scopus 로고    scopus 로고
    • A common enzyme connects notch signaling and Alzheimer's disease
    • Kopan R, Goate A. A common enzyme connects notch signaling and Alzheimer's disease. Genes Dev 2000;14:2799-806.
    • (2000) Genes Dev , vol.14 , pp. 2799-2806
    • Kopan, R.1    Goate, A.2
  • 12
    • 0034073379 scopus 로고    scopus 로고
    • SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function
    • Zhou S, Fujimuro M, Hsieh JJ, et al. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function. Mol Cell Biol 2000;2400-10.
    • (2000) Mol Cell Biol , pp. 2400-2410
    • Zhou, S.1    Fujimuro, M.2    Hsieh, J.J.3
  • 13
    • 0036837899 scopus 로고    scopus 로고
    • Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors
    • Wu L, Sun T, Kobayashi K, Gao P, Griffin JD. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol 2002;22:7688-700.
    • (2002) Mol Cell Biol , vol.22 , pp. 7688-7700
    • Wu, L.1    Sun, T.2    Kobayashi, K.3    Gao, P.4    Griffin, J.D.5
  • 14
    • 0037087506 scopus 로고    scopus 로고
    • Notch: A membrane-bound transcription factor
    • Kopan R. Notch: a membrane-bound transcription factor. J Cell Sci 2002;115:1095-7.
    • (2002) J Cell Sci , vol.115 , pp. 1095-1097
    • Kopan, R.1
  • 15
    • 0034902568 scopus 로고    scopus 로고
    • Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): Implication for cell cycle disruption in transformation by Notch(ic)
    • Ronchini C, Capobianco AJ. Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol 2001;21:5925-34.
    • (2001) Mol Cell Biol , vol.21 , pp. 5925-5934
    • Ronchini, C.1    Capobianco, A.J.2
  • 16
    • 33746546368 scopus 로고    scopus 로고
    • c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
    • Weng AP, Millholland JM, Yashiro-Ohtani Y, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev 2006;20:2096-109.
    • (2006) Genes Dev , vol.20 , pp. 2096-2109
    • Weng, A.P.1    Millholland, J.M.2    Yashiro-Ohtani, Y.3
  • 17
    • 0031594575 scopus 로고    scopus 로고
    • NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
    • Oswald F, Liptay S, Adler G, Schmid RM. NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa. Mol Cell Biol 1998;18:2077-88. (Pubitemid 28152657)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.4 , pp. 2077-2088
    • Oswald, F.1    Liptay, S.2    Adler, G.3    Schmid, R.M.4
  • 18
    • 0033613401 scopus 로고    scopus 로고
    • Involvement of Notch1 in the development of mouse mammary tumors
    • Dievart A, Beaulieu N, Jolicoeur P. Involvement of Notch1 in the development of mouse mammary tumors. Oncogene 1999;18:5973-81.
    • (1999) Oncogene , vol.18 , pp. 5973-5981
    • Dievart, A.1    Beaulieu, N.2    Jolicoeur, P.3
  • 19
    • 0030910099 scopus 로고    scopus 로고
    • Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH
    • Chen Y, Fischer WH, Gill GN. Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH. J Biol Chem 1997;272:14110-4.
    • (1997) J Biol Chem , vol.272 , pp. 14110-14114
    • Chen, Y.1    Fischer, W.H.2    Gill, G.N.3
  • 21
    • 0030811418 scopus 로고    scopus 로고
    • Notch receptors, partners and regulators: From conserved domains to powerful functions
    • Egan SE, St-Pierre B, Leow CC. Notch receptors, partners and regulators: from conserved domains to powerful functions. Curr Top Microbiol Immunol 1998;228:273-324.
    • (1998) Curr Top Microbiol Immunol , vol.228 , pp. 273-324
    • Egan, S.E.1    St-Pierre, B.2    Leow, C.C.3
  • 22
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen LW, Bird J, West DC, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991;66:649-61.
    • (1991) Cell , vol.66 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3
  • 23
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004;306:269-71.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1    Ferrando, A.A.2    Lee, W.3
  • 25
    • 0034729760 scopus 로고    scopus 로고
    • Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays
    • Leethanakul C, Patel V, Gillespie J, et al. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene 2000;19:3220-4.
    • (2000) Oncogene , vol.19 , pp. 3220-3224
    • Leethanakul, C.1    Patel, V.2    Gillespie, J.3
  • 26
    • 33745685874 scopus 로고    scopus 로고
    • Notch3 gene amplification in ovarian cancer
    • Park JT, Li M, Nakayama K, et al. Notch3 gene amplification in ovarian cancer. Cancer Res 2006;66:6312-8.
    • (2006) Cancer Res , vol.66 , pp. 6312-6318
    • Park, J.T.1    Li, M.2    Nakayama, K.3
  • 27
    • 33645473185 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
    • Wang Z, Zhang Y, Li Y, et al. Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006;5:483-93.
    • (2006) Mol Cancer Ther , vol.5 , pp. 483-493
    • Wang, Z.1    Zhang, Y.2    Li, Y.3
  • 28
    • 0030920376 scopus 로고    scopus 로고
    • The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)
    • Gallahan D, Callahan R. The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene 1997;14:1883-90. (Pubitemid 27217801)
    • (1997) Oncogene , vol.14 , Issue.16 , pp. 1883-1890
    • Gallahan, D.1    Callahan, R.2
  • 29
    • 0034642524 scopus 로고    scopus 로고
    • Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines
    • Imatani A, Callahan R. Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines. Oncogene 2000;19:223-31.
    • (2000) Oncogene , vol.19 , pp. 223-231
    • Imatani, A.1    Callahan, R.2
  • 30
    • 32944470488 scopus 로고    scopus 로고
    • Aberrant activation of notch signaling in human breast cancer
    • Stylianou S, Clarke RB, Brennan K. Aberrant activation of notch signaling in human breast cancer. Cancer Res 2006;66:1517-25.
    • (2006) Cancer Res , vol.66 , pp. 1517-1525
    • Stylianou, S.1    Clarke, R.B.2    Brennan, K.3
  • 31
    • 40949092796 scopus 로고    scopus 로고
    • NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells
    • Yamaguchi N, Oyama T, Ito E, et al. NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells. Cancer Res 2008;68:1881-8.
    • (2008) Cancer Res , vol.68 , pp. 1881-1888
    • Yamaguchi, N.1    Oyama, T.2    Ito, E.3
  • 32
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    • Reedijk M, Odorcic S, Chang L, et al. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 2005;65:8530-7.
    • (2005) Cancer Res , vol.65 , pp. 8530-8537
    • Reedijk, M.1    Odorcic, S.2    Chang, L.3
  • 33
    • 34249098132 scopus 로고    scopus 로고
    • High-level JAG1 mRNA and protein predict poor outcome in breast cancer
    • Dickson BC, Mulligan AM, Zhang H, et al. High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod Pathol 2007;20:685-93.
    • (2007) Mod Pathol , vol.20 , pp. 685-693
    • Dickson, B.C.1    Mulligan, A.M.2    Zhang, H.3
  • 34
    • 51649090695 scopus 로고    scopus 로고
    • JAG1 expression is associated with a basal phenotype and recurrence in lymph nodenegative breast cancer
    • Reedijk M, Pinnaduwage D, Dickson BC, et al. JAG1 expression is associated with a basal phenotype and recurrence in lymph nodenegative breast cancer. Breast Cancer Res Treat 2008;111:439-48.
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 439-448
    • Reedijk, M.1    Pinnaduwage, D.2    Dickson, B.C.3
  • 36
    • 48549103124 scopus 로고    scopus 로고
    • Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
    • Rizzo P, Miao H, D'Souza G, et al. Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res 2008;68:5226-35.
    • (2008) Cancer Res , vol.68 , pp. 5226-5235
    • Rizzo, P.1    Miao, H.2    D'Souza, G.3
  • 37
    • 50649125794 scopus 로고    scopus 로고
    • ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor
    • Osipo C, Patel P, Rizzo P, et al. ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. Oncogene 2008;27:5019-32.
    • (2008) Oncogene , vol.27 , pp. 5019-5032
    • Osipo, C.1    Patel, P.2    Rizzo, P.3
  • 38
    • 22244460522 scopus 로고    scopus 로고
    • Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
    • Zeng Q, Li S, Chepeha DB, et al. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell 2005;8:13-23.
    • (2005) Cancer Cell , vol.8 , pp. 13-23
    • Zeng, Q.1    Li, S.2    Chepeha, D.B.3
  • 39
    • 77953414969 scopus 로고    scopus 로고
    • Notch regulates the angiogenic response via induction of VEGFR-1
    • Funahashi Y, Shawber CJ, Vorontchikhina M, et al. Notch regulates the angiogenic response via induction of VEGFR-1. J Angiogenes Res 2010;2:3.
    • (2010) J Angiogenes Res , vol.2 , pp. 3
    • Funahashi, Y.1    Shawber, C.J.2    Vorontchikhina, M.3
  • 40
    • 36048978608 scopus 로고    scopus 로고
    • Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
    • Shawber CJ, Funahashi Y, Francisco E, et al. Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest 2007;117:3369-82.
    • (2007) J Clin Invest , vol.117 , pp. 3369-3382
    • Shawber, C.J.1    Funahashi, Y.2    Francisco, E.3
  • 41
    • 0036433637 scopus 로고    scopus 로고
    • Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression
    • Taylor KL, Henderson AM, Hughes CC. Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvasc Res 2002;64:372-83.
    • (2002) Microvasc Res , vol.64 , pp. 372-383
    • Taylor, K.L.1    Henderson, A.M.2    Hughes, C.C.3
  • 42
    • 33748359703 scopus 로고    scopus 로고
    • Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer
    • Patel NS, Dobbie MS, Rochester M, et al. Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. Clin Cancer Res 2006;12:4836-44.
    • (2006) Clin Cancer Res , vol.12 , pp. 4836-4844
    • Patel, N.S.1    Dobbie, M.S.2    Rochester, M.3
  • 43
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • Noguera-Troise I, Daly C, Papadopoulos NJ, et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006;444:1032-7.
    • (2006) Nature , vol.444 , pp. 1032-1037
    • Noguera-Troise, I.1    Daly, C.2    Papadopoulos, N.J.3
  • 45
    • 18044387648 scopus 로고    scopus 로고
    • Raf kinase as a target for anticancer therapeutics
    • Sridhar SS, Hedley D, Siu LL. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther 2005;4:677-85.
    • (2005) Mol Cancer Ther , vol.4 , pp. 677-685
    • Sridhar, S.S.1    Hedley, D.2    Siu, L.L.3
  • 46
    • 74549133972 scopus 로고    scopus 로고
    • Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis
    • Mittal S, Subramanyam D, Dey D, Kumar RV, Rangarajan A. Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis. Mol Cancer 2009;8:128.
    • (2009) Mol Cancer , vol.8 , pp. 128
    • Mittal, S.1    Subramanyam, D.2    Dey, D.3    Kumar, R.V.4    Rangarajan, A.5
  • 47
    • 0036734148 scopus 로고    scopus 로고
    • Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
    • Weijzen S, Rizzo P, Braid M, et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med 2002;8:979-86.
    • (2002) Nat Med , vol.8 , pp. 979-986
    • Weijzen, S.1    Rizzo, P.2    Braid, M.3
  • 48
    • 0034738965 scopus 로고    scopus 로고
    • Ras pathway signals are required for notch-mediated oncogenesis
    • Fitzgerald K, Harrington A, Leder P. Ras pathway signals are required for notch-mediated oncogenesis. Oncogene 2000;19:4191-8.
    • (2000) Oncogene , vol.19 , pp. 4191-4198
    • Fitzgerald, K.1    Harrington, A.2    Leder, P.3
  • 49
    • 34547603970 scopus 로고    scopus 로고
    • The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1
    • Liao WR, Hsieh RH, Hsu KW, et al. The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1. Carcinogenesis 2007;28:1867-76.
    • (2007) Carcinogenesis , vol.28 , pp. 1867-1876
    • Liao, W.R.1    Hsieh, R.H.2    Hsu, K.W.3
  • 50
    • 33646415906 scopus 로고    scopus 로고
    • Survival signaling by Notch1: Mammalian target of rapamycin (mTOR)-dependent inhibition of p53
    • Mungamuri SK, Yang X, Thor AD, Somasundaram K. Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53. Cancer Res 2006;66:4715-24.
    • (2006) Cancer Res , vol.66 , pp. 4715-4724
    • Mungamuri, S.K.1    Yang, X.2    Thor, A.D.3    Somasundaram, K.4
  • 51
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-7.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 53
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-8.
    • (2003) Cancer Res , vol.63 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 54
    • 18944375734 scopus 로고    scopus 로고
    • Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
    • Dontu G, Jackson KW, McNicholas E, et al. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res 2004;6:R605-15.
    • (2004) Breast Cancer Res , vol.6
    • Dontu, G.1    Jackson, K.W.2    McNicholas, E.3
  • 55
    • 34247581697 scopus 로고    scopus 로고
    • Novel cell culture technique for primary ductal carcinoma in situ: Role of Notch and epidermal growth factor receptor signaling pathways
    • Farnie G, Clarke RB, Spence K, et al. Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. J Natl Cancer Inst 2007;99:616-27.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 616-627
    • Farnie, G.1    Clarke, R.B.2    Spence, K.3
  • 56
    • 33847637262 scopus 로고    scopus 로고
    • p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres
    • Sansone P, Storci G, Giovannini C, et al. p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres. Stem Cells 2007;25:807-15.
    • (2007) Stem Cells , vol.25 , pp. 807-815
    • Sansone, P.1    Storci, G.2    Giovannini, C.3
  • 57
    • 36849039660 scopus 로고    scopus 로고
    • IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    • Sansone P, Storci G, Tavolari S, et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest 2007;117:3988-4002.
    • (2007) J Clin Invest , vol.117 , pp. 3988-4002
    • Sansone, P.1    Storci, G.2    Tavolari, S.3
  • 58
    • 69049107970 scopus 로고    scopus 로고
    • Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors
    • Bane AL, Pinnaduwage D, Colby S, et al. Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors. Breast Cancer Res Treat 2009; 117:183-91.
    • (2009) Breast Cancer Res Treat , vol.117 , pp. 183-191
    • Bane, A.L.1    Pinnaduwage, D.2    Colby, S.3
  • 59
    • 63849329353 scopus 로고    scopus 로고
    • A functional Notch-survivin gene signature in basal breast cancer
    • Lee CW, Simin K, Liu Q, et al. A functional Notch-survivin gene signature in basal breast cancer. Breast Cancer Res 2008;10:R97.
    • (2008) Breast Cancer Res , vol.10
    • Lee, C.W.1    Simin, K.2    Liu, Q.3
  • 60
    • 0242456129 scopus 로고    scopus 로고
    • Notch signaling as a therapeutic target in cancer: A new approach to the development of cell fate modifying agents
    • Nickoloff BJ, Osborne BA, Miele L. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents. Oncogene 2003;22:6598-608.
    • (2003) Oncogene , vol.22 , pp. 6598-6608
    • Nickoloff, B.J.1    Osborne, B.A.2    Miele, L.3
  • 62
    • 18844386841 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors
    • Paris D, Quadros A, Patel N, et al. Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors. Eur J Pharmacol 2005;S14:1-15.
    • (2005) Eur J Pharmacol , vol.14 , pp. 1-15
    • Paris, D.1    Quadros, A.2    Patel, N.3
  • 63
    • 75349105363 scopus 로고    scopus 로고
    • NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts
    • Fan X, Khaki L, Zhu TS, et al. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 2010;28:5-16.
    • (2010) Stem Cells , vol.28 , pp. 5-16
    • Fan, X.1    Khaki, L.2    Zhu, T.S.3
  • 64
    • 33847083871 scopus 로고    scopus 로고
    • Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling
    • Lewis HD, Leveridge M, Strack PR, et al. Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling. Chem Biol 2007;14: 209-19.
    • (2007) Chem Biol , vol.14 , pp. 209-219
    • Lewis, H.D.1    Leveridge, M.2    Strack, P.R.3
  • 66
    • 0842324623 scopus 로고    scopus 로고
    • Multiple niches for Notch in cancer: Context is everything
    • Weng AP, Aster JC. Multiple niches for Notch in cancer: context is everything. Curr Opin Genet Dev 2004;14:48-54.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 48-54
    • Weng, A.P.1    Aster, J.C.2
  • 67
    • 78751503445 scopus 로고    scopus 로고
    • Targeting notch signalling and estrogen receptor pathways in human breast cancer stem cells
    • Abstract 22066
    • Luraguiz N. Targeting notch signalling and estrogen receptor pathways in human breast cancer stem cells. American Society of Clinical Oncology Annual Meeting 2008: Abstract 22066.
    • American Society of Clinical Oncology Annual Meeting 2008
    • Luraguiz, N.1
  • 68
    • 67149138004 scopus 로고    scopus 로고
    • Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells
    • Rasul S, Balasubramanian R, Filipovic A, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer 2009;100:1879-88.
    • (2009) Br J Cancer , vol.100 , pp. 1879-1888
    • Rasul, S.1    Balasubramanian, R.2    Filipovic, A.3
  • 69
    • 77950292495 scopus 로고    scopus 로고
    • Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model
    • Efferson CL, Winkelmann CT, Ware C, et al. Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. Cancer Res 2010;70:2476-84.
    • (2010) Cancer Res , vol.70 , pp. 2476-2484
    • Efferson, C.L.1    Winkelmann, C.T.2    Ware, C.3
  • 70
    • 78751487556 scopus 로고    scopus 로고
    • The additive effects of gamma secretase inhibitor and ionizing radiation in MDA-MD-231 breast cancer cell line
    • Abstract 14594
    • Chi A. The additive effects of gamma secretase inhibitor and ionizing radiation in MDA-MD-231 breast cancer cell line. American Society of Clinical Oncology Annual Meeting 2008: Abstract 14594.
    • American Society of Clinical Oncology Annual Meeting 2008
    • Chi, A.1
  • 71
    • 77951139188 scopus 로고    scopus 로고
    • Therapeutic antibody targeting of individual Notch receptors
    • Wu Y, Cain-Hom C, Choy L, et al. Therapeutic antibody targeting of individual Notch receptors. Nature 2010;464:1052-7.
    • (2010) Nature , vol.464 , pp. 1052-1057
    • Wu, Y.1    Cain-Hom, C.2    Choy, L.3
  • 72
    • 50849111710 scopus 로고    scopus 로고
    • Rational targeting of Notch signaling in cancer
    • Rizzo P, Osipo C, Foreman K, et al. Rational targeting of Notch signaling in cancer. Oncogene 2008;27:5124-31.
    • (2008) Oncogene , vol.27 , pp. 5124-5131
    • Rizzo, P.1    Osipo, C.2    Foreman, K.3
  • 73
    • 78751506527 scopus 로고    scopus 로고
    • Phase 1 pharmacokinetic (PK), and phrmacodynamic (PD) trial of the novel oral Notch inhibitor MK-0752 in patients (pts) with advanced breast cancer (BC) and other solid tumors
    • Abstract 10574
    • Krop I. Phase 1 pharmacokinetic (PK), and phrmacodynamic (PD) trial of the novel oral Notch inhibitor MK-0752 in patients (pts) with advanced breast cancer (BC) and other solid tumors. American Society of Clinical Oncology 2006 Annual Meeting: Abstract 10574.
    • American Society of Clinical Oncology 2006 Annual Meeting
    • Krop, I.1
  • 74
    • 78751488565 scopus 로고    scopus 로고
    • A Notch Signalling Pathway Inhibitor for Patients with Advanced Breast Cancer (0752-014)
    • Merck. [Internet] Bethesda, MD: National Library of Medicine, Available from
    • Merck. A Notch Signalling Pathway Inhibitor for Patients with Advanced Breast Cancer (0752-014). Clinical Trialsgov [Internet] Bethesda, MD: National Library of Medicine, 2000. Available from: http//clinicaltrials.gov/show/ NCT00106145.
    • (2000) Clinical Trialsgov
  • 75
    • 78751497834 scopus 로고    scopus 로고
    • Study of MK-0752 in combination with tamoxifen or letrozole to Treat Early Stage Breast Cancer
    • University L. [Internet]. Bethesda, MD: National Library of Medicine (US); Available from
    • University L. Study of MK-0752 in combination with tamoxifen or letrozole to Treat Early Stage Breast Cancer. Clinical Trialsgov [Internet]. Bethesda, MD: National Library of Medicine (US); 2000. Available from: http//clinicaltrials.gov/show/NCT00756717.
    • (2000) Clinical Trialsgov
  • 76
    • 78751495762 scopus 로고    scopus 로고
    • Phase I/II study of MK-0752 followed by Docetaxel in Advanced Metastatic Breast Cancer
    • Center UoM. [Internet]. Bethesda, MD: National Library of Medicine (US); Available from
    • Center UoM. Phase I/II study of MK-0752 followed by Docetaxel in Advanced Metastatic Breast Cancer. Clinical Trials.gov [Internet]. Bethesda, MD: National Library of Medicine (US); 2000. Available from: http://clinicaltrials. gov/show/NCT00645333.
    • (2000) Clinical Trials.gov
  • 78
    • 78751542032 scopus 로고    scopus 로고
    • GDC-0449 and R04929097 in Treating Women with Advanced Breast Cancer
    • Institute BAKC. [Internet]. Bethesda, MD: National Library of Medicine (US); Available from
    • Institute BAKC. GDC-0449 and R04929097 in Treating Women with Advanced Breast Cancer. Clinical Trialsgov [Internet]. Bethesda, MD: National Library of Medicine (US); 2000. Available from: http://clinicaltrials.gov/show/NCT01071564.
    • (2000) Clinical Trialsgov
  • 79
    • 0036070186 scopus 로고    scopus 로고
    • Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation
    • Lawson ND, Vogel AM, Weinstein BM. Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 2002;3:127-36.
    • (2002) Dev Cell , vol.3 , pp. 127-136
    • Lawson, N.D.1    Vogel, A.M.2    Weinstein, B.M.3
  • 80
    • 18944407603 scopus 로고    scopus 로고
    • Mammary stem cells, self-renewal pathways, and carcinogenesis
    • DOI 10.1186/bcr1021, 86
    • Liu S, Dontu G, Wicha MS. Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res 2005;7:86-95. (Pubitemid 40704127)
    • (2005) Breast Cancer Research , vol.7 , Issue.3 , pp. 86-95
    • Liu, S.1    Dontu, G.2    Wicha, M.S.3
  • 81
    • 77955842543 scopus 로고    scopus 로고
    • Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS)
    • Bai F, Tagen M, Colotta C, et al. Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci 2010;878:2348-52.
    • (2010) J Chromatogr B Analyt Technol Biomed Life Sci , vol.878 , pp. 2348-2352
    • Bai, F.1    Tagen, M.2    Colotta, C.3
  • 82
    • 70350236531 scopus 로고    scopus 로고
    • Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties
    • Luistro L, He W, Smith M, et al. Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. Cancer Res 2009;69: 7672-80.
    • (2009) Cancer Res , vol.69 , pp. 7672-7680
    • Luistro, L.1    He, W.2    Smith, M.3
  • 83
    • 66749119621 scopus 로고    scopus 로고
    • Evidence for allosteric interactions of antagonist binding to the smoothened receptor
    • Rominger CM, Bee WL, Copeland RA, et al. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther 2009;329:995-1005.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 995-1005
    • Rominger, C.M.1    Bee, W.L.2    Copeland, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.