Inhibition of angiogenesis and tumor growth by β and γ-secretase inhibitors

European Journal of Pharmacology

Volumn 514, Issue 1, 2005, Pages 1-15

  Paris, Daniel ^a   Quadros, Amita ^a   Patel, Nikunj ^a   DelleDonne, Anthony ^a   Humphrey, James ^a   Mullan, Michael ^a  

^a ROSKAMP INSTITUTE   (United States)

Author keywords

Amyloid precursor protein; Angiogenesis; Presenilin; Secretase; Tumor growth

Indexed keywords

7 AMINO 4 CHLORO 3 METHOXYISOCOUMARIN; [BENZYL[1 (CARBAMOYL 2 PHENYLETHYLCARBAMOYL) 3 METHYLBUTYLCARBAMOYL]HYDROXY 5 PHENYLPENTYL]CARBAMIC ACID TERT BUTYL ESTER; AMYLOID BETA PROTEIN; BETA SECRETASE; BETA SECRETASE INHIBITOR; CARBAMIC ACID DERIVATIVE; ESTER DERIVATIVE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; ISOCOUMARIN DERIVATIVE; L 685458; L 685485; N [N (3,5 DIFLUOROPHENACETYLALANYL)]PHENYLGLYCINE TERT BUTYL ESTER; OM 99 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANGIOGENESIS; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG SELECTIVITY; ENDOTHELIUM; ERYTHROLEUKEMIA; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ADENOCARCINOMA; MEDICAL RESEARCH; MICROVASCULATURE; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE; PRIORITY JOURNAL; RAT; SEQUENCE HOMOLOGY; TUMOR GROWTH; XENOTRANSPLANTATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; CAPILLARIES; CARBAMATES; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; ENDOTHELIAL CELLS; FEMALE; HUMANS; MICE; MICE, NUDE; MORPHOGENESIS; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; OLIGOPEPTIDES; PROTEASE INHIBITORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 18844386841     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.02.050     Document Type: Article

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