Neuroprotection against Aβ and glutamate toxicity by melatonin: Are GABA receptors involved?

Neurotoxicity Research

Volumn 5, Issue 5, 2003, Pages 323-327

  Lima, Andréa C Paula ^a   Louzada, Paulo Roberto ^a   Mello, Fernando G ^a   Ferreira, Sérgio T ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Amyloid; GABA; Glutamate; Melatonin; Neuroprotection

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR BLOCKING AGENT; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); ANTIOXIDANT; FLUORESCENT DYE; GLUTAMIC ACID; MELATONIN; PEPTIDE FRAGMENT; PICROTOXIN; THIAZOLE DERIVATIVE; THIOFLAVINE;

ANIMAL; ARTICLE; CHICK EMBRYO; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; LIGHT; NERVE CELL; RADIATION SCATTERING; RETINA;

AMYLOID BETA-PROTEIN; ANIMALS; ANTIOXIDANTS; CHICK EMBRYO; EXCITATORY AMINO ACID ANTAGONISTS; FLUORESCENT DYES; GABA ANTAGONISTS; GLUTAMIC ACID; LIGHT; MELATONIN; NEURONS; PEPTIDE FRAGMENTS; PICROTOXIN; RECEPTORS, GABA; RETINA; SCATTERING, RADIATION; THIAZOLES;

EID: 1242264014     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033152     Document Type: Article

References (13)

1. Blanchard BJ, G Konopka, M Russell and VM Ingram (1997) Mechanism and prevention of neurotoxicity caused by beta-amyloid peptides: Relation to Alzheimer's disease. Brain Res. 776, 40-50.
2. Espinar A, A Garcia-Oliva, EM Isorna, A Quesada, FA Prada and JM Guerrero (2000) Neuroprotection by melatonin from glutamate-induced excitotoxicity during development of the cerebellum in the chick embryo. J. Pineal Res. 28, 81-88.
3. Lipton SA and PA Rosemberg (1994) Excitatory amino acids as a final common pathway for neurologic disorders. New Engl. J. Med. 330, 613-622.
4. 1-42 aggregation and neurotoxicity in embryonic avian retina. Neurosci. Lett. 301, 59-63.
5. Mattson MP, B Cheng, D Davis, K Bryant, I Liberbug and RE Rydel (1992) β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vunerable to excitotoxicity. J. Neurosci. 12, 376-389.
6. Niles LP (1991) Melatonin interaction with the benzodiazepine-GABA receptor complex in the CNS in kinurenine and serotonine pathways: progress in trytophan research. Adv. Exp. Med. Biol. 294, 267-277.
7. Pappolla MA, M Sos, RA Omar, RJ Bick, DL Hickson-Bick, RJ Reiter, S Efthimiopoulos and NK Robakis (1997) Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. J. Neurosci. 17, 1683-1690.
8. Pappolla MA, P Bozner, C Soto, H Shao, NK Robakis, M Zagorski, B Frangioni and J Ghiso (1998) Inhibition of Alzheimer β-fibrilogenesis by melatonin. J. Biol. Chem. 273, 7185-7188.
9. Pappola MA, MJ Simovich, T Bryant-Thomas, Y-J Chyan, B Poeggler, M Dubocovich, R Bick, G Perry, F Cruz-Sanchez and SA Smith (2002) The neuroprotective effects of melatonin against the Alzheimer β-protein are not mediated by melatonin membrane receptors. J. Pineal Res. 32, 135-142.
10. Tan DX, LC Manchester, RJ Reiter, W Qi, SJ Kim and GH El-Sokkary (1998) Melatonin protects hippocampal neurons in vivo against kainic acid-induced damage in mice. J. Neurosci. Res. 54, 382-389.
11. Tenn CC and LP Niles (1995) Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: Involvement of a GABAergic mechanism. J. Pharmacol. Exp. Ther. 274, 84-89.
12. Tenn CC and LP Niles (1997) Mechanisms underlying the antidopaminergic effect of clonazepam and melatonin in striatum. Neuropharmacology 36, 1659-1663.
13. Westlind-Danielsson AW and G Arnerup (2001) Spontaneous in vitro formation of supramolecular β-amyloid structures, "β-amy balls", byβ-amyloid 1-40 peptide. Biochemistry 40, 14376-14743.