Amyloid-β decreases nitric oxide production in cultured retinal neurons: A possible mechanism for synaptic dysfunction in alzheimer's disease?

Neurochemical Research

Volumn 36, Issue 1, 2011, Pages 163-169

  Oliveira, Leandro T ^a   Louzada, Paulo Roberto ^a   De Mello, Fernando G ^a   Ferreira, Sérgio T ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Alzheimer's disease; Amyloid ; Neurotoxicity; Nitric oxide; Nitric oxide syntase; Retina

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; GLUTAMATE RECEPTOR; GLUTAMIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; INCUBATION TIME; NERVE CELL CULTURE; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RETINA NERVE CELL; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CELLS, CULTURED; CHICK EMBRYO; ENZYME INHIBITORS; GLUTAMIC ACID; NEURONS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; PEPTIDE FRAGMENTS; RETINA; SYNAPSES;

EID: 78651291545     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-010-0287-z     Document Type: Article

References (60)

1. DJ Selkoe 2001 Alzheimer's disease: genes, proteins, and therapy Physiol Rev 81 741 766 1:CAS:528:DC%2BD3MXislCrsLc%3D 11274343
2. MP Mattson 2004 Pathways towards and away from Alzheimer's disease Nature 5 631 639 10.1038/nature02621 (Pubitemid 39061671)
3. DJ Selkoe 1999 Translating cell biology into therapeutic advances in Alzheimer's disease Nature 24 23 31
4. X Zhu G Perry PI Moreira G Aliev AD Cash K Hirai VA Smith 2006 Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease J Alzheimers Dis 9 147 153 16873962 (Pubitemid 44078642)
5. C Haass DJ Selkoe 2007 Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide Nat Rev Mol Cell Biol 8 101 112 1:CAS:528:DC%2BD2sXotFKmtw%3D%3D 10.1038/nrm2101 17245412 (Pubitemid 46432529)
6. ST Ferreira MN Vieira FG De Felice 2007 Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases IUBMB Life 59 332 345 1:CAS:528:DC%2BD2sXlt1Kqsrc%3D 10.1080/15216540701283882 17505973 (Pubitemid 46763764)
7. CJ Pike AJ Walencewicz CG Glabe CW Cotman 1991 In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity Brain Res 1 311 314 10.1016/0006-8993(91)91553-D
8. NW Kowall AC McKee BA Yankner MF Beal 1992 In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment Neurobiol Aging 13 537 542 1:CAS:528:DyaK3sXltlOgtQ%3D%3D 10.1016/0197-4580(92)90053-Z 1461341
9. PR Louzada AC Paula-Lima FG de Mello ST Ferreira 2001 Dual role of glutamatergic neurotransmission on amyloid beta(1-42) aggregation and neurotoxicity in embryonic avian retina Neurosci Lett 23 59 63 10.1016/S0304-3940(01)01585-3 (Pubitemid 32182394)
10. PR Louzada AC Lima DL Mendonca-Silva F Noel FG De Mello ST Ferreira 2004 Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders FASEB J 18 511 518 1:CAS:528:DC%2BD2cXisFWks7s%3D 10.1096/fj.03-0739com 15003996 (Pubitemid 38326307)
11. FG De Felice PT Velasco MP Lambert K Viola SJ Fernandez ST Ferreira WL Klein 2007 Abeta oligomers induce neuronal oxidative stress through an N-methyl-d-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine J Biol Chem 13 11590 11601 10.1074/jbc.M607483200 (Pubitemid 47100810)
12. GM Shankar BL Bloodgood M Townsend DM Walsh DJ Selkoe BL Sabatini 2007 Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway J Neurosci Mar 14 2866 2875 10.1523/JNEUROSCI.4970-06.2007 (Pubitemid 46438992)
13. HO McCarthy JA Coulter T Robson DG Hirst 2008 Gene therapy via inducible nitric oxide synthase: a tool for the treatment of a diverse range of pathological conditions J Pharm Pharmacol 60 8 999 1017 1:CAS:528: DC%2BD1cXptFCjsL8%3D 10.1211/jpp.60.8.0007 18644193
14. S Moncada EA Higgs 2006 Nitric oxide and the vascular endothelium Handb Exp Pharmacol 176 213 254 10.1007/3-540-32967-6-7 16999221
15. S Moncada JP Bolanos 2006 Nitric oxide, cell bioenergetics and neurodegeneration J Neurochem 97 1676 1689 1:CAS:528:DC%2BD28Xnt1Ons7Y%3D 10.1111/j.1471-4159.2006.03988.x 16805776 (Pubitemid 43873660)
16. JS Beckman WH Koppenol 1996 Nitric oxide, superoxide and peroxinitrite: The good, the bad and the ugly Am J Phys 71 1424 1437
17. U Keil A Bonert CA Marques I Scherping J Weyermann JB Strosznajder F Muller-Spahn C Haass C Czech L Pradier WE Muller A Eckert 2004 Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis J Biol Chem 26 50310 50320 10.1074/jbc.M405600200 (Pubitemid 39577847)
18. U Keil A Bonert CA Marques JB Strosznajder F Muller-Spahn WE Muller A Eckert 2004 Elevated nitric oxide production mediates beta-amyloid-induced mitochondria failure Pol J Pharmacol 56 631 634 1:CAS:528:DC%2BD2MXisVeit70%3D 15591653
19. Z Xie M Wei TE Morgan P Fabrizio D Han CE Finch VD Longo 2002 Peroxynitrite mediates neurotoxicity of amyloid beta-peptide 1-42- and lipopolysaccharide-activated microglia J Neurosci 22 3484 3492 1:CAS:528:DC%2BD38Xjs1SgsrY%3D 11978825
20. G Venturini M Colasanti T Persichini E Fioravanti P Ascenzi L Palomba O Cantoni G Musci 2002 Beta-amyloid inhibits NOS activity by subtracting NADPH availability FASEB J 16 1970 1972 1:CAS:528:DC%2BD38Xps1OjsLg%3D 12397094
21. TC Ju SD Chen CC Liu DI Yang 2005 Protective effects of S-nitrosoglutathione against amyloid beta-peptide neurotoxicity Free Radic Biol Med 1 938 949 10.1016/j.freeradbiomed.2004.12.019 (Pubitemid 40326195)
22. GR Thatcher BM Bennett JN Reynolds 2006 NO chimeras as therapeutic agents in Alzheimer's disease Curr Alzheimer Res 3 237 245 1:CAS:528: DC%2BD28XntFGlsbk%3D 10.2174/156720506777632925 16842101 (Pubitemid 43988137)
23. EP Huang 1997 Synaptic plasticity: a role for nitric oxide in LTP Curr Biol 1 141 143 10.1016/S0960-9822(97)70073-3
24. C Holscher 1997 Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity Trends Neurosci 20 298 303 1:CAS:528:DyaK2sXksVCjtbY%3D 10.1016/S0166-2236(97)01065-5 9223222 (Pubitemid 27348739)
25. RA Hopper J Garthwaite 2006 Tonic and phasic nitric oxide signals in hippocampal long-term potentiation J Neurosci 8 11513 11521 10.1523/JNEUROSCI. 2259-06.2006 (Pubitemid 44772122)
26. HW Wang JF Pasternak H Kuo H Ristic MP Lambert B Chromy KL Viola WL Klein WB Stine GA Krafft BL Trommer 2002 Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus Brain Res 11 133 140 10.1016/S0006-8993(01)03058-X (Pubitemid 34102301)
27. DM Walsh I Klyubin JV Fadeeva WK Cullen R Anwyl MS Wolfe MJ Rowan DJ Selkoe 2002 Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo Nature 4 535 539 10.1038/416535a (Pubitemid 34288854)
28. PN Lacor MC Buniel PW Furlow AS Clemente PT Velasco M Wood KL Viola WL Klein 2007 Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease J Neurosci 24 796 807 10.1523/JNEUROSCI.3501-06.2007 (Pubitemid 46174498)
29. FG De Felice MN Vieira TR Bomfim H Decker PT Velasco MP Lambert KL Viola WQ Zhao ST Ferreira WL Klein 2009 Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers Proc Natl Acad Sci USA 10 1971 1976 10.1073/pnas.0809158106
30. N Origlia S Capsoni A Cattaneo F Fang O Arancio SD Yan L Domenici 2009 Abeta-dependent inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE J Alzheimers Dis 17 59 68 1:CAS:528: DC%2BD1MXmsFKgu7Y%3D 19221410
31. FG De Felice JC Houzel J Garcia-Abreu PR Louzada Jr RC Afonso MN Meirelles R Lent VM Neto ST Ferreira 2001 Inhibition of Alzheimer's disease beta-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy FASEB J 15 1297 1299 11344119
32. AC Paula-Lima PR Louzada FG De Mello ST Ferreira 2003 Neuroprotection against Abeta and glutamate toxicity by melatonin: are GABA receptors involved? Neurotox Res 5 323 327 10.1007/BF03033152 14715451
33. S Hossain M Hashimoto M Katakura K Miwa T Shimada O Shido 2009 Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells J Neurochem 111 568 579 1:CAS:528:DC%2BD1MXhtlSitrbI 10.1111/j.1471-4159.2009.06336.x 19686246
34. AC Paula-Lima FG De Felice J Brito-Moreira ST Ferreira 2005 Activation of GABA(A) receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in rat hippocampal and cortical neurons Neuropharmacology 49 1140 1148 1:CAS:528:DC%2BD2MXht1ejs77P 10.1016/j.neuropharm.2005.06.015 16150468 (Pubitemid 41608638)
35. LC Green DA Wagner J Glogowski PL Skipper JS Wishnok SR Tannenbaum 1982 Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids Anal Biochem 126 131 138 1:CAS:528:DyaL38XlvFGgtLY%3D 10.1016/0003-2697(82)90118-X 7181105 (Pubitemid 13203451)
36. Feelisch M, Stamler JS (1996) Methods in nitric oxide research. Wiley, USA
37. C Romano Q Chen JW Olney 1998 The intact isolated (ex vivo) retina as a model system for the study of excitotoxicity Prog Retin Eye Res 17 465 483 1:CAS:528:DyaK1cXmvFSqurw%3D 10.1016/S1350-9462(98)00008-1 9777647 (Pubitemid 28432978)
38. H Yin L Chen X Chen X Liu 2008 Soluble amyloid beta oligomers may contribute to apoptosis of retinal ganglion cells in glaucoma Med Hypotheses 71 77 80 1:CAS:528:DC%2BD1cXmsVGntbY%3D 10.1016/j.mehy.2008.01.030 18406539
39. T Dentchev AH Milam VM Lee JQ Trojanowski JL Dunaief 2003 Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas Mol Vis 14 184 190
40. A Ning J Cui E To KH Ashe J Matsubara 2008 Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease Invest Ophthalmol Vis Sci 49 5136 5143 10.1167/iovs.08-1849 18566467
41. MP Mattson 2003 Excitotoxic, excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders Neuromol Med 3 65 94 1:CAS:528:DC%2BD3sXksFGmt78%3D 10.1385/NMM:3:2:65 (Pubitemid 37012494)
42. SA Lipton 2006 Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond Nat Rev Drug Discov 5 160 170 1:CAS:528:DC%2BD28Xhslaquro%3D 10.1038/nrd1958 16424917
43. S O'Mahony T Harkany AA Rensink I Abraham GI De Jong JL Varga M Zarandi B Penke C Nyakas PG Luiten BE Leonard 1998 Beta-amyloid-induced cholinergic denervation correlates with enhanced nitric oxide synthase activity in rat cerebral cortex: reversal by NMDA receptor blockade Brain Res Bull 45 405 411 10.1016/S0361-9230(97)00405-X 9527015 (Pubitemid 28144619)
44. C Nathan N Calingasan J Nezezon A Ding MS Lucia K La Perle M Fuortes M Lin S Ehrt NS Kwon J Chen Y Vodovotz K Kipiani MF Beal 2005 Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase J Exp Med 7 1163 1169 10.1084/jem.20051529 (Pubitemid 41586946)
45. DK Lahiri D Chen YW Ge M Farlow G Kotwal A Kanthasamy DK Ingram NH Greig 2003 Does nitric oxide synthase contribute to the pathogenesis of Alzheimer's disease? Effects of beta-amyloid deposition on NOS in transgenic mouse brain with AD pathology Ann NY Acad Sci 1010 639 642 1:CAS:528:DC%2BD2cXisFeru7g%3D 10.1196/annals.1299.117 15033804 (Pubitemid 38265058)
46. I Margaill M Allix RG Boulu M Plotkine 1997 Dose- and time-dependence of l-NAME neuroprotection in transient focal cerebral ischaemia in rats Br J Pharmacol 120 160 163 1:CAS:528:DyaK2sXot12ltw%3D%3D 10.1038/sj.bjp.0700889 9117092 (Pubitemid 27042575)
47. HS Sharma RD Badgaiyan P Alm S Mohanty L Wiklund 2005 Neuroprotective effects of nitric oxide synthase inhibitors in spinal cord injury-induced pathophysiology and motor functions: an experimental study in the rat Ann NY Acad Sci 1053 422 434 1:CAS:528:DC%2BD28XotlKqug%3D%3D 10.1196/annals.1344.037 16179549 (Pubitemid 43031123)
48. JM Galasso TJ Bazzett JB Becker RL Albin 1995 Synergistic effect of intrastriatal co-administration of l-NAME and quinolinic acid Neuroreport 31 1505 1508 10.1097/00001756-199507310-00010
49. F Perez-Severiano B Escalante C Rios 1998 Nitric oxide synthase inhibition prevents acute quinolinate-induced striatal neurotoxicity Neurochem Res 23 1297 1302 1:CAS:528:DyaK1cXmvVOrs7o%3D 10.1023/A:1020700401678 9804286 (Pubitemid 28495700)
50. R Zhang L Zhang Z Zhang Y Wang M Lu M Lapointe M Chopp 2001 A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats Ann Neurol 50 602 611 1:CAS:528:DC%2BD3MXovVGhtbs%3D 10.1002/ana.1249 11706966 (Pubitemid 33021918)
51. A Hashiguchi S Yano M Morioka J Hamada Y Ushio Y Takeuchi 2004 K.Fukunaga Up-regulation of endothelial nitric oxide synthase via phosphatidylinositol 3-kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil hippocampus J Cereb Blood Flow Metab 24 271 279 1:CAS:528:DC%2BD2cXjtFejs7k%3D 10.1097/01.WCB.0000110539.96047.FC 15091107
52. M Endres U Laufs JK Liao MA Moskowitz 2004 Targeting eNOS for stroke protection Trends Neurosci 27 283 289 1:CAS:528:DC%2BD2cXjtl2luro%3D 10.1016/j.tins.2004.03.009 15111011 (Pubitemid 38529957)
53. NJ Patel MJ Chen AA Russo-Neustadt 2010 Norepinephrine and nitric oxide promote cell survival signaling in hippocampal neurons Eur J Pharmacol 10 1 9 10.1016/j.ejphar.2010.01.012
54. IM Araujo AF Ambrosio EC Leal PF Santos AP Carvalho CM Carvalho 2003 Neuronal nitric oxide synthase proteolysis limits the involvement of nitric oxide in kainate-induced neurotoxicity in hippocampal neurons J Neurochem 85 791 800 1:CAS:528:DC%2BD3sXnslyrtr4%3D 10.1046/j.1471-4159.2003.01731.x 12694405
55. AM Lopez-Colome E Lopez 2003 Glutamate receptors coupled to nitric oxide synthesis in embryonic retina Dev Neurosci 25 293 300 1:CAS:528: DC%2BD3sXovVOgtro%3D 10.1159/000073505 14614255 (Pubitemid 37465054)
56. RD Hawkins H Son O Arancio 1998 Nitric oxide as a retrograde messenger during long-term potentiation in hippocampus Prog Brain Res 118 155 172 1:STN:280:DyaK1M7jtFagsA%3D%3D 10.1016/S0079-6123(08)63206-9 9932440
57. SH Yun G Gamkrelidze WB Stine PM Sullivan JF Pasternak MJ Ladu BL Trommer 2006 Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus Neurosci Lett 31 162 165 10.1016/j.neulet.2006.04.065 (Pubitemid 43977795)
58. JM Zhang MN Wu JS Qi JT Qiao 2006 Amyloid beta-protein fragment 31-35 suppresses long-term potentiation in hippocampal CA1 region of rats in vivo Synapse 60 307 313 1:CAS:528:DC%2BD28Xot1Onsrs%3D 10.1002/syn.20302 16786537 (Pubitemid 44134351)
59. D Puzzo O Arancio 2006 Fibrillar beta-amyloid impairs the late phase of long term potentiation Curr Alzheimer Res 3 179 183 1:CAS:528: DC%2BD28XntFGlsLY%3D 10.2174/156720506777632871 16842092 (Pubitemid 43988129)
60. BE Bisel KM Henkins KD Parfitt 2007 Alzheimer amyloid beta-peptide Abeta25-35 blocks adenylate cyclase-mediated forms of hippocampal long-term potentiation Ann NY Acad Sci 1097 58 63 1:CAS:528:DC%2BD2sXks1yrs78%3D 10.1196/annals.1379.020 17413011 (Pubitemid 47084895)